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Q12986

- NFX1_HUMAN

UniProt

Q12986 - NFX1_HUMAN

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Protein
Transcriptional repressor NF-X1
Gene
NFX1, NFX2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri358 – 40952RING-type; atypical
Add
BLAST
Zinc fingeri453 – 47119NF-X1-type 1
Add
BLAST
Zinc fingeri506 – 52520NF-X1-type 2
Add
BLAST
Zinc fingeri567 – 58620NF-X1-type 3
Add
BLAST
Zinc fingeri632 – 65524NF-X1-type 4
Add
BLAST
Zinc fingeri694 – 71320NF-X1-type 5
Add
BLAST
Zinc fingeri721 – 74020NF-X1-type 6
Add
BLAST
Zinc fingeri832 – 85423NF-X1-type 7
Add
BLAST
Zinc fingeri863 – 88422NF-X1-type 8
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. ligase activity Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. inflammatory response Source: ProtInc
  2. negative regulation of MHC class II biosynthetic process Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  4. transcription from RNA polymerase II promoter Source: ProtInc
  5. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Ligase, Repressor

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor NF-X1 (EC:6.3.2.-)
Alternative name(s):
Nuclear transcription factor, X box-binding protein 1
Gene namesi
Name:NFX1
Synonyms:NFX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:7803. NFX1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi20 – 201F → A: Reduces PABPC1 and PABC4 binding. 1 Publication

Organism-specific databases

PharmGKBiPA31608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11201120Transcriptional repressor NF-X1
PRO_0000055979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501Phosphoserine1 Publication

Post-translational modificationi

Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ12986.
PaxDbiQ12986.
PRIDEiQ12986.

PTM databases

PhosphoSiteiQ12986.

Expressioni

Inductioni

By IFNG/IFN-gamma.

Gene expression databases

BgeeiQ12986.
CleanExiHS_NFX1.
GenevestigatoriQ12986.

Interactioni

Subunit structurei

Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4.2 Publications

Protein-protein interaction databases

BioGridi110865. 41 interactions.
IntActiQ12986. 2 interactions.
STRINGi9606.ENSP00000368856.

Structurei

3D structure databases

ProteinModelPortaliQ12986.
SMRiQ12986. Positions 354-413.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini994 – 106269R3H
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 2618Interaction with PABPC1 and PABC4
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1084 – 10896Poly-Pro

Domaini

The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.

Sequence similaritiesi

Belongs to the NFX1 family.
Contains 1 R3H domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000006942.
HOVERGENiHBG003827.
InParanoidiQ12986.
KOiK12236.
OMAiSKLSDMQ.
OrthoDBiEOG7NCV2M.
PhylomeDBiQ12986.
TreeFamiTF105889.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR001374. R3H_ss-bd.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000967. Znf_NFX1.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 5 hits.
[Graphical view]
SMARTiSM00393. R3H. 1 hit.
SM00184. RING. 1 hit.
SM00438. ZnF_NFX. 9 hits.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q12986-1) [UniParc]FASTAAdd to Basket

Also known as: NFX-123

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS     50
PPPCHLSRQV PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG 100
LQNQPWQKLR NEKHHIRVKK AQSLAEQTSD TAGLESSTRS ESGTDLREHS 150
PSESEKEVVG ADPRGAKPKK ATQFVYSYGR GPKVKGKLKC EWSNRTTPKP 200
EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR YPQKRPPWEV 250
EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL 300
AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ 350
LTTEKYECMV CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ 400
SGWRCPACQN VSAHVPNTYT CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG 450
QDCPHSCNLL CHPGPCPPCP AFMTKTCECG RTRHTVRCGQ AVSVHCSNPC 500
ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV LCGTDVGKSD 550
GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP 600
LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC 650
GPCSRTSVIS CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN 700
EICCVDKEHK CPLICGRKLR CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC 750
GASVIYPPVP CGTRPPECTQ TCARVHECDH PVYHSCHSEE KCPPCTFLTQ 800
KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL CHKGECLVDE 850
PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI 900
CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE 950
CSALERKKRL AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV 1000
EKEMETLVEA VNKGKNSKKS HSFPPMNRDH RRIIHDLAQV YGLESVSYDS 1050
EPKRNVVVTA IRGKSVCPPT TLTGVLEREM QARPPPPIPH HRHQSDKNPG 1100
SSNLQKITKE PIIDYFDVQD 1120
Length:1,120
Mass (Da):124,395
Last modified:May 20, 2008 - v2
Checksum:iF2203BE1DB6437E6
GO
Isoform 2 (identifier: Q12986-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1014-1024: GKNSKKSHSFP → VEVETSHWTFL
     1025-1120: Missing.

Show »
Length:1,024
Mass (Da):113,623
Checksum:i4228E14EEF42E3BC
GO
Isoform 3 (identifier: Q12986-3) [UniParc]FASTAAdd to Basket

Also known as: NFX-91

The sequence of this isoform differs from the canonical sequence as follows:
     809-833: FRSNIPCHLVDISCGLPCSATLPCG → QSHYWASTQKKRSHYMKKIPAHACL
     834-1120: Missing.

Show »
Length:833
Mass (Da):92,679
Checksum:iAD2A1E26911EA705
GO

Sequence cautioni

The sequence AAA69517.1 differs from that shown. Reason: Frameshift at positions 78, 202 and 284.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti731 – 7311H → Y.
Corresponds to variant rs5017299 [ dbSNP | Ensembl ].
VAR_043380
Natural varianti760 – 7601P → S.
Corresponds to variant rs2860036 [ dbSNP | Ensembl ].
VAR_043381
Natural varianti1086 – 10861P → Q.
Corresponds to variant rs2274866 [ dbSNP | Ensembl ].
VAR_043382

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei809 – 83325FRSNI…TLPCG → QSHYWASTQKKRSHYMKKIP AHACL in isoform 3.
VSP_033682Add
BLAST
Alternative sequencei834 – 1120287Missing in isoform 3.
VSP_033683Add
BLAST
Alternative sequencei1014 – 102411GKNSKKSHSFP → VEVETSHWTFL in isoform 2.
VSP_033684Add
BLAST
Alternative sequencei1025 – 112096Missing in isoform 2.
VSP_033685Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791G → A in AAA69517. 1 Publication
Sequence conflicti186 – 1861G → E in AAA69517. 1 Publication
Sequence conflicti312 – 3121Q → P in AAA69517. 1 Publication
Sequence conflicti419 – 4202YT → FS in AAA69517. 1 Publication
Sequence conflicti560 – 5601I → T in AAA69517. 1 Publication
Sequence conflicti653 – 6531C → V in AAA69517. 1 Publication
Sequence conflicti678 – 6781E → EA in BAF84332. 1 Publication
Sequence conflicti714 – 7141I → N in AAA69517. 1 Publication
Sequence conflicti786 – 7861C → G in AAA69517. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332009 mRNA. Translation: AAK16545.1.
AK291643 mRNA. Translation: BAF84332.1.
AL356472, AL356218 Genomic DNA. Translation: CAH72745.1.
AL356472, AL356218 Genomic DNA. Translation: CAH72746.1.
AL356472 Genomic DNA. Translation: CAH72747.3.
AL356218, AL356472 Genomic DNA. Translation: CAI13304.1.
AL356218, AL356472 Genomic DNA. Translation: CAI13305.1.
CH471071 Genomic DNA. Translation: EAW58510.1.
CH471071 Genomic DNA. Translation: EAW58511.1.
BC012151 mRNA. Translation: AAH12151.1.
U15306 mRNA. Translation: AAA69517.1. Frameshift.
CCDSiCCDS6538.1. [Q12986-1]
CCDS6539.1. [Q12986-2]
CCDS6540.1. [Q12986-3]
PIRiI38869.
RefSeqiNP_002495.2. NM_002504.4. [Q12986-1]
NP_667344.1. NM_147133.2. [Q12986-2]
XP_005251531.1. XM_005251474.2.
UniGeneiHs.413074.

Genome annotation databases

EnsembliENST00000318524; ENSP00000317695; ENSG00000086102. [Q12986-3]
ENST00000379521; ENSP00000368836; ENSG00000086102. [Q12986-2]
ENST00000379540; ENSP00000368856; ENSG00000086102. [Q12986-1]
GeneIDi4799.
KEGGihsa:4799.
UCSCiuc003zso.3. human. [Q12986-3]
uc003zsp.2. human. [Q12986-2]
uc003zsq.3. human. [Q12986-1]

Polymorphism databases

DMDMi189047116.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332009 mRNA. Translation: AAK16545.1 .
AK291643 mRNA. Translation: BAF84332.1 .
AL356472 , AL356218 Genomic DNA. Translation: CAH72745.1 .
AL356472 , AL356218 Genomic DNA. Translation: CAH72746.1 .
AL356472 Genomic DNA. Translation: CAH72747.3 .
AL356218 , AL356472 Genomic DNA. Translation: CAI13304.1 .
AL356218 , AL356472 Genomic DNA. Translation: CAI13305.1 .
CH471071 Genomic DNA. Translation: EAW58510.1 .
CH471071 Genomic DNA. Translation: EAW58511.1 .
BC012151 mRNA. Translation: AAH12151.1 .
U15306 mRNA. Translation: AAA69517.1 . Frameshift.
CCDSi CCDS6538.1. [Q12986-1 ]
CCDS6539.1. [Q12986-2 ]
CCDS6540.1. [Q12986-3 ]
PIRi I38869.
RefSeqi NP_002495.2. NM_002504.4. [Q12986-1 ]
NP_667344.1. NM_147133.2. [Q12986-2 ]
XP_005251531.1. XM_005251474.2.
UniGenei Hs.413074.

3D structure databases

ProteinModelPortali Q12986.
SMRi Q12986. Positions 354-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110865. 41 interactions.
IntActi Q12986. 2 interactions.
STRINGi 9606.ENSP00000368856.

PTM databases

PhosphoSitei Q12986.

Polymorphism databases

DMDMi 189047116.

Proteomic databases

MaxQBi Q12986.
PaxDbi Q12986.
PRIDEi Q12986.

Protocols and materials databases

DNASUi 4799.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318524 ; ENSP00000317695 ; ENSG00000086102 . [Q12986-3 ]
ENST00000379521 ; ENSP00000368836 ; ENSG00000086102 . [Q12986-2 ]
ENST00000379540 ; ENSP00000368856 ; ENSG00000086102 . [Q12986-1 ]
GeneIDi 4799.
KEGGi hsa:4799.
UCSCi uc003zso.3. human. [Q12986-3 ]
uc003zsp.2. human. [Q12986-2 ]
uc003zsq.3. human. [Q12986-1 ]

Organism-specific databases

CTDi 4799.
GeneCardsi GC09P033280.
HGNCi HGNC:7803. NFX1.
MIMi 603255. gene.
neXtProti NX_Q12986.
PharmGKBi PA31608.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000006942.
HOVERGENi HBG003827.
InParanoidi Q12986.
KOi K12236.
OMAi SKLSDMQ.
OrthoDBi EOG7NCV2M.
PhylomeDBi Q12986.
TreeFami TF105889.

Miscellaneous databases

ChiTaRSi NFX1. human.
GeneWikii NFX1.
GenomeRNAii 4799.
NextBioi 18492.
PROi Q12986.
SOURCEi Search...

Gene expression databases

Bgeei Q12986.
CleanExi HS_NFX1.
Genevestigatori Q12986.

Family and domain databases

Gene3Di 3.30.1370.50. 1 hit.
InterProi IPR001374. R3H_ss-bd.
IPR019786. Zinc_finger_PHD-type_CS.
IPR000967. Znf_NFX1.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
[Graphical view ]
Pfami PF01424. R3H. 1 hit.
PF01422. zf-NF-X1. 5 hits.
[Graphical view ]
SMARTi SM00393. R3H. 1 hit.
SM00184. RING. 1 hit.
SM00438. ZnF_NFX. 9 hits.
[Graphical view ]
SUPFAMi SSF82708. SSF82708. 1 hit.
PROSITEi PS51061. R3H. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Li J.M., Sah J.H., Zhou Z.M.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor."
    Song Z., Krishna S., Thanos D., Strominger J.L., Ono S.J.
    J. Exp. Med. 180:1763-1774(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-1120 (ISOFORM 1).
  7. "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination."
    Lorick K.L., Jensen J.P., Fang S., Ong A.M., Hatakeyama S., Weissman A.M.
    Proc. Natl. Acad. Sci. U.S.A. 96:11364-11369(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E2-DEPENDENT UBIQUITIN-PROTEIN LIGASE.
  8. "Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex."
    Gewin L., Myers H., Kiyono T., Galloway D.A.
    Genes Dev. 18:2269-2282(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HPV16 E6, FUNCTION.
  9. "NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells."
    Katzenellenbogen R.A., Egelkrout E.M., Vliet-Gregg P., Gewin L.C., Gafken P.R., Galloway D.A.
    J. Virol. 81:3786-3796(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PABPC1 AND PABPC4, MUTAGENESIS OF PHE-20.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNFX1_HUMAN
AccessioniPrimary (citable) accession number: Q12986
Secondary accession number(s): A8K6H8
, Q5VXW6, Q96EL5, Q9BXI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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