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Q12K60

- PDXA_SHEDO

UniProt

Q12K60 - PDXA_SHEDO

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, Sden_2887
Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Metal bindingi164 – 1641Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi209 – 2091Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi264 – 2641Divalent metal cation; shared with dimeric partner By similarity
Binding sitei272 – 2721Substrate By similarity
Binding sitei281 – 2811Substrate By similarity
Binding sitei290 – 2901Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciSDEN318161:GHKQ-2996-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:Sden_2887
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001982: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3283284-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_1000128260Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi318161.Sden_2887.

Structurei

3D structure databases

ProteinModelPortaliQ12K60.
SMRiQ12K60. Positions 2-322.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiEQNSAYV.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12K60-1 [UniParc]FASTAAdd to Basket

« Hide

MTKRIAITAG EPASIGPDLV ITLAQQAWPA ELVVCANPEL LLARAAKLGL    50
PLRLIPYHSE NKPQPQAAGT LTIAPFELAA EVECGVLNEL NSAYVVDTLR 100
FAGEKNMSRE FDAVVTGPVH KGIINQAGIA FSGHTEYFAV QANCQDVVMM 150
LAAPGLQVAL MTTHIPLAYV AKAITRERLH HIIHILHKEL KSKFGLGSPK 200
IYVCGLNPHA GEDGHIGREE LDVMIPALNE LRAQGIQLVG PLPADTLFQP 250
KYLQDADVIL AMYHDQGLPV LKSLGFGKSV NITLGLPYIR TSVDHGTALE 300
LAGTGLADSG SFTCALNKAI ELASKVSN 328
Length:328
Mass (Da):35,054
Last modified:August 22, 2006 - v1
Checksum:i6C050F2226CB0A02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE56166.1.
RefSeqiYP_563889.1. NC_007954.1.

Genome annotation databases

EnsemblBacteriaiABE56166; ABE56166; Sden_2887.
GeneIDi4019412.
KEGGisdn:Sden_2887.
PATRICi23491808. VBISheDen79529_3032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE56166.1 .
RefSeqi YP_563889.1. NC_007954.1.

3D structure databases

ProteinModelPortali Q12K60.
SMRi Q12K60. Positions 2-322.
ModBasei Search...

Protein-protein interaction databases

STRINGi 318161.Sden_2887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE56166 ; ABE56166 ; Sden_2887 .
GeneIDi 4019412.
KEGGi sdn:Sden_2887.
PATRICi 23491808. VBISheDen79529_3032.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi EQNSAYV.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci SDEN318161:GHKQ-2996-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Entry informationi

Entry nameiPDXA_SHEDO
AccessioniPrimary (citable) accession number: Q12K60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 22, 2006
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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