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Q12999 (TSN31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-31

Short name=Tspan-31
Alternative name(s):
Sarcoma-amplified sequence
Gene names
Name:TSPAN31
Synonyms:SAS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Tetraspanin-31
PRO_0000219270

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 4411Extracellular Potential
Transmembrane45 – 6521Helical; Potential
Topological domain66 – 727Cytoplasmic Potential
Transmembrane73 – 9321Helical; Potential
Topological domain94 – 17380Extracellular Potential
Transmembrane174 – 19421Helical; Potential
Topological domain195 – 21016Cytoplasmic Potential

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q12999 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8A1FF8CC5319755E

FASTA21023,053
        10         20         30         40         50         60 
MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI AVGVFLLLIA 

        70         80         90        100        110        120 
VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN RSKQTDVINA SWWVMSNKTR 

       130        140        150        160        170        180 
DELERSFDCC GLFNLTTLYQ QDYDFCTAIC KSQSPTCQMC GEKFLKHSDE ALKILGGVGL 

       190        200        210 
FFSFTEILGV WLAMRFRNQK DPRANPSAFL 

« Hide

References

« Hide 'large scale' references
[1]"SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins."
Jankowski S.A., Mitchell D.S., Smith S.H., Trent J.M., Meltzer P.S.
Oncogene 9:1205-1211(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Osteosarcoma.
[2]"Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers."
Elkahloun A.G., Krizman D.B., Wang Z., Hofmann T.A., Roe B.A., Meltzer P.S.
Genomics 42:295-301(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Roe B.A.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 76-77 AND 205-210.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01160 mRNA. Translation: AAA17782.1.
U81031 Genomic DNA. Translation: AAC39524.2.
AK315765 mRNA. Translation: BAG38117.1.
CR407647 mRNA. Translation: CAG28575.1.
CH471054 Genomic DNA. Translation: EAW97057.1.
BC010377 mRNA. Translation: AAH10377.1.
PIRI58391.
RefSeqNP_005972.1. NM_005981.3.
UniGeneHs.632708.

3D structure databases

ProteinModelPortalQ12999.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112209. 1 interaction.
STRING9606.ENSP00000257910.

Polymorphism databases

DMDM6174973.

Proteomic databases

PaxDbQ12999.
PRIDEQ12999.

Protocols and materials databases

DNASU6302.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257910; ENSP00000257910; ENSG00000135452.
GeneID6302.
KEGGhsa:6302.
UCSCuc001spt.3. human.

Organism-specific databases

CTD6302.
GeneCardsGC12P058138.
HGNCHGNC:10539. TSPAN31.
HPAHPA057489.
MIM181035. gene.
neXtProtNX_Q12999.
PharmGKBPA34949.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279074.
HOGENOMHOG000005650.
HOVERGENHBG009195.
InParanoidQ12999.
KOK17356.
OMAVFLFQFG.
OrthoDBEOG7D2FFF.
PhylomeDBQ12999.
TreeFamTF323367.

Gene expression databases

ArrayExpressQ12999.
BgeeQ12999.
CleanExHS_TSPAN31.
GenevestigatorQ12999.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
ProtoNetSearch...

Other

ChiTaRSTSPAN31. human.
GeneWikiTSPAN31.
GenomeRNAi6302.
NextBio24467.
PROQ12999.
SOURCESearch...

Entry information

Entry nameTSN31_HUMAN
AccessionPrimary (citable) accession number: Q12999
Secondary accession number(s): O00577, Q53X76
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM