Reviewed, UniProtKB/Swiss-Prot Q12988 (HSPB3_HUMAN)

Names and origin

Protein names

Recommended name:
    Heat shock protein beta-3
      Short name=HspB3
Alternative name(s):
    Heat shock 17 kDa protein

Gene names

Name:	HSPB3
Synonyms:	HSPL27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Inhibitor of actin polymerization.
Sequence similarities	Belongs to the small heat shock protein (HSP20) family.

Ontologies

Keywords
Biological process	Stress response
Gene Ontology (GO)
Biological process	response to heat Inferred from electronic annotation. Source: InterPro response to unfolded protein Ref.1 Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 150	150	Heat shock protein beta-3		PRO_0000125936

Sequences

	Sequence		Length	Mass (Da)
	Q12988-1 [UniParc]. Last modified May 1, 1999. Version 2. Checksum: CE5A4DF34CD38715	FASTA	150	16,966
	10 20 30 40 50 60 MAKIILRHLI EIPVRYQEEF EARGLEDCRL DHALYALPGP TIVDLRKTRA AQSPPVDSAA 70 80 90 100 110 120 ETPPREGKSH FQILLDVVQF LPEDIIIQTF EGWLLIKAQH GTRMDEHGFI SRSFTRQYKL 130 140 150 PDGVEIKDLS AVLCHDGILV VEVKDPVGTK

References

[1]	"HspB3, the most deviating of the six known human small heat shock proteins." Boelens W.C., van Boekel M.A., de Jong W.W. Biochim. Biophys. Acta 1388:513-516(1998) [PubMed: 9858786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family -- HSPL27." Lam W.Y., Wing Tsui S.K.W., Law P.T.W., Luk S.C., Fung K.P., Lee C.Y., Waye M.M.Y. Biochim. Biophys. Acta 1314:120-124(1996) [PubMed: 8972725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[3]	Waye M.M.Y. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15590 mRNA. Translation: AAD05360.1. Y17782 mRNA. Translation: CAA76848.1.
RefSeq	NP_006299.1.
UniGene	Hs.41707
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q12988.
Genome annotation databases
Ensembl	ENSG00000169271. Homo sapiens. [Contig view]
GeneID	8988.
KEGG	hsa:8988.
Organism-specific databases
H-InvDB	HIX0032082.
HGNC	HGNC:5248. HSPB3.
MIM	604624. gene.
PharmGKB	PA29513.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q12988.
HOVERGEN	Q12988.
Gene expression databases
ArrayExpress	Q12988.
CleanEx	HS_HSPB3.
GermOnline	ENSG00000169271. Homo sapiens.
Family and domain databases
InterPro	IPR001436. Alpha-crystallin/HSP. IPR002068. Hsp20. [Graphical view]
Pfam	PF00011. HSP20. 1 hit. [Graphical view]
PRINTS	PR00299. ACRYSTALLIN.
PROSITE	PS01031. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33707.
SOURCE	Search...

Entry information

Entry name

HSPB3_HUMAN

Accession

Primary (citable) accession number: Q12988

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	November 25, 2008
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)