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Q12CT8 (GUAC_POLSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP reductase

EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:Bpro_1718
OrganismPolaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]
Taxonomic identifier296591 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP-Rule MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP-Rule MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentGMP reductase complex

Inferred from electronic annotation. Source: UniProtKB-EC

   Molecular_functionGMP reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325GMP reductase HAMAP-Rule MF_01511
PRO_0000294282

Regions

Nucleotide binding202 – 22524NADP Potential

Sites

Active site1731Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12CT8 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 030A46B033E60830

FASTA32535,566
        10         20         30         40         50         60 
MEIFDYENVL LLPRKCRVES RSECNAGVAL GGRTFRIPVV PANMKTVVDE NICAWMAKNG 

        70         80         90        100        110        120 
YFYVMHRFDL DNLQFVKNMK AKGVYASISL GVKKPDYDTV DQFVAEGLAP EYITIDIAHG 

       130        140        150        160        170        180 
HADTVQRMIA YLKQKLPASF VIAGNVATPE AVIDLENWGA DATKVGIGPG KVCITKMKTG 

       190        200        210        220        230        240 
FGTGGWQLSA LKWCARVATK PIIADGGIRE HGDIAKSIRF GATMVMIGSL LAGLEESPGK 

       250        260        270        280        290        300 
TVEVDGKLFK EYYGSASDFN KGEYKHVEGK RILEPIKGTL ADTLREMEED IQSSISYAGG 

       310        320 
KKLMDIRKAN YVILGGDNAG EHLLM 

« Hide

References

[1]"Complete sequence of chromosome of Polaromonas sp. JS666."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000316 Genomic DNA. Translation: ABE43654.1.
RefSeqYP_548552.1. NC_007948.1.

3D structure databases

ProteinModelPortalQ12CT8.
SMRQ12CT8. Positions 3-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING296591.Bpro_1718.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE43654; ABE43654; Bpro_1718.
GeneID4015620.
KEGGpol:Bpro_1718.
PATRIC22956531. VBIPolSp102244_1738.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
HOGENOMHOG000165753.
KOK00364.
OMAPDYITID.
OrthoDBEOG6GTZPV.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycPSP296591:GHI4-2439-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01511. GMP_reduct_type2.
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_POLSJ
AccessionPrimary (citable) accession number: Q12CT8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 22, 2006
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families