Q12CY2 (Q12CY2_POLSJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 1 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 1 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1 HAMAP MF_01401

Gene names

Name:	msrA1 HAMAP MF_01401
Ordered Locus Names:	Bpro_1674

Organism

Polaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]

Taxonomic identifier

296591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Polaromonas

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 SAAS SAAS002569 EMBL ABE43610.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	14	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	Q12CY2 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 71DAA5EA56EB328D	FASTA	180	20,261
	10 20 30 40 50 60 MPSSPQTITL GGGCFWCTEA VYVKVRGVTD VESGYSNGQA ERPSYDDVCT GRTGCNEVVK 70 80 90 100 110 120 LTYDPEEISL REILEIFFVI HDPTSLNRQG NDAGTQYRSG IYYSTPEQKQ VADDFIRQAS 130 140 150 160 170 180 QDKLFGNPIV TEVLPLANYW PAEAYHQDYF ENNPNQGYCA FVVGPKVEKF RKTFASRVKD

References

[1]

"Complete sequence of chromosome of Polaromonas sp. JS666." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000316 Genomic DNA. Translation: ABE43610.1.
RefSeq	YP_548508.1. NC_007948.1.
3D structure databases
ProteinModelPortal	Q12CY2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12CY2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4015693.
GenomeReviews	Gene locus Bpro_1674 in contig CP000316_GR.
KEGG	pol:Bpro_1674.
NMPDR	fig|296591.1.peg.2407.
PATRIC	22956441. VBIPolSp102244_1693.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	IDTEVGY.
PhylomeDB	Q12CY2.
ProtClustDB	CLSK723355.
Enzyme and pathway databases
BioCyc	PSP296591:BPRO_1674-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q12CY2_POLSJ

Accession

Primary (citable) accession number: Q12CY2

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)