Reviewed,
UniProtKB/Swiss-Prot Q12947 (FOXF2_HUMAN)
Last modified
June 16, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Forkhead box protein F2 Alternative name(s): Forkhead-related transcription factor 2 Forkhead-related activator 2 Short name=FREAC-2 Forkhead-related protein FKHL6 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 444 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable transcription activator for a number of lung-specific genes. |
| Subunit structure | Interacts with the transcription factors TBP and TFIIB. Ref.4 |
| Subcellular location | |
| Tissue specificity | Lung and placenta. |
| Domain | Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation. Ref.4 |
| Sequence similarities | Contains 1 fork-head DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| Molecular function | Activator |
| Gene Ontology (GO) | |
| Biological process | positive regulation of transcription, DNA-dependent Ref.2 Inferred from direct assay. Source: UniProtKB transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | transcription factor complex Ref.4 Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Ref.2 Ref.3Inferred from direct assay. Source: UniProtKB transcription activator activity Ref.2Inferred from direct assay. Source: UniProtKB transcription factor activity Ref.4Non-traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ABL1 | P00519 | 1 | EBI-1752316,EBI-375543 | |
| FYN | P06241 | 1 | EBI-1752316,EBI-515315 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 444 | 444 | Forkhead box protein F2 | PRO_0000091834 | |||||
Regions | |||||||||
| DNA binding | 99 – 190 | 92 | Fork-head | ||||||
| Compositional bias | 33 – 41 | 9 | Poly-Ala | ||||||
| Compositional bias | 46 – 55 | 10 | Poly-Ser | ||||||
| Compositional bias | 58 – 67 | 10 | Poly-Ser | ||||||
| Compositional bias | 77 – 84 | 8 | Poly-Gly | ||||||
| Compositional bias | 262 – 272 | 11 | Poly-His | ||||||
| Compositional bias | 301 – 306 | 6 | Poly-Gly | ||||||
| Compositional bias | 312 – 315 | 4 | Poly-Ser | ||||||
| Compositional bias | 429 – 432 | 4 | Poly-His | ||||||
Sequences
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References
| [1] | "The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3." Blixt A., Mahlapuu M., Bjursell C., Darnfors C., Johannesson T., Enerbaeck S., Carlsson P. Genomics 53:387-390(1998) [PubMed: 9799607] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2." Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P. J. Biol. Chem. 271:4482-4490(1996) [PubMed: 8626802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-444. Tissue: Lung. |
| [3] | "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending." Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P. EMBO J. 13:5002-5012(1994) [PubMed: 7957066] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB." Hellqvist M., Mahlapuu M., Blixt A., Enerbaeck S., Carlsson P. J. Biol. Chem. 273:23335-23343(1998) [PubMed: 9722567] [Abstract] Cited for: DOMAIN, INTERACTION WITH TBP AND TFIIB. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF084939, AF084938 Genomic DNA. Translation: AAD19875.1. U13220 mRNA. Translation: AAC32226.1. | |
| IPI | IPI00030319. |
| PIR | S51625. T09474. |
| RefSeq | NP_001443.1. |
| UniGene | Hs.484423 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1D5V based on UniProtKB Q99958. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q12947. 2 interactions. |
Proteomic databases | |
| PRIDE | Q12947. |
Genome annotation databases | |
| Ensembl | ENSG00000137273. Homo sapiens. [Contig view] |
| GeneID | 2295. |
| KEGG | hsa:2295. |
Organism-specific databases | |
| GeneCards | GC06P001335. |
| H-InvDB | HIX0032954. |
| HGNC | HGNC:3810. FOXF2. |
| MIM | 603250. gene. |
| PharmGKB | PA28227. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q12947. |
| HOVERGEN | Q12947. |
| OMA | Q12947. PSHAHPH. |
Gene expression databases | |
| ArrayExpress | Q12947. |
| Bgee | Q12947. |
| CleanEx | HS_FOXF2. |
| GermOnline | ENSG00000137273. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. Wing_hlx_DNA_bd. [Graphical view] |
| Gene3D | G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| PANTHER | PTHR11829. Fork_box_protein. 1 hit. |
| Pfam | PF00250. Fork_head. 1 hit. [Graphical view] |
| PRINTS | PR00053. FORKHEAD. |
| ProDom | PD000425. TF_Fork_head. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00339. FH. 1 hit. [Graphical view] |
| PROSITE | PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 9315. |
| SOURCE | Search... |
Entry information
| Entry name | FOXF2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q12947 Secondary accession number(s): Q9UQ85 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


