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Q12BZ9 (HEMH_POLSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Bpro_2013
OrganismPolaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]
Taxonomic identifier296591 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Polaromonas

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Ferrochelatase HAMAP MF_00323
PRO_1000059485

Sites

Metal binding2131Iron By similarity
Metal binding2941Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12BZ9 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 33BA0941C3964AE8

FASTA36741,079
        10         20         30         40         50         60 
MSFAPEPSFS HGKPPAASCA TAILLCNLGT PDAPTAPALR RYLAEFLSDP RVVEIPRPIW 

        70         80         90        100        110        120 
WLILHGIILR LRPKKSATKY ASIWTPEGSP LKVWTQKQAL MLRGYLGARG HTVEVRYAMR 

       130        140        150        160        170        180 
YGNPSIASQL NQLKADGATR ILILPAYPQY SGTTTASVFD AVYSWAARVR RIPEFRFVNN 

       190        200        210        220        230        240 
YHDDPGYISA LAERVRTHWR HYGQAGQLVM SFHGVPERTL KLGDPYHCEC HKTARLLAEK 

       250        260        270        280        290        300 
LGLGKDRYKV TFQSRFGKAK WLEPYTEPTL IRMAQAGIER VDVVCPGFTG DCLETLEEIA 

       310        320        330        340        350        360 
MEARHAFLKA GGKEFHYIEC LNDSPTWIAA LAEFSARQLA GWPTQAPRDT EALRKSGERA 


LAMGAPR

« Hide

References

[1]"Complete sequence of chromosome of Polaromonas sp. JS666."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000316 Genomic DNA. Translation: ABE43943.1.
RefSeqYP_548841.1. NC_007948.1.

3D structure databases

ProteinModelPortalQ12BZ9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12BZ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4015344.
GenomeReviewsGene locus Bpro_2013 in contig CP000316_GR.
KEGGpol:Bpro_2013.
NMPDRfig|296591.1.peg.2593.
PATRIC22957125. VBIPolSp102244_2033.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
PhylomeDBQ12BZ9.
ProtClustDBCLSK951224.

Enzyme and pathway databases

BioCycPSP296591:BPRO_2013-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_POLSJ
AccessionPrimary (citable) accession number: Q12BZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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