ID   Q12K57_SHEDO            Unreviewed;       273 AA.
AC   Q12K57;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=bis(5'-nucleosyl)-tetraphosphatase (symmetrical) {ECO:0000256|ARBA:ARBA00012506};
DE            EC=3.6.1.41 {ECO:0000256|ARBA:ARBA00012506};
DE   AltName: Full=Ap4A hydrolase {ECO:0000256|ARBA:ARBA00032248};
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00031248};
DE   AltName: Full=Diadenosine tetraphosphatase {ECO:0000256|ARBA:ARBA00033210};
GN   OrderedLocusNames=Sden_2890 {ECO:0000313|EMBL:ABE56169.1};
OS   Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318161 {ECO:0000313|EMBL:ABE56169.1, ECO:0000313|Proteomes:UP000001982};
RN   [1] {ECO:0000313|EMBL:ABE56169.1, ECO:0000313|Proteomes:UP000001982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS217 / ATCC BAA-1090 / DSM 15013
RC   {ECO:0000313|Proteomes:UP000001982};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Shewanella denitrificans OS217.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield
CC       ADP. {ECO:0000256|ARBA:ARBA00003413}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2
CC         H(+); Xref=Rhea:RHEA:24252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58141, ChEBI:CHEBI:456216; EC=3.6.1.41;
CC         Evidence={ECO:0000256|ARBA:ARBA00001682};
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
CC       {ECO:0000256|ARBA:ARBA00005419}.
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DR   EMBL; CP000302; ABE56169.1; -; Genomic_DNA.
DR   RefSeq; WP_011497318.1; NC_007954.1.
DR   AlphaFoldDB; Q12K57; -.
DR   STRING; 318161.Sden_2890; -.
DR   KEGG; sdn:Sden_2890; -.
DR   eggNOG; COG0639; Bacteria.
DR   HOGENOM; CLU_056184_2_0_6; -.
DR   OrthoDB; 9807890at2; -.
DR   Proteomes; UP000001982; Chromosome.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:UniProtKB-EC.
DR   CDD; cd07422; MPP_ApaH; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   NCBIfam; TIGR00668; apaH; 1.
DR   PANTHER; PTHR42850:SF11; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [SYMMETRICAL]; 1.
DR   PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001982}.
FT   DOMAIN          5..144
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
SQ   SEQUENCE   273 AA;  31181 MW;  2A6179865BBED830 CRC64;
     MAHYFVGDIQ GCFTELELLL QKVGFNPSID ELWAVGDLVA RGPDSLATLR YLKSLDNSAK
     LVLGNHDLHL LAVQGKLKSA NPMDKLNELL AADDIKILID WLREQPLAQY LPEHNIVMTH
     AGVPPQWDLA RLKIEAEQVS QALKRSDYLE SLIANMYING PVHWHEDLIG IERHRYCINA
     LTRMRYLHLD GSLEFNCKLP PQENHDAKLK PWFSFDSLTS EKIKVFGHWA ALMGETHVER
     TQALDTACCW GKHLTLWQVE NNEKITQTNI NSR
//