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Q12GY8

- Q12GY8_POLSJ

UniProt

Q12GY8 - Q12GY8_POLSJ

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Protein
Submitted name:

Short-chain dehydrogenase/reductase SDR

Gene

Bpro_0239

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871NADP; via carbonyl oxygenImported
Binding sitei157 – 1571NADPImported
Binding sitei161 – 1611NADPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPImported
Nucleotide bindingi34 – 363NADPImported
Nucleotide bindingi60 – 612NADPImported
Nucleotide bindingi187 – 1959NADPImported

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciPSP296591:GHI4-960-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Short-chain dehydrogenase/reductase SDRImported
Gene namesi
Ordered Locus Names:Bpro_0239Imported
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)Imported
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000001983: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 PotentialImportedAdd
BLAST
Chaini30 – 248219 PotentialImportedPRO_5000116452Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_0239.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IQGX-ray1.85A/B/C/D2-248[»]
ProteinModelPortaliQ12GY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG1028.
OMAiRRMSTRY.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12GY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKVVLITGG SRGIGAASAL LAARQGYAVA VNYASNSAAA DEVVRQIREA
60 70 80 90 100
GGQALAVQAD VAKEREVLAM FETVDAQLGR LSALVNNAGV VDQTTRVDGI
110 120 130 140 150
TLERLQRMFE INVFGSFLCA REAVKRMSTR YGGSGGSIVN VSSAAARLGS
160 170 180 190 200
PGQYVDYAAA KGAIDTFTLG LAKEVATEGI RVNAVRPGII ETDIHASGGL
210 220 230 240
PNRARDVAPQ VPMQRAGTAR EVAEAIVWLL GDQASYTTGA LLDVTGGR
Length:248
Mass (Da):25,750
Last modified:August 22, 2006 - v1
Checksum:i95FF3E42B76C3696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE42204.1.
RefSeqiWP_011481213.1. NC_007948.1.
YP_547102.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE42204; ABE42204; Bpro_0239.
GeneIDi4011917.
KEGGipol:Bpro_0239.
PATRICi22953524. VBIPolSp102244_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE42204.1 .
RefSeqi WP_011481213.1. NC_007948.1.
YP_547102.1. NC_007948.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IQG X-ray 1.85 A/B/C/D 2-248 [» ]
ProteinModelPortali Q12GY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 296591.Bpro_0239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE42204 ; ABE42204 ; Bpro_0239 .
GeneIDi 4011917.
KEGGi pol:Bpro_0239.
PATRICi 22953524. VBIPolSp102244_0251.

Phylogenomic databases

eggNOGi COG1028.
OMAi RRMSTRY.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

BioCyci PSP296591:GHI4-960-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS666 / ATCC BAA-500Imported.
  2. "Crystal structure of oxidoreductase from Polaromonas sp. in NADP bound form."
    New York Structural Genomics Research Consortium (NYSGRC)
    Niedzialkowska E., Majorek K.A., Porebski P.J., Al Obaidi N., Hammonds J., Hillerich B., Seidel R., Bonanno J.B., Almo S.C., Minor W.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2-248 IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ12GY8_POLSJ
AccessioniPrimary (citable) accession number: Q12GY8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3