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Q12947 (FOXF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein F2
Alternative name(s):
Forkhead-related activator 2
Short name=FREAC-2
Forkhead-related protein FKHL6
Forkhead-related transcription factor 2
Gene names
Name:FOXF2
Synonyms:FKHL6, FREAC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcription activator for a number of lung-specific genes.

Subunit structure

Interacts with the transcription factors TBP and TFIIB. Ref.6

Subcellular location

Nucleus.

Tissue specificity

Lung and placenta.

Domain

Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation. Ref.6

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processembryonic camera-type eye morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract development

Inferred from electronic annotation. Source: Ensembl

epithelial to mesenchymal transition

Non-traceable author statement PubMed 19220249. Source: UniProtKB

establishment of planar polarity of embryonic epithelium

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

genitalia development

Inferred from mutant phenotype PubMed 19276632. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from mutant phenotype PubMed 19276632. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.4. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.4. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay Ref.6. Source: UniProtKB

transcription factor complex

Inferred from direct assay Ref.6. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay Ref.5. Source: MGI

sequence-specific DNA binding

Inferred from direct assay Ref.5Ref.4. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.6. Source: UniProtKB

transcription factor binding

Inferred from physical interaction Ref.6. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Forkhead box protein F2
PRO_0000091834

Regions

DNA binding99 – 19092Fork-head
Compositional bias33 – 419Poly-Ala
Compositional bias46 – 5510Poly-Ser
Compositional bias58 – 6710Poly-Ser
Compositional bias77 – 848Poly-Gly
Compositional bias262 – 27211Poly-His
Compositional bias301 – 3066Poly-Gly
Compositional bias312 – 3154Poly-Ser
Compositional bias429 – 4324Poly-His

Sequences

Sequence LengthMass (Da)Tools
Q12947 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 32BDC5F373CFB147

FASTA44445,993
        10         20         30         40         50         60 
MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS SSSASCASSS 

        70         80         90        100        110        120 
SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK PPYSYIALIV MAIQSSPSKR 

       130        140        150        160        170        180 
LTLSEIYQFL QARFPFFRGA YQGWKNSVRH NLSLNECFIK LPKGLGRPGK GHYWTIDPAS 

       190        200        210        220        230        240 
EFMFEEGSFR RRPRGFRRKC QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ 

       250        260        270        280        290        300 
GGYGGLDMMP AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA 

       310        320        330        340        350        360 
GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK QPPALTPSSN 

       370        380        390        400        410        420 
PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS TPVCDRKDFV LNFNGISSFH 

       430        440 
PSASGSYYHH HHQSVCQDIK PCVM 

« Hide

References

« Hide 'large scale' references
[1]"The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3."
Blixt A., Mahlapuu M., Bjursell C., Darnfors C., Johannesson T., Enerbaeck S., Carlsson P.
Genomics 53:387-390(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-444.
Tissue: Lung.
[5]"Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
[6]"The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB."
Hellqvist M., Mahlapuu M., Blixt A., Enerbaeck S., Carlsson P.
J. Biol. Chem. 273:23335-23343(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN, INTERACTION WITH TBP AND TFIIB.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF084939, AF084938 Genomic DNA. Translation: AAD19875.1.
AL034346 Genomic DNA. Translation: CAI22285.1.
CH471087 Genomic DNA. Translation: EAW55072.1.
U13220 mRNA. Translation: AAC32226.1.
CCDSCCDS4472.1.
PIRS51625.
T09474.
RefSeqNP_001443.1. NM_001452.1.
UniGeneHs.484423.

3D structure databases

ProteinModelPortalQ12947.
SMRQ12947. Positions 100-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108584. 2 interactions.
IntActQ12947. 2 interactions.
STRING9606.ENSP00000259806.

PTM databases

PhosphoSiteQ12947.

Polymorphism databases

DMDM8247925.

Proteomic databases

MaxQBQ12947.
PaxDbQ12947.
PRIDEQ12947.

Protocols and materials databases

DNASU2295.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259806; ENSP00000259806; ENSG00000137273.
GeneID2295.
KEGGhsa:2295.
UCSCuc003mtm.3. human.

Organism-specific databases

CTD2295.
GeneCardsGC06P001390.
HGNCHGNC:3810. FOXF2.
MIM603250. gene.
neXtProtNX_Q12947.
PharmGKBPA28227.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000060124.
HOVERGENHBG051644.
InParanoidQ12947.
KOK09399.
OMAEYGPDSS.
OrthoDBEOG7D59PX.
PhylomeDBQ12947.
TreeFamTF351598.

Enzyme and pathway databases

SignaLinkQ12947.

Gene expression databases

BgeeQ12947.
CleanExHS_FOXF2.
GenevestigatorQ12947.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2295.
NextBio9315.
PROQ12947.
SOURCESearch...

Entry information

Entry nameFOXF2_HUMAN
AccessionPrimary (citable) accession number: Q12947
Secondary accession number(s): Q5TGJ1, Q9UQ85
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM