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Q12986 (NFX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional repressor NF-X1

EC=6.3.2.-
Alternative name(s):
Nuclear transcription factor, X box-binding protein 1
Gene names
Name:NFX1
Synonyms:NFX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1120 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. Ref.7 Ref.8 Ref.9

Subunit structure

Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4. Ref.8 Ref.9

Subcellular location

Nucleus.

Induction

By IFNG/IFN-gamma.

Domain

The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.

Post-translational modification

Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated.

Sequence similarities

Belongs to the NFX1 family.

Contains 8 NF-X1-type zinc fingers.

Contains 1 R3H domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence AAA69517.1 differs from that shown. Reason: Frameshift at positions 78, 202 and 284.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q12986-1)

Also known as: NFX-123;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q12986-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1014-1024: GKNSKKSHSFP → VEVETSHWTFL
     1025-1120: Missing.
Isoform 3 (identifier: Q12986-3)

Also known as: NFX-91;

The sequence of this isoform differs from the canonical sequence as follows:
     809-833: FRSNIPCHLVDISCGLPCSATLPCG → QSHYWASTQKKRSHYMKKIPAHACL
     834-1120: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11201120Transcriptional repressor NF-X1
PRO_0000055979

Regions

Domain994 – 106269R3H
Zinc finger358 – 40952RING-type; atypical
Zinc finger453 – 47119NF-X1-type 1
Zinc finger506 – 52520NF-X1-type 2
Zinc finger567 – 58620NF-X1-type 3
Zinc finger632 – 65524NF-X1-type 4
Zinc finger694 – 71320NF-X1-type 5
Zinc finger721 – 74020NF-X1-type 6
Zinc finger832 – 85423NF-X1-type 7
Zinc finger863 – 88422NF-X1-type 8
Region9 – 2618Interaction with PABPC1 and PABC4
Compositional bias1084 – 10896Poly-Pro

Amino acid modifications

Modified residue501Phosphoserine Ref.11

Natural variations

Alternative sequence809 – 83325FRSNI…TLPCG → QSHYWASTQKKRSHYMKKIP AHACL in isoform 3.
VSP_033682
Alternative sequence834 – 1120287Missing in isoform 3.
VSP_033683
Alternative sequence1014 – 102411GKNSKKSHSFP → VEVETSHWTFL in isoform 2.
VSP_033684
Alternative sequence1025 – 112096Missing in isoform 2.
VSP_033685
Natural variant7311H → Y.
Corresponds to variant rs5017299 [ dbSNP | Ensembl ].
VAR_043380
Natural variant7601P → S.
Corresponds to variant rs2860036 [ dbSNP | Ensembl ].
VAR_043381
Natural variant10861P → Q.
Corresponds to variant rs2274866 [ dbSNP | Ensembl ].
VAR_043382

Experimental info

Mutagenesis201F → A: Reduces PABPC1 and PABC4 binding. Ref.9
Sequence conflict1791G → A in AAA69517. Ref.1
Sequence conflict1861G → E in AAA69517. Ref.1
Sequence conflict3121Q → P in AAA69517. Ref.1
Sequence conflict419 – 4202YT → FS in AAA69517. Ref.1
Sequence conflict5601I → T in AAA69517. Ref.1
Sequence conflict6531C → V in AAA69517. Ref.1
Sequence conflict6781E → EA in BAF84332. Ref.2
Sequence conflict7141I → N in AAA69517. Ref.1
Sequence conflict7861C → G in AAA69517. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (NFX-123) [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: F2203BE1DB6437E6

FASTA1,120124,395
        10         20         30         40         50         60 
MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS PPPCHLSRQV 

        70         80         90        100        110        120 
PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG LQNQPWQKLR NEKHHIRVKK 

       130        140        150        160        170        180 
AQSLAEQTSD TAGLESSTRS ESGTDLREHS PSESEKEVVG ADPRGAKPKK ATQFVYSYGR 

       190        200        210        220        230        240 
GPKVKGKLKC EWSNRTTPKP EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR 

       250        260        270        280        290        300 
YPQKRPPWEV EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL 

       310        320        330        340        350        360 
AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ LTTEKYECMV 

       370        380        390        400        410        420 
CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ SGWRCPACQN VSAHVPNTYT 

       430        440        450        460        470        480 
CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG QDCPHSCNLL CHPGPCPPCP AFMTKTCECG 

       490        500        510        520        530        540 
RTRHTVRCGQ AVSVHCSNPC ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV 

       550        560        570        580        590        600 
LCGTDVGKSD GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP 

       610        620        630        640        650        660 
LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC GPCSRTSVIS 

       670        680        690        700        710        720 
CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN EICCVDKEHK CPLICGRKLR 

       730        740        750        760        770        780 
CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC GASVIYPPVP CGTRPPECTQ TCARVHECDH 

       790        800        810        820        830        840 
PVYHSCHSEE KCPPCTFLTQ KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL 

       850        860        870        880        890        900 
CHKGECLVDE PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI 

       910        920        930        940        950        960 
CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE CSALERKKRL 

       970        980        990       1000       1010       1020 
AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV EKEMETLVEA VNKGKNSKKS 

      1030       1040       1050       1060       1070       1080 
HSFPPMNRDH RRIIHDLAQV YGLESVSYDS EPKRNVVVTA IRGKSVCPPT TLTGVLEREM 

      1090       1100       1110       1120 
QARPPPPIPH HRHQSDKNPG SSNLQKITKE PIIDYFDVQD 

« Hide

Isoform 2 [UniParc].

Checksum: 4228E14EEF42E3BC
Show »

FASTA1,024113,623
Isoform 3 (NFX-91) [UniParc].

Checksum: AD2A1E26911EA705
Show »

FASTA83392,679

References

« Hide 'large scale' references
[1]Li J.M., Sah J.H., Zhou Z.M.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[6]"A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor."
Song Z., Krishna S., Thanos D., Strominger J.L., Ono S.J.
J. Exp. Med. 180:1763-1774(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-1120 (ISOFORM 1).
[7]"RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination."
Lorick K.L., Jensen J.P., Fang S., Ong A.M., Hatakeyama S., Weissman A.M.
Proc. Natl. Acad. Sci. U.S.A. 96:11364-11369(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS AN E2-DEPENDENT UBIQUITIN-PROTEIN LIGASE.
[8]"Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex."
Gewin L., Myers H., Kiyono T., Galloway D.A.
Genes Dev. 18:2269-2282(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HPV16 E6, FUNCTION.
[9]"NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells."
Katzenellenbogen R.A., Egelkrout E.M., Vliet-Gregg P., Gewin L.C., Gafken P.R., Galloway D.A.
J. Virol. 81:3786-3796(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PABPC1 AND PABPC4, MUTAGENESIS OF PHE-20.
[10]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF332009 mRNA. Translation: AAK16545.1.
AK291643 mRNA. Translation: BAF84332.1.
AL356472, AL356218 Genomic DNA. Translation: CAH72745.1.
AL356472, AL356218 Genomic DNA. Translation: CAH72746.1.
AL356472 Genomic DNA. Translation: CAH72747.3.
AL356218, AL356472 Genomic DNA. Translation: CAI13304.1.
AL356218, AL356472 Genomic DNA. Translation: CAI13305.1.
CH471071 Genomic DNA. Translation: EAW58510.1.
CH471071 Genomic DNA. Translation: EAW58511.1.
BC012151 mRNA. Translation: AAH12151.1.
U15306 mRNA. Translation: AAA69517.1. Frameshift.
CCDSCCDS6538.1. [Q12986-1]
CCDS6539.1. [Q12986-2]
CCDS6540.1. [Q12986-3]
PIRI38869.
RefSeqNP_002495.2. NM_002504.4. [Q12986-1]
NP_667344.1. NM_147133.2. [Q12986-2]
XP_005251531.1. XM_005251474.2.
UniGeneHs.413074.

3D structure databases

ProteinModelPortalQ12986.
SMRQ12986. Positions 354-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110865. 42 interactions.
IntActQ12986. 2 interactions.
STRING9606.ENSP00000368856.

PTM databases

PhosphoSiteQ12986.

Polymorphism databases

DMDM189047116.

Proteomic databases

MaxQBQ12986.
PaxDbQ12986.
PRIDEQ12986.

Protocols and materials databases

DNASU4799.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318524; ENSP00000317695; ENSG00000086102. [Q12986-3]
ENST00000379521; ENSP00000368836; ENSG00000086102. [Q12986-2]
ENST00000379540; ENSP00000368856; ENSG00000086102. [Q12986-1]
GeneID4799.
KEGGhsa:4799.
UCSCuc003zso.3. human. [Q12986-3]
uc003zsp.2. human. [Q12986-2]
uc003zsq.3. human. [Q12986-1]

Organism-specific databases

CTD4799.
GeneCardsGC09P033280.
HGNCHGNC:7803. NFX1.
MIM603255. gene.
neXtProtNX_Q12986.
PharmGKBPA31608.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000006942.
HOVERGENHBG003827.
InParanoidQ12986.
KOK12236.
OMASKLSDMQ.
OrthoDBEOG7NCV2M.
PhylomeDBQ12986.
TreeFamTF105889.

Gene expression databases

BgeeQ12986.
CleanExHS_NFX1.
GenevestigatorQ12986.

Family and domain databases

Gene3D3.30.1370.50. 1 hit.
InterProIPR001374. R3H_ss-bd.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000967. Znf_NFX1.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
[Graphical view]
PfamPF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 5 hits.
[Graphical view]
SMARTSM00393. R3H. 1 hit.
SM00184. RING. 1 hit.
SM00438. ZnF_NFX. 9 hits.
[Graphical view]
SUPFAMSSF82708. SSF82708. 1 hit.
PROSITEPS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNFX1. human.
GeneWikiNFX1.
GenomeRNAi4799.
NextBio18492.
PROQ12986.
SOURCESearch...

Entry information

Entry nameNFX1_HUMAN
AccessionPrimary (citable) accession number: Q12986
Secondary accession number(s): A8K6H8 expand/collapse secondary AC list , Q5VXW6, Q96EL5, Q9BXI1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 20, 2008
Last modified: July 9, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM