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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Bpro_1072
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
Proteomesi
  • UP000001983 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Transmembranei100 – 120HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei193 – 213HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Transmembranei289 – 309HelicalUniRule annotationAdd BLAST21
Transmembranei314 – 334HelicalUniRule annotationAdd BLAST21
Transmembranei369 – 389HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003325421 – 392Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST392

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_1072.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12EL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSLAQWLQ SISPEFGSFR VFQYLTFRAV MAALTALLIG LLAGPFVIRR
60 70 80 90 100
LISLKIGQPI REYAMQTHLS KSGTPTMGGV LILMSIGIST LLWFDLSNRF
110 120 130 140 150
VWIVLLVTLG FGAIGWADDW RKVVLKDPEG MRSREKYLWQ SLIGLVAALY
160 170 180 190 200
LVFSISESSN LRVLELFFSW VQSGFDVDLP PKAGLLVPFV KEISYPLGVF
210 220 230 240 250
GFVILTYLVI VGSSNAVNLT DGLDGLAIMP VVMVGSALGV FAYVTGSAVY
260 270 280 290 300
SKYLFFPHIP GSGELLIFCS AMAGAGLAFL WFNTHPAQVF MGDVGALALG
310 320 330 340 350
AALGTIAVIV RQEIVLAIMG GIFVVEALSV MMQVIWFKYT KKRYGEGRRL
360 370 380 390
FKMAPLHHHF EKSGWKETQV VVRFWIITML LCLVGLSTLK LR
Length:392
Mass (Da):43,278
Last modified:April 29, 2008 - v2
Checksum:i1DE8FF3B02406300
GO

Sequence cautioni

The sequence ABE43024 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE43024.1. Different initiation.
RefSeqiWP_041388408.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE43024; ABE43024; Bpro_1072.
KEGGipol:Bpro_1072.

Similar proteinsi

Entry informationi

Entry nameiMRAY_POLSJ
AccessioniPrimary (citable) accession number: Q12EL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 5, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families