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Q129C4 (LEXA_POLSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LexA repressor

EC=3.4.21.88
Gene names
Name:lexA
Ordered Locus Names:Bpro_2954
OrganismPolaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]
Taxonomic identifier296591 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP-Rule MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor LexA. HAMAP-Rule MF_00015

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00015

Sequence similarities

Belongs to the peptidase S24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234LexA repressor HAMAP-Rule MF_00015
PRO_0000322753

Regions

DNA binding41 – 6121H-T-H motif By similarity

Sites

Active site1521For autocatalytic cleavage activity By similarity
Active site1891For autocatalytic cleavage activity By similarity
Site117 – 1182Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q129C4 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 982F5BFA335F020C

FASTA23425,883
        10         20         30         40         50         60 
MSILNDFSHL SSEGPKLTAR QQQILELIQS AITRTGAPPT RAEIANELGF KSANAAEEHL 

        70         80         90        100        110        120 
QALARKGVIE LVSGTSRGIR LRSDTLRSIH ESRVKQFSLP LQSLAQLALP LVGRVAAGSP 

       130        140        150        160        170        180 
ILAQEHIEQT YYFESSLFQR QPDYLLKVRG MSMRDAGIID GDLLAVKQAK EARNGQIVVA 

       190        200        210        220        230 
RIGDEVTVKR FRRTKHLIEL LPENPDFKTI VVEPGEPFEL EGLAVGLIRN TMLI 

« Hide

References

[1]"Complete sequence of chromosome of Polaromonas sp. JS666."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000316 Genomic DNA. Translation: ABE44868.1.
RefSeqYP_549766.1. NC_007948.1.

3D structure databases

ProteinModelPortalQ129C4.
SMRQ129C4. Positions 17-81, 108-230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING296591.Bpro_2954.

Protein family/group databases

MEROPSS24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE44868; ABE44868; Bpro_2954.
GeneID4014373.
KEGGpol:Bpro_2954.
PATRIC22959088. VBIPolSp102244_3003.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1974.
HOGENOMHOG000232167.
KOK01356.
OMAQNTANNG.
OrthoDBEOG6JHRHJ.
ProtClustDBPRK00215.

Enzyme and pathway databases

BioCycPSP296591:GHI4-3675-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPMF_00015. LexA.
InterProIPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
SUPFAMSSF51306. SSF51306. 1 hit.
TIGRFAMsTIGR00498. lexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLEXA_POLSJ
AccessionPrimary (citable) accession number: Q129C4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 22, 2006
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries