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Q12999

- TSN31_HUMAN

UniProt

Q12999 - TSN31_HUMAN

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Protein
Tetraspanin-31
Gene
TSPAN31, SAS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-31
Short name:
Tspan-31
Alternative name(s):
Sarcoma-amplified sequence
Gene namesi
Name:TSPAN31
Synonyms:SAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10539. TSPAN31.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Topological domaini34 – 4411Extracellular Reviewed prediction
Add
BLAST
Transmembranei45 – 6521Helical; Reviewed prediction
Add
BLAST
Topological domaini66 – 727Cytoplasmic Reviewed prediction
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Topological domaini94 – 17380Extracellular Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Topological domaini195 – 21016Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Tetraspanin-31
PRO_0000219270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ12999.
PaxDbiQ12999.
PRIDEiQ12999.

Expressioni

Gene expression databases

ArrayExpressiQ12999.
BgeeiQ12999.
CleanExiHS_TSPAN31.
GenevestigatoriQ12999.

Organism-specific databases

HPAiHPA057489.

Interactioni

Protein-protein interaction databases

BioGridi112209. 1 interaction.
STRINGi9606.ENSP00000257910.

Structurei

3D structure databases

ProteinModelPortaliQ12999.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279074.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ12999.
KOiK17356.
OMAiLDCCGLF.
OrthoDBiEOG7D2FFF.
PhylomeDBiQ12999.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.

Sequencei

Sequence statusi: Complete.

Q12999-1 [UniParc]FASTAAdd to Basket

« Hide

MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI    50
AVGVFLLLIA VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN 100
RSKQTDVINA SWWVMSNKTR DELERSFDCC GLFNLTTLYQ QDYDFCTAIC 150
KSQSPTCQMC GEKFLKHSDE ALKILGGVGL FFSFTEILGV WLAMRFRNQK 200
DPRANPSAFL 210
Length:210
Mass (Da):23,053
Last modified:November 1, 1996 - v1
Checksum:i8A1FF8CC5319755E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01160 mRNA. Translation: AAA17782.1.
U81031 Genomic DNA. Translation: AAC39524.2.
AK315765 mRNA. Translation: BAG38117.1.
CR407647 mRNA. Translation: CAG28575.1.
CH471054 Genomic DNA. Translation: EAW97057.1.
BC010377 mRNA. Translation: AAH10377.1.
CCDSiCCDS8952.1.
PIRiI58391.
RefSeqiNP_005972.1. NM_005981.3.
UniGeneiHs.632708.

Genome annotation databases

EnsembliENST00000257910; ENSP00000257910; ENSG00000135452.
GeneIDi6302.
KEGGihsa:6302.
UCSCiuc001spt.3. human.

Polymorphism databases

DMDMi6174973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01160 mRNA. Translation: AAA17782.1 .
U81031 Genomic DNA. Translation: AAC39524.2 .
AK315765 mRNA. Translation: BAG38117.1 .
CR407647 mRNA. Translation: CAG28575.1 .
CH471054 Genomic DNA. Translation: EAW97057.1 .
BC010377 mRNA. Translation: AAH10377.1 .
CCDSi CCDS8952.1.
PIRi I58391.
RefSeqi NP_005972.1. NM_005981.3.
UniGenei Hs.632708.

3D structure databases

ProteinModelPortali Q12999.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112209. 1 interaction.
STRINGi 9606.ENSP00000257910.

Polymorphism databases

DMDMi 6174973.

Proteomic databases

MaxQBi Q12999.
PaxDbi Q12999.
PRIDEi Q12999.

Protocols and materials databases

DNASUi 6302.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257910 ; ENSP00000257910 ; ENSG00000135452 .
GeneIDi 6302.
KEGGi hsa:6302.
UCSCi uc001spt.3. human.

Organism-specific databases

CTDi 6302.
GeneCardsi GC12P058138.
HGNCi HGNC:10539. TSPAN31.
HPAi HPA057489.
MIMi 181035. gene.
neXtProti NX_Q12999.
PharmGKBi PA34949.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279074.
HOGENOMi HOG000005650.
HOVERGENi HBG009195.
InParanoidi Q12999.
KOi K17356.
OMAi LDCCGLF.
OrthoDBi EOG7D2FFF.
PhylomeDBi Q12999.
TreeFami TF323367.

Miscellaneous databases

ChiTaRSi TSPAN31. human.
GeneWikii TSPAN31.
GenomeRNAii 6302.
NextBioi 24467.
PROi Q12999.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q12999.
Bgeei Q12999.
CleanExi HS_TSPAN31.
Genevestigatori Q12999.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins."
    Jankowski S.A., Mitchell D.S., Smith S.H., Trent J.M., Meltzer P.S.
    Oncogene 9:1205-1211(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Osteosarcoma.
  2. "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers."
    Elkahloun A.G., Krizman D.B., Wang Z., Hofmann T.A., Roe B.A., Meltzer P.S.
    Genomics 42:295-301(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Roe B.A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 76-77 AND 205-210.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiTSN31_HUMAN
AccessioniPrimary (citable) accession number: Q12999
Secondary accession number(s): O00577, Q53X76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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