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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (Sden_1559)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciSDEN318161:GHKQ-3633-MONOMER.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:Sden_3514
OrganismiShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Taxonomic identifieri318161 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001982 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Glycerol-3-phosphate acyltransferasePRO_1000049456Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318161.Sden_3514.

Structurei

3D structure databases

ProteinModelPortaliQ12ID7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi308 – 3136HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12ID7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNYDSIFIK SLRWIQKWLV QTIVVPHDPL TDLNLDPSKP VVYVMKTESI
60 70 80 90 100
SDLAALSGIT ANFGLPSPYD PLTLDKVSIA RVVCLEGRKP MIGQREGGEK
110 120 130 140 150
FLDSFTQLLA LHKQDKQLDI QLVPVSLYWG RTPGKEDDTM KAAVFERENP
160 170 180 190 200
TWLRKFFMIL FLGRHNFVQF SNAVSLRHMA DEHGTDKSIA HKLVRVARVH
210 220 230 240 250
FRRQRKVMTG PLLPNRQALF NALLKSESIK KAIEEEATNK KISIEKARET
260 270 280 290 300
AIVYLDEIAA DYSDSLVRIT ERFLTWLWNK LYSGINIERA EQVRQLHHDG
310 320 330 340 350
HEIVYVPCHR SHMDYLLISY ILYYQGMVPP HIAAGINLNF WPAGPMFRRG
360 370 380 390 400
GAFFIRRSFN GNKLYTAVFR EYLDQLFAKG YSVEYFTEGG RSRTGRLLAP
410 420 430 440 450
KTGMIAMTMN SVLRGIERPV TLVPVYLGYD HVMEVATYHK ELSGKKKQKE
460 470 480 490 500
SLWQVFGAIR KLGNFGQGYV NFGEPINMQN FLTEQAPEWR AELAKDPEQK
510 520 530 540 550
PSWFTPAVNV LANRVMTNIN GAAAASSVTL TSLILLASEQ NALERTQLER
560 570 580 590 600
QLDLYLNLLK KVPYTPFTSV AQGDSQQVVD HCLGLNKFIS TRDALGEIIS
610 620 630 640 650
IDPKIAVTMS YYRNNIIHLM VVPSLIASCL VQYEVRSRSE IKAIVNDFYP
660 670 680 690 700
LLKAELFMGI ADLDSYIDDI IDLLIEEQLV EESAGLSIVE SHISQLWLMA
710 720 730 740 750
QTVSETLQRY AIIFNLLAHK PNVERADLEN DSHLLAQRLG ALHGITAPEF
760 770 780 790 800
YDKKLYNTLS VKLKELGYLS AVEKQVDVAR IRDHANGLLW SSVRQTIIDS

VAAEHGH
Length:807
Mass (Da):91,643
Last modified:August 22, 2006 - v1
Checksum:iC582FD38ECB0542C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000302 Genomic DNA. Translation: ABE56789.1.
RefSeqiWP_011497929.1. NC_007954.1.

Genome annotation databases

EnsemblBacteriaiABE56789; ABE56789; Sden_3514.
KEGGisdn:Sden_3514.
PATRICi23493140. VBISheDen79529_3688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000302 Genomic DNA. Translation: ABE56789.1.
RefSeqiWP_011497929.1. NC_007954.1.

3D structure databases

ProteinModelPortaliQ12ID7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318161.Sden_3514.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE56789; ABE56789; Sden_3514.
KEGGisdn:Sden_3514.
PATRICi23493140. VBISheDen79529_3688.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
BioCyciSDEN318161:GHKQ-3633-MONOMER.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_SHEDO
AccessioniPrimary (citable) accession number: Q12ID7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.