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Q12JN5 (PUR7_SHEDO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:Sden_3063
OrganismShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]
Taxonomic identifier318161 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000117847

Sequences

Sequence LengthMass (Da)Tools
Q12JN5 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: B97AE14920D2FF0E

FASTA36740,762
        10         20         30         40         50         60 
MSLADSVLAV NNDLPIRTDK PVHSGKVRSV YWLTESDSRR LINDKGYKVP LDTPLAIMVI 

        70         80         90        100        110        120 
SDRISAFDCI FHGEGGLQGI PGKGAALNAI SNHWFKLFAE QGLADSHILD IPHPFVWIVQ 

       130        140        150        160        170        180 
KARPIKVEAI CRQYITGSMW RAYAKGEREF CGIRLPEGLK KDQKLPELII TPSTKGILTG 

       190        200        210        220        230        240 
IPGVPAQDDV NISRQDIEAN YQAFGFESLS DIDLYETLLK DGFKVISDAL AQLDQVFVDT 

       250        260        270        280        290        300 
KFEFGYVTDK NGQSKLIYMD EVGTPDSSRI WDGAAYRDSK IVENSKEGFR QFLLNHVADA 

       310        320        330        340        350        360 
DVLLNKDRMP EREALARDNA LPLDAMMNVS RTYTGVAEKV TGKTITLAAN PKADIIAILK 


KNYGLID

« Hide

References

[1]"Complete sequence of Shewanella denitrificans OS217."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000302 Genomic DNA. Translation: ABE56341.1.
RefSeqYP_564064.1. NC_007954.1.

3D structure databases

ProteinModelPortalQ12JN5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12JN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4019589.
GenomeReviewsGene locus Sden_3063 in contig CP000302_GR.
KEGGsdn:Sden_3063.
NMPDRfig|318161.14.peg.2971.
PATRIC23492184. VBISheDen79529_3219.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHBG555040.
OMASSRIWDG.
PhylomeDBQ12JN5.
ProtClustDBPRK13960.

Enzyme and pathway databases

BioCycSDEN318161:SDEN_3063-MONOMER.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR014106. PurC_vibrio.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR02735. PurC_vibrio. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_SHEDO
AccessionPrimary (citable) accession number: Q12JN5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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