Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q12E97 (TYPH_POLSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Ordered Locus Names:Bpro_1194
OrganismPolaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]
Taxonomic identifier296591 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Putative thymidine phosphorylase HAMAP-Rule MF_00703
PRO_0000314706

Sequences

Sequence LengthMass (Da)Tools
Q12E97 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 39A4B6625FA46595

FASTA51153,699
        10         20         30         40         50         60 
MQTPPTPLSS LTPHKLRLRR LGIDTYQEPV LYMHRDCRVC HSEGFEAQSR VELALGDRTI 

        70         80         90        100        110        120 
VATLNVVSGD FLAPDEAGLS EAAWRLLGAQ EGDMVSPRHP APIESLGHVR AKVYGRHLTQ 

       130        140        150        160        170        180 
AAITAVIEDV TAGRYSDLQL AAFVTACAGD RLDQEETVSL TRAMVAAGER IDWGEGLVMD 

       190        200        210        220        230        240 
KHCVGGLPGN RTTMVIVPIV AACGLRMPKT SSRAITSPAG TADTMETLAP VDLDVAQIRR 

       250        260        270        280        290        300 
VVERTGGCVV WGGAVRLSPA DDILIRVERP LDLDSQGQLV ASILSKKVAA GSTHVLIDMP 

       310        320        330        340        350        360 
VGPTAKVRSA EAADLLGRLL GQVGQTLGLR MRVVQTDGLA PVGRGIGPAL EARDVLAVLR 

       370        380        390        400        410        420 
NLATAPADLA QRSLLLAGEV LEFGGAAPAG GGLALASAVL ADGRAWRKFQ DICAAQGGLR 

       430        440        450        460        470        480 
EPPVAAHQQA VHALRSGSVL AIDNRRLARI AKLAGAPGAA CAGIDLHVRP GEFVERGQPL 

       490        500        510 
FTLHAATPGE LAYALEYAAS QAETVHVLED A 

« Hide

References

[1]"Complete sequence of chromosome of Polaromonas sp. JS666."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000316 Genomic DNA. Translation: ABE43145.1.
RefSeqYP_548043.1. NC_007948.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING296591.Bpro_1194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE43145; ABE43145; Bpro_1194.
GeneID4012163.
KEGGpol:Bpro_1194.
PATRIC22955486. VBIPolSp102244_1226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000252767.
KOK00758.
OMACHSEGFE.
OrthoDBEOG61ZTGG.
ProtClustDBPRK04350.

Enzyme and pathway databases

BioCycPSP296591:GHI4-1915-MONOMER.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_00703. Thymid_phosp_2.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_POLSJ
AccessionPrimary (citable) accession number: Q12E97
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families