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Q12I35 (Q12I35_SHEDO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-threonine 3-dehydrogenase HAMAP MF_00627
EC=1.1.1.103 HAMAP MF_00627
Gene names
Name:tdh HAMAP MF_00627
Ordered Locus Names:Sden_3616
OrganismShewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) [Complete proteome] [HAMAP] EMBL ABE56891.1
Taxonomic identifier318161 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00627

Pathway

Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627

Subunit structure

Homotetramer By similarity. HAMAP MF_00627

Subcellular location

Cytoplasm By similarity HAMAP MF_00627.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. HAMAP MF_00627

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding391Zinc 1; catalytic By similarity HAMAP MF_00627
Metal binding641Zinc 1; catalytic By similarity HAMAP MF_00627
Metal binding941Zinc 2 By similarity HAMAP MF_00627
Metal binding971Zinc 2 By similarity HAMAP MF_00627
Metal binding1001Zinc 2 By similarity HAMAP MF_00627
Metal binding1081Zinc 2 By similarity HAMAP MF_00627
Metal binding1491Zinc 1; catalytic By similarity HAMAP MF_00627

Sequences

Sequence LengthMass (Da)Tools
Q12I35 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 851BAA2A03BF83FE

FASTA34237,156
        10         20         30         40         50         60 
MMKALSKLKA EKGIWMVDAP KPVMGHNDLL IKIRKTAICG TDMHIYNWDE WAQKTIPVPM 

        70         80         90        100        110        120 
VVGHEYVGEV VDMGVEVRGF TVGDRVSGEG HITCGHCRNC RGGRTHLCRN TTGVGVNREG 

       130        140        150        160        170        180 
SFAEYLVIPA FNAFKIPADI SDDLAAIFDP FGNAVHTALS FDLVGEDVLI TGAGPIGIMA 

       190        200        210        220        230        240 
AAVCKHVGAR HVVITDVNEY RLELARKMGA TRAVNVSKEN LTDVMTELGM TEGFDVGLEM 

       250        260        270        280        290        300 
SGVPSAFHGM LDTMNHGGKI AMLGIPGGEM AIDWSKVIFK GLIIKGIYGR EMFETWYKMA 

       310        320        330        340 
SLIQSGLDLS PIITHHFAID DFQLGFEAMG SGQSGKVILN WD

« Hide

References

[1]"Complete sequence of Shewanella denitrificans OS217."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OS217 / ATCC BAA-1090 / DSM 15013.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000302 Genomic DNA. Translation: ABE56891.1.
RefSeqYP_564614.1. NC_007954.1.

3D structure databases

ProteinModelPortalQ12I35.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12I35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4020173.
GenomeReviewsGene locus Sden_3616 in contig CP000302_GR.
KEGGsdn:Sden_3616.
NMPDRfig|318161.14.peg.3509.
PATRIC23493356. VBISheDen79529_3793.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1063.
HOGENOMHBG753318.
OMAMMRSGMS.
PhylomeDBQ12I35.
ProtClustDBPRK05396.

Enzyme and pathway databases

BioCycSDEN318161:SDEN_3616-MONOMER.

Family and domain databases

HAMAPMF_00627. Thr_dehydrog.
[Tree]
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR004627. L-Threonine_3-DHase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00060.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
TIGRFAMsTIGR00692. Tdh. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ12I35_SHEDO
AccessionPrimary (citable) accession number: Q12I35
Entry history
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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