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Q12L24

- NADK_SHEDO

UniProt

Q12L24 - NADK_SHEDO

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Protein
NAD kinase
Gene
nadK, Sden_2573
Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor By similarity
Binding sitei174 – 1741NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei193 – 1931NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902NAD By similarity
Nucleotide bindingi163 – 1642NAD By similarity
Nucleotide bindingi204 – 2096NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEN318161:GHKQ-2674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Sden_2573
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001982: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309NAD kinaseUniRule annotation
PRO_1000079512Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318161.Sden_2573.

Structurei

3D structure databases

ProteinModelPortaliQ12L24.
SMRiQ12L24. Positions 21-309.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12L24-1 [UniParc]FASTAAdd to Basket

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MGINSDVSRP RARSTPNMSK KFQTIGLIGK PHHQGTNQTI EKLHLWLTAQ    50
GYTVLVEERV SAELEIEFQA VDLVEIGERC DLAIVVGGDG NMLGAARVLA 100
RYDVAVIGVN RGNLGFLTDL PPDGFETQLA QVLGGEFETE HRFLLEAEVH 150
RHGMIKASNT AVNEAVLHPG KIAHMIQFEV YIDEQFMYSQ RADGMIVSTP 200
TGSTAYSLSA GGAILTPNLQ ALILVPMFPH TLSCRPIVVD ACSTIKLVVS 250
PDNGENLEVS CDGHVHLSVL PGDEIIIRRS QQRLMLIHPK GHNYFHVLRN 300
KLGWGSKLF 309
Length:309
Mass (Da):33,932
Last modified:August 22, 2006 - v1
Checksum:i90C3406E23359E96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE55852.1.
RefSeqiYP_563575.1. NC_007954.1.

Genome annotation databases

EnsemblBacteriaiABE55852; ABE55852; Sden_2573.
GeneIDi4019090.
KEGGisdn:Sden_2573.
PATRICi23491146. VBISheDen79529_2709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE55852.1 .
RefSeqi YP_563575.1. NC_007954.1.

3D structure databases

ProteinModelPortali Q12L24.
SMRi Q12L24. Positions 21-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318161.Sden_2573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE55852 ; ABE55852 ; Sden_2573 .
GeneIDi 4019090.
KEGGi sdn:Sden_2573.
PATRICi 23491146. VBISheDen79529_2709.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SDEN318161:GHKQ-2674-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Entry informationi

Entry nameiNADK_SHEDO
AccessioniPrimary (citable) accession number: Q12L24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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