Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi393 – 400ATP8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbA (EC:3.6.3.-)
Gene namesi
Name:msbA
Ordered Locus Names:Sden_2199
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001982 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalAdd BLAST21
Transmembranei80 – 100HelicalAdd BLAST21
Transmembranei159 – 179HelicalAdd BLAST21
Transmembranei182 – 202HelicalAdd BLAST21
Transmembranei267 – 287HelicalAdd BLAST21
Transmembranei295 – 315HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716521 – 600Lipid A export ATP-binding/permease protein MsbAAdd BLAST600

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi318161.Sden_2199.

Structurei

3D structure databases

ProteinModelPortaliQ12M46.
SMRiQ12M46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 327ABC transmembrane type-1Add BLAST301
Domaini359 – 596ABC transporterAdd BLAST238

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12M46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASPKNEMS TVFKRLMTYV MPMKGMLTLS ILGLIVYGLV DAAFIAFIKP
60 70 80 90 100
FIDEGFSQNP TVVAGVELPT SGGFSANKDV MLMAPLVVIG MFTLRGVANF
110 120 130 140 150
VSTYCISYLS AQLIMDMRQQ VFEHYLRLPV SYIDRENSGN LISRVTFDTE
160 170 180 190 200
QIARASGSAL ISIVRDSITV IGMLALMFFY SWKLSLCILV IGPLMGVVIS
210 220 230 240 250
IVSKRFRKVS VQIQSAMGGV TATTEQMIKG HKNVLSFGGQ ETESKRFYEV
260 270 280 290 300
NDRNRYQNMK LAMAQSVSQP VIMIIGSFAL AFVLYAASLD SMKLELTAGT
310 320 330 340 350
FAAILGAMLA MLQPIKNLTR VNAEFQRGIA ACTTVFELLD TLPESDTGAH
360 370 380 390 400
QVERVQGHLR FDNVSFSYPG QAKPALNNID FDVKPGKTVA LVGRSGSGKS
410 420 430 440 450
TMASLITRFY TGLEQGDIRL DDVSIYDYSL KSLRSQVALV SQQVTLFNDS
460 470 480 490 500
IANNIAYAYP GEVSREQILK AATLAHAMEF IEQLPEGLDT QVGENGVLLS
510 520 530 540 550
GGQRQRIAIA RAMLRDAPVL ILDEATSALD TESEKAIQLG LDNLRHNRTS
560 570 580 590 600
IVIAHRLSTI ESADEILVID QGKIIERGTH ASLIEKKGAY AGLYQMQFGE
Length:600
Mass (Da):65,698
Last modified:August 22, 2006 - v1
Checksum:iCAF6A9CA279766EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000302 Genomic DNA. Translation: ABE55480.1.
RefSeqiWP_011496633.1. NC_007954.1.

Genome annotation databases

EnsemblBacteriaiABE55480; ABE55480; Sden_2199.
KEGGisdn:Sden_2199.

Similar proteinsi

Entry informationi

Entry nameiMSBA_SHEDO
AccessioniPrimary (citable) accession number: Q12M46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 22, 2006
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families