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Q12BW3 (Q12BW3_POLSJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123
Gene names
Name:acsA HAMAP MF_01123
Ordered Locus Names:Bpro_2049
OrganismPolaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]
Taxonomic identifier296591 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Polaromonas

Protein attributes

Sequence length665 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5341 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6301N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
Q12BW3 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 481FF1FE5174C67D

FASTA66572,408
        10         20         30         40         50         60 
MSSAPSNIES VLVENRVFPP GPATVKAARI SGMEAYNAMC READKDFDRF WARLARDNLS 

        70         80         90        100        110        120 
WKKPFSQVLD ESNAPFYQWF ADGELNASYN CLDRHLGTPT ESKKAIIFES DDGKATSVTY 

       130        140        150        160        170        180 
KELHARVSQF ASALKGLGVK KGDRVIIYMP MTIEGVVAMQ ACARIGATHS VVFGGFSAKS 

       190        200        210        220        230        240 
LQERIQDAGA VAVITANYQL RGGKELPLKA IVDEGIAMGG CESIKNVVVY QRTATPCNMV 

       250        260        270        280        290        300 
AGRDSLMHEI TARAAATCEP EFVGAEHPLF ILYTSGSTGK PKGVQHSTGG YLLWAKLTMD 

       310        320        330        340        350        360 
WTFDIQPADV FWCTADIGWI TGHTYVAYGP LAAGATQVIF EGIPTYPNAG RFWQMIEKHK 

       370        380        390        400        410        420 
VTIFYTAPTA IRSLIKAAEG DEKIHPARSD LSSLRILGTV GEPINPEAWM WYYKNIGGER 

       430        440        450        460        470        480 
CPIVDTFWQT ESGGHMITPL PGATPLVPGS CTLPLPGIMA AIVDETGKDL PNGSGGLLVV 

       490        500        510        520        530        540 
KRPWPSMIRG IWNDPERFKK SYFPEEMGGT MYLAGDGAVR NADNGYFRIT GRIDDVLNVS 

       550        560        570        580        590        600 
GHRMGTMEIE SALVAHSTLV AEAAVVGRPD DLTGEAIVAF VVLKRSRPTG DEAKAIAKEL 

       610        620        630        640        650        660 
RDWVGKEIGP IAKPKDIRFG DNLPKTRSGK IMRRLLRGIA KGEALTQDTS TLENPAILDQ 


LSENL

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References

[1]"Complete sequence of chromosome of Polaromonas sp. JS666."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000316 Genomic DNA. Translation: ABE43979.1.
RefSeqYP_548877.1. NC_007948.1.

3D structure databases

ProteinModelPortalQ12BW3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ12BW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4015313.
GenomeReviewsGene locus Bpro_2049 in contig CP000316_GR.
KEGGpol:Bpro_2049.
NMPDRfig|296591.1.peg.2556.
PATRIC22957209. VBIPolSp102244_2071.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMASHISSME.
PhylomeDBQ12BW3.
ProtClustDBCLSK951547.

Enzyme and pathway databases

BioCycPSP296591:BPRO_2049-MONOMER.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ12BW3_POLSJ
AccessionPrimary (citable) accession number: Q12BW3
Entry history
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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