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Q12GY8

- Q12GY8_POLSJ

UniProt

Q12GY8 - Q12GY8_POLSJ

Protein
Submitted name:

Short-chain dehydrogenase/reductase SDR

Gene

Bpro_0239

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871NADP; via carbonyl oxygenImported
    Binding sitei157 – 1571NADPImported
    Binding sitei161 – 1611NADPImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADPImported
    Nucleotide bindingi34 – 363NADPImported
    Nucleotide bindingi60 – 612NADPImported
    Nucleotide bindingi187 – 1959NADPImported

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. oxidoreductase activity Source: InterPro

    Keywords - Ligandi

    NADPImported, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciPSP296591:GHI4-960-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Short-chain dehydrogenase/reductase SDRImported
    Gene namesi
    Ordered Locus Names:Bpro_0239Imported
    OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)Imported
    Taxonomic identifieri296591 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000001983: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929 PotentialImportedAdd
    BLAST
    Chaini30 – 248219 PotentialImportedPRO_5000116452Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi296591.Bpro_0239.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IQGX-ray1.85A/B/C/D2-248[»]
    ProteinModelPortaliQ12GY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG1028.
    OMAiRRMSTRY.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12GY8-1 [UniParc]FASTAAdd to Basket

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    MSKVVLITGG SRGIGAASAL LAARQGYAVA VNYASNSAAA DEVVRQIREA    50
    GGQALAVQAD VAKEREVLAM FETVDAQLGR LSALVNNAGV VDQTTRVDGI 100
    TLERLQRMFE INVFGSFLCA REAVKRMSTR YGGSGGSIVN VSSAAARLGS 150
    PGQYVDYAAA KGAIDTFTLG LAKEVATEGI RVNAVRPGII ETDIHASGGL 200
    PNRARDVAPQ VPMQRAGTAR EVAEAIVWLL GDQASYTTGA LLDVTGGR 248
    Length:248
    Mass (Da):25,750
    Last modified:August 22, 2006 - v1
    Checksum:i95FF3E42B76C3696
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000316 Genomic DNA. Translation: ABE42204.1.
    RefSeqiWP_011481213.1. NC_007948.1.
    YP_547102.1. NC_007948.1.

    Genome annotation databases

    EnsemblBacteriaiABE42204; ABE42204; Bpro_0239.
    GeneIDi4011917.
    KEGGipol:Bpro_0239.
    PATRICi22953524. VBIPolSp102244_0251.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000316 Genomic DNA. Translation: ABE42204.1 .
    RefSeqi WP_011481213.1. NC_007948.1.
    YP_547102.1. NC_007948.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IQG X-ray 1.85 A/B/C/D 2-248 [» ]
    ProteinModelPortali Q12GY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 296591.Bpro_0239.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE42204 ; ABE42204 ; Bpro_0239 .
    GeneIDi 4011917.
    KEGGi pol:Bpro_0239.
    PATRICi 22953524. VBIPolSp102244_0251.

    Phylogenomic databases

    eggNOGi COG1028.
    OMAi RRMSTRY.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    BioCyci PSP296591:GHI4-960-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JS666 / ATCC BAA-500Imported.
    2. "Crystal structure of oxidoreductase from Polaromonas sp. in NADP bound form."
      New York Structural Genomics Research Consortium (NYSGRC)
      Niedzialkowska E., Majorek K.A., Porebski P.J., Al Obaidi N., Hammonds J., Hillerich B., Seidel R., Bonanno J.B., Almo S.C., Minor W.
      Submitted (JAN-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2-248 IN COMPLEX WITH NADP.

    Entry informationi

    Entry nameiQ12GY8_POLSJ
    AccessioniPrimary (citable) accession number: Q12GY8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 22, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3