Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q12947

- FOXF2_HUMAN

UniProt

Q12947 - FOXF2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Forkhead box protein F2

Gene

FOXF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable transcription activator for a number of lung-specific genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi99 – 19092Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  6. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. embryonic camera-type eye morphogenesis Source: Ensembl
  2. embryonic digestive tract development Source: Ensembl
  3. epithelial to mesenchymal transition Source: UniProtKB
  4. establishment of planar polarity of embryonic epithelium Source: Ensembl
  5. extracellular matrix organization Source: Ensembl
  6. genitalia development Source: UniProtKB
  7. negative regulation of transcription, DNA-templated Source: Ensembl
  8. palate development Source: UniProtKB
  9. positive regulation of transcription, DNA-templated Source: UniProtKB
  10. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ12947.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein F2
Alternative name(s):
Forkhead-related activator 2
Short name:
FREAC-2
Forkhead-related protein FKHL6
Forkhead-related transcription factor 2
Gene namesi
Name:FOXF2
Synonyms:FKHL6, FREAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:3810. FOXF2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Forkhead box protein F2PRO_0000091834Add
BLAST

Proteomic databases

MaxQBiQ12947.
PaxDbiQ12947.
PRIDEiQ12947.

PTM databases

PhosphoSiteiQ12947.

Expressioni

Tissue specificityi

Lung and placenta.

Gene expression databases

BgeeiQ12947.
CleanExiHS_FOXF2.
GenevestigatoriQ12947.

Interactioni

Subunit structurei

Interacts with the transcription factors TBP and TFIIB.1 Publication

Protein-protein interaction databases

BioGridi108584. 7 interactions.
IntActiQ12947. 2 interactions.
STRINGi9606.ENSP00000259806.

Structurei

3D structure databases

ProteinModelPortaliQ12947.
SMRiQ12947. Positions 100-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 419Poly-Ala
Compositional biasi46 – 5510Poly-Ser
Compositional biasi58 – 6710Poly-Ser
Compositional biasi77 – 848Poly-Gly
Compositional biasi262 – 27211Poly-HisAdd
BLAST
Compositional biasi301 – 3066Poly-Gly
Compositional biasi312 – 3154Poly-Ser
Compositional biasi429 – 4324Poly-His

Domaini

Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.1 Publication

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118794.
HOGENOMiHOG000060124.
HOVERGENiHBG051644.
InParanoidiQ12947.
KOiK09399.
OMAiEYGPDSS.
OrthoDBiEOG7D59PX.
PhylomeDBiQ12947.
TreeFamiTF351598.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12947-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS
60 70 80 90 100
SSSASCASSS SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK
110 120 130 140 150
PPYSYIALIV MAIQSSPSKR LTLSEIYQFL QARFPFFRGA YQGWKNSVRH
160 170 180 190 200
NLSLNECFIK LPKGLGRPGK GHYWTIDPAS EFMFEEGSFR RRPRGFRRKC
210 220 230 240 250
QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ GGYGGLDMMP
260 270 280 290 300
AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA
310 320 330 340 350
GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK
360 370 380 390 400
QPPALTPSSN PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS
410 420 430 440
TPVCDRKDFV LNFNGISSFH PSASGSYYHH HHQSVCQDIK PCVM
Length:444
Mass (Da):45,993
Last modified:May 30, 2000 - v2
Checksum:i32BDC5F373CFB147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084939, AF084938 Genomic DNA. Translation: AAD19875.1.
AL034346 Genomic DNA. Translation: CAI22285.1.
CH471087 Genomic DNA. Translation: EAW55072.1.
U13220 mRNA. Translation: AAC32226.1.
CCDSiCCDS4472.1.
PIRiS51625.
T09474.
RefSeqiNP_001443.1. NM_001452.1.
UniGeneiHs.484423.

Genome annotation databases

EnsembliENST00000259806; ENSP00000259806; ENSG00000137273.
GeneIDi2295.
KEGGihsa:2295.
UCSCiuc003mtm.3. human.

Polymorphism databases

DMDMi8247925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084939 , AF084938 Genomic DNA. Translation: AAD19875.1 .
AL034346 Genomic DNA. Translation: CAI22285.1 .
CH471087 Genomic DNA. Translation: EAW55072.1 .
U13220 mRNA. Translation: AAC32226.1 .
CCDSi CCDS4472.1.
PIRi S51625.
T09474.
RefSeqi NP_001443.1. NM_001452.1.
UniGenei Hs.484423.

3D structure databases

ProteinModelPortali Q12947.
SMRi Q12947. Positions 100-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108584. 7 interactions.
IntActi Q12947. 2 interactions.
STRINGi 9606.ENSP00000259806.

PTM databases

PhosphoSitei Q12947.

Polymorphism databases

DMDMi 8247925.

Proteomic databases

MaxQBi Q12947.
PaxDbi Q12947.
PRIDEi Q12947.

Protocols and materials databases

DNASUi 2295.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259806 ; ENSP00000259806 ; ENSG00000137273 .
GeneIDi 2295.
KEGGi hsa:2295.
UCSCi uc003mtm.3. human.

Organism-specific databases

CTDi 2295.
GeneCardsi GC06P001390.
HGNCi HGNC:3810. FOXF2.
MIMi 603250. gene.
neXtProti NX_Q12947.
PharmGKBi PA28227.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118794.
HOGENOMi HOG000060124.
HOVERGENi HBG051644.
InParanoidi Q12947.
KOi K09399.
OMAi EYGPDSS.
OrthoDBi EOG7D59PX.
PhylomeDBi Q12947.
TreeFami TF351598.

Enzyme and pathway databases

SignaLinki Q12947.

Miscellaneous databases

GenomeRNAii 2295.
NextBioi 9315.
PROi Q12947.
SOURCEi Search...

Gene expression databases

Bgeei Q12947.
CleanExi HS_FOXF2.
Genevestigatori Q12947.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3."
    Blixt A., Mahlapuu M., Bjursell C., Darnfors C., Johannesson T., Enerbaeck S., Carlsson P.
    Genomics 53:387-390(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
    Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
    J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-444.
    Tissue: Lung.
  5. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
    Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
    EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
  6. "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB."
    Hellqvist M., Mahlapuu M., Blixt A., Enerbaeck S., Carlsson P.
    J. Biol. Chem. 273:23335-23343(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, INTERACTION WITH TBP AND TFIIB.

Entry informationi

Entry nameiFOXF2_HUMAN
AccessioniPrimary (citable) accession number: Q12947
Secondary accession number(s): Q5TGJ1, Q9UQ85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3