Q12E97 (TYPH_POLSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Bpro_1194

Organism

Polaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]

Taxonomic identifier

296591 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Polaromonas

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314706

Sequences

	Sequence		Length	Mass (Da)
	Q12E97 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 39A4B6625FA46595	FASTA	511	53,699
	10 20 30 40 50 60 MQTPPTPLSS LTPHKLRLRR LGIDTYQEPV LYMHRDCRVC HSEGFEAQSR VELALGDRTI 70 80 90 100 110 120 VATLNVVSGD FLAPDEAGLS EAAWRLLGAQ EGDMVSPRHP APIESLGHVR AKVYGRHLTQ 130 140 150 160 170 180 AAITAVIEDV TAGRYSDLQL AAFVTACAGD RLDQEETVSL TRAMVAAGER IDWGEGLVMD 190 200 210 220 230 240 KHCVGGLPGN RTTMVIVPIV AACGLRMPKT SSRAITSPAG TADTMETLAP VDLDVAQIRR 250 260 270 280 290 300 VVERTGGCVV WGGAVRLSPA DDILIRVERP LDLDSQGQLV ASILSKKVAA GSTHVLIDMP 310 320 330 340 350 360 VGPTAKVRSA EAADLLGRLL GQVGQTLGLR MRVVQTDGLA PVGRGIGPAL EARDVLAVLR 370 380 390 400 410 420 NLATAPADLA QRSLLLAGEV LEFGGAAPAG GGLALASAVL ADGRAWRKFQ DICAAQGGLR 430 440 450 460 470 480 EPPVAAHQQA VHALRSGSVL AIDNRRLARI AKLAGAPGAA CAGIDLHVRP GEFVERGQPL 490 500 510 FTLHAATPGE LAYALEYAAS QAETVHVLED A

References

[1]

"Complete sequence of chromosome of Polaromonas sp. JS666." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000316 Genomic DNA. Translation: ABE43145.1.
RefSeq	YP_548043.1. NC_007948.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	296591.Bpro_1194.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE43145; ABE43145; Bpro_1194.
GeneID	4012163.
KEGG	pol:Bpro_1194.
PATRIC	22955486. VBIPolSp102244_1226.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	PSP296591:GHI4-1915-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_POLSJ

Accession

Primary (citable) accession number: Q12E97

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program