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Q12IP4

- PUR9_SHEDO

UniProt

Q12IP4 - PUR9_SHEDO

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSDEN318161:GHKQ-3520-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Sden_3407
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001982: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Bifunctional purine biosynthesis protein PurHPRO_1000018951Add
BLAST

Proteomic databases

PRIDEiQ12IP4.

Interactioni

Protein-protein interaction databases

STRINGi318161.Sden_3407.

Structurei

3D structure databases

ProteinModelPortaliQ12IP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12IP4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTVRPIRRA LLSVSDKTGI LEFAQALHAH GVELLSTGGT ARLLAEHGLP
60 70 80 90 100
VIEASDHTGH PEIMDGRVKT LHPKIHGGIL ARRGQDEAVM AENNILPIDL
110 120 130 140 150
VVVNLYPFAS TVANPDCTLA DAVENIDIGG PTMVRAAAKN HQDVTIVVNA
160 170 180 190 200
SDYARVLAEM KTNQGSTTLK IRFELAVAAF EHTAAYDGMI ANYFGNLVAM
210 220 230 240 250
DADTSDEQQA LHQESSFPRT FNSQFIKKQD LRYGENSHQK AAFYVDPQID
260 270 280 290 300
EASVASAIQL QGKALSYNNI ADTDAALECV KEFDGPACVI VKHANPCGVA
310 320 330 340 350
LGKDLLDAYN RAYQTDPTSA FGGIIAFNGE LDAATASAIV ERQFVEVIIA
360 370 380 390 400
PSVSQAARDI VAAKANVRLL ECGKWETKTT SLDYKRVNGG LLVQDRDQGM
410 420 430 440 450
VGLADIKVVS KRQPTEAELK DLLFCWKVAK FVKSNAIVYA KEGMTIGVGA
460 470 480 490 500
GQMSRVYSAK IAGIKASDEG LVVENSVMAS DAFFPFRDGI DAAAAAGISC
510 520 530
IIQPGGSIRD EEIIKAADEH GMAMVFTGMR HFRH
Length:534
Mass (Da):57,417
Last modified:August 22, 2006 - v1
Checksum:i3A8A98B790C40A57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE56682.1.
RefSeqiWP_011497824.1. NC_007954.1.
YP_564405.1. NC_007954.1.

Genome annotation databases

EnsemblBacteriaiABE56682; ABE56682; Sden_3407.
GeneIDi4019955.
KEGGisdn:Sden_3407.
PATRICi23492906. VBISheDen79529_3577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE56682.1 .
RefSeqi WP_011497824.1. NC_007954.1.
YP_564405.1. NC_007954.1.

3D structure databases

ProteinModelPortali Q12IP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318161.Sden_3407.

Proteomic databases

PRIDEi Q12IP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE56682 ; ABE56682 ; Sden_3407 .
GeneIDi 4019955.
KEGGi sdn:Sden_3407.
PATRICi 23492906. VBISheDen79529_3577.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SDEN318161:GHKQ-3520-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Entry informationi

Entry nameiPUR9_SHEDO
AccessioniPrimary (citable) accession number: Q12IP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3