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Q12986

- NFX1_HUMAN

UniProt

Q12986 - NFX1_HUMAN

Protein

Transcriptional repressor NF-X1

Gene

NFX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri358 – 40952RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47119NF-X1-type 1Add
    BLAST
    Zinc fingeri506 – 52520NF-X1-type 2Add
    BLAST
    Zinc fingeri567 – 58620NF-X1-type 3Add
    BLAST
    Zinc fingeri632 – 65524NF-X1-type 4Add
    BLAST
    Zinc fingeri694 – 71320NF-X1-type 5Add
    BLAST
    Zinc fingeri721 – 74020NF-X1-type 6Add
    BLAST
    Zinc fingeri832 – 85423NF-X1-type 7Add
    BLAST
    Zinc fingeri863 – 88422NF-X1-type 8Add
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. ligase activity Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: ProtInc
    2. negative regulation of MHC class II biosynthetic process Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
    4. transcription from RNA polymerase II promoter Source: ProtInc
    5. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Ligase, Repressor

    Keywords - Biological processi

    Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional repressor NF-X1 (EC:6.3.2.-)
    Alternative name(s):
    Nuclear transcription factor, X box-binding protein 1
    Gene namesi
    Name:NFX1
    Synonyms:NFX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:7803. NFX1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi20 – 201F → A: Reduces PABPC1 and PABC4 binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA31608.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11201120Transcriptional repressor NF-X1PRO_0000055979Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501Phosphoserine1 Publication

    Post-translational modificationi

    Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated.

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ12986.
    PaxDbiQ12986.
    PRIDEiQ12986.

    PTM databases

    PhosphoSiteiQ12986.

    Expressioni

    Inductioni

    By IFNG/IFN-gamma.

    Gene expression databases

    BgeeiQ12986.
    CleanExiHS_NFX1.
    GenevestigatoriQ12986.

    Interactioni

    Subunit structurei

    Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4.2 Publications

    Protein-protein interaction databases

    BioGridi110865. 41 interactions.
    IntActiQ12986. 2 interactions.
    STRINGi9606.ENSP00000368856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12986.
    SMRiQ12986. Positions 354-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini994 – 106269R3HPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni9 – 2618Interaction with PABPC1 and PABC4Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1084 – 10896Poly-Pro

    Domaini

    The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.

    Sequence similaritiesi

    Belongs to the NFX1 family.Curated
    Contains 8 NF-X1-type zinc fingers.Curated
    Contains 1 R3H domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri358 – 40952RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47119NF-X1-type 1Add
    BLAST
    Zinc fingeri506 – 52520NF-X1-type 2Add
    BLAST
    Zinc fingeri567 – 58620NF-X1-type 3Add
    BLAST
    Zinc fingeri632 – 65524NF-X1-type 4Add
    BLAST
    Zinc fingeri694 – 71320NF-X1-type 5Add
    BLAST
    Zinc fingeri721 – 74020NF-X1-type 6Add
    BLAST
    Zinc fingeri832 – 85423NF-X1-type 7Add
    BLAST
    Zinc fingeri863 – 88422NF-X1-type 8Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000006942.
    HOVERGENiHBG003827.
    InParanoidiQ12986.
    KOiK12236.
    OMAiSKLSDMQ.
    OrthoDBiEOG7NCV2M.
    PhylomeDBiQ12986.
    TreeFamiTF105889.

    Family and domain databases

    Gene3Di3.30.1370.50. 1 hit.
    InterProiIPR001374. R3H_ss-bd.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR000967. Znf_NFX1.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    [Graphical view]
    PfamiPF01424. R3H. 1 hit.
    PF01422. zf-NF-X1. 5 hits.
    [Graphical view]
    SMARTiSM00393. R3H. 1 hit.
    SM00184. RING. 1 hit.
    SM00438. ZnF_NFX. 9 hits.
    [Graphical view]
    SUPFAMiSSF82708. SSF82708. 1 hit.
    PROSITEiPS51061. R3H. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q12986-1) [UniParc]FASTAAdd to Basket

    Also known as: NFX-123

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS     50
    PPPCHLSRQV PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG 100
    LQNQPWQKLR NEKHHIRVKK AQSLAEQTSD TAGLESSTRS ESGTDLREHS 150
    PSESEKEVVG ADPRGAKPKK ATQFVYSYGR GPKVKGKLKC EWSNRTTPKP 200
    EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR YPQKRPPWEV 250
    EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL 300
    AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ 350
    LTTEKYECMV CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ 400
    SGWRCPACQN VSAHVPNTYT CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG 450
    QDCPHSCNLL CHPGPCPPCP AFMTKTCECG RTRHTVRCGQ AVSVHCSNPC 500
    ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV LCGTDVGKSD 550
    GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP 600
    LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC 650
    GPCSRTSVIS CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN 700
    EICCVDKEHK CPLICGRKLR CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC 750
    GASVIYPPVP CGTRPPECTQ TCARVHECDH PVYHSCHSEE KCPPCTFLTQ 800
    KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL CHKGECLVDE 850
    PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI 900
    CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE 950
    CSALERKKRL AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV 1000
    EKEMETLVEA VNKGKNSKKS HSFPPMNRDH RRIIHDLAQV YGLESVSYDS 1050
    EPKRNVVVTA IRGKSVCPPT TLTGVLEREM QARPPPPIPH HRHQSDKNPG 1100
    SSNLQKITKE PIIDYFDVQD 1120
    Length:1,120
    Mass (Da):124,395
    Last modified:May 20, 2008 - v2
    Checksum:iF2203BE1DB6437E6
    GO
    Isoform 2 (identifier: Q12986-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1014-1024: GKNSKKSHSFP → VEVETSHWTFL
         1025-1120: Missing.

    Show »
    Length:1,024
    Mass (Da):113,623
    Checksum:i4228E14EEF42E3BC
    GO
    Isoform 3 (identifier: Q12986-3) [UniParc]FASTAAdd to Basket

    Also known as: NFX-91

    The sequence of this isoform differs from the canonical sequence as follows:
         809-833: FRSNIPCHLVDISCGLPCSATLPCG → QSHYWASTQKKRSHYMKKIPAHACL
         834-1120: Missing.

    Show »
    Length:833
    Mass (Da):92,679
    Checksum:iAD2A1E26911EA705
    GO

    Sequence cautioni

    The sequence AAA69517.1 differs from that shown. Reason: Frameshift at positions 78, 202 and 284.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791G → A in AAA69517. 1 PublicationCurated
    Sequence conflicti186 – 1861G → E in AAA69517. 1 PublicationCurated
    Sequence conflicti312 – 3121Q → P in AAA69517. 1 PublicationCurated
    Sequence conflicti419 – 4202YT → FS in AAA69517. 1 PublicationCurated
    Sequence conflicti560 – 5601I → T in AAA69517. 1 PublicationCurated
    Sequence conflicti653 – 6531C → V in AAA69517. 1 PublicationCurated
    Sequence conflicti678 – 6781E → EA in BAF84332. (PubMed:14702039)Curated
    Sequence conflicti714 – 7141I → N in AAA69517. 1 PublicationCurated
    Sequence conflicti786 – 7861C → G in AAA69517. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti731 – 7311H → Y.
    Corresponds to variant rs5017299 [ dbSNP | Ensembl ].
    VAR_043380
    Natural varianti760 – 7601P → S.
    Corresponds to variant rs2860036 [ dbSNP | Ensembl ].
    VAR_043381
    Natural varianti1086 – 10861P → Q.
    Corresponds to variant rs2274866 [ dbSNP | Ensembl ].
    VAR_043382

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei809 – 83325FRSNI…TLPCG → QSHYWASTQKKRSHYMKKIP AHACL in isoform 3. CuratedVSP_033682Add
    BLAST
    Alternative sequencei834 – 1120287Missing in isoform 3. CuratedVSP_033683Add
    BLAST
    Alternative sequencei1014 – 102411GKNSKKSHSFP → VEVETSHWTFL in isoform 2. 2 PublicationsVSP_033684Add
    BLAST
    Alternative sequencei1025 – 112096Missing in isoform 2. 2 PublicationsVSP_033685Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332009 mRNA. Translation: AAK16545.1.
    AK291643 mRNA. Translation: BAF84332.1.
    AL356472, AL356218 Genomic DNA. Translation: CAH72745.1.
    AL356472, AL356218 Genomic DNA. Translation: CAH72746.1.
    AL356472 Genomic DNA. Translation: CAH72747.3.
    AL356218, AL356472 Genomic DNA. Translation: CAI13304.1.
    AL356218, AL356472 Genomic DNA. Translation: CAI13305.1.
    CH471071 Genomic DNA. Translation: EAW58510.1.
    CH471071 Genomic DNA. Translation: EAW58511.1.
    BC012151 mRNA. Translation: AAH12151.1.
    U15306 mRNA. Translation: AAA69517.1. Frameshift.
    CCDSiCCDS6538.1. [Q12986-1]
    CCDS6539.1. [Q12986-2]
    CCDS6540.1. [Q12986-3]
    PIRiI38869.
    RefSeqiNP_002495.2. NM_002504.4. [Q12986-1]
    NP_667344.1. NM_147133.2. [Q12986-2]
    XP_005251531.1. XM_005251474.2.
    UniGeneiHs.413074.

    Genome annotation databases

    EnsembliENST00000318524; ENSP00000317695; ENSG00000086102. [Q12986-3]
    ENST00000379521; ENSP00000368836; ENSG00000086102. [Q12986-2]
    ENST00000379540; ENSP00000368856; ENSG00000086102. [Q12986-1]
    GeneIDi4799.
    KEGGihsa:4799.
    UCSCiuc003zso.3. human. [Q12986-3]
    uc003zsp.2. human. [Q12986-2]
    uc003zsq.3. human. [Q12986-1]

    Polymorphism databases

    DMDMi189047116.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332009 mRNA. Translation: AAK16545.1 .
    AK291643 mRNA. Translation: BAF84332.1 .
    AL356472 , AL356218 Genomic DNA. Translation: CAH72745.1 .
    AL356472 , AL356218 Genomic DNA. Translation: CAH72746.1 .
    AL356472 Genomic DNA. Translation: CAH72747.3 .
    AL356218 , AL356472 Genomic DNA. Translation: CAI13304.1 .
    AL356218 , AL356472 Genomic DNA. Translation: CAI13305.1 .
    CH471071 Genomic DNA. Translation: EAW58510.1 .
    CH471071 Genomic DNA. Translation: EAW58511.1 .
    BC012151 mRNA. Translation: AAH12151.1 .
    U15306 mRNA. Translation: AAA69517.1 . Frameshift.
    CCDSi CCDS6538.1. [Q12986-1 ]
    CCDS6539.1. [Q12986-2 ]
    CCDS6540.1. [Q12986-3 ]
    PIRi I38869.
    RefSeqi NP_002495.2. NM_002504.4. [Q12986-1 ]
    NP_667344.1. NM_147133.2. [Q12986-2 ]
    XP_005251531.1. XM_005251474.2.
    UniGenei Hs.413074.

    3D structure databases

    ProteinModelPortali Q12986.
    SMRi Q12986. Positions 354-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110865. 41 interactions.
    IntActi Q12986. 2 interactions.
    STRINGi 9606.ENSP00000368856.

    PTM databases

    PhosphoSitei Q12986.

    Polymorphism databases

    DMDMi 189047116.

    Proteomic databases

    MaxQBi Q12986.
    PaxDbi Q12986.
    PRIDEi Q12986.

    Protocols and materials databases

    DNASUi 4799.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318524 ; ENSP00000317695 ; ENSG00000086102 . [Q12986-3 ]
    ENST00000379521 ; ENSP00000368836 ; ENSG00000086102 . [Q12986-2 ]
    ENST00000379540 ; ENSP00000368856 ; ENSG00000086102 . [Q12986-1 ]
    GeneIDi 4799.
    KEGGi hsa:4799.
    UCSCi uc003zso.3. human. [Q12986-3 ]
    uc003zsp.2. human. [Q12986-2 ]
    uc003zsq.3. human. [Q12986-1 ]

    Organism-specific databases

    CTDi 4799.
    GeneCardsi GC09P033280.
    HGNCi HGNC:7803. NFX1.
    MIMi 603255. gene.
    neXtProti NX_Q12986.
    PharmGKBi PA31608.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000006942.
    HOVERGENi HBG003827.
    InParanoidi Q12986.
    KOi K12236.
    OMAi SKLSDMQ.
    OrthoDBi EOG7NCV2M.
    PhylomeDBi Q12986.
    TreeFami TF105889.

    Miscellaneous databases

    ChiTaRSi NFX1. human.
    GeneWikii NFX1.
    GenomeRNAii 4799.
    NextBioi 18492.
    PROi Q12986.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q12986.
    CleanExi HS_NFX1.
    Genevestigatori Q12986.

    Family and domain databases

    Gene3Di 3.30.1370.50. 1 hit.
    InterProi IPR001374. R3H_ss-bd.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR000967. Znf_NFX1.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    [Graphical view ]
    Pfami PF01424. R3H. 1 hit.
    PF01422. zf-NF-X1. 5 hits.
    [Graphical view ]
    SMARTi SM00393. R3H. 1 hit.
    SM00184. RING. 1 hit.
    SM00438. ZnF_NFX. 9 hits.
    [Graphical view ]
    SUPFAMi SSF82708. SSF82708. 1 hit.
    PROSITEi PS51061. R3H. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Li J.M., Sah J.H., Zhou Z.M.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    6. "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor."
      Song Z., Krishna S., Thanos D., Strominger J.L., Ono S.J.
      J. Exp. Med. 180:1763-1774(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-1120 (ISOFORM 1).
    7. "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination."
      Lorick K.L., Jensen J.P., Fang S., Ong A.M., Hatakeyama S., Weissman A.M.
      Proc. Natl. Acad. Sci. U.S.A. 96:11364-11369(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AN E2-DEPENDENT UBIQUITIN-PROTEIN LIGASE.
    8. "Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex."
      Gewin L., Myers H., Kiyono T., Galloway D.A.
      Genes Dev. 18:2269-2282(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HPV16 E6, FUNCTION.
    9. "NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells."
      Katzenellenbogen R.A., Egelkrout E.M., Vliet-Gregg P., Gewin L.C., Gafken P.R., Galloway D.A.
      J. Virol. 81:3786-3796(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PABPC1 AND PABPC4, MUTAGENESIS OF PHE-20.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiNFX1_HUMAN
    AccessioniPrimary (citable) accession number: Q12986
    Secondary accession number(s): A8K6H8
    , Q5VXW6, Q96EL5, Q9BXI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3