Q12947Q5TGJ1Q9UQ85FOXF2_HUMANForkhead box protein F2Forkhead-related activator 2FREAC-2Forkhead-related protein FKHL6Forkhead-related transcription factor 2FOXF2FKHL6FREAC2Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoThe two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3.NUCLEOTIDE SEQUENCE [GENOMIC DNA]SUBCELLULAR LOCATIONThe DNA sequence and analysis of human chromosome 6.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.NUCLEOTIDE SEQUENCE [MRNA] OF 37-444TISSUE SPECIFICITYCloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.PARTIAL NUCLEOTIDE SEQUENCE [MRNA]The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB.DOMAININTERACTION WITH TBP AND TFIIBForkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-beta-Catenin Signaling Axis.FUNCTIONSUBCELLULAR LOCATIONTISSUE SPECIFICITYProbable transcription activator for a number of lung-specific genes (PubMed:8626802). Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064).Interacts with the transcription factors TBP and TFIIB.NucleusLung and placenta (PubMed:8626802). Predominantly expressed in gastrointestinal tract including stomach (PubMed:29374064).Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.ActivatorDNA-bindingNucleusReference proteomeTranscriptionTranscription regulationMTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM
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