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Q12947

- FOXF2_HUMAN

UniProt

Q12947 - FOXF2_HUMAN

Protein

Forkhead box protein F2

Gene

FOXF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Probable transcription activator for a number of lung-specific genes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi99 – 19092Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    6. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. embryonic camera-type eye morphogenesis Source: Ensembl
    2. embryonic digestive tract development Source: Ensembl
    3. epithelial to mesenchymal transition Source: UniProtKB
    4. establishment of planar polarity of embryonic epithelium Source: Ensembl
    5. extracellular matrix organization Source: Ensembl
    6. genitalia development Source: UniProtKB
    7. negative regulation of transcription, DNA-templated Source: Ensembl
    8. palate development Source: UniProtKB
    9. positive regulation of transcription, DNA-templated Source: UniProtKB
    10. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ12947.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein F2
    Alternative name(s):
    Forkhead-related activator 2
    Short name:
    FREAC-2
    Forkhead-related protein FKHL6
    Forkhead-related transcription factor 2
    Gene namesi
    Name:FOXF2
    Synonyms:FKHL6, FREAC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:3810. FOXF2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcription factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28227.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Forkhead box protein F2PRO_0000091834Add
    BLAST

    Proteomic databases

    MaxQBiQ12947.
    PaxDbiQ12947.
    PRIDEiQ12947.

    PTM databases

    PhosphoSiteiQ12947.

    Expressioni

    Tissue specificityi

    Lung and placenta.

    Gene expression databases

    BgeeiQ12947.
    CleanExiHS_FOXF2.
    GenevestigatoriQ12947.

    Interactioni

    Subunit structurei

    Interacts with the transcription factors TBP and TFIIB.1 Publication

    Protein-protein interaction databases

    BioGridi108584. 2 interactions.
    IntActiQ12947. 2 interactions.
    STRINGi9606.ENSP00000259806.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12947.
    SMRiQ12947. Positions 100-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 419Poly-Ala
    Compositional biasi46 – 5510Poly-Ser
    Compositional biasi58 – 6710Poly-Ser
    Compositional biasi77 – 848Poly-Gly
    Compositional biasi262 – 27211Poly-HisAdd
    BLAST
    Compositional biasi301 – 3066Poly-Gly
    Compositional biasi312 – 3154Poly-Ser
    Compositional biasi429 – 4324Poly-His

    Domaini

    Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.1 Publication

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000060124.
    HOVERGENiHBG051644.
    InParanoidiQ12947.
    KOiK09399.
    OMAiEYGPDSS.
    OrthoDBiEOG7D59PX.
    PhylomeDBiQ12947.
    TreeFamiTF351598.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12947-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS    50
    SSSASCASSS SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK 100
    PPYSYIALIV MAIQSSPSKR LTLSEIYQFL QARFPFFRGA YQGWKNSVRH 150
    NLSLNECFIK LPKGLGRPGK GHYWTIDPAS EFMFEEGSFR RRPRGFRRKC 200
    QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ GGYGGLDMMP 250
    AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA 300
    GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK 350
    QPPALTPSSN PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS 400
    TPVCDRKDFV LNFNGISSFH PSASGSYYHH HHQSVCQDIK PCVM 444
    Length:444
    Mass (Da):45,993
    Last modified:May 30, 2000 - v2
    Checksum:i32BDC5F373CFB147
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084939, AF084938 Genomic DNA. Translation: AAD19875.1.
    AL034346 Genomic DNA. Translation: CAI22285.1.
    CH471087 Genomic DNA. Translation: EAW55072.1.
    U13220 mRNA. Translation: AAC32226.1.
    CCDSiCCDS4472.1.
    PIRiS51625.
    T09474.
    RefSeqiNP_001443.1. NM_001452.1.
    UniGeneiHs.484423.

    Genome annotation databases

    EnsembliENST00000259806; ENSP00000259806; ENSG00000137273.
    GeneIDi2295.
    KEGGihsa:2295.
    UCSCiuc003mtm.3. human.

    Polymorphism databases

    DMDMi8247925.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084939 , AF084938 Genomic DNA. Translation: AAD19875.1 .
    AL034346 Genomic DNA. Translation: CAI22285.1 .
    CH471087 Genomic DNA. Translation: EAW55072.1 .
    U13220 mRNA. Translation: AAC32226.1 .
    CCDSi CCDS4472.1.
    PIRi S51625.
    T09474.
    RefSeqi NP_001443.1. NM_001452.1.
    UniGenei Hs.484423.

    3D structure databases

    ProteinModelPortali Q12947.
    SMRi Q12947. Positions 100-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108584. 2 interactions.
    IntActi Q12947. 2 interactions.
    STRINGi 9606.ENSP00000259806.

    PTM databases

    PhosphoSitei Q12947.

    Polymorphism databases

    DMDMi 8247925.

    Proteomic databases

    MaxQBi Q12947.
    PaxDbi Q12947.
    PRIDEi Q12947.

    Protocols and materials databases

    DNASUi 2295.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259806 ; ENSP00000259806 ; ENSG00000137273 .
    GeneIDi 2295.
    KEGGi hsa:2295.
    UCSCi uc003mtm.3. human.

    Organism-specific databases

    CTDi 2295.
    GeneCardsi GC06P001390.
    HGNCi HGNC:3810. FOXF2.
    MIMi 603250. gene.
    neXtProti NX_Q12947.
    PharmGKBi PA28227.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000060124.
    HOVERGENi HBG051644.
    InParanoidi Q12947.
    KOi K09399.
    OMAi EYGPDSS.
    OrthoDBi EOG7D59PX.
    PhylomeDBi Q12947.
    TreeFami TF351598.

    Enzyme and pathway databases

    SignaLinki Q12947.

    Miscellaneous databases

    GenomeRNAii 2295.
    NextBioi 9315.
    PROi Q12947.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q12947.
    CleanExi HS_FOXF2.
    Genevestigatori Q12947.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3."
      Blixt A., Mahlapuu M., Bjursell C., Darnfors C., Johannesson T., Enerbaeck S., Carlsson P.
      Genomics 53:387-390(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
      Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
      J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-444.
      Tissue: Lung.
    5. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
      Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
      EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    6. "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB."
      Hellqvist M., Mahlapuu M., Blixt A., Enerbaeck S., Carlsson P.
      J. Biol. Chem. 273:23335-23343(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN, INTERACTION WITH TBP AND TFIIB.

    Entry informationi

    Entry nameiFOXF2_HUMAN
    AccessioniPrimary (citable) accession number: Q12947
    Secondary accession number(s): Q5TGJ1, Q9UQ85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3