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Q129H3

- TRMB_POLSJ

UniProt

Q129H3 - TRMB_POLSJ

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei75 – 751S-adenosyl-L-methionineUniRule annotation
Binding sitei100 – 1001S-adenosyl-L-methionineUniRule annotation
Binding sitei127 – 1271S-adenosyl-L-methionineUniRule annotation
Active sitei150 – 1501By similarity
Binding sitei150 – 1501S-adenosyl-L-methionineUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Binding sitei186 – 1861SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPSP296591:GHI4-3626-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Bpro_2905
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000001983: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246tRNA (guanine-N(7)-)-methyltransferasePRO_0000288197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_2905.

Structurei

3D structure databases

ProteinModelPortaliQ129H3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni156 – 1616Interaction with RNAUniRule annotation
Regioni225 – 2284Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiQDNFLCC.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q129H3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIENPSPSAA NLPEHPSTDA SHPRNIRSFV RRTGRTTVGQ AKAFADVGPR
60 70 80 90 100
FLLAYKAEPL DFAAAFGRVA PTILEIGFGM GEATAHIAAL SPDKNFLCCE
110 120 130 140 150
VHTPGVGALL KRIQEQTLGN IRILQHDAVE VIDNMLPAGS LDGVHIFFPD
160 170 180 190 200
PWHKKKHNKR RLIQAPLIAK LAARLKPGGY LHCATDWQPY AEQILEVLSA
210 220 230 240
EALLKNTADA SGGGYAPKPD YRPLTKFENR GIKLGHGVWD VVFTRV
Length:246
Mass (Da):26,881
Last modified:August 22, 2006 - v1
Checksum:iC243B2080AA4C5C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000316 Genomic DNA. Translation: ABE44819.1.
RefSeqiWP_011483817.1. NC_007948.1.
YP_549717.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE44819; ABE44819; Bpro_2905.
GeneIDi4014441.
KEGGipol:Bpro_2905.
PATRICi22958984. VBIPolSp102244_2951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000316 Genomic DNA. Translation: ABE44819.1 .
RefSeqi WP_011483817.1. NC_007948.1.
YP_549717.1. NC_007948.1.

3D structure databases

ProteinModelPortali Q129H3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 296591.Bpro_2905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE44819 ; ABE44819 ; Bpro_2905 .
GeneIDi 4014441.
KEGGi pol:Bpro_2905.
PATRICi 22958984. VBIPolSp102244_2951.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi QDNFLCC.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PSP296591:GHI4-3626-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS666 / ATCC BAA-500.

Entry informationi

Entry nameiTRMB_POLSJ
AccessioniPrimary (citable) accession number: Q129H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 22, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3