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Q12979

- ABR_HUMAN

UniProt

Q12979 - ABR_HUMAN

Protein

Active breakpoint cluster region-related protein

Gene

ABR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them.

    GO - Molecular functioni

    1. GTPase activator activity Source: ProtInc
    2. Rac GTPase activator activity Source: Ensembl
    3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. apoptotic signaling pathway Source: Reactome
    3. brain development Source: Ensembl
    4. inner ear morphogenesis Source: Ensembl
    5. negative regulation of cell migration Source: Ensembl
    6. negative regulation of inflammatory response Source: Ensembl
    7. negative regulation of neutrophil degranulation Source: Ensembl
    8. neuromuscular process controlling balance Source: Ensembl
    9. neurotrophin TRK receptor signaling pathway Source: Reactome
    10. positive regulation of apoptotic process Source: Reactome
    11. positive regulation of phagocytosis Source: Ensembl
    12. regulation of small GTPase mediated signal transduction Source: Reactome
    13. response to lipopolysaccharide Source: Ensembl
    14. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    GTPase activation, Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Active breakpoint cluster region-related protein
    Gene namesi
    Name:ABR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:81. ABR.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Active breakpoint cluster region-related proteinPRO_0000080902Add
    BLAST

    Proteomic databases

    MaxQBiQ12979.
    PaxDbiQ12979.
    PRIDEiQ12979.

    PTM databases

    PhosphoSiteiQ12979.

    Expressioni

    Tissue specificityi

    Highly enriched in the brain. Much weaker expression in heart, lung and muscle.

    Gene expression databases

    ArrayExpressiQ12979.
    BgeeiQ12979.
    CleanExiHS_ABR.
    GenevestigatoriQ12979.

    Organism-specific databases

    HPAiHPA053618.
    HPA054824.

    Interactioni

    Protein-protein interaction databases

    BioGridi106547. 6 interactions.
    IntActiQ12979. 3 interactions.
    MINTiMINT-7240931.
    STRINGi9606.ENSP00000303909.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12979.
    SMRiQ12979. Positions 100-414, 660-805.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 284194DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini301 – 459159PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini463 – 595133C2PROSITE-ProRule annotationAdd
    BLAST
    Domaini647 – 845199Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi417 – 4204Poly-Leu

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG267747.
    HOGENOMiHOG000006779.
    HOVERGENiHBG004165.
    InParanoidiQ12979.
    OMAiWPFLFLV.
    OrthoDBiEOG7BP81P.
    PhylomeDBiQ12979.
    TreeFamiTF105082.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q12979-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPLSHRGLP RLSWIDTLYS NFSYGTDEYD GEGNEEQKGP PEGSETMPYI    50
    DESPTMSPQL SARSQGGGDG VSPTPPEGLA PGVEAGKGLE MRKLVLSGFL 100
    ASEEIYINQL EALLLPMKPL KATATTSQPV LTIQQIETIF YKIQDIYEIH 150
    KEFYDNLCPK VQQWDSQVTM GHLFQKLASQ LGVYKAFVDN YKVALETAEK 200
    CSQSNNQFQK ISEELKVKGP KDSKDSHTSV TMEALLYKPI DRVTRSTLVL 250
    HDLLKHTPVD HPDYPLLQDA LRISQNFLSS INEDIDPRRT AVTTPKGETR 300
    QLVKDGFLVE VSESSRKLRH VFLFTDVLLC AKLKKTSAGK HQQYDCKWYI 350
    PLADLVFPSP EESEASPQVH PFPDHELEDM KMKISALKSE IQKEKANKGQ 400
    SRAIERLKKK MFENEFLLLL NSPTIPFRIH NRNGKSYLFL LSSDYERSEW 450
    REAIQKLQKK DLQAFVLSSV ELQVLTGSCF KLRTVHNIPV TSNKDDDESP 500
    GLYGFLHVIV HSAKGFKQSA NLYCTLEVDS FGYFVSKAKT RVFRDTAEPK 550
    WDEEFEIELE GSQSLRILCY EKCYDKTKVN KDNNEIVDKI MGKGQIQLDP 600
    QTVETKNWHT DVIEMNGIKV EFSMKFTSRD MSLKRTPSKK QTGVFGVKIS 650
    VVTKRERSKV PYIVRQCVEE VEKRGIEEVG IYRISGVATD IQALKAVFDA 700
    NNKDILLMLS DMDINAIAGT LKLYFRELPE PLLTDRLYPA FMEGIALSDP 750
    AAKENCMMHL LRSLPDPNLI TFLFLLEHLK RVAEKEPINK MSLHNLATVF 800
    GPTLLRPSEV ESKAHLTSAA DIWSHDVMAQ VQVLLYYLQH PPISFAELKR 850
    NTLYFSTDV 859
    Length:859
    Mass (Da):97,598
    Last modified:November 16, 2011 - v2
    Checksum:i3A5BE3AD2455A194
    GO
    Isoform Short (identifier: Q12979-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: MEPLSHRGLP...PTPPEGLAPG → MEEEEEAIGL...SGSPFLVAVK

    Show »
    Length:822
    Mass (Da):93,707
    Checksum:i2B4632AC57FE8663
    GO
    Isoform 3 (identifier: Q12979-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-48: MEPLSHRGLP...GPPEGSETMP → MTDVLPQPDC...RVRNKLLRNK
         49-597: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:310
    Mass (Da):35,101
    Checksum:i23285EBBDBDE2B0E
    GO
    Isoform 4 (identifier: Q12979-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-46: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:813
    Mass (Da):92,425
    Checksum:iE14F70FFE3A3F5D2
    GO

    Sequence cautioni

    The sequence AAC37518.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671G → R in AAC50063. (PubMed:8262969)Curated
    Sequence conflicti483 – 4831R → K in BAG54051. (PubMed:14702039)Curated
    Sequence conflicti625 – 6251K → R in BAH13263. (PubMed:14702039)Curated
    Sequence conflicti657 – 6604RSKV → VQGA in AAC37519. (PubMed:8349582)Curated
    Sequence conflicti761 – 7611L → V in AAC37519. (PubMed:8349582)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti517 – 5171K → R.1 Publication
    Corresponds to variant rs34169260 [ dbSNP | Ensembl ].
    VAR_057186

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282MEPLS…GLAPG → MEEEEEAIGLLDKVLEDEDV FLLEECELGTPTSPGSGSPF LVAVK in isoform Short. CuratedVSP_001815Add
    BLAST
    Alternative sequencei1 – 4848MEPLS…SETMP → MTDVLPQPDCSPKAGREPLA LEESGSKRPPNTGARLWGRV RNKLLRNK in isoform 3. 1 PublicationVSP_046029Add
    BLAST
    Alternative sequencei1 – 4646Missing in isoform 4. 1 PublicationVSP_046148Add
    BLAST
    Alternative sequencei49 – 597549Missing in isoform 3. 1 PublicationVSP_046030Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01147 mRNA. Translation: AAC50063.1.
    L19704 Genomic DNA. Translation: AAC37519.1.
    L19705 Genomic DNA. Translation: AAC37518.1. Different initiation.
    AK124547 mRNA. Translation: BAG54051.1.
    AK300336 mRNA. Translation: BAH13263.1.
    AC015884 Genomic DNA. No translation available.
    AC016292 Genomic DNA. No translation available.
    AC144836 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90631.1.
    CH471108 Genomic DNA. Translation: EAW90633.1.
    CH471108 Genomic DNA. Translation: EAW90634.1.
    CH471108 Genomic DNA. Translation: EAW90635.1.
    CCDSiCCDS10999.1. [Q12979-1]
    CCDS11000.1. [Q12979-2]
    CCDS54060.1. [Q12979-4]
    CCDS58497.1. [Q12979-3]
    PIRiA47485.
    A49307.
    RefSeqiNP_001083.2. NM_001092.4. [Q12979-2]
    NP_001153218.1. NM_001159746.2. [Q12979-4]
    NP_001243776.1. NM_001256847.2. [Q12979-3]
    NP_001269078.1. NM_001282149.1.
    NP_068781.2. NM_021962.4. [Q12979-1]
    UniGeneiHs.159306.

    Genome annotation databases

    EnsembliENST00000291107; ENSP00000291107; ENSG00000159842. [Q12979-2]
    ENST00000302538; ENSP00000303909; ENSG00000159842. [Q12979-1]
    ENST00000543210; ENSP00000445198; ENSG00000159842. [Q12979-3]
    ENST00000544583; ENSP00000442048; ENSG00000159842. [Q12979-4]
    ENST00000574437; ENSP00000461565; ENSG00000159842. [Q12979-4]
    GeneIDi29.
    KEGGihsa:29.
    UCSCiuc002fsd.4. human. [Q12979-1]
    uc002fsg.4. human. [Q12979-2]

    Polymorphism databases

    DMDMi357528764.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01147 mRNA. Translation: AAC50063.1 .
    L19704 Genomic DNA. Translation: AAC37519.1 .
    L19705 Genomic DNA. Translation: AAC37518.1 . Different initiation.
    AK124547 mRNA. Translation: BAG54051.1 .
    AK300336 mRNA. Translation: BAH13263.1 .
    AC015884 Genomic DNA. No translation available.
    AC016292 Genomic DNA. No translation available.
    AC144836 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90631.1 .
    CH471108 Genomic DNA. Translation: EAW90633.1 .
    CH471108 Genomic DNA. Translation: EAW90634.1 .
    CH471108 Genomic DNA. Translation: EAW90635.1 .
    CCDSi CCDS10999.1. [Q12979-1 ]
    CCDS11000.1. [Q12979-2 ]
    CCDS54060.1. [Q12979-4 ]
    CCDS58497.1. [Q12979-3 ]
    PIRi A47485.
    A49307.
    RefSeqi NP_001083.2. NM_001092.4. [Q12979-2 ]
    NP_001153218.1. NM_001159746.2. [Q12979-4 ]
    NP_001243776.1. NM_001256847.2. [Q12979-3 ]
    NP_001269078.1. NM_001282149.1.
    NP_068781.2. NM_021962.4. [Q12979-1 ]
    UniGenei Hs.159306.

    3D structure databases

    ProteinModelPortali Q12979.
    SMRi Q12979. Positions 100-414, 660-805.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106547. 6 interactions.
    IntActi Q12979. 3 interactions.
    MINTi MINT-7240931.
    STRINGi 9606.ENSP00000303909.

    PTM databases

    PhosphoSitei Q12979.

    Polymorphism databases

    DMDMi 357528764.

    Proteomic databases

    MaxQBi Q12979.
    PaxDbi Q12979.
    PRIDEi Q12979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291107 ; ENSP00000291107 ; ENSG00000159842 . [Q12979-2 ]
    ENST00000302538 ; ENSP00000303909 ; ENSG00000159842 . [Q12979-1 ]
    ENST00000543210 ; ENSP00000445198 ; ENSG00000159842 . [Q12979-3 ]
    ENST00000544583 ; ENSP00000442048 ; ENSG00000159842 . [Q12979-4 ]
    ENST00000574437 ; ENSP00000461565 ; ENSG00000159842 . [Q12979-4 ]
    GeneIDi 29.
    KEGGi hsa:29.
    UCSCi uc002fsd.4. human. [Q12979-1 ]
    uc002fsg.4. human. [Q12979-2 ]

    Organism-specific databases

    CTDi 29.
    GeneCardsi GC17M000907.
    HGNCi HGNC:81. ABR.
    HPAi HPA053618.
    HPA054824.
    MIMi 600365. gene.
    neXtProti NX_Q12979.
    PharmGKBi PA24417.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267747.
    HOGENOMi HOG000006779.
    HOVERGENi HBG004165.
    InParanoidi Q12979.
    OMAi WPFLFLV.
    OrthoDBi EOG7BP81P.
    PhylomeDBi Q12979.
    TreeFami TF105082.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Miscellaneous databases

    ChiTaRSi ABR. human.
    GenomeRNAii 29.
    NextBioi 101.
    PROi Q12979.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q12979.
    Bgeei Q12979.
    CleanExi HS_ABR.
    Genevestigatori Q12979.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 2 hits.
    2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF00169. PH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins."
      Tan E.-C., Leung T., Manser E., Lim L.
      J. Biol. Chem. 268:27291-27298(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Tissue: Hippocampus.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT ARG-517.
      Tissue: Cerebellum and Placenta.
    3. "Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain."
      Heisterkamp N., Kaartinen V., van Soest S., Bokoch G.M., Groffen J.
      J. Biol. Chem. 268:16903-16906(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Tissue: Fibroblast.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 436-597.

    Entry informationi

    Entry nameiABR_HUMAN
    AccessioniPrimary (citable) accession number: Q12979
    Secondary accession number(s): B3KW89
    , B7Z6H7, D3DTH3, D3DTH4, F5H3S2, F5H8B3, Q13693, Q13694
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3