Q12999 (TSN31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetraspanin-31
Short name=Tspan-31

Alternative name(s):
Sarcoma-amplified sequence

Gene names

Name:	TSPAN31
Synonyms:	SAS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of cell proliferation Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Tetraspanin-31		PRO_0000219270
Regions
	Topological domain	1 – 12	12	Cytoplasmic Potential
	Transmembrane	13 – 33	21	Helical; Potential
	Topological domain	34 – 44	11	Extracellular Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Topological domain	66 – 72	7	Cytoplasmic Potential
	Transmembrane	73 – 93	21	Helical; Potential
	Topological domain	94 – 173	80	Extracellular Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Topological domain	195 – 210	16	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Glycosylation	134	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q12999 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8A1FF8CC5319755E	FASTA	210	23,053
	10 20 30 40 50 60 MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI AVGVFLLLIA 70 80 90 100 110 120 VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN RSKQTDVINA SWWVMSNKTR 130 140 150 160 170 180 DELERSFDCC GLFNLTTLYQ QDYDFCTAIC KSQSPTCQMC GEKFLKHSDE ALKILGGVGL 190 200 210 FFSFTEILGV WLAMRFRNQK DPRANPSAFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins." Jankowski S.A., Mitchell D.S., Smith S.H., Trent J.M., Meltzer P.S. Oncogene 9:1205-1211(1994) [PubMed: 8134123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Osteosarcoma.
[2]	"Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers." Elkahloun A.G., Krizman D.B., Wang Z., Hofmann T.A., Roe B.A., Meltzer P.S. Genomics 42:295-301(1997) [PubMed: 9192850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Roe B.A. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 76-77 AND 205-210.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U01160 mRNA. Translation: AAA17782.1. U81031 Genomic DNA. Translation: AAC39524.2. BC010377 mRNA. Translation: AAH10377.1.
IPI	IPI00030418.
PIR	I58391.
RefSeq	NP_005972.1. NM_005981.3.
UniGene	Hs.632708.
3D structure databases
ProteinModelPortal	Q12999.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12999.
Polymorphism databases
DMDM	6174973.
Proteomic databases
PRIDE	Q12999.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257910; ENSP00000257910; ENSG00000135452.
GeneID	6302.
KEGG	hsa:6302.
UCSC	uc001spt.1. human.
Organism-specific databases
CTD	6302.
GeneCards	GC12P058138.
H-InvDB	HIX0010752.
HGNC	HGNC:10539. TSPAN31.
MIM	181035. gene.
neXtProt	NX_Q12999.
PharmGKB	PA34949.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19151.
HOGENOM	HBG444881.
HOVERGEN	HBG009195.
InParanoid	Q12999.
OMA	VFIFQFG.
OrthoDB	EOG48GW4J.
PhylomeDB	Q12999.
Gene expression databases
ArrayExpress	Q12999.
Bgee	Q12999.
CleanEx	HS_TSPAN31.
Genevestigator	Q12999.
GermOnline	ENSG00000135452. Homo sapiens.
Family and domain databases
InterPro	IPR018499. Tetraspanin. IPR000301. Tetraspanin_subgr. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PRINTS	PR00259. TMFOUR.
PROSITE	PS00421. TM4_1. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	24467.
SOURCE	Search...

Entry information

Entry name

TSN31_HUMAN

Accession

Primary (citable) accession number: Q12999
Secondary accession number(s): O00577

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.