Q12J15 (AROQ_SHEDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type II DHQase

Gene names

Name:	aroQ
Ordered Locus Names:	Sden_3285

Organism

Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP]

Taxonomic identifier

318161 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › Shewanella denitrificans

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP-Rule MF_00169
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00169
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00169
Subunit structure	Homododecamer By similarity.
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	3-dehydroquinate dehydratase HAMAP-Rule MF_00169		PRO_1000097619
Regions
	Region	102 – 103	2	Substrate binding By similarity
Sites
	Active site	26	1	Proton acceptor By similarity
	Active site	101	1	Proton donor By similarity
	Binding site	75	1	Substrate By similarity
	Binding site	81	1	Substrate By similarity
	Binding site	88	1	Substrate By similarity
	Binding site	112	1	Substrate By similarity
	Site	21	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12J15 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 4719A0DBF89A9243	FASTA	151	16,384
	10 20 30 40 50 60 MSTTVKILLL NGPNLNLLGR REPGHYGHQT LATIVSELST QAQQASVSLE HLQSNAEHEL 70 80 90 100 110 120 IDAIHATDAQ FIIINPAAFT HTSVALRDAL LGVAIPFIEV HLSNVHAREP FRQHSYFSDK 130 140 150 ALGVICGLGA QGYKFALQAA LSHLSDKQLQ S

References

[1]

"Complete sequence of Shewanella denitrificans OS217." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000302 Genomic DNA. Translation: ABE56561.1.
RefSeq	YP_564284.1. NC_007954.1.
3D structure databases
ProteinModelPortal	Q12J15.
SMR	Q12J15. Positions 6-149.
ModBase	Search...
Protein-protein interaction databases
STRING	318161.Sden_3285.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE56561; ABE56561; Sden_3285.
GeneID	4019833.
KEGG	sdn:Sden_3285.
PATRIC	23492658. VBISheDen79529_3453.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0757.
HOGENOM	HOG000217278.
KO	K03786.
OMA	RREPGHY.
ProtClustDB	PRK05395.
Enzyme and pathway databases
BioCyc	SDEN318161:GHKQ-3412-MONOMER.
UniPathway	UPA00053; UER00086.
Family and domain databases
Gene3D	3.40.50.9100. 1 hit.
HAMAP	MF_00169. AroQ.
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
PANTHER	PTHR21272. PTHR21272. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. aroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROQ_SHEDO

Accession

Primary (citable) accession number: Q12J15

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program