Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Forkhead box protein L1

Gene

FOXL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi48 – 13992Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding, bending Source: UniProtKB
  • sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central
  • sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ12952.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein L1
Alternative name(s):
Forkhead-related protein FKHL11
Forkhead-related transcription factor 7
Short name:
FREAC-7
Gene namesi
Name:FOXL1
Synonyms:FKHL11, FREAC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:3817. FOXL1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28234.

Polymorphism and mutation databases

BioMutaiFOXL1.
DMDMi13638268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Forkhead box protein L1PRO_0000091859Add
BLAST

Proteomic databases

PaxDbiQ12952.
PRIDEiQ12952.

Expressioni

Gene expression databases

BgeeiQ12952.
CleanExiHS_FOXL1.
ExpressionAtlasiQ12952. baseline and differential.
GenevisibleiQ12952. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326272.

Structurei

3D structure databases

ProteinModelPortaliQ12952.
SMRiQ12952. Positions 49-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000112632.
HOVERGENiHBG051650.
InParanoidiQ12952.
KOiK09405.
OMAiLRPPFNA.
PhylomeDBiQ12952.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP
60 70 80 90 100
PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN
110 120 130 140 150
LSLNDCFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPGPG
160 170 180 190 200
APEAKRPRAE THQRSAEAQP EAGSGAGGSG PAISRLQAAP AGPSPLLDGP
210 220 230 240 250
SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP GSPLRPASRS
260 270 280 290 300
SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA
310 320 330 340
SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ
Length:345
Mass (Da):36,490
Last modified:April 27, 2001 - v2
Checksum:i015D86B57DF3BBC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315075 Genomic DNA. Translation: AAG40312.1.
AC009108 Genomic DNA. No translation available.
BC117226 mRNA. Translation: AAI17227.1.
U13225 Genomic DNA. Translation: AAA92042.1.
CCDSiCCDS10959.1.
PIRiS51630.
RefSeqiNP_005241.1. NM_005250.2.
UniGeneiHs.533830.

Genome annotation databases

EnsembliENST00000320241; ENSP00000326272; ENSG00000176678.
GeneIDi2300.
KEGGihsa:2300.
UCSCiuc002fjr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315075 Genomic DNA. Translation: AAG40312.1.
AC009108 Genomic DNA. No translation available.
BC117226 mRNA. Translation: AAI17227.1.
U13225 Genomic DNA. Translation: AAA92042.1.
CCDSiCCDS10959.1.
PIRiS51630.
RefSeqiNP_005241.1. NM_005250.2.
UniGeneiHs.533830.

3D structure databases

ProteinModelPortaliQ12952.
SMRiQ12952. Positions 49-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326272.

Polymorphism and mutation databases

BioMutaiFOXL1.
DMDMi13638268.

Proteomic databases

PaxDbiQ12952.
PRIDEiQ12952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320241; ENSP00000326272; ENSG00000176678.
GeneIDi2300.
KEGGihsa:2300.
UCSCiuc002fjr.3. human.

Organism-specific databases

CTDi2300.
GeneCardsiGC16P086612.
HGNCiHGNC:3817. FOXL1.
MIMi603252. gene.
neXtProtiNX_Q12952.
PharmGKBiPA28234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000112632.
HOVERGENiHBG051650.
InParanoidiQ12952.
KOiK09405.
OMAiLRPPFNA.
PhylomeDBiQ12952.
TreeFamiTF316127.

Enzyme and pathway databases

SignaLinkiQ12952.

Miscellaneous databases

GenomeRNAii2300.
NextBioi9337.
PROiQ12952.
SOURCEiSearch...

Gene expression databases

BgeeiQ12952.
CleanExiHS_FOXL1.
ExpressionAtlasiQ12952. baseline and differential.
GenevisibleiQ12952. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome."
    Fang J., Dagenais S.L., Erickson R.P., Arlt M.F., Glynn M.W., Gorski J.L., Seaver L.H., Glover T.W.
    Am. J. Hum. Genet. 67:1382-1388(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
    Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
    EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-149.

Entry informationi

Entry nameiFOXL1_HUMAN
AccessioniPrimary (citable) accession number: Q12952
Secondary accession number(s): Q17RR1, Q9H242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 27, 2001
Last modified: July 22, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.