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Q12IP4

- PUR9_SHEDO

UniProt

Q12IP4 - PUR9_SHEDO

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Sden_3407
Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSDEN318161:GHKQ-3520-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Sden_3407
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001982: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018951Add
BLAST

Proteomic databases

PRIDEiQ12IP4.

Interactioni

Protein-protein interaction databases

STRINGi318161.Sden_3407.

Structurei

3D structure databases

ProteinModelPortaliQ12IP4.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12IP4-1 [UniParc]FASTAAdd to Basket

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MNTVRPIRRA LLSVSDKTGI LEFAQALHAH GVELLSTGGT ARLLAEHGLP    50
VIEASDHTGH PEIMDGRVKT LHPKIHGGIL ARRGQDEAVM AENNILPIDL 100
VVVNLYPFAS TVANPDCTLA DAVENIDIGG PTMVRAAAKN HQDVTIVVNA 150
SDYARVLAEM KTNQGSTTLK IRFELAVAAF EHTAAYDGMI ANYFGNLVAM 200
DADTSDEQQA LHQESSFPRT FNSQFIKKQD LRYGENSHQK AAFYVDPQID 250
EASVASAIQL QGKALSYNNI ADTDAALECV KEFDGPACVI VKHANPCGVA 300
LGKDLLDAYN RAYQTDPTSA FGGIIAFNGE LDAATASAIV ERQFVEVIIA 350
PSVSQAARDI VAAKANVRLL ECGKWETKTT SLDYKRVNGG LLVQDRDQGM 400
VGLADIKVVS KRQPTEAELK DLLFCWKVAK FVKSNAIVYA KEGMTIGVGA 450
GQMSRVYSAK IAGIKASDEG LVVENSVMAS DAFFPFRDGI DAAAAAGISC 500
IIQPGGSIRD EEIIKAADEH GMAMVFTGMR HFRH 534
Length:534
Mass (Da):57,417
Last modified:August 22, 2006 - v1
Checksum:i3A8A98B790C40A57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE56682.1.
RefSeqiWP_011497824.1. NC_007954.1.
YP_564405.1. NC_007954.1.

Genome annotation databases

EnsemblBacteriaiABE56682; ABE56682; Sden_3407.
GeneIDi4019955.
KEGGisdn:Sden_3407.
PATRICi23492906. VBISheDen79529_3577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000302 Genomic DNA. Translation: ABE56682.1 .
RefSeqi WP_011497824.1. NC_007954.1.
YP_564405.1. NC_007954.1.

3D structure databases

ProteinModelPortali Q12IP4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 318161.Sden_3407.

Proteomic databases

PRIDEi Q12IP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE56682 ; ABE56682 ; Sden_3407 .
GeneIDi 4019955.
KEGGi sdn:Sden_3407.
PATRICi 23492906. VBISheDen79529_3577.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SDEN318161:GHKQ-3520-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Entry informationi

Entry nameiPUR9_SHEDO
AccessioniPrimary (citable) accession number: Q12IP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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