Reviewed, UniProtKB/Swiss-Prot Q12955 (ANK3_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin-3
      Short name=ANK-3
Alternative name(s):
    Ankyrin-G

Gene names

Name:

ANK3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	4377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments.
Subunit structure	May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG. Ref.3
Subcellular location	Cytoplasm › cytoskeleton.
Tissue specificity	Expressed in brain, neurons and other tissues. Ref.1
Sequence similarities	Contains 23 ANK repeats. Contains 1 death domain. Contains 1 ZU5 domain.
Sequence caution	The sequence CAH73232.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40518.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI41373.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	establishment of protein localization Ref.3 Inferred from mutant phenotype. Source: UniProtKB signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	basolateral plasma membrane Ref.3 Inferred from direct assay. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Ref.3 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4377	4377	Ankyrin-3		PRO_0000066886
Regions
	Repeat	73 – 102	30	ANK 1
	Repeat	106 – 135	30	ANK 2
	Repeat	139 – 168	30	ANK 3
	Repeat	172 – 201	30	ANK 4
	Repeat	203 – 230	28	ANK 5
	Repeat	234 – 263	30	ANK 6
	Repeat	267 – 296	30	ANK 7
	Repeat	300 – 329	30	ANK 8
	Repeat	333 – 362	30	ANK 9
	Repeat	366 – 395	30	ANK 10
	Repeat	399 – 428	30	ANK 11
	Repeat	432 – 461	30	ANK 12
	Repeat	465 – 494	30	ANK 13
	Repeat	498 – 527	30	ANK 14
	Repeat	531 – 560	30	ANK 15
	Repeat	564 – 593	30	ANK 16
	Repeat	597 – 626	30	ANK 17
	Repeat	630 – 659	30	ANK 18
	Repeat	663 – 692	30	ANK 19
	Repeat	696 – 725	30	ANK 20
	Repeat	729 – 758	30	ANK 21
	Repeat	762 – 791	30	ANK 22
	Repeat	795 – 825	31	ANK 23
	Domain	982 – 1089	108	ZU5
	Domain	4090 – 4174	85	Death
	Compositional bias	1519 – 1898	380	Ser-rich
	Compositional bias	2247 – 2250	4	Poly-Thr
	Compositional bias	2393 – 2396	4	Poly-Glu
	Compositional bias	3205 – 3211	7	Poly-Glu
	Compositional bias	3255 – 3259	5	Poly-Pro
	Compositional bias	3482 – 3487	6	Poly-Ser
	Compositional bias	3785 – 3791	7	Poly-Asn
	Compositional bias	3957 – 3981	25	Thr-rich
Amino acid modifications
	Modified residue	533	1	Phosphotyrosine Ref.4
	Modified residue	1459	1	Phosphoserine Ref.7
	Modified residue	4298	1	Phosphoserine Ref.5
	Cross-link	4338		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6
Natural variations
	Natural variant	2885	1	H → Q: dbSNP rs11599164.		VAR_059115
	Natural variant	3117	1	I → V: dbSNP rs28932171.		VAR_059116
	Natural variant	3123	1	K → R: dbSNP rs10821668.		VAR_059117
	Natural variant	4257	1	I → V: dbSNP rs12261793.		VAR_054333
Experimental info
	Sequence conflict	1036 – 1043	8	MVEGEGLA → HGERRGIS in AAA64834. Ref.1
	Sequence conflict	1418	1	P → R in AAA64834. Ref.1
	Sequence conflict	1574	1	F → L in AAA64834. Ref.1
	Sequence conflict	1685	1	A → R in AAA64834. Ref.1
	Sequence conflict	1726	1	P → A in AAA64834. Ref.1
	Sequence conflict	2062 – 2063	2	ER → GG in AAA64834. Ref.1
	Sequence conflict	2146	1	S → T in AAA64834. Ref.1
	Sequence conflict	3919	1	H → P in AAA64834. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q12955-1 [UniParc]. Last modified September 1, 2009. Version 3. Checksum: F6F9FABD09F15C13	FASTA	4,377	480,410
	10 20 30 40 50 60 MAHAASQLKK NRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY 70 80 90 100 110 120 IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA 130 140 150 160 170 180 EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVKFLL DNGASQSLAT EDGFTPLAVA 190 200 210 220 230 240 LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH 250 260 270 280 290 300 IAAHYGNINV ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD 310 320 330 340 350 360 GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV QLLLQHNVPV 370 380 390 400 410 420 DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG FTPLHIACKK NRIKVMELLL 430 440 450 460 470 480 KHGASIQAVT ESGLTPIHVA AFMGHVNIVS QLMHHGASPN TTNVRGETAL HMAARSGQAE 490 500 510 520 530 540 VVRYLVQDGA QVEAKAKDDQ TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA 550 560 570 580 590 600 REGHEDVAAF LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT 610 620 630 640 650 660 PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL LEYGADANAV 670 680 690 700 710 720 TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP LHLAAQEDRV NVAEVLVNQG 730 740 750 760 770 780 AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN 790 800 810 820 830 840 VLLQNNASPN ELTVNGNTAL GIARRLGYIS VVDTLKIVTE ETMTTTTVTE KHKMNVPETM 850 860 870 880 890 900 NEVLDMSDDE VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE 910 920 930 940 950 960 GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT FTREFDSDSL 970 980 990 1000 1010 1020 RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS RHHGMRIIIP PRKCTAPTRI 1030 1040 1050 1060 1070 1080 TCRLVKRHKL ANPPPMVEGE GLASRLVEMG PAGAQFLGPV IVEIPHFGSM RGKERELIVL 1090 1100 1110 1120 1130 1140 RSENGETWKE HQFDSKNEDL TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI 1150 1160 1170 1180 1190 1200 KQESNQIGPE GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS 1210 1220 1230 1240 1250 1260 PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG GTSPAQWEDI 1270 1280 1290 1300 1310 1320 TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ LYRELICVPY MAKFVVFAKM 1330 1340 1350 1360 1370 1380 NDPVESSLRC FCMTDDKVDK TLEQQENFEE VARSKDIEVL EGKPIYVDCY GNLAPLTKGG 1390 1400 1410 1420 1430 1440 QQLVFNFYSF KENRLPFSIK IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK 1450 1460 1470 1480 1490 1500 KETESDQDDE IEKTDRRQSF ASLALRKRYS YLTEPGMIER STGATRSLPT TYSYKPFFST 1510 1520 1530 1540 1550 1560 RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK STLGASTTSS 1570 1580 1590 1600 1610 1620 VKSISDVASP IRSFRTMSSP IKTVVSQSPY NIQVSSGTLA RAPAVTEATP LKGLASNSTF 1630 1640 1650 1660 1670 1680 SSRTSPVTTA GSLLERSSIT MTPPASPKSN INMYSSSLPF KSIITSAAPL ISSPLKSVVS 1690 1700 1710 1720 1730 1740 PVKSAVDVIS SAKITMASSL SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT 1750 1760 1770 1780 1790 1800 LQEKISSATN SVSSVVSAAT DTVEKVFSTT TAMPFSPLRS YVSAAPSAFQ SLRTPSASAL 1810 1820 1830 1840 1850 1860 YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSNSFTKSAA ALLSPIKTLT 1870 1880 1890 1900 1910 1920 TETHPQPHFS RTSSPVKSSL FLAPSALKLS TPSSLSSSQE ILKDVAEMKE DLMRMTAILQ 1930 1940 1950 1960 1970 1980 TDVPEEKPFQ PELPKEGRID DEEPFKIVEK VKEDLVKVSE ILKKDVCVDN KGSPKSPKSD 1990 2000 2010 2020 2030 2040 KGHSPEDDWI EFSSEEIREA RQQAAASQSP SLPERVQVKA KAASEKDYNL TKVIDYLTND 2050 2060 2070 2080 2090 2100 IGSSSLTNLK YKFEDAKKDG EERQKRVLKP AIALQEHKLK MPPASMRTST SEKELCKMAD 2110 2120 2130 2140 2150 2160 SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK PLFHEVPIPP 2170 2180 2190 2200 2210 2220 VITETRTEVV HVIRSYDPSA GDVPQTQPEE PVSPKPSPTF MELEPKPTTS SIKEKVKAFQ 2230 2240 2250 2260 2270 2280 MKASSEEDDH NRVLSKGMRV KEETHITTTT RMVYHSPPGG EGASERIEET MSVHDIMKAF 2290 2300 2310 2320 2330 2340 QSGRDPSKEL AGLFEHKSAV SPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA 2350 2360 2370 2380 2390 2400 EPTEVIIRET KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE 2410 2420 2430 2440 2450 2460 ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD DELSELRGES 2470 2480 2490 2500 2510 2520 YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK RSREKIATAP KKEILSKIYK 2530 2540 2550 2560 2570 2580 DVSENGVGKV SKDEHFDKVT VLHYSGNVSS PKHAMWMRFT EDRLDRGREK LIYEDRVDRT 2590 2600 2610 2620 2630 2640 VKEAEEKLTE VSQFFRDKTE KLNDELQSPE KKARPKNGKE YSSQSPTSSS PEKVLLTELL 2650 2660 2670 2680 2690 2700 ASNDEWVKAR QHGPDGQGFP KAEEKAPSLP SSPEKMVLSQ QTEDSKSTVE AKGSISQSKA 2710 2720 2730 2740 2750 2760 PDGPQSGFQL KQSKLSSIRL KFEQGTHAKS KDMSQEDRKS DGQSRIPVKK IQESKLPVYQ 2770 2780 2790 2800 2810 2820 VFAREKQQKA IDLPDESVSV QKDFMVLKTK DEHAQSNEIV VNDSGSDNVK KQRTEMSSKA 2830 2840 2850 2860 2870 2880 MPDSFSEQQA KDLACHITSD LATRGPWDKK VFRTWESSGA TNNKSQKEKL SHVLVHDVRE 2890 2900 2910 2920 2930 2940 NHIGHPESKS VDQKNEFMSV TERERKLLTN GSLSEIKEMT VKSPSKKVLY REYVVKEGDH 2950 2960 2970 2980 2990 3000 PGGLLDQPSR RSESSAVSHI PVRVADERRM LSSNIPDGFC EQSAFPKHEL SQKLSQSSMS 3010 3020 3030 3040 3050 3060 KETVETQHFN SIEDEKVTYS EISKVSKHQS YVGLCPPLEE TETSPTKSPD SLEFSPGKES 3070 3080 3090 3100 3110 3120 PSSDVFDHSP IDGLEKLAPL AQTEGGKEIK TLPVYVSFVQ VGKQYEKEIQ QGGVKKIISQ 3130 3140 3150 3160 3170 3180 ECKTVQETRG TFYTTRQQKQ PPSPQGSPED DTLEQVSFLD SSGKSPLTPE TPSSEEVSYE 3190 3200 3210 3220 3230 3240 FTSKTPDSLI AYIPGKPSPI PEVSEESEEE EQAKSTSLKQ TTVEETAVER EMPNDVSKDS 3250 3260 3270 3280 3290 3300 NQRPKNNRVA YIEFPPPPPL DADQIESDKK HHYLPEKEVD MIEVNLQDEH DKYQLAEPVI 3310 3320 3330 3340 3350 3360 RVQPPSPVPP GADVSDSSDD ESIYQPVPVK KYTFKLKEVD DEQKEKPKAS AEKASNQKEL 3370 3380 3390 3400 3410 3420 ESNGSGKDNE FGLGLDSPQN EIAQNGNNDQ SITECSIATT AEFSHDTDAT EIDSLDGYDL 3430 3440 3450 3460 3470 3480 QDEDDGLTES DSKLPIQAME IKKDIWNTEG ILKPADRSFS QSKLEVIEEE GKVGPDEDKP 3490 3500 3510 3520 3530 3540 PSKSSSSEKT PDKTDQKSGA QFFTLEGRHP DRSVFPDTYF SYKVDEEFAT PFKTVATKGL 3550 3560 3570 3580 3590 3600 DFDPWSNNRG DDEVFDSKSR EDETKPFGLA VEDRSPATTP DTTPARTPTD ESTPTSEPNP 3610 3620 3630 3640 3650 3660 FPFHEGKMFE MTRSGAIDMS KRDFVEERLQ FFQIGEHTSE GKSGDQGEGD KSMVTATPQP 3670 3680 3690 3700 3710 3720 QSGDTTVETN LERNVETPTV EPNPSIPTSG ECQEGTSSSG SLEKSAAATN TSKVDPKLRT 3730 3740 3750 3760 3770 3780 PIKMGISAST MTMKKEGPGE ITDKIEAVMT SCQGLENETI TMISNTANSQ MGVRPHEKHD 3790 3800 3810 3820 3830 3840 FQKDNFNNNN NLDSSTIQTD NIMSNIVLTE HSAPTCTTEK DNPVKVSSGK KTGVLQGHCV 3850 3860 3870 3880 3890 3900 RDKQKVLGEQ QKTKELIGIR QKSKLPIKAT SPKDTFPPNH MSNTKASKMK QVSQSEKTKA 3910 3920 3930 3940 3950 3960 LTTSSCVDVK SRIPVKNTHR DNIIAVRKAC ATQKQGQPEK GKAKQLPSKL PVKVRSTCVT 3970 3980 3990 4000 4010 4020 TTTTTATTTT TTTTTTTTSC TVKVRKSQLK EVCKHSIEYF KGISGETLKL VDRLSEEEKK 4030 4040 4050 4060 4070 4080 MQSELSDEEE STSRNTSLSE TSRGGQPSVT TKSARDKKTE AAPLKSKSEK AGSEKRSSRR 4090 4100 4110 4120 4130 4140 TGPQSPCERT DIRMAIVADH LGLSWTELAR ELNFSVDEIN QIRVENPNSL ISQSFMLLKK 4150 4160 4170 4180 4190 4200 WVTRDGKNAT TDALTSVLTK INRIDIVTLL EGPIFDYGNI SGTRSFADEN NVFHDPVDGW 4210 4220 4230 4240 4250 4260 QNETSSGNLE SCAQARRVTG GLLDRLDDSP DQCRDSITSY LKGEAGKFEA NGSHTEITPE 4270 4280 4290 4300 4310 4320 AKTKSYFPES QNDVGKQSTK ETLKPKIHGS GHVEEPASPL AAYQKSLEET SKLIIEETKP 4330 4340 4350 4360 4370 CVPVSMKKMS RTSPADGKPR LSLHEEEGSS GSEQKQGEGF KVKTKKEIRH VEKKSHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier." Kordeli E., Lambert S., Bennett V. J. Biol. Chem. 270:2352-2359(1995) [PubMed: 7836469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain stem.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells." Lopez C., Metral S., Eladari D., Drevensek S., Gane P., Chambrey R., Bennett V., Cartron J.-P., Le Van Kim C., Colin Y. J. Biol. Chem. 280:8221-8228(2005) [PubMed: 15611082] [Abstract] Cited for: INTERACTION WITH RHBG.
[4]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-533, MASS SPECTROMETRY.
[5]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4298, MASS SPECTROMETRY.
[6]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed: 17370265] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-4338, MASS SPECTROMETRY.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1459, MASS SPECTROMETRY.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Wikipedia

Ankyrin entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	U13616 mRNA. Translation: AAA64834.1. AL359267 , AC023904, AL359377, AL592430 Genomic DNA. Translation: CAH73232.1. Sequence problems. AL592430 , AC023904, AL359267, AL359377 Genomic DNA. Translation: CAI40518.1. Sequence problems. AL359377 , AC023904, AL359267, AL592430 Genomic DNA. Translation: CAI41373.1. Sequence problems.
IPI	IPI00921566.
PIR	A55575.
RefSeq	NP_001140.2. NP_066267.2.
UniGene	Hs.499725
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q12955.
PTM databases
PhosphoSite	Q12955.
Proteomic databases
PRIDE	Q12955.
Genome annotation databases
Ensembl	ENST00000373827; ENSP00000362933; ENSG00000151150; Homo sapiens. [Genome view]
GeneID	288.
KEGG	hsa:288.
Organism-specific databases
CTD	288.
GeneCards	GC10M061458.
H-InvDB	HIX0008849.
HGNC	HGNC:494. ANK3.
HPA	CAB015179.
MIM	600465. gene.
PharmGKB	PA24800.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q12955.
HOVERGEN	Q12955.
OMA	SYEFTSK
OrthoDB	EOG9VHNS3
Gene expression databases
ArrayExpress	Q12955.
Bgee	Q12955.
CleanEx	HS_ANK3.
Genevestigator	Q12955.
GermOnline	ENSG00000151150. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000488. Death. IPR011029. DEATH-like. IPR000906. ZU5. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 4 hits. G3DSA:1.10.533.10. DEATH_like. 1 hit.
Pfam	PF00023. Ank. 24 hits. PF00531. Death. 1 hit. PF00791. ZU5. 1 hit. [Graphical view]
SMART	SM00248. ANK. 22 hits. SM00005. DEATH. 1 hit. SM00218. ZU5. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 21 hits. PS50017. DEATH_DOMAIN. 1 hit. PS51145. ZU5. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	1175.
SOURCE	Search...

Entry information

Entry name

ANK3_HUMAN

Accession

Primary (citable) accession number: Q12955
Secondary accession number(s): Q5VXD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	September 1, 2009
Last modified:	November 24, 2009
This is version 88 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.