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Q12952

- FOXL1_HUMAN

UniProt

Q12952 - FOXL1_HUMAN

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Protein

Forkhead box protein L1

Gene

FOXL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi48 – 13992Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. DNA binding, bending Source: UniProtKB
  3. sequence-specific DNA binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. heart development Source: DFLAT
  2. multicellular organismal development Source: UniProtKB
  3. organ morphogenesis Source: UniProtKB
  4. Peyer's patch morphogenesis Source: Ensembl
  5. proteoglycan biosynthetic process Source: UniProtKB
  6. regulation of Wnt signaling pathway Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. visceral mesoderm-endoderm interaction involved in midgut development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ12952.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein L1
Alternative name(s):
Forkhead-related protein FKHL11
Forkhead-related transcription factor 7
Short name:
FREAC-7
Gene namesi
Name:FOXL1
Synonyms:FKHL11, FREAC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:3817. FOXL1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Forkhead box protein L1PRO_0000091859Add
BLAST

Proteomic databases

PaxDbiQ12952.
PRIDEiQ12952.

Expressioni

Gene expression databases

BgeeiQ12952.
CleanExiHS_FOXL1.
ExpressionAtlasiQ12952. baseline and differential.
GenevestigatoriQ12952.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326272.

Structurei

3D structure databases

ProteinModelPortaliQ12952.
SMRiQ12952. Positions 49-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000112632.
HOVERGENiHBG051650.
InParanoidiQ12952.
KOiK09405.
OMAiPFLSYFP.
PhylomeDBiQ12952.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12952-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP
60 70 80 90 100
PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN
110 120 130 140 150
LSLNDCFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPGPG
160 170 180 190 200
APEAKRPRAE THQRSAEAQP EAGSGAGGSG PAISRLQAAP AGPSPLLDGP
210 220 230 240 250
SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP GSPLRPASRS
260 270 280 290 300
SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA
310 320 330 340
SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ
Length:345
Mass (Da):36,490
Last modified:April 27, 2001 - v2
Checksum:i015D86B57DF3BBC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315075 Genomic DNA. Translation: AAG40312.1.
AC009108 Genomic DNA. No translation available.
BC117226 mRNA. Translation: AAI17227.1.
U13225 Genomic DNA. Translation: AAA92042.1.
CCDSiCCDS10959.1.
PIRiS51630.
RefSeqiNP_005241.1. NM_005250.2.
UniGeneiHs.533830.

Genome annotation databases

EnsembliENST00000320241; ENSP00000326272; ENSG00000176678.
GeneIDi2300.
KEGGihsa:2300.
UCSCiuc002fjr.3. human.

Polymorphism databases

DMDMi13638268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315075 Genomic DNA. Translation: AAG40312.1 .
AC009108 Genomic DNA. No translation available.
BC117226 mRNA. Translation: AAI17227.1 .
U13225 Genomic DNA. Translation: AAA92042.1 .
CCDSi CCDS10959.1.
PIRi S51630.
RefSeqi NP_005241.1. NM_005250.2.
UniGenei Hs.533830.

3D structure databases

ProteinModelPortali Q12952.
SMRi Q12952. Positions 49-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000326272.

Polymorphism databases

DMDMi 13638268.

Proteomic databases

PaxDbi Q12952.
PRIDEi Q12952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320241 ; ENSP00000326272 ; ENSG00000176678 .
GeneIDi 2300.
KEGGi hsa:2300.
UCSCi uc002fjr.3. human.

Organism-specific databases

CTDi 2300.
GeneCardsi GC16P086612.
HGNCi HGNC:3817. FOXL1.
MIMi 603252. gene.
neXtProti NX_Q12952.
PharmGKBi PA28234.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118904.
HOGENOMi HOG000112632.
HOVERGENi HBG051650.
InParanoidi Q12952.
KOi K09405.
OMAi PFLSYFP.
PhylomeDBi Q12952.
TreeFami TF316127.

Enzyme and pathway databases

SignaLinki Q12952.

Miscellaneous databases

GenomeRNAii 2300.
NextBioi 9337.
PROi Q12952.
SOURCEi Search...

Gene expression databases

Bgeei Q12952.
CleanExi HS_FOXL1.
ExpressionAtlasi Q12952. baseline and differential.
Genevestigatori Q12952.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome."
    Fang J., Dagenais S.L., Erickson R.P., Arlt M.F., Glynn M.W., Gorski J.L., Seaver L.H., Glover T.W.
    Am. J. Hum. Genet. 67:1382-1388(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
    Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
    EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-149.

Entry informationi

Entry nameiFOXL1_HUMAN
AccessioniPrimary (citable) accession number: Q12952
Secondary accession number(s): Q17RR1, Q9H242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3