Q12955 (ANK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin-3
Short name=ANK-3

Alternative name(s):
Ankyrin-G

Gene names

Name:

ANK3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4377 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In skeletal muscle, required for costamere localization of DMD and betaDAG1 By similarity. Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments.
Subunit structure	Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres By similarity. Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) By similarity. May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG. Ref.5
Subcellular location	Cytoplasm › cytoskeleton. Cell junction › synapse › postsynaptic cell membrane By similarity. Lysosome By similarity. Note: In skeletal muscle, localized at costameres and neuromuscular junctions By similarity. In macrophages, associated with lysosomes By similarity.
Tissue specificity	Expressed in brain, neurons and other tissues. Ref.1
Domain	The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin By similarity.
Involvement in disease	Genetic variations in ANK3 are associated with autism spectrum disorders susceptibility.
Sequence similarities	Contains 23 ANK repeats. Contains 1 death domain. Contains 2 ZU5 domains.
Sequence caution	The sequence CAH73232.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40518.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI41373.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Lysosome Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi to plasma membrane protein transport Inferred from mutant phenotype PubMed 17620337. Source: BHF-UCL axon guidance Inferred from electronic annotation. Source: Compara axonogenesis Inferred from sequence or structural similarity. Source: BHF-UCL cytokinesis after mitosis Inferred from mutant phenotype PubMed 14757759PubMed 17620337. Source: BHF-UCL maintenance of protein location in plasma membrane Inferred from genetic interaction PubMed 17620337. Source: BHF-UCL membrane assembly Inferred from mutant phenotype PubMed 14757759PubMed 17620337. Source: BHF-UCL positive regulation of gene expression Inferred from sequence or structural similarity PubMed 18180363. Source: BHF-UCL positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential Inferred from sequence or structural similarity PubMed 18180363. Source: BHF-UCL positive regulation of membrane potential Inferred from sequence or structural similarity PubMed 18180363. Source: BHF-UCL positive regulation of sodium ion transmembrane transporter activity Inferred from sequence or structural similarity PubMed 18180363. Source: BHF-UCL positive regulation of sodium ion transport Inferred from sequence or structural similarity PubMed 18180363. Source: BHF-UCL protein targeting to plasma membrane Inferred from mutant phenotype PubMed 17620337. Source: BHF-UCL regulation of action potential in neuron Inferred from sequence or structural similarity. Source: BHF-UCL regulation of potassium ion transport Inferred from sequence or structural similarity. Source: BHF-UCL signal transduction Inferred from electronic annotation. Source: InterPro synapse organization Inferred from electronic annotation. Source: Compara
Cellular_component	T-tubule Inferred from sequence or structural similarity. Source: BHF-UCL axon initial segment Inferred from sequence or structural similarity. Source: BHF-UCL basolateral plasma membrane Inferred from direct assay Ref.5. Source: UniProtKB cell surface Inferred from sequence or structural similarity PubMed 21223964. Source: BHF-UCL costamere Traceable author statement PubMed 21223964. Source: BHF-UCL intercalated disc Inferred from sequence or structural similarity. Source: BHF-UCL lateral plasma membrane Inferred from direct assay PubMed 14757759. Source: BHF-UCL lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell node of Ranvier Inferred from sequence or structural similarity. Source: BHF-UCL postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell spectrin-associated cytoskeleton Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	cadherin binding Inferred from sequence or structural similarity. Source: BHF-UCL ion channel binding Inferred from sequence or structural similarity. Source: BHF-UCL protein binding, bridging Inferred from sequence or structural similarity. Source: BHF-UCL spectrin binding Inferred from sequence or structural similarity. Source: BHF-UCL structural constituent of cytoskeleton Inferred from mutant phenotype PubMed 17620337. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12955-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12955-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRK → MSEEPKEKNAKPAHRKRKG
     872-872: G → GNRCTWYKIPKVQEFTVKS
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Isoform 3 (identifier: Q12955-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKK → MASSASSSPAGTEDSAPAQGGFGSDYSRSSR
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4377	4377	Ankyrin-3		PRO_0000066886
Regions
	Repeat	73 – 102	30	ANK 1
	Repeat	106 – 135	30	ANK 2
	Repeat	139 – 168	30	ANK 3
	Repeat	172 – 201	30	ANK 4
	Repeat	203 – 230	28	ANK 5
	Repeat	234 – 263	30	ANK 6
	Repeat	267 – 296	30	ANK 7
	Repeat	300 – 329	30	ANK 8
	Repeat	333 – 362	30	ANK 9
	Repeat	366 – 395	30	ANK 10
	Repeat	399 – 428	30	ANK 11
	Repeat	432 – 461	30	ANK 12
	Repeat	465 – 494	30	ANK 13
	Repeat	498 – 527	30	ANK 14
	Repeat	531 – 560	30	ANK 15
	Repeat	564 – 593	30	ANK 16
	Repeat	597 – 626	30	ANK 17
	Repeat	630 – 659	30	ANK 18
	Repeat	663 – 692	30	ANK 19
	Repeat	696 – 725	30	ANK 20
	Repeat	729 – 758	30	ANK 21
	Repeat	762 – 791	30	ANK 22
	Repeat	795 – 825	31	ANK 23
	Domain	982 – 1107	126	ZU5 1
	Domain	1108 – 1272	165	ZU5 2
	Domain	4090 – 4174	85	Death
	Region	1273 – 1407	135	UPA domain By similarity
	Compositional bias	1519 – 1898	380	Ser-rich
	Compositional bias	2247 – 2250	4	Poly-Thr
	Compositional bias	2393 – 2396	4	Poly-Glu
	Compositional bias	3205 – 3211	7	Poly-Glu
	Compositional bias	3255 – 3259	5	Poly-Pro
	Compositional bias	3482 – 3487	6	Poly-Ser
	Compositional bias	3785 – 3791	7	Poly-Asn
	Compositional bias	3957 – 3981	25	Thr-rich
Amino acid modifications
	Modified residue	39	1	Phosphoserine Ref.8
	Modified residue	847	1	Phosphoserine Ref.8
	Modified residue	1445	1	Phosphoserine Ref.8
	Modified residue	4298	1	Phosphoserine Ref.8
	Cross-link	4338		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6
Natural variations
	Alternative sequence	1 – 37	37	MAHAA…RDRKK → MASSASSSPAGTEDSAPAQG GFGSDYSRSSR in isoform 3.		VSP_044348
	Alternative sequence	1 – 36	36	MAHAA…SRDRK → MSEEPKEKNAKPAHRKRKG in isoform 2.		VSP_044349
	Alternative sequence	872	1	G → GNRCTWYKIPKVQEFTVKS in isoform 2.		VSP_044350
	Alternative sequence	1442 – 1450	9	Missing in isoform 2 and isoform 3.		VSP_044351
	Alternative sequence	1478 – 4081	2604	Missing in isoform 2 and isoform 3.		VSP_044352
	Alternative sequence	4082	1	G → S in isoform 2 and isoform 3.		VSP_044353
	Alternative sequence	4199	1	G → GYPSLQVELETPTGLHYTPP TPFQQDDYFSDISSIESPLR TPSRLSDGLVPSQGNIEHSA DGPPVVTAEDASLEDSKLED SVPLTEMPEAVDVDESQLEN VCLS in isoform 2 and isoform 3.		VSP_044354
	Natural variant	1569	1	S → A Associated with autism susceptibility. Ref.9		VAR_068702
	Natural variant	2318	1	K → R. Corresponds to variant rs59021407 [ dbSNP | Ensembl ].		VAR_061013
	Natural variant	2885	1	H → Q. Corresponds to variant rs11599164 [ dbSNP | Ensembl ].		VAR_059115
	Natural variant	2996	1	Q → H. Corresponds to variant rs41274672 [ dbSNP | Ensembl ].		VAR_061014
	Natural variant	3117	1	I → V. Corresponds to variant rs28932171 [ dbSNP | Ensembl ].		VAR_059116
	Natural variant	3123	1	K → R. Corresponds to variant rs10821668 [ dbSNP | Ensembl ].		VAR_059117
	Natural variant	3720	1	T → M Associated with autism susceptibility. Ref.9		VAR_068703
	Natural variant	4255	1	T → P Associated with autism susceptibility. Ref.9		VAR_068704
	Natural variant	4257	1	I → V. Corresponds to variant rs12261793 [ dbSNP | Ensembl ].		VAR_054333
Experimental info
	Sequence conflict	197	1	T → A in CAI56716. Ref.3
	Sequence conflict	222	1	L → P in CAD97900. Ref.3
	Sequence conflict	327	1	I → V in CAD97900. Ref.3
	Sequence conflict	338	1	L → W in BAG58523. Ref.2
	Sequence conflict	523	1	A → T in CAD97900. Ref.3
	Sequence conflict	578	1	L → P in CAI56716. Ref.3
	Sequence conflict	1036 – 1043	8	MVEGEGLA → HGERRGIS in AAA64834. Ref.1
	Sequence conflict	1237	1	D → G in CAI56716. Ref.3
	Sequence conflict	1418	1	P → R in AAA64834. Ref.1
	Sequence conflict	1455	1	D → E in BAG58523. Ref.2
	Sequence conflict	1574	1	F → L in AAA64834. Ref.1
	Sequence conflict	1685	1	A → R in AAA64834. Ref.1
	Sequence conflict	1726	1	P → A in AAA64834. Ref.1
	Sequence conflict	2062 – 2063	2	ER → GG in AAA64834. Ref.1
	Sequence conflict	2146	1	S → T in AAA64834. Ref.1
	Sequence conflict	3919	1	H → P in AAA64834. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 1, 2009. Version 3. Checksum: F6F9FABD09F15C13	FASTA	4,377	480,410
	10 20 30 40 50 60 MAHAASQLKK NRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY 70 80 90 100 110 120 IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA 130 140 150 160 170 180 EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVKFLL DNGASQSLAT EDGFTPLAVA 190 200 210 220 230 240 LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH 250 260 270 280 290 300 IAAHYGNINV ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD 310 320 330 340 350 360 GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV QLLLQHNVPV 370 380 390 400 410 420 DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG FTPLHIACKK NRIKVMELLL 430 440 450 460 470 480 KHGASIQAVT ESGLTPIHVA AFMGHVNIVS QLMHHGASPN TTNVRGETAL HMAARSGQAE 490 500 510 520 530 540 VVRYLVQDGA QVEAKAKDDQ TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA 550 560 570 580 590 600 REGHEDVAAF LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT 610 620 630 640 650 660 PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL LEYGADANAV 670 680 690 700 710 720 TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP LHLAAQEDRV NVAEVLVNQG 730 740 750 760 770 780 AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN 790 800 810 820 830 840 VLLQNNASPN ELTVNGNTAL GIARRLGYIS VVDTLKIVTE ETMTTTTVTE KHKMNVPETM 850 860 870 880 890 900 NEVLDMSDDE VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE 910 920 930 940 950 960 GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT FTREFDSDSL 970 980 990 1000 1010 1020 RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS RHHGMRIIIP PRKCTAPTRI 1030 1040 1050 1060 1070 1080 TCRLVKRHKL ANPPPMVEGE GLASRLVEMG PAGAQFLGPV IVEIPHFGSM RGKERELIVL 1090 1100 1110 1120 1130 1140 RSENGETWKE HQFDSKNEDL TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI 1150 1160 1170 1180 1190 1200 KQESNQIGPE GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS 1210 1220 1230 1240 1250 1260 PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG GTSPAQWEDI 1270 1280 1290 1300 1310 1320 TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ LYRELICVPY MAKFVVFAKM 1330 1340 1350 1360 1370 1380 NDPVESSLRC FCMTDDKVDK TLEQQENFEE VARSKDIEVL EGKPIYVDCY GNLAPLTKGG 1390 1400 1410 1420 1430 1440 QQLVFNFYSF KENRLPFSIK IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK 1450 1460 1470 1480 1490 1500 KETESDQDDE IEKTDRRQSF ASLALRKRYS YLTEPGMIER STGATRSLPT TYSYKPFFST 1510 1520 1530 1540 1550 1560 RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK STLGASTTSS 1570 1580 1590 1600 1610 1620 VKSISDVASP IRSFRTMSSP IKTVVSQSPY NIQVSSGTLA RAPAVTEATP LKGLASNSTF 1630 1640 1650 1660 1670 1680 SSRTSPVTTA GSLLERSSIT MTPPASPKSN INMYSSSLPF KSIITSAAPL ISSPLKSVVS 1690 1700 1710 1720 1730 1740 PVKSAVDVIS SAKITMASSL SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT 1750 1760 1770 1780 1790 1800 LQEKISSATN SVSSVVSAAT DTVEKVFSTT TAMPFSPLRS YVSAAPSAFQ SLRTPSASAL 1810 1820 1830 1840 1850 1860 YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSNSFTKSAA ALLSPIKTLT 1870 1880 1890 1900 1910 1920 TETHPQPHFS RTSSPVKSSL FLAPSALKLS TPSSLSSSQE ILKDVAEMKE DLMRMTAILQ 1930 1940 1950 1960 1970 1980 TDVPEEKPFQ PELPKEGRID DEEPFKIVEK VKEDLVKVSE ILKKDVCVDN KGSPKSPKSD 1990 2000 2010 2020 2030 2040 KGHSPEDDWI EFSSEEIREA RQQAAASQSP SLPERVQVKA KAASEKDYNL TKVIDYLTND 2050 2060 2070 2080 2090 2100 IGSSSLTNLK YKFEDAKKDG EERQKRVLKP AIALQEHKLK MPPASMRTST SEKELCKMAD 2110 2120 2130 2140 2150 2160 SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK PLFHEVPIPP 2170 2180 2190 2200 2210 2220 VITETRTEVV HVIRSYDPSA GDVPQTQPEE PVSPKPSPTF MELEPKPTTS SIKEKVKAFQ 2230 2240 2250 2260 2270 2280 MKASSEEDDH NRVLSKGMRV KEETHITTTT RMVYHSPPGG EGASERIEET MSVHDIMKAF 2290 2300 2310 2320 2330 2340 QSGRDPSKEL AGLFEHKSAV SPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA 2350 2360 2370 2380 2390 2400 EPTEVIIRET KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE 2410 2420 2430 2440 2450 2460 ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD DELSELRGES 2470 2480 2490 2500 2510 2520 YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK RSREKIATAP KKEILSKIYK 2530 2540 2550 2560 2570 2580 DVSENGVGKV SKDEHFDKVT VLHYSGNVSS PKHAMWMRFT EDRLDRGREK LIYEDRVDRT 2590 2600 2610 2620 2630 2640 VKEAEEKLTE VSQFFRDKTE KLNDELQSPE KKARPKNGKE YSSQSPTSSS PEKVLLTELL 2650 2660 2670 2680 2690 2700 ASNDEWVKAR QHGPDGQGFP KAEEKAPSLP SSPEKMVLSQ QTEDSKSTVE AKGSISQSKA 2710 2720 2730 2740 2750 2760 PDGPQSGFQL KQSKLSSIRL KFEQGTHAKS KDMSQEDRKS DGQSRIPVKK IQESKLPVYQ 2770 2780 2790 2800 2810 2820 VFAREKQQKA IDLPDESVSV QKDFMVLKTK DEHAQSNEIV VNDSGSDNVK KQRTEMSSKA 2830 2840 2850 2860 2870 2880 MPDSFSEQQA KDLACHITSD LATRGPWDKK VFRTWESSGA TNNKSQKEKL SHVLVHDVRE 2890 2900 2910 2920 2930 2940 NHIGHPESKS VDQKNEFMSV TERERKLLTN GSLSEIKEMT VKSPSKKVLY REYVVKEGDH 2950 2960 2970 2980 2990 3000 PGGLLDQPSR RSESSAVSHI PVRVADERRM LSSNIPDGFC EQSAFPKHEL SQKLSQSSMS 3010 3020 3030 3040 3050 3060 KETVETQHFN SIEDEKVTYS EISKVSKHQS YVGLCPPLEE TETSPTKSPD SLEFSPGKES 3070 3080 3090 3100 3110 3120 PSSDVFDHSP IDGLEKLAPL AQTEGGKEIK TLPVYVSFVQ VGKQYEKEIQ QGGVKKIISQ 3130 3140 3150 3160 3170 3180 ECKTVQETRG TFYTTRQQKQ PPSPQGSPED DTLEQVSFLD SSGKSPLTPE TPSSEEVSYE 3190 3200 3210 3220 3230 3240 FTSKTPDSLI AYIPGKPSPI PEVSEESEEE EQAKSTSLKQ TTVEETAVER EMPNDVSKDS 3250 3260 3270 3280 3290 3300 NQRPKNNRVA YIEFPPPPPL DADQIESDKK HHYLPEKEVD MIEVNLQDEH DKYQLAEPVI 3310 3320 3330 3340 3350 3360 RVQPPSPVPP GADVSDSSDD ESIYQPVPVK KYTFKLKEVD DEQKEKPKAS AEKASNQKEL 3370 3380 3390 3400 3410 3420 ESNGSGKDNE FGLGLDSPQN EIAQNGNNDQ SITECSIATT AEFSHDTDAT EIDSLDGYDL 3430 3440 3450 3460 3470 3480 QDEDDGLTES DSKLPIQAME IKKDIWNTEG ILKPADRSFS QSKLEVIEEE GKVGPDEDKP 3490 3500 3510 3520 3530 3540 PSKSSSSEKT PDKTDQKSGA QFFTLEGRHP DRSVFPDTYF SYKVDEEFAT PFKTVATKGL 3550 3560 3570 3580 3590 3600 DFDPWSNNRG DDEVFDSKSR EDETKPFGLA VEDRSPATTP DTTPARTPTD ESTPTSEPNP 3610 3620 3630 3640 3650 3660 FPFHEGKMFE MTRSGAIDMS KRDFVEERLQ FFQIGEHTSE GKSGDQGEGD KSMVTATPQP 3670 3680 3690 3700 3710 3720 QSGDTTVETN LERNVETPTV EPNPSIPTSG ECQEGTSSSG SLEKSAAATN TSKVDPKLRT 3730 3740 3750 3760 3770 3780 PIKMGISAST MTMKKEGPGE ITDKIEAVMT SCQGLENETI TMISNTANSQ MGVRPHEKHD 3790 3800 3810 3820 3830 3840 FQKDNFNNNN NLDSSTIQTD NIMSNIVLTE HSAPTCTTEK DNPVKVSSGK KTGVLQGHCV 3850 3860 3870 3880 3890 3900 RDKQKVLGEQ QKTKELIGIR QKSKLPIKAT SPKDTFPPNH MSNTKASKMK QVSQSEKTKA 3910 3920 3930 3940 3950 3960 LTTSSCVDVK SRIPVKNTHR DNIIAVRKAC ATQKQGQPEK GKAKQLPSKL PVKVRSTCVT 3970 3980 3990 4000 4010 4020 TTTTTATTTT TTTTTTTTSC TVKVRKSQLK EVCKHSIEYF KGISGETLKL VDRLSEEEKK 4030 4040 4050 4060 4070 4080 MQSELSDEEE STSRNTSLSE TSRGGQPSVT TKSARDKKTE AAPLKSKSEK AGSEKRSSRR 4090 4100 4110 4120 4130 4140 TGPQSPCERT DIRMAIVADH LGLSWTELAR ELNFSVDEIN QIRVENPNSL ISQSFMLLKK 4150 4160 4170 4180 4190 4200 WVTRDGKNAT TDALTSVLTK INRIDIVTLL EGPIFDYGNI SGTRSFADEN NVFHDPVDGW 4210 4220 4230 4240 4250 4260 QNETSSGNLE SCAQARRVTG GLLDRLDDSP DQCRDSITSY LKGEAGKFEA NGSHTEITPE 4270 4280 4290 4300 4310 4320 AKTKSYFPES QNDVGKQSTK ETLKPKIHGS GHVEEPASPL AAYQKSLEET SKLIIEETKP 4330 4340 4350 4360 4370 CVPVSMKKMS RTSPADGKPR LSLHEEEGSS GSEQKQGEGF KVKTKKEIRH VEKKSHS
	Isoform 2 [UniParc]. Checksum: C02C08780B3918ED	FASTA	1,868	204,142
	10 20 30 40 50 60 MSEEPKEKNA KPAHRKRKGK KSDANASYLR AARAGHLEKA LDYIKNGVDI NICNQNGLNA 70 80 90 100 110 120 LHLASKEGHV EVVSELLQRE ANVDAATKKG NTALHIASLA GQAEVVKVLV TNGANVNAQS 130 140 150 160 170 180 QNGFTPLYMA AQENHLEVVK FLLDNGASQS LATEDGFTPL AVALQQGHDQ VVSLLLENDT 190 200 210 220 230 240 KGKVRLPALH IAARKDDTKA AALLLQNDNN ADVESKSGFT PLHIAAHYGN INVATLLLNR 250 260 270 280 290 300 AAAVDFTARN DITPLHVASK RGNANMVKLL LDRGAKIDAK TRDGLTPLHC GARSGHEQVV 310 320 330 340 350 360 EMLLDRAAPI LSKTKNGLSP LHMATQGDHL NCVQLLLQHN VPVDDVTNDY LTALHVAAHC 370 380 390 400 410 420 GHYKVAKVLL DKKANPNAKA LNGFTPLHIA CKKNRIKVME LLLKHGASIQ AVTESGLTPI 430 440 450 460 470 480 HVAAFMGHVN IVSQLMHHGA SPNTTNVRGE TALHMAARSG QAEVVRYLVQ DGAQVEAKAK 490 500 510 520 530 540 DDQTPLHISA RLGKADIVQQ LLQQGASPNA ATTSGYTPLH LSAREGHEDV AAFLLDHGAS 550 560 570 580 590 600 LSITTKKGFT PLHVAAKYGK LEVANLLLQK SASPDAAGKS GLTPLHVAAH YDNQKVALLL 610 620 630 640 650 660 LDQGASPHAA AKNGYTPLHI AAKKNQMDIA TTLLEYGADA NAVTRQGIAS VHLAAQEGHV 670 680 690 700 710 720 DMVSLLLGRN ANVNLSNKSG LTPLHLAAQE DRVNVAEVLV NQGAHVDAQT KMGYTPLHVG 730 740 750 760 770 780 CHYGNIKIVN FLLQHSAKVN AKTKNGYTPL HQAAQQGHTH IINVLLQNNA SPNELTVNGN 790 800 810 820 830 840 TALGIARRLG YISVVDTLKI VTEETMTTTT VTEKHKMNVP ETMNEVLDMS DDEVRKANAP 850 860 870 880 890 900 EMLSDGEYIS DVEEGNRCTW YKIPKVQEFT VKSEDAMTGD TDKYLGPQDL KELGDDSLPA 910 920 930 940 950 960 EGYMGFSLGA RSASLRSFSS DRSYTLNRSS YARDSMMIEE LLVPSKEQHL TFTREFDSDS 970 980 990 1000 1010 1020 LRHYSWAADT LDNVNLVSSP IHSGFLVSFM VDARGGSMRG SRHHGMRIII PPRKCTAPTR 1030 1040 1050 1060 1070 1080 ITCRLVKRHK LANPPPMVEG EGLASRLVEM GPAGAQFLGP VIVEIPHFGS MRGKERELIV 1090 1100 1110 1120 1130 1140 LRSENGETWK EHQFDSKNED LTELLNGMDE ELDSPEELGK KRICRIITKD FPQYFAVVSR 1150 1160 1170 1180 1190 1200 IKQESNQIGP EGGILSSTTV PLVQASFPEG ALTKRIRVGL QAQPVPDEIV KKILGNKATF 1210 1220 1230 1240 1250 1260 SPIVTVEPRR RKFHKPITMT IPVPPPSGEG VSNGYKGDTT PNLRLLCSIT GGTSPAQWED 1270 1280 1290 1300 1310 1320 ITGTTPLTFI KDCVSFTTNV SARFWLADCH QVLETVGLAT QLYRELICVP YMAKFVVFAK 1330 1340 1350 1360 1370 1380 MNDPVESSLR CFCMTDDKVD KTLEQQENFE EVARSKDIEV LEGKPIYVDC YGNLAPLTKG 1390 1400 1410 1420 1430 1440 GQQLVFNFYS FKENRLPFSI KIRDTSQEPC GRLSFLKEPK TTKGLPQTAV CNLNITLPAH 1450 1460 1470 1480 1490 1500 KKIEKTDRRQ SFASLALRKR YSYLTEPGMS PQSPCERTDI RMAIVADHLG LSWTELAREL 1510 1520 1530 1540 1550 1560 NFSVDEINQI RVENPNSLIS QSFMLLKKWV TRDGKNATTD ALTSVLTKIN RIDIVTLLEG 1570 1580 1590 1600 1610 1620 PIFDYGNISG TRSFADENNV FHDPVDGYPS LQVELETPTG LHYTPPTPFQ QDDYFSDISS 1630 1640 1650 1660 1670 1680 IESPLRTPSR LSDGLVPSQG NIEHSADGPP VVTAEDASLE DSKLEDSVPL TEMPEAVDVD 1690 1700 1710 1720 1730 1740 ESQLENVCLS WQNETSSGNL ESCAQARRVT GGLLDRLDDS PDQCRDSITS YLKGEAGKFE 1750 1760 1770 1780 1790 1800 ANGSHTEITP EAKTKSYFPE SQNDVGKQST KETLKPKIHG SGHVEEPASP LAAYQKSLEE 1810 1820 1830 1840 1850 1860 TSKLIIEETK PCVPVSMKKM SRTSPADGKP RLSLHEEEGS SGSEQKQGEG FKVKTKKEIR HVEKKSHS
	Isoform 3 [UniParc]. Checksum: 06C904B8371BB406	FASTA	1,861	202,592
	10 20 30 40 50 60 MASSASSSPA GTEDSAPAQG GFGSDYSRSS RKSDANASYL RAARAGHLEK ALDYIKNGVD 70 80 90 100 110 120 INICNQNGLN ALHLASKEGH VEVVSELLQR EANVDAATKK GNTALHIASL AGQAEVVKVL 130 140 150 160 170 180 VTNGANVNAQ SQNGFTPLYM AAQENHLEVV KFLLDNGASQ SLATEDGFTP LAVALQQGHD 190 200 210 220 230 240 QVVSLLLEND TKGKVRLPAL HIAARKDDTK AAALLLQNDN NADVESKSGF TPLHIAAHYG 250 260 270 280 290 300 NINVATLLLN RAAAVDFTAR NDITPLHVAS KRGNANMVKL LLDRGAKIDA KTRDGLTPLH 310 320 330 340 350 360 CGARSGHEQV VEMLLDRAAP ILSKTKNGLS PLHMATQGDH LNCVQLLLQH NVPVDDVTND 370 380 390 400 410 420 YLTALHVAAH CGHYKVAKVL LDKKANPNAK ALNGFTPLHI ACKKNRIKVM ELLLKHGASI 430 440 450 460 470 480 QAVTESGLTP IHVAAFMGHV NIVSQLMHHG ASPNTTNVRG ETALHMAARS GQAEVVRYLV 490 500 510 520 530 540 QDGAQVEAKA KDDQTPLHIS ARLGKADIVQ QLLQQGASPN AATTSGYTPL HLSAREGHED 550 560 570 580 590 600 VAAFLLDHGA SLSITTKKGF TPLHVAAKYG KLEVANLLLQ KSASPDAAGK SGLTPLHVAA 610 620 630 640 650 660 HYDNQKVALL LLDQGASPHA AAKNGYTPLH IAAKKNQMDI ATTLLEYGAD ANAVTRQGIA 670 680 690 700 710 720 SVHLAAQEGH VDMVSLLLGR NANVNLSNKS GLTPLHLAAQ EDRVNVAEVL VNQGAHVDAQ 730 740 750 760 770 780 TKMGYTPLHV GCHYGNIKIV NFLLQHSAKV NAKTKNGYTP LHQAAQQGHT HIINVLLQNN 790 800 810 820 830 840 ASPNELTVNG NTALGIARRL GYISVVDTLK IVTEETMTTT TVTEKHKMNV PETMNEVLDM 850 860 870 880 890 900 SDDEVRKANA PEMLSDGEYI SDVEEGEDAM TGDTDKYLGP QDLKELGDDS LPAEGYMGFS 910 920 930 940 950 960 LGARSASLRS FSSDRSYTLN RSSYARDSMM IEELLVPSKE QHLTFTREFD SDSLRHYSWA 970 980 990 1000 1010 1020 ADTLDNVNLV SSPIHSGFLV SFMVDARGGS MRGSRHHGMR IIIPPRKCTA PTRITCRLVK 1030 1040 1050 1060 1070 1080 RHKLANPPPM VEGEGLASRL VEMGPAGAQF LGPVIVEIPH FGSMRGKERE LIVLRSENGE 1090 1100 1110 1120 1130 1140 TWKEHQFDSK NEDLTELLNG MDEELDSPEE LGKKRICRII TKDFPQYFAV VSRIKQESNQ 1150 1160 1170 1180 1190 1200 IGPEGGILSS TTVPLVQASF PEGALTKRIR VGLQAQPVPD EIVKKILGNK ATFSPIVTVE 1210 1220 1230 1240 1250 1260 PRRRKFHKPI TMTIPVPPPS GEGVSNGYKG DTTPNLRLLC SITGGTSPAQ WEDITGTTPL 1270 1280 1290 1300 1310 1320 TFIKDCVSFT TNVSARFWLA DCHQVLETVG LATQLYRELI CVPYMAKFVV FAKMNDPVES 1330 1340 1350 1360 1370 1380 SLRCFCMTDD KVDKTLEQQE NFEEVARSKD IEVLEGKPIY VDCYGNLAPL TKGGQQLVFN 1390 1400 1410 1420 1430 1440 FYSFKENRLP FSIKIRDTSQ EPCGRLSFLK EPKTTKGLPQ TAVCNLNITL PAHKKIEKTD 1450 1460 1470 1480 1490 1500 RRQSFASLAL RKRYSYLTEP GMSPQSPCER TDIRMAIVAD HLGLSWTELA RELNFSVDEI 1510 1520 1530 1540 1550 1560 NQIRVENPNS LISQSFMLLK KWVTRDGKNA TTDALTSVLT KINRIDIVTL LEGPIFDYGN 1570 1580 1590 1600 1610 1620 ISGTRSFADE NNVFHDPVDG YPSLQVELET PTGLHYTPPT PFQQDDYFSD ISSIESPLRT 1630 1640 1650 1660 1670 1680 PSRLSDGLVP SQGNIEHSAD GPPVVTAEDA SLEDSKLEDS VPLTEMPEAV DVDESQLENV 1690 1700 1710 1720 1730 1740 CLSWQNETSS GNLESCAQAR RVTGGLLDRL DDSPDQCRDS ITSYLKGEAG KFEANGSHTE 1750 1760 1770 1780 1790 1800 ITPEAKTKSY FPESQNDVGK QSTKETLKPK IHGSGHVEEP ASPLAAYQKS LEETSKLIIE 1810 1820 1830 1840 1850 1860 ETKPCVPVSM KKMSRTSPAD GKPRLSLHEE EGSSGSEQKQ GEGFKVKTKK EIRHVEKKSH S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier." Kordeli E., Lambert S., Bennett V. J. Biol. Chem. 270:2352-2359(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Brain stem.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Hippocampus.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Cervix and Fetal kidney.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells." Lopez C., Metral S., Eladari D., Drevensek S., Gane P., Chambrey R., Bennett V., Cartron J.-P., Le Van Kim C., Colin Y. J. Biol. Chem. 280:8221-8228(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RHBG.
[6]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-4338, MASS SPECTROMETRY. Tissue: Mammary cancer.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-847; SER-1445 AND SER-4298, MASS SPECTROMETRY.
[9]	"Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility." Bi C., Wu J., Jiang T., Liu Q., Cai W., Yu P., Cai T., Zhao M., Jiang Y.H., Sun Z.S. Hum. Mutat. 33:1635-1638(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ALA-1569; MET-3720 AND PRO-4255, ASSOCIATION WITH AUTISM SUSCEPTIBILITY.
+	Additional computationally mapped references.

Web resources

Wikipedia

Ankyrin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U13616 mRNA. Translation: AAA64834.1. AK295661 mRNA. Translation: BAG58523.1. BX537917 mRNA. Translation: CAD97900.2. BX648574 mRNA. Translation: CAI56716.1. AL359267 , AC023904, AL359377, AL592430 Genomic DNA. Translation: CAH73232.1. Sequence problems. AL592430 , AC023904, AL359267, AL359377 Genomic DNA. Translation: CAI40518.1. Sequence problems. AL359377 , AC023904, AL359267, AL592430 Genomic DNA. Translation: CAI41373.1. Sequence problems.
IPI	IPI00921566.
PIR	A55575.
RefSeq	NP_001191332.1. NM_001204403.1. NP_001191333.1. NM_001204404.1. NP_066267.2. NM_020987.3.
UniGene	Hs.499725.
3D structure databases
ProteinModelPortal	Q12955.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-49017N.
IntAct	Q12955. 2 interactions.
STRING	9606.ENSP00000280772.
PTM databases
PhosphoSite	Q12955.
Polymorphism databases
DMDM	257051061.
Proteomic databases
PaxDb	Q12955.
PRIDE	Q12955.
ProMEX	Q12955.
Protocols and materials databases
DNASU	288.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280772; ENSP00000280772; ENSG00000151150. ENST00000373827; ENSP00000362933; ENSG00000151150. ENST00000503366; ENSP00000425236; ENSG00000151150.
GeneID	288.
KEGG	hsa:288.
UCSC	uc001jky.3. human. uc001jkz.4. human. uc010qih.2. human.
Organism-specific databases
CTD	288.
GeneCards	GC10M061788.
H-InvDB	HIX0008849.
HGNC	HGNC:494. ANK3.
HPA	CAB015179.
MIM	600465. gene.
neXtProt	NX_Q12955.
PharmGKB	PA24800.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000012873.
HOVERGEN	HBG024337.
InParanoid	Q12955.
KO	K10380.
OMA	SYEFTSK.
PhylomeDB	Q12955.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	Q12955.
Bgee	Q12955.
CleanEx	HS_ANK3.
Genevestigator	Q12955.
GermOnline	ENSG00000151150. Homo sapiens.
Family and domain databases
Gene3D	1.10.533.10. 1 hit. 1.25.40.20. 3 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR000906. ZU5. [Graphical view]
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 7 hits. PF00531. Death. 1 hit. PF00791. ZU5. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 22 hits. SM00005. DEATH. 1 hit. SM00218. ZU5. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 2 hits. SSF47986. DEATH_like. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 21 hits. PS50017. DEATH_DOMAIN. 1 hit. PS51145. ZU5. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ANK3. human.
GenomeRNAi	288.
NextBio	1175.
SOURCE	Search...

Entry information

Entry name

ANK3_HUMAN

Accession

Primary (citable) accession number: Q12955
Secondary accession number(s): B4DIL1 , E9PE32, Q5CZH9, Q5VXD5, Q7Z3G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	September 1, 2009
Last modified:	May 29, 2013
This is version 125 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.