Reviewed, UniProtKB/Swiss-Prot Q12950 (FOXD4_HUMAN)

Names and origin

Protein names

Recommended name:
    Forkhead box protein D4
Alternative name(s):
    Forkhead-related protein FKHL9
    Forkhead-related transcription factor 5
      Short name=FREAC-5
    Myeloid factor-alpha

Gene names

Name:	FOXD4
Synonyms:	FKHL9, FOXD4A, FREAC5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	multicellular organismal development Non-traceable author statement. Source: UniProtKB regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular function	DNA bending activity Ref.4 Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding Ref.4 Inferred from sequence or structural similarity. Source: UniProtKB transcription factor activity Traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Forkhead box protein D4		PRO_0000091821
Regions
	DNA binding	104 – 198	95	Fork-head
	Compositional bias	205 – 297	93	Pro-rich
Natural variations
	Natural variant	134	1	I → F: dbSNP rs10959293.		VAR_028177
	Natural variant	136	1	G → D: dbSNP rs2492216.		VAR_028178
	Natural variant	152	1	I → V: dbSNP rs7031810.		VAR_028179

Sequences

	Sequence		Length	Mass (Da)
	Q12950-1 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 951686AAB0588231	FASTA	439	47,251
	10 20 30 40 50 60 MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS LQPGLQVARW 70 80 90 100 110 120 GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR QPAKPPSSYI ALITMAILQS 130 140 150 160 170 180 PHKRLTLSGI CAFISGRFPY YRRKFPAWQN SIRHNLSLND CFVKIPREPG RPGKGNYWSL 190 200 210 220 230 240 DPASQDMFDN GSFLRRRKRF QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ 250 260 270 280 290 300 PVPGAYPNTG PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV 310 320 330 340 350 360 LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP CSSDRQACRT 370 380 390 400 410 420 ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA VAEGSGLTSL AAPLGGEGTS 430 PVFLVSPTPS SLAESAGPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens myeloid factor-alpha genomic sequence." Freyaldenhoven B.S., Fried C., Wielckens K. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-152.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Chondrosarcoma.
[4]	"Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending." Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P. EMBO J. 13:5002-5012(1994) [PubMed: 7957066] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-204, VARIANT ASP-136.
[5]	"Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions." Fan Y., Newman T., Linardopoulou E., Trask B.J. Genome Res. 12:1663-1672(2002) [PubMed: 12421752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-413. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF343004 Genomic DNA. Translation: AAL73341.1. AL449043 Genomic DNA. Translation: CAH70545.1. BC089432 mRNA. Translation: AAH89432.1. U13223 mRNA. Translation: AAA92040.1. AF452724 mRNA. Translation: AAN64909.1.
PIR	S51628.
UniGene	Hs.584759
3D structure databases
HSSP	HSSP built from PDB template 2HDC based on UniProtKB Q63245.
SMR	Q12950. Positions 104-199.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000170122. Homo sapiens. [Contig view]
KEGG	hsa:2298.
Organism-specific databases
HGNC	HGNC:3805. FOXD4.
MIM	601092. gene.
PharmGKB	PA28222.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q12950.
Gene expression databases
CleanEx	HS_FOXD4.
GermOnline	ENSG00000184492. Homo sapiens.
Family and domain databases
InterPro	IPR001766. TF_Fork_head. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHER	PTHR11829. Fork_box_protein. 1 hit.
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
ProDom	PD000425. TF_Fork_head. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. False negative. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9327.
SOURCE	Search...

Entry information

Entry name

FOXD4_HUMAN

Accession

Primary (citable) accession number: Q12950
Secondary accession number(s): Q5VVK1, Q8WXT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 17, 2006
Last modified:	November 4, 2008
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)