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Q12999

- TSN31_HUMAN

UniProt

Q12999 - TSN31_HUMAN

Protein

Tetraspanin-31

Gene

TSPAN31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. positive regulation of cell proliferation Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-31
    Short name:
    Tspan-31
    Alternative name(s):
    Sarcoma-amplified sequence
    Gene namesi
    Name:TSPAN31
    Synonyms:SAS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10539. TSPAN31.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34949.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Tetraspanin-31PRO_0000219270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ12999.
    PaxDbiQ12999.
    PRIDEiQ12999.

    Expressioni

    Gene expression databases

    ArrayExpressiQ12999.
    BgeeiQ12999.
    CleanExiHS_TSPAN31.
    GenevestigatoriQ12999.

    Organism-specific databases

    HPAiHPA057489.

    Interactioni

    Protein-protein interaction databases

    BioGridi112209. 1 interaction.
    STRINGi9606.ENSP00000257910.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12999.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 4411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 727CytoplasmicSequence Analysis
    Topological domaini94 – 17380ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini195 – 21016CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG279074.
    HOGENOMiHOG000005650.
    HOVERGENiHBG009195.
    InParanoidiQ12999.
    KOiK17356.
    OMAiLDCCGLF.
    OrthoDBiEOG7D2FFF.
    PhylomeDBiQ12999.
    TreeFamiTF323367.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.

    Sequencei

    Sequence statusi: Complete.

    Q12999-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI    50
    AVGVFLLLIA VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN 100
    RSKQTDVINA SWWVMSNKTR DELERSFDCC GLFNLTTLYQ QDYDFCTAIC 150
    KSQSPTCQMC GEKFLKHSDE ALKILGGVGL FFSFTEILGV WLAMRFRNQK 200
    DPRANPSAFL 210
    Length:210
    Mass (Da):23,053
    Last modified:November 1, 1996 - v1
    Checksum:i8A1FF8CC5319755E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01160 mRNA. Translation: AAA17782.1.
    U81031 Genomic DNA. Translation: AAC39524.2.
    AK315765 mRNA. Translation: BAG38117.1.
    CR407647 mRNA. Translation: CAG28575.1.
    CH471054 Genomic DNA. Translation: EAW97057.1.
    BC010377 mRNA. Translation: AAH10377.1.
    CCDSiCCDS8952.1.
    PIRiI58391.
    RefSeqiNP_005972.1. NM_005981.3.
    UniGeneiHs.632708.

    Genome annotation databases

    EnsembliENST00000257910; ENSP00000257910; ENSG00000135452.
    GeneIDi6302.
    KEGGihsa:6302.
    UCSCiuc001spt.3. human.

    Polymorphism databases

    DMDMi6174973.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01160 mRNA. Translation: AAA17782.1 .
    U81031 Genomic DNA. Translation: AAC39524.2 .
    AK315765 mRNA. Translation: BAG38117.1 .
    CR407647 mRNA. Translation: CAG28575.1 .
    CH471054 Genomic DNA. Translation: EAW97057.1 .
    BC010377 mRNA. Translation: AAH10377.1 .
    CCDSi CCDS8952.1.
    PIRi I58391.
    RefSeqi NP_005972.1. NM_005981.3.
    UniGenei Hs.632708.

    3D structure databases

    ProteinModelPortali Q12999.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112209. 1 interaction.
    STRINGi 9606.ENSP00000257910.

    Polymorphism databases

    DMDMi 6174973.

    Proteomic databases

    MaxQBi Q12999.
    PaxDbi Q12999.
    PRIDEi Q12999.

    Protocols and materials databases

    DNASUi 6302.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257910 ; ENSP00000257910 ; ENSG00000135452 .
    GeneIDi 6302.
    KEGGi hsa:6302.
    UCSCi uc001spt.3. human.

    Organism-specific databases

    CTDi 6302.
    GeneCardsi GC12P058138.
    HGNCi HGNC:10539. TSPAN31.
    HPAi HPA057489.
    MIMi 181035. gene.
    neXtProti NX_Q12999.
    PharmGKBi PA34949.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279074.
    HOGENOMi HOG000005650.
    HOVERGENi HBG009195.
    InParanoidi Q12999.
    KOi K17356.
    OMAi LDCCGLF.
    OrthoDBi EOG7D2FFF.
    PhylomeDBi Q12999.
    TreeFami TF323367.

    Miscellaneous databases

    ChiTaRSi TSPAN31. human.
    GeneWikii TSPAN31.
    GenomeRNAii 6302.
    NextBioi 24467.
    PROi Q12999.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q12999.
    Bgeei Q12999.
    CleanExi HS_TSPAN31.
    Genevestigatori Q12999.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    ProtoNeti Search...

    Publicationsi

    1. "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins."
      Jankowski S.A., Mitchell D.S., Smith S.H., Trent J.M., Meltzer P.S.
      Oncogene 9:1205-1211(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Osteosarcoma.
    2. "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers."
      Elkahloun A.G., Krizman D.B., Wang Z., Hofmann T.A., Roe B.A., Meltzer P.S.
      Genomics 42:295-301(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Roe B.A.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 76-77 AND 205-210.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiTSN31_HUMAN
    AccessioniPrimary (citable) accession number: Q12999
    Secondary accession number(s): O00577, Q53X76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3