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Protein

Forkhead box protein D4

Gene

FOXD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 198Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

  • DNA binding, bending Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4
Alternative name(s):
Forkhead-related protein FKHL9
Forkhead-related transcription factor 5
Short name:
FREAC-5
Myeloid factor-alpha
Gene namesi
Name:FOXD4
Synonyms:FKHL9, FOXD4A, FREAC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000170122.5
HGNCiHGNC:3805 FOXD4
MIMi601092 gene
neXtProtiNX_Q12950

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170122
PharmGKBiPA28222

Polymorphism and mutation databases

BioMutaiFOXD4
DMDMi311033480

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918211 – 439Forkhead box protein D4Add BLAST439

Proteomic databases

PaxDbiQ12950
PeptideAtlasiQ12950
PRIDEiQ12950

PTM databases

iPTMnetiQ12950
PhosphoSitePlusiQ12950

Expressioni

Gene expression databases

BgeeiENSG00000170122
CleanExiHS_FOXD4
GenevisibleiQ12950 HS

Organism-specific databases

HPAiHPA012836

Interactioni

Protein-protein interaction databases

BioGridi108587, 40 interactors
IntActiQ12950, 15 interactors
MINTiQ12950
STRINGi9606.ENSP00000371940

Structurei

3D structure databases

ProteinModelPortaliQ12950
SMRiQ12950
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi205 – 297Pro-richAdd BLAST93

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOVERGENiHBG051641
InParanoidiQ12950
KOiK09397
OMAiRVSCKGS
OrthoDBiEOG091G0HW9
PhylomeDBiQ12950
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q12950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS
60 70 80 90 100
LQPGLQVARW GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR
110 120 130 140 150
QPAKPPSSYI ALITMAILQS PHKRLTLSGI CAFISDRFPY YRRKFPAWQN
160 170 180 190 200
SIRHNLSLND CFVKIPREPG RPGKGNYWSL DPASQDMFDN GSFLRRRKRF
210 220 230 240 250
QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ PVPGAYPNTG
260 270 280 290 300
PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV
310 320 330 340 350
LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP
360 370 380 390 400
CSSDRQACRT ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA
410 420 430
VAEGSGLTSL AAPLGGEGTS PVFLVSPTPS SLAESAGPS
Length:439
Mass (Da):47,309
Last modified:November 2, 2010 - v4
Checksum:i0CAB30E9283535A2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028177134I → F. Corresponds to variant dbSNP:rs10959293Ensembl.1
Natural variantiVAR_028178136D → G1 PublicationCorresponds to variant dbSNP:rs2492216Ensembl.1
Natural variantiVAR_028179152I → V1 PublicationCorresponds to variant dbSNP:rs7031810Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343004 Genomic DNA Translation: AAL73341.1
AL449043 Genomic DNA No translation available.
BC089432 mRNA Translation: AAH89432.1
BC136570 mRNA Translation: AAI36571.1
BC136571 mRNA Translation: AAI36572.1
U13223 mRNA Translation: AAA92040.1
AF452724 mRNA Translation: AAN64909.1
CCDSiCCDS34975.1
PIRiS51628
RefSeqiNP_997188.2, NM_207305.4
UniGeneiHs.584759

Genome annotation databases

EnsembliENST00000382500; ENSP00000371940; ENSG00000170122
GeneIDi2298
KEGGihsa:2298
UCSCiuc003zfz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXD4_HUMAN
AccessioniPrimary (citable) accession number: Q12950
Secondary accession number(s): B2RN05
, B9EGL7, Q5VVK1, Q8WXT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 151 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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