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Reviewed, UniProtKB/Swiss-Prot Q12LR7 (ASTB_SHEDO)

Last modified June 16, 2009. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    N-succinylarginine dihydrolase
    EC=3.5.3.23
Gene names
Name: astB
Ordered Locus Names: Sden_2329
OrganismShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]
Taxonomic identifier318161 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

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Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO2 By similarity.

Catalytic activity

N(2)-succinyl-L-arginine + 2 H2O = N(2)-succinyl-L-ornithine + 2 NH3 + CO2. HAMAP MF_01172

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5. HAMAP MF_01172

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the succinylarginine dihydrolase family.

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Ontologies

Keywords
   Biological processArginine metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

   Molecular functionN-succinylarginine dihydrolase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444N-succinylarginine dihydrolase HAMAP MF_01172
PRO_0000262374

Regions

Region19 – 2810Substrate binding By similarity
Region137 – 1382Substrate binding By similarity

Sites

Active site1741 By similarity
Active site2501 By similarity
Active site3681Nucleophile By similarity
Binding site1101Substrate By similarity
Binding site2141Substrate By similarity
Binding site2521Substrate By similarity
Binding site3621Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q12LR7-1 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 1C234388F30C80A0

FASTA44448,882
        10         20         30         40         50         60 
MKHFEANFDG LVGPTHNYAG LSFGNVASYS NAAQTANPKA AAKQGLQKAK ALADLGMTQG 

        70         80         90        100        110        120 
VLAPQERPDL YTLRRIGFSG SDAEVIQKAA KQAPALLNAC CSASSMWTAN AATVSPSADT 

       130        140        150        160        170        180 
RDGKVHFTPA NLVDKLHRSI EPITTANILK ATFKDPHFFQ HHAHLPEHAH FGDEGAANHT 

       190        200        210        220        230        240 
RLCGEYGHSG VELFVYGQEA TNPNAPKPKK YPARQTLEAS QAIARLHQLE DESTVFMQQN 

       250        260        270        280        290        300 
PDVIDQGVFH NDVISVGNQN VLFYHEQAFL NTDAKFDEIR RKMNADMHFV KVATSQVSID 

       310        320        330        340        350        360 
DAVKSYLFNT QIITLPSGEM TIIAPTDCQE NLAVFAYLNE LVTLGTPIKQ VRYYDVKQSM 

       370        380        390        400        410        420 
QNGGGPACLR LRVALNDQEL AAVNQDTLMN DALFGRLNTW VEKHYRDSLS VKDLADPQLI 

       430        440 
VESRTALDEL TQILKLGSVY QFQK

« Hide

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References

[1]"Complete sequence of Shewanella denitrificans OS217."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000302 Genomic DNA. Translation: ABE55609.1.
RefSeqYP_563332.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4018822.
GenomeReviewsGene locus Sden_2329 in contig CP000302_GR.
KEGGsdn:Sden_2329.
NMPDRfig|318161.14.peg.2269.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ12LR7.
OMAQ12LR7. KMKALME.

Enzyme and pathway databases

BioCycSDEN318161:SDEN_2329-MON.

Family and domain databases

HAMAPMF_01172.
[Tree]
InterProIPR007079. SuccinylArg_d-Hdrlase_AstB.
[Graphical view]
Gene3DG3DSA:3.75.10.20. SuccinylArg_di_hydro. 1 hit.
PfamPF04996. AstB. 1 hit.
[Graphical view]
TIGRFAMsTIGR03241. arg_catab_astB. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameASTB_SHEDO
AccessionPrimary (citable) accession number: Q12LR7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 22, 2006
Last modified: June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents