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Q12955

- ANK3_HUMAN

UniProt

Q12955 - ANK3_HUMAN

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Protein

Ankyrin-3

Gene

ANK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments.By similarity
Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.

GO - Molecular functioni

  1. cadherin binding Source: BHF-UCL
  2. cytoskeletal protein binding Source: BHF-UCL
  3. ion channel binding Source: BHF-UCL
  4. protein binding, bridging Source: BHF-UCL
  5. spectrin binding Source: BHF-UCL
  6. structural constituent of cytoskeleton Source: BHF-UCL

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. axonogenesis Source: BHF-UCL
  3. cytoskeletal anchoring at plasma membrane Source: ProtInc
  4. establishment of protein localization Source: UniProtKB
  5. Golgi to plasma membrane protein transport Source: BHF-UCL
  6. maintenance of protein location in plasma membrane Source: BHF-UCL
  7. membrane assembly Source: BHF-UCL
  8. mitotic cytokinesis Source: BHF-UCL
  9. neuromuscular junction development Source: Ensembl
  10. neuronal action potential Source: BHF-UCL
  11. plasma membrane organization Source: BHF-UCL
  12. positive regulation of cell communication by electrical coupling Source: Ensembl
  13. positive regulation of gene expression Source: BHF-UCL
  14. positive regulation of homotypic cell-cell adhesion Source: Ensembl
  15. positive regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  16. positive regulation of membrane potential Source: BHF-UCL
  17. positive regulation of protein targeting to membrane Source: Ensembl
  18. positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  19. positive regulation of sodium ion transport Source: BHF-UCL
  20. protein localization to plasma membrane Source: BHF-UCL
  21. protein targeting to plasma membrane Source: BHF-UCL
  22. regulation of potassium ion transport Source: BHF-UCL
  23. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22266. Interaction between L1 and Ankyrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin-3
Short name:
ANK-3
Alternative name(s):
Ankyrin-G
Gene namesi
Name:ANK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:494. ANK3.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication. Cell projectionaxon By similarity. Cell membranesarcolemma 1 Publication. Cell junctionsynapsepostsynaptic cell membrane By similarity. Lysosome By similarity
Note: In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes.By similarity
Isoform 5 : Cytoplasmcytoskeleton 1 Publication. Golgi apparatus 1 Publication

GO - Cellular componenti

  1. axon initial segment Source: BHF-UCL
  2. basolateral plasma membrane Source: UniProtKB
  3. cell surface Source: BHF-UCL
  4. costamere Source: BHF-UCL
  5. dendrite Source: Ensembl
  6. endoplasmic reticulum Source: ProtInc
  7. Golgi apparatus Source: ProtInc
  8. intercalated disc Source: BHF-UCL
  9. lateral plasma membrane Source: BHF-UCL
  10. lysosome Source: UniProtKB-KW
  11. neuromuscular junction Source: Ensembl
  12. node of Ranvier Source: BHF-UCL
  13. paranode region of axon Source: Ensembl
  14. plasma membrane Source: BHF-UCL
  15. postsynaptic membrane Source: UniProtKB-KW
  16. sarcolemma Source: BHF-UCL
  17. sarcoplasmic reticulum Source: Ensembl
  18. spectrin-associated cytoskeleton Source: BHF-UCL
  19. T-tubule Source: BHF-UCL
  20. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Lysosome, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Genetic variations in ANK3 may be associated with autism spectrum disorders susceptibility.
Mental retardation, autosomal recessive 37 (MRT37) [MIM:615493]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT37 patients manifest delayed global development with speech delay, hypotonia, spasticity, and a sleep disorder. Severe behavioral abnormalities include aggression, hyperactivity, and grinding of the teeth.
Note: The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in ANK3 predicted to result in frameshift and premature truncation, has been shown to be the cause of moderate intellectual disability, an ADHD-like phenotype and behavioral problems in a consanguineous family (PubMed:23390136).1 Publication

Keywords - Diseasei

Mental retardation

Organism-specific databases

MIMi615493. phenotype.
Orphaneti356996. Intellectual disability - hypotonia - spasticity - sleep disorder.
3140. Schizophrenia.
PharmGKBiPA24800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43774377Ankyrin-3PRO_0000066886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391Phosphoserine1 Publication
Modified residuei847 – 8471Phosphoserine1 Publication
Modified residuei1445 – 14451Phosphoserine1 Publication
Modified residuei4298 – 42981Phosphoserine1 Publication
Cross-linki4338 – 4338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ12955.
PaxDbiQ12955.
PRIDEiQ12955.
ProMEXiQ12955.

PTM databases

PhosphoSiteiQ12955.

Expressioni

Tissue specificityi

Expressed in brain, neurons, muscles and other tissues.2 Publications

Developmental stagei

Up-regulated during muscle cell differentiation.1 Publication

Gene expression databases

BgeeiQ12955.
CleanExiHS_ANK3.
ExpressionAtlasiQ12955. baseline and differential.
GenevestigatoriQ12955.

Organism-specific databases

HPAiCAB013249.
CAB015179.
HPA055643.

Interactioni

Subunit structurei

Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity). Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG. Interacts with PLEC and FLNC.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SMAD2Q157962EBI-2691178,EBI-1040141

Protein-protein interaction databases

BioGridi106785. 14 interactions.
DIPiDIP-49017N.
IntActiQ12955. 3 interactions.
STRINGi9606.ENSP00000280772.

Structurei

3D structure databases

ProteinModelPortaliQ12955.
SMRiQ12955. Positions 14-871, 982-1442, 4090-4167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati73 – 10230ANK 1Add
BLAST
Repeati106 – 13530ANK 2Add
BLAST
Repeati139 – 16830ANK 3Add
BLAST
Repeati172 – 20130ANK 4Add
BLAST
Repeati203 – 23028ANK 5Add
BLAST
Repeati234 – 26330ANK 6Add
BLAST
Repeati267 – 29630ANK 7Add
BLAST
Repeati300 – 32930ANK 8Add
BLAST
Repeati333 – 36230ANK 9Add
BLAST
Repeati366 – 39530ANK 10Add
BLAST
Repeati399 – 42830ANK 11Add
BLAST
Repeati432 – 46130ANK 12Add
BLAST
Repeati465 – 49430ANK 13Add
BLAST
Repeati498 – 52730ANK 14Add
BLAST
Repeati531 – 56030ANK 15Add
BLAST
Repeati564 – 59330ANK 16Add
BLAST
Repeati597 – 62630ANK 17Add
BLAST
Repeati630 – 65930ANK 18Add
BLAST
Repeati663 – 69230ANK 19Add
BLAST
Repeati696 – 72530ANK 20Add
BLAST
Repeati729 – 75830ANK 21Add
BLAST
Repeati762 – 79130ANK 22Add
BLAST
Repeati795 – 82531ANK 23Add
BLAST
Domaini982 – 1107126ZU5 1PROSITE-ProRule annotationAdd
BLAST
Domaini1108 – 1272165ZU5 2PROSITE-ProRule annotationAdd
BLAST
Domaini4090 – 417485DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1273 – 1407135UPA domainBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1519 – 1898380Ser-richAdd
BLAST
Compositional biasi2247 – 22504Poly-Thr
Compositional biasi2393 – 23964Poly-Glu
Compositional biasi3205 – 32117Poly-Glu
Compositional biasi3255 – 32595Poly-Pro
Compositional biasi3482 – 34876Poly-Ser
Compositional biasi3785 – 37917Poly-Asn
Compositional biasi3957 – 398125Thr-richAdd
BLAST

Domaini

The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin (By similarity).By similarity

Sequence similaritiesi

Contains 23 ANK repeats.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation
Contains 2 ZU5 domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118950.
HOGENOMiHOG000012873.
HOVERGENiHBG024337.
InParanoidiQ12955.
KOiK10380.
OMAiSYEFTSK.
OrthoDBiEOG7P02H2.
PhylomeDBiQ12955.
TreeFamiTF351263.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00023. Ank. 3 hits.
PF12796. Ank_2. 6 hits.
PF00531. Death. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 22 hits.
SM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q12955-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHAASQLKK NRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR
60 70 80 90 100
AGHLEKALDY IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV
110 120 130 140 150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
160 170 180 190 200
NHLEVVKFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
210 220 230 240 250
VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH IAAHYGNINV
260 270 280 290 300
ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD
310 320 330 340 350
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV
360 370 380 390 400
QLLLQHNVPV DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG
410 420 430 440 450
FTPLHIACKK NRIKVMELLL KHGASIQAVT ESGLTPIHVA AFMGHVNIVS
460 470 480 490 500
QLMHHGASPN TTNVRGETAL HMAARSGQAE VVRYLVQDGA QVEAKAKDDQ
510 520 530 540 550
TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA REGHEDVAAF
560 570 580 590 600
LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT
610 620 630 640 650
PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL
660 670 680 690 700
LEYGADANAV TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP
710 720 730 740 750
LHLAAQEDRV NVAEVLVNQG AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL
760 770 780 790 800
QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN VLLQNNASPN ELTVNGNTAL
810 820 830 840 850
GIARRLGYIS VVDTLKIVTE ETMTTTTVTE KHKMNVPETM NEVLDMSDDE
860 870 880 890 900
VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE
910 920 930 940 950
GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT
960 970 980 990 1000
FTREFDSDSL RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS
1010 1020 1030 1040 1050
RHHGMRIIIP PRKCTAPTRI TCRLVKRHKL ANPPPMVEGE GLASRLVEMG
1060 1070 1080 1090 1100
PAGAQFLGPV IVEIPHFGSM RGKERELIVL RSENGETWKE HQFDSKNEDL
1110 1120 1130 1140 1150
TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI KQESNQIGPE
1160 1170 1180 1190 1200
GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS
1210 1220 1230 1240 1250
PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG
1260 1270 1280 1290 1300
GTSPAQWEDI TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ
1310 1320 1330 1340 1350
LYRELICVPY MAKFVVFAKM NDPVESSLRC FCMTDDKVDK TLEQQENFEE
1360 1370 1380 1390 1400
VARSKDIEVL EGKPIYVDCY GNLAPLTKGG QQLVFNFYSF KENRLPFSIK
1410 1420 1430 1440 1450
IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK KETESDQDDE
1460 1470 1480 1490 1500
IEKTDRRQSF ASLALRKRYS YLTEPGMIER STGATRSLPT TYSYKPFFST
1510 1520 1530 1540 1550
RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK
1560 1570 1580 1590 1600
STLGASTTSS VKSISDVASP IRSFRTMSSP IKTVVSQSPY NIQVSSGTLA
1610 1620 1630 1640 1650
RAPAVTEATP LKGLASNSTF SSRTSPVTTA GSLLERSSIT MTPPASPKSN
1660 1670 1680 1690 1700
INMYSSSLPF KSIITSAAPL ISSPLKSVVS PVKSAVDVIS SAKITMASSL
1710 1720 1730 1740 1750
SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT LQEKISSATN
1760 1770 1780 1790 1800
SVSSVVSAAT DTVEKVFSTT TAMPFSPLRS YVSAAPSAFQ SLRTPSASAL
1810 1820 1830 1840 1850
YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSNSFTKSAA
1860 1870 1880 1890 1900
ALLSPIKTLT TETHPQPHFS RTSSPVKSSL FLAPSALKLS TPSSLSSSQE
1910 1920 1930 1940 1950
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ PELPKEGRID DEEPFKIVEK
1960 1970 1980 1990 2000
VKEDLVKVSE ILKKDVCVDN KGSPKSPKSD KGHSPEDDWI EFSSEEIREA
2010 2020 2030 2040 2050
RQQAAASQSP SLPERVQVKA KAASEKDYNL TKVIDYLTND IGSSSLTNLK
2060 2070 2080 2090 2100
YKFEDAKKDG EERQKRVLKP AIALQEHKLK MPPASMRTST SEKELCKMAD
2110 2120 2130 2140 2150
SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK
2160 2170 2180 2190 2200
PLFHEVPIPP VITETRTEVV HVIRSYDPSA GDVPQTQPEE PVSPKPSPTF
2210 2220 2230 2240 2250
MELEPKPTTS SIKEKVKAFQ MKASSEEDDH NRVLSKGMRV KEETHITTTT
2260 2270 2280 2290 2300
RMVYHSPPGG EGASERIEET MSVHDIMKAF QSGRDPSKEL AGLFEHKSAV
2310 2320 2330 2340 2350
SPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA EPTEVIIRET
2360 2370 2380 2390 2400
KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE
2410 2420 2430 2440 2450
ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD
2460 2470 2480 2490 2500
DELSELRGES YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK
2510 2520 2530 2540 2550
RSREKIATAP KKEILSKIYK DVSENGVGKV SKDEHFDKVT VLHYSGNVSS
2560 2570 2580 2590 2600
PKHAMWMRFT EDRLDRGREK LIYEDRVDRT VKEAEEKLTE VSQFFRDKTE
2610 2620 2630 2640 2650
KLNDELQSPE KKARPKNGKE YSSQSPTSSS PEKVLLTELL ASNDEWVKAR
2660 2670 2680 2690 2700
QHGPDGQGFP KAEEKAPSLP SSPEKMVLSQ QTEDSKSTVE AKGSISQSKA
2710 2720 2730 2740 2750
PDGPQSGFQL KQSKLSSIRL KFEQGTHAKS KDMSQEDRKS DGQSRIPVKK
2760 2770 2780 2790 2800
IQESKLPVYQ VFAREKQQKA IDLPDESVSV QKDFMVLKTK DEHAQSNEIV
2810 2820 2830 2840 2850
VNDSGSDNVK KQRTEMSSKA MPDSFSEQQA KDLACHITSD LATRGPWDKK
2860 2870 2880 2890 2900
VFRTWESSGA TNNKSQKEKL SHVLVHDVRE NHIGHPESKS VDQKNEFMSV
2910 2920 2930 2940 2950
TERERKLLTN GSLSEIKEMT VKSPSKKVLY REYVVKEGDH PGGLLDQPSR
2960 2970 2980 2990 3000
RSESSAVSHI PVRVADERRM LSSNIPDGFC EQSAFPKHEL SQKLSQSSMS
3010 3020 3030 3040 3050
KETVETQHFN SIEDEKVTYS EISKVSKHQS YVGLCPPLEE TETSPTKSPD
3060 3070 3080 3090 3100
SLEFSPGKES PSSDVFDHSP IDGLEKLAPL AQTEGGKEIK TLPVYVSFVQ
3110 3120 3130 3140 3150
VGKQYEKEIQ QGGVKKIISQ ECKTVQETRG TFYTTRQQKQ PPSPQGSPED
3160 3170 3180 3190 3200
DTLEQVSFLD SSGKSPLTPE TPSSEEVSYE FTSKTPDSLI AYIPGKPSPI
3210 3220 3230 3240 3250
PEVSEESEEE EQAKSTSLKQ TTVEETAVER EMPNDVSKDS NQRPKNNRVA
3260 3270 3280 3290 3300
YIEFPPPPPL DADQIESDKK HHYLPEKEVD MIEVNLQDEH DKYQLAEPVI
3310 3320 3330 3340 3350
RVQPPSPVPP GADVSDSSDD ESIYQPVPVK KYTFKLKEVD DEQKEKPKAS
3360 3370 3380 3390 3400
AEKASNQKEL ESNGSGKDNE FGLGLDSPQN EIAQNGNNDQ SITECSIATT
3410 3420 3430 3440 3450
AEFSHDTDAT EIDSLDGYDL QDEDDGLTES DSKLPIQAME IKKDIWNTEG
3460 3470 3480 3490 3500
ILKPADRSFS QSKLEVIEEE GKVGPDEDKP PSKSSSSEKT PDKTDQKSGA
3510 3520 3530 3540 3550
QFFTLEGRHP DRSVFPDTYF SYKVDEEFAT PFKTVATKGL DFDPWSNNRG
3560 3570 3580 3590 3600
DDEVFDSKSR EDETKPFGLA VEDRSPATTP DTTPARTPTD ESTPTSEPNP
3610 3620 3630 3640 3650
FPFHEGKMFE MTRSGAIDMS KRDFVEERLQ FFQIGEHTSE GKSGDQGEGD
3660 3670 3680 3690 3700
KSMVTATPQP QSGDTTVETN LERNVETPTV EPNPSIPTSG ECQEGTSSSG
3710 3720 3730 3740 3750
SLEKSAAATN TSKVDPKLRT PIKMGISAST MTMKKEGPGE ITDKIEAVMT
3760 3770 3780 3790 3800
SCQGLENETI TMISNTANSQ MGVRPHEKHD FQKDNFNNNN NLDSSTIQTD
3810 3820 3830 3840 3850
NIMSNIVLTE HSAPTCTTEK DNPVKVSSGK KTGVLQGHCV RDKQKVLGEQ
3860 3870 3880 3890 3900
QKTKELIGIR QKSKLPIKAT SPKDTFPPNH MSNTKASKMK QVSQSEKTKA
3910 3920 3930 3940 3950
LTTSSCVDVK SRIPVKNTHR DNIIAVRKAC ATQKQGQPEK GKAKQLPSKL
3960 3970 3980 3990 4000
PVKVRSTCVT TTTTTATTTT TTTTTTTTSC TVKVRKSQLK EVCKHSIEYF
4010 4020 4030 4040 4050
KGISGETLKL VDRLSEEEKK MQSELSDEEE STSRNTSLSE TSRGGQPSVT
4060 4070 4080 4090 4100
TKSARDKKTE AAPLKSKSEK AGSEKRSSRR TGPQSPCERT DIRMAIVADH
4110 4120 4130 4140 4150
LGLSWTELAR ELNFSVDEIN QIRVENPNSL ISQSFMLLKK WVTRDGKNAT
4160 4170 4180 4190 4200
TDALTSVLTK INRIDIVTLL EGPIFDYGNI SGTRSFADEN NVFHDPVDGW
4210 4220 4230 4240 4250
QNETSSGNLE SCAQARRVTG GLLDRLDDSP DQCRDSITSY LKGEAGKFEA
4260 4270 4280 4290 4300
NGSHTEITPE AKTKSYFPES QNDVGKQSTK ETLKPKIHGS GHVEEPASPL
4310 4320 4330 4340 4350
AAYQKSLEET SKLIIEETKP CVPVSMKKMS RTSPADGKPR LSLHEEEGSS
4360 4370
GSEQKQGEGF KVKTKKEIRH VEKKSHS
Length:4,377
Mass (Da):480,410
Last modified:September 1, 2009 - v3
Checksum:iF6F9FABD09F15C13
GO
Isoform 2 (identifier: Q12955-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRK → MSEEPKEKNAKPAHRKRKG
     872-872: G → GNRCTWYKIPKVQEFTVKS
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Show »
Length:1,868
Mass (Da):204,142
Checksum:iC02C08780B3918ED
GO
Isoform 3 (identifier: Q12955-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKK → MASSASSSPAGTEDSAPAQGGFGSDYSRSSR
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Show »
Length:1,861
Mass (Da):202,592
Checksum:i06C904B8371BB406
GO
Isoform 4 (identifier: Q12955-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-866: Missing.
     867-872: SDVEEG → MALPQS
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Note: Ref.3 (CAB66645) sequence(s) differ(s) from that shown due to (a) frameshift(s) in position(s) 810.

Show »
Length:1,001
Mass (Da):111,099
Checksum:iEF695AFF21999D1E
GO
Isoform 5 (identifier: Q12955-7) [UniParc]FASTAAdd to Basket

Also known as: AnkG119, Golgi ankyrin

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAHAAS → MNLRCD
     7-385: Missing.
     850-870: Missing.
     913-918: Missing.
     1036-1043: MVEGEGLA → HGERRGIS
     1442-1450: Missing.
     1478-1880: IERSTGATRS...RTSSPVKSSL → TSCTVKVRKS...IRHVEKKSHS
     1881-4377: Missing.

Note: Avidly binds beta spectrin.

Show »
Length:1,465
Mass (Da):160,947
Checksum:i7B43551F7DB9691D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971T → A in CAI56716. (PubMed:17974005)Curated
Sequence conflicti222 – 2221L → P in CAD97900. (PubMed:17974005)Curated
Sequence conflicti327 – 3271I → V in CAD97900. (PubMed:17974005)Curated
Sequence conflicti338 – 3381L → W in BAG58523. (PubMed:14702039)Curated
Sequence conflicti523 – 5231A → T in CAD97900. (PubMed:17974005)Curated
Sequence conflicti578 – 5781L → P in CAI56716. (PubMed:17974005)Curated
Sequence conflicti921 – 9211R → G in CAB66645. (PubMed:11230166)Curated
Sequence conflicti977 – 9771S → P in CAB66645. (PubMed:11230166)Curated
Sequence conflicti1237 – 12371D → G in CAI56716. (PubMed:17974005)Curated
Sequence conflicti1418 – 14181P → R in AAA64834. (PubMed:7836469)Curated
Sequence conflicti1455 – 14551D → E in BAG58523. (PubMed:14702039)Curated
Sequence conflicti1574 – 15741F → L in AAA64834. (PubMed:7836469)Curated
Sequence conflicti1685 – 16851A → R in AAA64834. (PubMed:7836469)Curated
Sequence conflicti1726 – 17261P → A in AAA64834. (PubMed:7836469)Curated
Sequence conflicti2062 – 20632ER → GG in AAA64834. (PubMed:7836469)Curated
Sequence conflicti2146 – 21461S → T in AAA64834. (PubMed:7836469)Curated
Sequence conflicti3919 – 39191H → P in AAA64834. (PubMed:7836469)Curated
Sequence conflicti4137 – 41371L → F in CAB66645. (PubMed:11230166)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1569 – 15691S → A Found in a patient with autism; unknown pathological significance. 1 Publication
VAR_068702
Natural varianti2318 – 23181K → R.
Corresponds to variant rs59021407 [ dbSNP | Ensembl ].
VAR_061013
Natural varianti2885 – 28851H → Q.
Corresponds to variant rs11599164 [ dbSNP | Ensembl ].
VAR_059115
Natural varianti2996 – 29961Q → H.
Corresponds to variant rs41274672 [ dbSNP | Ensembl ].
VAR_061014
Natural varianti3117 – 31171I → V.
Corresponds to variant rs28932171 [ dbSNP | Ensembl ].
VAR_059116
Natural varianti3123 – 31231K → R.
Corresponds to variant rs10821668 [ dbSNP | Ensembl ].
VAR_059117
Natural varianti3720 – 37201T → M Found in a patient with autism; unknown pathological significance. 1 Publication
VAR_068703
Natural varianti4255 – 42551T → P Found in a patient with autism; unknown pathological significance. 1 Publication
VAR_068704
Natural varianti4257 – 42571I → V.
Corresponds to variant rs12261793 [ dbSNP | Ensembl ].
VAR_054333

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 866866Missing in isoform 4. 1 PublicationVSP_046885Add
BLAST
Alternative sequencei1 – 3737MAHAA…RDRKK → MASSASSSPAGTEDSAPAQG GFGSDYSRSSR in isoform 3. 1 PublicationVSP_044348Add
BLAST
Alternative sequencei1 – 3636MAHAA…SRDRK → MSEEPKEKNAKPAHRKRKG in isoform 2. 1 PublicationVSP_044349Add
BLAST
Alternative sequencei1 – 66MAHAAS → MNLRCD in isoform 5. 1 PublicationVSP_053753
Alternative sequencei7 – 385379Missing in isoform 5. 1 PublicationVSP_053754Add
BLAST
Alternative sequencei850 – 87021Missing in isoform 5. 1 PublicationVSP_053755Add
BLAST
Alternative sequencei867 – 8726SDVEEG → MALPQS in isoform 4. 1 PublicationVSP_046886
Alternative sequencei872 – 8721G → GNRCTWYKIPKVQEFTVKS in isoform 2. 1 PublicationVSP_044350
Alternative sequencei913 – 9186Missing in isoform 5. 1 PublicationVSP_053756
Alternative sequencei1036 – 10438MVEGEGLA → HGERRGIS in isoform 5. 1 PublicationVSP_053757
Alternative sequencei1442 – 14509Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_044351
Alternative sequencei1478 – 40812604Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_044352Add
BLAST
Alternative sequencei1478 – 1880403IERST…VKSSL → TSCTVKVRKSQLKEVCKHSI EYFKGISGETLKLVDRLSEE EKKMQSELSDEEESTSRNTS LSETSRGGQPSVTTKSARDK KTEAAPLKSKSEKAGSEKRS SRRTGPQSPCERTDIRMAIV ADHLGLSWTELARELNFSVD EINQIRVENPNSLISQSFML LKKWVTRDGKNATTDALTSV LTKINRIDIVTLLEGPIFDY GNISGTRSFADENNVFHDPV DGWQNETSSGNLESCAQARR VTGGLLDRLDDSPDQCRDSI TSYLKGEAGKFEANGSHTEI TPEAKTKSYFPESQNDVGKQ STKETLKPKIHGSGHVEEPA SPLAAYQKSLEETSKLSKLI IEETKPCVPVSMKKMSRTSP ADGKPRLSLHEEEGSSGSEQ KQGEGFKVKTKKEIRHVEKK SHS in isoform 5. 1 PublicationVSP_053758Add
BLAST
Alternative sequencei1881 – 43772497Missing in isoform 5. 1 PublicationVSP_053759Add
BLAST
Alternative sequencei4082 – 40821G → S in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_044353
Alternative sequencei4199 – 41991G → GYPSLQVELETPTGLHYTPP TPFQQDDYFSDISSIESPLR TPSRLSDGLVPSQGNIEHSA DGPPVVTAEDASLEDSKLED SVPLTEMPEAVDVDESQLEN VCLS in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_044354

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13616 mRNA. Translation: AAA64834.1.
U43965 mRNA. Translation: AAB08437.1.
AL136710 mRNA. Translation: CAB66645.1. Frameshift.
AK295661 mRNA. Translation: BAG58523.1.
BX537917 mRNA. Translation: CAD97900.2.
BX648574 mRNA. Translation: CAI56716.1.
AC022390 Genomic DNA. No translation available.
AC023904 Genomic DNA. No translation available.
AL359267 Genomic DNA. No translation available.
AL359377 Genomic DNA. No translation available.
AL391707 Genomic DNA. No translation available.
AL592430 Genomic DNA. No translation available.
AL607065 Genomic DNA. No translation available.
CCDSiCCDS55711.1. [Q12955-4]
CCDS55712.1. [Q12955-5]
CCDS7258.1. [Q12955-3]
CCDS7259.1. [Q12955-6]
PIRiA55575.
RefSeqiNP_001140.2. NM_001149.3. [Q12955-6]
NP_001191332.1. NM_001204403.1. [Q12955-5]
NP_001191333.1. NM_001204404.1. [Q12955-4]
NP_066267.2. NM_020987.3. [Q12955-3]
UniGeneiHs.499725.

Genome annotation databases

EnsembliENST00000280772; ENSP00000280772; ENSG00000151150. [Q12955-3]
ENST00000355288; ENSP00000347436; ENSG00000151150. [Q12955-6]
ENST00000373827; ENSP00000362933; ENSG00000151150. [Q12955-5]
ENST00000503366; ENSP00000425236; ENSG00000151150. [Q12955-4]
GeneIDi288.
KEGGihsa:288.
UCSCiuc001jky.3. human. [Q12955-3]
uc001jkz.4. human. [Q12955-5]
uc010qih.2. human. [Q12955-4]

Polymorphism databases

DMDMi257051061.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Ankyrin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13616 mRNA. Translation: AAA64834.1 .
U43965 mRNA. Translation: AAB08437.1 .
AL136710 mRNA. Translation: CAB66645.1 . Frameshift.
AK295661 mRNA. Translation: BAG58523.1 .
BX537917 mRNA. Translation: CAD97900.2 .
BX648574 mRNA. Translation: CAI56716.1 .
AC022390 Genomic DNA. No translation available.
AC023904 Genomic DNA. No translation available.
AL359267 Genomic DNA. No translation available.
AL359377 Genomic DNA. No translation available.
AL391707 Genomic DNA. No translation available.
AL592430 Genomic DNA. No translation available.
AL607065 Genomic DNA. No translation available.
CCDSi CCDS55711.1. [Q12955-4 ]
CCDS55712.1. [Q12955-5 ]
CCDS7258.1. [Q12955-3 ]
CCDS7259.1. [Q12955-6 ]
PIRi A55575.
RefSeqi NP_001140.2. NM_001149.3. [Q12955-6 ]
NP_001191332.1. NM_001204403.1. [Q12955-5 ]
NP_001191333.1. NM_001204404.1. [Q12955-4 ]
NP_066267.2. NM_020987.3. [Q12955-3 ]
UniGenei Hs.499725.

3D structure databases

ProteinModelPortali Q12955.
SMRi Q12955. Positions 14-871, 982-1442, 4090-4167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106785. 14 interactions.
DIPi DIP-49017N.
IntActi Q12955. 3 interactions.
STRINGi 9606.ENSP00000280772.

PTM databases

PhosphoSitei Q12955.

Polymorphism databases

DMDMi 257051061.

Proteomic databases

MaxQBi Q12955.
PaxDbi Q12955.
PRIDEi Q12955.
ProMEXi Q12955.

Protocols and materials databases

DNASUi 288.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280772 ; ENSP00000280772 ; ENSG00000151150 . [Q12955-3 ]
ENST00000355288 ; ENSP00000347436 ; ENSG00000151150 . [Q12955-6 ]
ENST00000373827 ; ENSP00000362933 ; ENSG00000151150 . [Q12955-5 ]
ENST00000503366 ; ENSP00000425236 ; ENSG00000151150 . [Q12955-4 ]
GeneIDi 288.
KEGGi hsa:288.
UCSCi uc001jky.3. human. [Q12955-3 ]
uc001jkz.4. human. [Q12955-5 ]
uc010qih.2. human. [Q12955-4 ]

Organism-specific databases

CTDi 288.
GeneCardsi GC10M061788.
H-InvDB HIX0008849.
HGNCi HGNC:494. ANK3.
HPAi CAB013249.
CAB015179.
HPA055643.
MIMi 600465. gene.
615493. phenotype.
neXtProti NX_Q12955.
Orphaneti 356996. Intellectual disability - hypotonia - spasticity - sleep disorder.
3140. Schizophrenia.
PharmGKBi PA24800.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00760000118950.
HOGENOMi HOG000012873.
HOVERGENi HBG024337.
InParanoidi Q12955.
KOi K10380.
OMAi SYEFTSK.
OrthoDBi EOG7P02H2.
PhylomeDBi Q12955.
TreeFami TF351263.

Enzyme and pathway databases

Reactomei REACT_22266. Interaction between L1 and Ankyrins.

Miscellaneous databases

ChiTaRSi ANK3. human.
GeneWikii ANK3.
GenomeRNAii 288.
NextBioi 1175.
PROi Q12955.
SOURCEi Search...

Gene expression databases

Bgeei Q12955.
CleanExi HS_ANK3.
ExpressionAtlasi Q12955. baseline and differential.
Genevestigatori Q12955.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
1.25.40.20. 3 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR000906. ZU5_dom.
[Graphical view ]
Pfami PF00023. Ank. 3 hits.
PF12796. Ank_2. 6 hits.
PF00531. Death. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 22 hits.
SM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 3 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier."
    Kordeli E., Lambert S., Bennett V.
    J. Biol. Chem. 270:2352-2359(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain stem.
  2. "Identification of a small cytoplasmic ankyrin (AnkG119) in the kidney and muscle that binds beta I sigma spectrin and associates with the Golgi apparatus."
    Devarajan P., Stabach P.R., Mann A.S., Ardito T., Kashgarian M., Morrow J.S.
    J. Cell Biol. 133:819-830(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION (ISOFORM 5), SUBCELLULAR LOCATION (ISOFORM 5).
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Kidney.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cervix and Fetal kidney.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells."
    Lopez C., Metral S., Eladari D., Drevensek S., Gane P., Chambrey R., Bennett V., Cartron J.-P., Le Van Kim C., Colin Y.
    J. Biol. Chem. 280:8221-8228(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RHBG.
  8. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-4338.
    Tissue: Mammary cancer.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C."
    Maiweilidan Y., Klauza I., Kordeli E.
    Exp. Cell Res. 317:724-736(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLEC AND FLNC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-847; SER-1445 AND SER-4298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility."
    Bi C., Wu J., Jiang T., Liu Q., Cai W., Yu P., Cai T., Zhao M., Jiang Y.H., Sun Z.S.
    Hum. Mutat. 33:1635-1638(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALA-1569; MET-3720 AND PRO-4255, POSSIBLE INVOLMENT IN SUSCEPTIBILITY TO AUTISM.
  13. Cited for: INVOLMENT IN MRT37.

Entry informationi

Entry nameiANK3_HUMAN
AccessioniPrimary (citable) accession number: Q12955
Secondary accession number(s): B1AQT2
, B4DIL1, E9PE32, Q13484, Q5CZH9, Q5VXD5, Q7Z3G4, Q9H0P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3