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Protein

Tetraspanin-31

Gene

TSPAN31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-31
Short name:
Tspan-31
Alternative name(s):
Sarcoma-amplified sequence
Gene namesi
Name:TSPAN31
Synonyms:SAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10539. TSPAN31.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 44ExtracellularSequence analysisAdd BLAST11
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 173ExtracellularSequence analysisAdd BLAST80
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 210CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6302.
OpenTargetsiENSG00000135452.
PharmGKBiPA34949.

Polymorphism and mutation databases

BioMutaiTSPAN31.
DMDMi6174973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192701 – 210Tetraspanin-31Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ12999.
PeptideAtlasiQ12999.
PRIDEiQ12999.

PTM databases

PhosphoSitePlusiQ12999.

Expressioni

Gene expression databases

BgeeiENSG00000135452.
CleanExiHS_TSPAN31.
ExpressionAtlasiQ12999. baseline and differential.
GenevisibleiQ12999. HS.

Organism-specific databases

HPAiHPA057489.

Interactioni

Protein-protein interaction databases

BioGridi112209. 1 interactor.
STRINGi9606.ENSP00000257910.

Structurei

3D structure databases

ProteinModelPortaliQ12999.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ12999.
KOiK17356.
OMAiMNRGQQE.
OrthoDBiEOG091G0PBF.
PhylomeDBiQ12999.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.

Sequencei

Sequence statusi: Complete.

Q12999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI
60 70 80 90 100
AVGVFLLLIA VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN
110 120 130 140 150
RSKQTDVINA SWWVMSNKTR DELERSFDCC GLFNLTTLYQ QDYDFCTAIC
160 170 180 190 200
KSQSPTCQMC GEKFLKHSDE ALKILGGVGL FFSFTEILGV WLAMRFRNQK
210
DPRANPSAFL
Length:210
Mass (Da):23,053
Last modified:November 1, 1996 - v1
Checksum:i8A1FF8CC5319755E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01160 mRNA. Translation: AAA17782.1.
U81031 Genomic DNA. Translation: AAC39524.2.
AK315765 mRNA. Translation: BAG38117.1.
CR407647 mRNA. Translation: CAG28575.1.
CH471054 Genomic DNA. Translation: EAW97057.1.
BC010377 mRNA. Translation: AAH10377.1.
CCDSiCCDS8952.1.
PIRiI58391.
RefSeqiNP_005972.1. NM_005981.4.
UniGeneiHs.632708.

Genome annotation databases

EnsembliENST00000257910; ENSP00000257910; ENSG00000135452.
GeneIDi6302.
KEGGihsa:6302.
UCSCiuc001spt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01160 mRNA. Translation: AAA17782.1.
U81031 Genomic DNA. Translation: AAC39524.2.
AK315765 mRNA. Translation: BAG38117.1.
CR407647 mRNA. Translation: CAG28575.1.
CH471054 Genomic DNA. Translation: EAW97057.1.
BC010377 mRNA. Translation: AAH10377.1.
CCDSiCCDS8952.1.
PIRiI58391.
RefSeqiNP_005972.1. NM_005981.4.
UniGeneiHs.632708.

3D structure databases

ProteinModelPortaliQ12999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112209. 1 interactor.
STRINGi9606.ENSP00000257910.

PTM databases

PhosphoSitePlusiQ12999.

Polymorphism and mutation databases

BioMutaiTSPAN31.
DMDMi6174973.

Proteomic databases

PaxDbiQ12999.
PeptideAtlasiQ12999.
PRIDEiQ12999.

Protocols and materials databases

DNASUi6302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257910; ENSP00000257910; ENSG00000135452.
GeneIDi6302.
KEGGihsa:6302.
UCSCiuc001spt.4. human.

Organism-specific databases

CTDi6302.
DisGeNETi6302.
GeneCardsiTSPAN31.
HGNCiHGNC:10539. TSPAN31.
HPAiHPA057489.
MIMi181035. gene.
neXtProtiNX_Q12999.
OpenTargetsiENSG00000135452.
PharmGKBiPA34949.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ12999.
KOiK17356.
OMAiMNRGQQE.
OrthoDBiEOG091G0PBF.
PhylomeDBiQ12999.
TreeFamiTF323367.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135452-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN31. human.
GeneWikiiTSPAN31.
GenomeRNAii6302.
PROiQ12999.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135452.
CleanExiHS_TSPAN31.
ExpressionAtlasiQ12999. baseline and differential.
GenevisibleiQ12999. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
ProtoNetiSearch...

Entry informationi

Entry nameiTSN31_HUMAN
AccessioniPrimary (citable) accession number: Q12999
Secondary accession number(s): O00577, Q53X76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.