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Protein

Tetraspanin-31

Gene

TSPAN31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-31
Short name:
Tspan-31
Alternative name(s):
Sarcoma-amplified sequence
Gene namesi
Name:TSPAN31
Synonyms:SAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10539. TSPAN31.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 4411ExtracellularSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Topological domaini66 – 727CytoplasmicSequence Analysis
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Topological domaini94 – 17380ExtracellularSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Topological domaini195 – 21016CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34949.

Polymorphism and mutation databases

BioMutaiTSPAN31.
DMDMi6174973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Tetraspanin-31PRO_0000219270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ12999.
PaxDbiQ12999.
PRIDEiQ12999.

Expressioni

Gene expression databases

BgeeiQ12999.
CleanExiHS_TSPAN31.
ExpressionAtlasiQ12999. baseline and differential.
GenevisibleiQ12999. HS.

Organism-specific databases

HPAiHPA057489.

Interactioni

Protein-protein interaction databases

BioGridi112209. 1 interaction.
STRINGi9606.ENSP00000257910.

Structurei

3D structure databases

ProteinModelPortaliQ12999.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279074.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ12999.
KOiK17356.
OMAiYQQDYAF.
OrthoDBiEOG7D2FFF.
PhylomeDBiQ12999.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.

Sequencei

Sequence statusi: Complete.

Q12999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI
60 70 80 90 100
AVGVFLLLIA VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN
110 120 130 140 150
RSKQTDVINA SWWVMSNKTR DELERSFDCC GLFNLTTLYQ QDYDFCTAIC
160 170 180 190 200
KSQSPTCQMC GEKFLKHSDE ALKILGGVGL FFSFTEILGV WLAMRFRNQK
210
DPRANPSAFL
Length:210
Mass (Da):23,053
Last modified:November 1, 1996 - v1
Checksum:i8A1FF8CC5319755E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01160 mRNA. Translation: AAA17782.1.
U81031 Genomic DNA. Translation: AAC39524.2.
AK315765 mRNA. Translation: BAG38117.1.
CR407647 mRNA. Translation: CAG28575.1.
CH471054 Genomic DNA. Translation: EAW97057.1.
BC010377 mRNA. Translation: AAH10377.1.
CCDSiCCDS8952.1.
PIRiI58391.
RefSeqiNP_005972.1. NM_005981.3.
UniGeneiHs.632708.

Genome annotation databases

EnsembliENST00000257910; ENSP00000257910; ENSG00000135452.
GeneIDi6302.
KEGGihsa:6302.
UCSCiuc001spt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01160 mRNA. Translation: AAA17782.1.
U81031 Genomic DNA. Translation: AAC39524.2.
AK315765 mRNA. Translation: BAG38117.1.
CR407647 mRNA. Translation: CAG28575.1.
CH471054 Genomic DNA. Translation: EAW97057.1.
BC010377 mRNA. Translation: AAH10377.1.
CCDSiCCDS8952.1.
PIRiI58391.
RefSeqiNP_005972.1. NM_005981.3.
UniGeneiHs.632708.

3D structure databases

ProteinModelPortaliQ12999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112209. 1 interaction.
STRINGi9606.ENSP00000257910.

Polymorphism and mutation databases

BioMutaiTSPAN31.
DMDMi6174973.

Proteomic databases

MaxQBiQ12999.
PaxDbiQ12999.
PRIDEiQ12999.

Protocols and materials databases

DNASUi6302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257910; ENSP00000257910; ENSG00000135452.
GeneIDi6302.
KEGGihsa:6302.
UCSCiuc001spt.3. human.

Organism-specific databases

CTDi6302.
GeneCardsiGC12P058138.
HGNCiHGNC:10539. TSPAN31.
HPAiHPA057489.
MIMi181035. gene.
neXtProtiNX_Q12999.
PharmGKBiPA34949.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279074.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ12999.
KOiK17356.
OMAiYQQDYAF.
OrthoDBiEOG7D2FFF.
PhylomeDBiQ12999.
TreeFamiTF323367.

Miscellaneous databases

ChiTaRSiTSPAN31. human.
GeneWikiiTSPAN31.
GenomeRNAii6302.
NextBioi24467.
PROiQ12999.
SOURCEiSearch...

Gene expression databases

BgeeiQ12999.
CleanExiHS_TSPAN31.
ExpressionAtlasiQ12999. baseline and differential.
GenevisibleiQ12999. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins."
    Jankowski S.A., Mitchell D.S., Smith S.H., Trent J.M., Meltzer P.S.
    Oncogene 9:1205-1211(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Osteosarcoma.
  2. "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers."
    Elkahloun A.G., Krizman D.B., Wang Z., Hofmann T.A., Roe B.A., Meltzer P.S.
    Genomics 42:295-301(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Roe B.A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 76-77 AND 205-210.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiTSN31_HUMAN
AccessioniPrimary (citable) accession number: Q12999
Secondary accession number(s): O00577, Q53X76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.