Reviewed, UniProtKB/Swiss-Prot Q12JA9 (ASTD2_SHEDO)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase 2
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase 2
      Short name=SGSD 2

Gene names

Name:	astD2
Ordered Locus Names:	Sden_3191

Organism

Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]

Taxonomic identifier

318161 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	N-succinylglutamate 5-semialdehyde dehydrogenase 2		PRO_0000262424
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12JA9-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 989D044D58AFB4C0	FASTA	486	51,409
	10 20 30 40 50 60 MTQYINGQWF AGLGHQVSSI NPATGQSIWN GVTATADQVN QAVDAARAAQ FDWFMLGFEA 70 80 90 100 110 120 RLSIVEAYRS ELEANKAQLA EVIAQETGKP QWETATEVGA MIGKIALSAA AHDKRTGTET 130 140 150 160 170 180 NELAAGRAVL RHKPHGVVAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS ELTPKVAEEM 190 200 210 220 230 240 LKLWDKAGLP KGVINLVQGE VETGKALASH PQIDGLFFTG SSRTGHILHQ QYAGHPGKIL 250 260 270 280 290 300 ALEMGGNNPL IVKGVSDTKA AVHDIIQSAY ISSGQRCTCA RRLYIEQGAA GDELIAQLIT 310 320 330 340 350 360 AVNNIQVGAW NSQPQPFMGS MISETAARGM VAAQATLQAL GGVSLVELAQ VEAGTGLVSP 370 380 390 400 410 420 GLIDVTQIAE LPDEEYFGPL LQLVRYTDFD EAIRLANATR YGLSAGLLAD NRDDYDYFLA 430 440 450 460 470 480 RIRAGIVNWN KQITGASGAA PFGGVGASGN HRASAFYAAD YCAYPVASME ADSVSMPASL SPGLSI

References

[1]

"Complete sequence of Shewanella denitrificans OS217." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000302 Genomic DNA. Translation: ABE56467.1.
RefSeq	YP_564190.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4019717.
GenomeReviews	Gene locus Sden_3191 in contig CP000302_GR.
KEGG	sdn:Sden_3191.
NMPDR	fig|318161.14.peg.3098.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q12JA9.
Enzyme and pathway databases
BioCyc	SDEN318161:SDEN_3191-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD2_SHEDO

Accession

Primary (citable) accession number: Q12JA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	August 22, 2006
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)