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Q12950

- FOXD4_HUMAN

UniProt

Q12950 - FOXD4_HUMAN

Protein

Forkhead box protein D4

Gene

FOXD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi104 – 19895Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding, bending Source: UniProtKB
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein D4
    Alternative name(s):
    Forkhead-related protein FKHL9
    Forkhead-related transcription factor 5
    Short name:
    FREAC-5
    Myeloid factor-alpha
    Gene namesi
    Name:FOXD4
    Synonyms:FKHL9, FOXD4A, FREAC5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:3805. FOXD4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28222.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Forkhead box protein D4PRO_0000091821Add
    BLAST

    Proteomic databases

    PaxDbiQ12950.
    PRIDEiQ12950.

    Expressioni

    Gene expression databases

    BgeeiQ12950.
    CleanExiHS_FOXD4.
    GenevestigatoriQ12950.

    Organism-specific databases

    HPAiHPA012836.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371940.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12950.
    SMRiQ12950. Positions 104-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi205 – 29793Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOVERGENiHBG051641.
    InParanoidiQ12950.
    KOiK09397.
    OMAiPRDDSEF.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiQ12950.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12950-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS    50
    LQPGLQVARW GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR 100
    QPAKPPSSYI ALITMAILQS PHKRLTLSGI CAFISDRFPY YRRKFPAWQN 150
    SIRHNLSLND CFVKIPREPG RPGKGNYWSL DPASQDMFDN GSFLRRRKRF 200
    QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ PVPGAYPNTG 250
    PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV 300
    LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP 350
    CSSDRQACRT ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA 400
    VAEGSGLTSL AAPLGGEGTS PVFLVSPTPS SLAESAGPS 439
    Length:439
    Mass (Da):47,309
    Last modified:November 2, 2010 - v4
    Checksum:i0CAB30E9283535A2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341I → F.
    Corresponds to variant rs10959293 [ dbSNP | Ensembl ].
    VAR_028177
    Natural varianti136 – 1361D → G.1 Publication
    Corresponds to variant rs2492216 [ dbSNP | Ensembl ].
    VAR_028178
    Natural varianti152 – 1521I → V.1 Publication
    Corresponds to variant rs7031810 [ dbSNP | Ensembl ].
    VAR_028179

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF343004 Genomic DNA. Translation: AAL73341.1.
    AL449043 Genomic DNA. Translation: CAH70545.1.
    BC089432 mRNA. Translation: AAH89432.1.
    BC136570 mRNA. Translation: AAI36571.1.
    BC136571 mRNA. Translation: AAI36572.1.
    U13223 mRNA. Translation: AAA92040.1.
    AF452724 mRNA. Translation: AAN64909.1.
    CCDSiCCDS34975.1.
    PIRiS51628.
    RefSeqiNP_997188.2. NM_207305.4.
    UniGeneiHs.584759.

    Genome annotation databases

    EnsembliENST00000382500; ENSP00000371940; ENSG00000170122.
    GeneIDi2298.
    KEGGihsa:2298.
    UCSCiuc003zfz.4. human.

    Polymorphism databases

    DMDMi311033480.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF343004 Genomic DNA. Translation: AAL73341.1 .
    AL449043 Genomic DNA. Translation: CAH70545.1 .
    BC089432 mRNA. Translation: AAH89432.1 .
    BC136570 mRNA. Translation: AAI36571.1 .
    BC136571 mRNA. Translation: AAI36572.1 .
    U13223 mRNA. Translation: AAA92040.1 .
    AF452724 mRNA. Translation: AAN64909.1 .
    CCDSi CCDS34975.1.
    PIRi S51628.
    RefSeqi NP_997188.2. NM_207305.4.
    UniGenei Hs.584759.

    3D structure databases

    ProteinModelPortali Q12950.
    SMRi Q12950. Positions 104-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371940.

    Polymorphism databases

    DMDMi 311033480.

    Proteomic databases

    PaxDbi Q12950.
    PRIDEi Q12950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382500 ; ENSP00000371940 ; ENSG00000170122 .
    GeneIDi 2298.
    KEGGi hsa:2298.
    UCSCi uc003zfz.4. human.

    Organism-specific databases

    CTDi 2298.
    GeneCardsi GC09M000116.
    HGNCi HGNC:3805. FOXD4.
    HPAi HPA012836.
    MIMi 601092. gene.
    neXtProti NX_Q12950.
    PharmGKBi PA28222.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOVERGENi HBG051641.
    InParanoidi Q12950.
    KOi K09397.
    OMAi PRDDSEF.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi Q12950.
    TreeFami TF316127.

    Miscellaneous databases

    GeneWikii FOXD4.
    GenomeRNAii 2298.
    NextBioi 9327.
    PROi Q12950.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q12950.
    CleanExi HS_FOXD4.
    Genevestigatori Q12950.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines."
      Freyaldenhoven B.S., Fried C., Wielckens K.
      Gene 294:131-140(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-136 AND VAL-152.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Chondrosarcoma and Testis.
    4. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
      Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
      EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-204.
    5. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
      Fan Y., Newman T., Linardopoulou E., Trask B.J.
      Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-413.
      Tissue: Heart.

    Entry informationi

    Entry nameiFOXD4_HUMAN
    AccessioniPrimary (citable) accession number: Q12950
    Secondary accession number(s): B2RN05
    , B9EGL7, Q5VVK1, Q8WXT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3