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Protein

Forkhead box protein D4

Gene

FOXD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 198Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

  • DNA binding, bending Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4
Alternative name(s):
Forkhead-related protein FKHL9
Forkhead-related transcription factor 5
Short name:
FREAC-5
Myeloid factor-alpha
Gene namesi
Name:FOXD4
Synonyms:FKHL9, FOXD4A, FREAC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:3805. FOXD4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170122.
PharmGKBiPA28222.

Polymorphism and mutation databases

BioMutaiFOXD4.
DMDMi311033480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918211 – 439Forkhead box protein D4Add BLAST439

Proteomic databases

EPDiQ12950.
PaxDbiQ12950.
PeptideAtlasiQ12950.
PRIDEiQ12950.

PTM databases

iPTMnetiQ12950.
PhosphoSitePlusiQ12950.

Expressioni

Gene expression databases

BgeeiENSG00000170122.
CleanExiHS_FOXD4.
GenevisibleiQ12950. HS.

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

BioGridi108587. 40 interactors.
IntActiQ12950. 15 interactors.
STRINGi9606.ENSP00000371940.

Structurei

3D structure databases

ProteinModelPortaliQ12950.
SMRiQ12950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi205 – 297Pro-richAdd BLAST93

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOVERGENiHBG051641.
InParanoidiQ12950.
KOiK09397.
OMAiRVSCKGS.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ12950.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS
60 70 80 90 100
LQPGLQVARW GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR
110 120 130 140 150
QPAKPPSSYI ALITMAILQS PHKRLTLSGI CAFISDRFPY YRRKFPAWQN
160 170 180 190 200
SIRHNLSLND CFVKIPREPG RPGKGNYWSL DPASQDMFDN GSFLRRRKRF
210 220 230 240 250
QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ PVPGAYPNTG
260 270 280 290 300
PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV
310 320 330 340 350
LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP
360 370 380 390 400
CSSDRQACRT ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA
410 420 430
VAEGSGLTSL AAPLGGEGTS PVFLVSPTPS SLAESAGPS
Length:439
Mass (Da):47,309
Last modified:November 2, 2010 - v4
Checksum:i0CAB30E9283535A2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028177134I → F. Corresponds to variant dbSNP:rs10959293Ensembl.1
Natural variantiVAR_028178136D → G1 PublicationCorresponds to variant dbSNP:rs2492216Ensembl.1
Natural variantiVAR_028179152I → V1 PublicationCorresponds to variant dbSNP:rs7031810Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343004 Genomic DNA. Translation: AAL73341.1.
AL449043 Genomic DNA. Translation: CAH70545.1.
BC089432 mRNA. Translation: AAH89432.1.
BC136570 mRNA. Translation: AAI36571.1.
BC136571 mRNA. Translation: AAI36572.1.
U13223 mRNA. Translation: AAA92040.1.
AF452724 mRNA. Translation: AAN64909.1.
CCDSiCCDS34975.1.
PIRiS51628.
RefSeqiNP_997188.2. NM_207305.4.
UniGeneiHs.584759.

Genome annotation databases

EnsembliENST00000382500; ENSP00000371940; ENSG00000170122.
GeneIDi2298.
KEGGihsa:2298.
UCSCiuc003zfz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343004 Genomic DNA. Translation: AAL73341.1.
AL449043 Genomic DNA. Translation: CAH70545.1.
BC089432 mRNA. Translation: AAH89432.1.
BC136570 mRNA. Translation: AAI36571.1.
BC136571 mRNA. Translation: AAI36572.1.
U13223 mRNA. Translation: AAA92040.1.
AF452724 mRNA. Translation: AAN64909.1.
CCDSiCCDS34975.1.
PIRiS51628.
RefSeqiNP_997188.2. NM_207305.4.
UniGeneiHs.584759.

3D structure databases

ProteinModelPortaliQ12950.
SMRiQ12950.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108587. 40 interactors.
IntActiQ12950. 15 interactors.
STRINGi9606.ENSP00000371940.

PTM databases

iPTMnetiQ12950.
PhosphoSitePlusiQ12950.

Polymorphism and mutation databases

BioMutaiFOXD4.
DMDMi311033480.

Proteomic databases

EPDiQ12950.
PaxDbiQ12950.
PeptideAtlasiQ12950.
PRIDEiQ12950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382500; ENSP00000371940; ENSG00000170122.
GeneIDi2298.
KEGGihsa:2298.
UCSCiuc003zfz.5. human.

Organism-specific databases

CTDi2298.
GeneCardsiFOXD4.
HGNCiHGNC:3805. FOXD4.
HPAiHPA012836.
MIMi601092. gene.
neXtProtiNX_Q12950.
OpenTargetsiENSG00000170122.
PharmGKBiPA28222.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOVERGENiHBG051641.
InParanoidiQ12950.
KOiK09397.
OMAiRVSCKGS.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ12950.
TreeFamiTF316127.

Miscellaneous databases

GeneWikiiFOXD4.
GenomeRNAii2298.
PROiQ12950.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170122.
CleanExiHS_FOXD4.
GenevisibleiQ12950. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFOXD4_HUMAN
AccessioniPrimary (citable) accession number: Q12950
Secondary accession number(s): B2RN05
, B9EGL7, Q5VVK1, Q8WXT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: March 15, 2017
This is version 143 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.