Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Short-chain dehydrogenase/reductase SDR

Gene

Bpro_0239

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871NADP; via carbonyl oxygenCombined sources
Binding sitei157 – 1571NADPCombined sources
Binding sitei161 – 1611NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPCombined sources
Nucleotide bindingi34 – 363NADPCombined sources
Nucleotide bindingi60 – 612NADPCombined sources
Nucleotide bindingi187 – 1959NADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciPSP296591:GHI4-960-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Short-chain dehydrogenase/reductase SDRImported
Gene namesi
Ordered Locus Names:Bpro_0239Imported
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)Imported
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000001983 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 PotentialImportedAdd
BLAST
Chaini30 – 248219 PotentialImportedPRO_5000116452Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_0239.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IQGX-ray1.85A/B/C/D2-248[»]
ProteinModelPortaliQ12GY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG1028.
OMAiRYWAYEL.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12GY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVVLITGG SRGIGAASAL LAARQGYAVA VNYASNSAAA DEVVRQIREA
60 70 80 90 100
GGQALAVQAD VAKEREVLAM FETVDAQLGR LSALVNNAGV VDQTTRVDGI
110 120 130 140 150
TLERLQRMFE INVFGSFLCA REAVKRMSTR YGGSGGSIVN VSSAAARLGS
160 170 180 190 200
PGQYVDYAAA KGAIDTFTLG LAKEVATEGI RVNAVRPGII ETDIHASGGL
210 220 230 240
PNRARDVAPQ VPMQRAGTAR EVAEAIVWLL GDQASYTTGA LLDVTGGR
Length:248
Mass (Da):25,750
Last modified:August 22, 2006 - v1
Checksum:i95FF3E42B76C3696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE42204.1.
RefSeqiWP_011481213.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE42204; ABE42204; Bpro_0239.
KEGGipol:Bpro_0239.
PATRICi22953524. VBIPolSp102244_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE42204.1.
RefSeqiWP_011481213.1. NC_007948.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IQGX-ray1.85A/B/C/D2-248[»]
ProteinModelPortaliQ12GY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi296591.Bpro_0239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE42204; ABE42204; Bpro_0239.
KEGGipol:Bpro_0239.
PATRICi22953524. VBIPolSp102244_0251.

Phylogenomic databases

eggNOGiCOG1028.
OMAiRYWAYEL.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

BioCyciPSP296591:GHI4-960-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS666 / ATCC BAA-500Imported.
  2. "Crystal structure of oxidoreductase from Polaromonas sp. in NADP bound form."
    New York Structural Genomics Research Consortium (NYSGRC)
    Niedzialkowska E., Majorek K.A., Porebski P.J., Al Obaidi N., Hammonds J., Hillerich B., Seidel R., Bonanno J.B., Almo S.C., Minor W.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2-248 IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ12GY8_POLSJ
AccessioniPrimary (citable) accession number: Q12GY8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.