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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Biosynthetic arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSDEN318161:G1G6C-2400-MONOMER
UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:Sden_2280
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001982 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000242671 – 636Biosynthetic arginine decarboxylaseAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ12LW6

Interactioni

Protein-protein interaction databases

STRINGi318161.Sden_2280

Structurei

3D structure databases

ProteinModelPortaliQ12LW6
SMRiQ12LW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni286 – 296Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI
OrthoDBiPOG091H04NG

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit

Sequencei

Sequence statusi: Complete.

Q12LW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDWTIEDAR AGYNVTHWSQ GFYGIGEAGE VTVSPDPLNP SNKVALDTLA
60 70 80 90 100
QDLVQAGIAL PVLVRFPQIL HHRVESLCDA FNQAIQKYEY QNDYLLVYPI
110 120 130 140 150
KVNQQKTVVE EILASQVSKE VPQLGLEAGS KPELMAVLAM AQKASSVIVC
160 170 180 190 200
NGYKDKEYVR LALIGEKLGH KVYIVLEKMS ELKMVLEEAR ELGVTPRLGL
210 220 230 240 250
RTRLAFQGKG KWQASGGEKS KFGLSAAQVL KVVDELKEAN MLESLQLLHF
260 270 280 290 300
HLGSQIANIR DIRQGVSEAG RFYCELRQLG ASINCFDVGG GLAVDYDGTR
310 320 330 340 350
SQSNNSMNYG LTEYANNIVN VLTDLCNEYE QPMPRIISES GRHLTAHHAV
360 370 380 390 400
LITDVIGTEA YMPENIQAPA EDAPQLLHNM WQSWTEISGR HDQRAIIEIY
410 420 430 440 450
HDSQSDIAEA HSLFAVGQLS LMDRAWAEQT NLRVCHEVKG LLSNNNRYHR
460 470 480 490 500
PVIDELNEKL ADKLFVNFSL FQSLPDAWGI DQVFPVLPLT CLDKAPERRA
510 520 530 540 550
VMLDITCDSD GIVDQYVDGQ GIETTLPVPA WDPANPYLIG FFMVGAYQEI
560 570 580 590 600
LGDMHNLFGD TNSAVVFVED NGKARIESTL DGDTVADVLR YVNLDADEFM
610 620 630
HTYEELVEQH IVEDERASIL EELQLGLKGY TYLEDF
Length:636
Mass (Da):71,065
Last modified:August 22, 2006 - v1
Checksum:i67F1E19B36DD55CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000302 Genomic DNA Translation: ABE55560.1
RefSeqiWP_011496711.1, NC_007954.1

Genome annotation databases

EnsemblBacteriaiABE55560; ABE55560; Sden_2280
KEGGisdn:Sden_2280

Similar proteinsi

Entry informationi

Entry nameiSPEA_SHEDO
AccessioniPrimary (citable) accession number: Q12LW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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