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Q12E97

- TYPH_POLSJ

UniProt

Q12E97 - TYPH_POLSJ

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Protein

Putative thymidine phosphorylase

Gene

Bpro_1194

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciPSP296591:GHI4-1915-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Ordered Locus Names:Bpro_1194
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000001983: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Putative thymidine phosphorylasePRO_0000314706Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_1194.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiIHYNDEA.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12E97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTPPTPLSS LTPHKLRLRR LGIDTYQEPV LYMHRDCRVC HSEGFEAQSR
60 70 80 90 100
VELALGDRTI VATLNVVSGD FLAPDEAGLS EAAWRLLGAQ EGDMVSPRHP
110 120 130 140 150
APIESLGHVR AKVYGRHLTQ AAITAVIEDV TAGRYSDLQL AAFVTACAGD
160 170 180 190 200
RLDQEETVSL TRAMVAAGER IDWGEGLVMD KHCVGGLPGN RTTMVIVPIV
210 220 230 240 250
AACGLRMPKT SSRAITSPAG TADTMETLAP VDLDVAQIRR VVERTGGCVV
260 270 280 290 300
WGGAVRLSPA DDILIRVERP LDLDSQGQLV ASILSKKVAA GSTHVLIDMP
310 320 330 340 350
VGPTAKVRSA EAADLLGRLL GQVGQTLGLR MRVVQTDGLA PVGRGIGPAL
360 370 380 390 400
EARDVLAVLR NLATAPADLA QRSLLLAGEV LEFGGAAPAG GGLALASAVL
410 420 430 440 450
ADGRAWRKFQ DICAAQGGLR EPPVAAHQQA VHALRSGSVL AIDNRRLARI
460 470 480 490 500
AKLAGAPGAA CAGIDLHVRP GEFVERGQPL FTLHAATPGE LAYALEYAAS
510
QAETVHVLED A
Length:511
Mass (Da):53,699
Last modified:August 22, 2006 - v1
Checksum:i39A4B6625FA46595
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE43145.1.
RefSeqiWP_011482146.1. NC_007948.1.
YP_548043.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE43145; ABE43145; Bpro_1194.
GeneIDi4012163.
KEGGipol:Bpro_1194.
PATRICi22955486. VBIPolSp102244_1226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE43145.1 .
RefSeqi WP_011482146.1. NC_007948.1.
YP_548043.1. NC_007948.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 296591.Bpro_1194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE43145 ; ABE43145 ; Bpro_1194 .
GeneIDi 4012163.
KEGGi pol:Bpro_1194.
PATRICi 22955486. VBIPolSp102244_1226.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi IHYNDEA.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

BioCyci PSP296591:GHI4-1915-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_00703. Thymid_phosp_2.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS666 / ATCC BAA-500.

Entry informationi

Entry nameiTYPH_POLSJ
AccessioniPrimary (citable) accession number: Q12E97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3