Q12AE4 (MSRB_POLSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	Bpro_2582

Organism

Polaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]

Taxonomic identifier

296591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Polaromonas

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 136	136	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000145376
Sites
	Active site	125	1	Nucleophile By similarity
	Metal binding	53	1	Zinc By similarity
	Metal binding	56	1	Zinc By similarity
	Metal binding	102	1	Zinc By similarity
	Metal binding	105	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12AE4 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 809B95DFAB3F00E0	FASTA	136	14,957
	10 20 30 40 50 60 MSTKIQKTDA EWKALLAEKG AEPVAFEVTR HAATERPFTG KYEDNYAQGT YRCICCDAEL 70 80 90 100 110 120 FDSSSKFDAG CGWPSFSQEL NKGAIEEHVD RAHGMTRTET VCANCGAHLG HVFPDGPTPT 130 GLRYCMNSAS LDFKPK

References

[1]

"Complete sequence of chromosome of Polaromonas sp. JS666." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000316 Genomic DNA. Translation: ABE44498.1.
RefSeq	YP_549396.1. NC_007948.1.
3D structure databases
ProteinModelPortal	Q12AE4.
SMR	Q12AE4. Positions 4-136.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12AE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4014770.
GenomeReviews	Gene locus Bpro_2582 in contig CP000316_GR.
KEGG	pol:Bpro_2582.
NMPDR	fig|296591.1.peg.295.
PATRIC	22958304. VBIPolSp102244_2614.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	YNDINDK.
PhylomeDB	Q12AE4.
ProtClustDB	CLSK953142.
Enzyme and pathway databases
BioCyc	PSP296591:BPRO_2582-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_POLSJ

Accession

Primary (citable) accession number: Q12AE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program