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Protein

Forkhead box protein F2

Gene

FOXF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcription activator for a number of lung-specific genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi99 – 190Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • cell differentiation Source: GO_Central
  • epithelial to mesenchymal transition Source: UniProtKB
  • genitalia development Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • roof of mouth development Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ12947
SIGNORiQ12947

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein F2
Alternative name(s):
Forkhead-related activator 2
Short name:
FREAC-2
Forkhead-related protein FKHL6
Forkhead-related transcription factor 2
Gene namesi
Name:FOXF2
Synonyms:FKHL6, FREAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137273.3
HGNCiHGNC:3810 FOXF2
MIMi603250 gene
neXtProtiNX_Q12947

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2295
OpenTargetsiENSG00000137273
PharmGKBiPA28227

Polymorphism and mutation databases

BioMutaiFOXF2
DMDMi8247925

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918341 – 444Forkhead box protein F2Add BLAST444

Proteomic databases

MaxQBiQ12947
PaxDbiQ12947
PeptideAtlasiQ12947
PRIDEiQ12947

PTM databases

iPTMnetiQ12947
PhosphoSitePlusiQ12947

Expressioni

Tissue specificityi

Lung and placenta.

Gene expression databases

BgeeiENSG00000137273
CleanExiHS_FOXF2
GenevisibleiQ12947 HS

Interactioni

Subunit structurei

Interacts with the transcription factors TBP and TFIIB.1 Publication

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108584, 14 interactors
IntActiQ12947, 3 interactors
MINTiQ12947
STRINGi9606.ENSP00000259806

Structurei

3D structure databases

ProteinModelPortaliQ12947
SMRiQ12947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 41Poly-Ala9
Compositional biasi46 – 55Poly-Ser10
Compositional biasi58 – 67Poly-Ser10
Compositional biasi77 – 84Poly-Gly8
Compositional biasi262 – 272Poly-HisAdd BLAST11
Compositional biasi301 – 306Poly-Gly6
Compositional biasi312 – 315Poly-Ser4
Compositional biasi429 – 432Poly-His4

Domaini

Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.1 Publication

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00900000140781
HOGENOMiHOG000060124
HOVERGENiHBG051644
InParanoidiQ12947
KOiK09399
OMAiMMPAGYD
OrthoDBiEOG091G11UK
PhylomeDBiQ12947
TreeFamiTF351598

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q12947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS
60 70 80 90 100
SSSASCASSS SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK
110 120 130 140 150
PPYSYIALIV MAIQSSPSKR LTLSEIYQFL QARFPFFRGA YQGWKNSVRH
160 170 180 190 200
NLSLNECFIK LPKGLGRPGK GHYWTIDPAS EFMFEEGSFR RRPRGFRRKC
210 220 230 240 250
QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ GGYGGLDMMP
260 270 280 290 300
AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA
310 320 330 340 350
GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK
360 370 380 390 400
QPPALTPSSN PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS
410 420 430 440
TPVCDRKDFV LNFNGISSFH PSASGSYYHH HHQSVCQDIK PCVM
Length:444
Mass (Da):45,993
Last modified:May 30, 2000 - v2
Checksum:i32BDC5F373CFB147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084939, AF084938 Genomic DNA Translation: AAD19875.1
AL034346 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55072.1
U13220 mRNA Translation: AAC32226.1
CCDSiCCDS4472.1
PIRiS51625
T09474
RefSeqiNP_001443.1, NM_001452.1
UniGeneiHs.484423

Genome annotation databases

EnsembliENST00000259806; ENSP00000259806; ENSG00000137273
GeneIDi2295
KEGGihsa:2295
UCSCiuc003mtm.3 human

Similar proteinsi

Entry informationi

Entry nameiFOXF2_HUMAN
AccessioniPrimary (citable) accession number: Q12947
Secondary accession number(s): Q5TGJ1, Q9UQ85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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