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Q12946 (FOXF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein F1
Alternative name(s):
Forkhead-related activator 1
Short name=FREAC-1
Forkhead-related protein FKHL5
Forkhead-related transcription factor 1
Gene names
Name:FOXF1
Synonyms:FKHL5, FREAC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcription activator for a number of lung-specific genes. Ref.1

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in lung and placenta. Ref.6

Developmental stage

Expressed in fetal lung. Ref.6

Domain

Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.

Involvement in disease

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]: A rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.

Sequence caution

The sequence AAC50399.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAC61576.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH89442.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAG36851.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DiseaseDisease mutation
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood vessel development

Inferred from mutant phenotype Ref.7. Source: DFLAT

branching involved in open tracheal system development

Inferred from mutant phenotype Ref.7. Source: DFLAT

cardiac left ventricle morphogenesis

Inferred from mutant phenotype Ref.7. Source: DFLAT

cellular response to cytokine stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

detection of wounding

Inferred from electronic annotation. Source: Ensembl

determination of left/right symmetry

Inferred from electronic annotation. Source: Ensembl

digestive tract development

Inferred from mutant phenotype Ref.7. Source: DFLAT

ductus arteriosus closure

Inferred from mutant phenotype Ref.7. Source: DFLAT

embryonic digestive tract morphogenesis

Inferred from mutant phenotype Ref.7. Source: DFLAT

embryonic ectodermal digestive tract morphogenesis

Inferred from mutant phenotype Ref.7. Source: DFLAT

embryonic foregut morphogenesis

Inferred from electronic annotation. Source: Ensembl

endocardial cushion development

Inferred from mutant phenotype Ref.7. Source: DFLAT

epithelial cell differentiation involved in mammary gland alveolus development

Inferred from electronic annotation. Source: Ensembl

epithelial tube branching involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

establishment of epithelial cell apical/basal polarity

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from mutant phenotype Ref.7. Source: DFLAT

in utero embryonic development

Inferred from mutant phenotype Ref.7. Source: DFLAT

lateral mesodermal cell differentiation

Inferred from electronic annotation. Source: Ensembl

lung alveolus development

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from mutant phenotype Ref.7. Source: DFLAT

lung lobe morphogenesis

Inferred from electronic annotation. Source: Ensembl

lung vasculature development

Inferred from mutant phenotype Ref.7. Source: DFLAT

mesenchyme migration

Inferred from electronic annotation. Source: Ensembl

midgut development

Inferred from mutant phenotype Ref.7. Source: DFLAT

morphogenesis of a branching structure

Inferred from mutant phenotype Ref.7. Source: DFLAT

negative regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of mast cell degranulation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

pancreas development

Inferred from mutant phenotype Ref.7. Source: DFLAT

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-substrate adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.1Ref.2. Source: UniProtKB

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

renal system development

Inferred from mutant phenotype Ref.7. Source: DFLAT

respiratory tube development

Inferred from mutant phenotype Ref.7. Source: DFLAT

right lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

single organismal cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from electronic annotation. Source: Ensembl

trachea development

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

ureter development

Inferred from mutant phenotype Ref.7. Source: DFLAT

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

venous blood vessel development

Inferred from mutant phenotype Ref.7. Source: DFLAT

   Cellular_componentnucleus

Inferred by curator Ref.2. Source: UniProtKB

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding

Inferred from direct assay Ref.2. Source: UniProtKB

DNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from sequence or structural similarity Ref.6. Source: UniProtKB

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Forkhead box protein F1
PRO_0000091832

Regions

DNA binding47 – 13892Fork-head

Natural variations

Natural variant491P → Q in ACDMPV. Ref.8
VAR_071016
Natural variant491P → S in ACDMPV. Ref.8
VAR_071017
Natural variant521S → F in ACDMPV. Ref.8
VAR_071018
Natural variant531Y → C in ACDMPV. Ref.8
VAR_071019
Natural variant741I → N in ACDMPV. Ref.8
VAR_071020
Natural variant851F → I in ACDMPV. Ref.8
VAR_071021
Natural variant851F → L in ACDMPV. Ref.8
VAR_071022
Natural variant851F → S in ACDMPV. Ref.8
VAR_071023
Natural variant861R → W in ACDMPV. Ref.8
VAR_071024
Natural variant911G → E in ACDMPV. Ref.8
VAR_071025
Natural variant911G → V in ACDMPV. Ref.8
VAR_071026
Natural variant961V → M in ACDMPV. Ref.8
VAR_071027
Natural variant971R → H in ACDMPV. Ref.8
VAR_071028
Natural variant981H → Q in ACDMPV. Ref.8
VAR_071029
Natural variant1011S → L in ACDMPV. Ref.8
VAR_071030
Natural variant1061F → L in ACDMPV. Ref.8
VAR_071031
Natural variant113 – 1197Missing in ACDMPV.
VAR_071032
Natural variant1191G → D in ACDMPV. Ref.8
VAR_071033
Natural variant1261P → L in ACDMPV. Ref.8
VAR_071034
Natural variant1391R → L in ACDMPV. Ref.8
VAR_071035
Natural variant3301R → W in ACDMPV; unknown pathological significance. Ref.8
VAR_071036

Sequences

Sequence LengthMass (Da)Tools
Q12946 [UniParc].

Last modified May 26, 2009. Version 2.
Checksum: CA3DE3CEFB94FC3E

FASTA37940,122
        10         20         30         40         50         60 
MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP YSYIALIVMA 

        70         80         90        100        110        120 
IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH 

       130        140        150        160        170        180 
YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS 

       190        200        210        220        230        240 
CPPNSLALEG GLGMMNGHLP GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD 

       250        260        270        280        290        300 
SSVPASPLLP TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL 

       310        320        330        340        350        360 
SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA MASSSMHSAG 

       370 
GGSYYHQQVT YQDIKPCVM 

« Hide

References

« Hide 'large scale' references
[1]"Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2."
Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
J. Biol. Chem. 271:4482-4490(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION.
Tissue: Lung.
[2]"FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces."
Mahlapuu M., Pelto-Huikko M., Aitola M., Enerbaeck S., Carlsson P.
Dev. Biol. 202:183-195(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Chondrosarcoma.
[6]"Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."
Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Fetus.
[7]"Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations."
Stankiewicz P., Sen P., Bhatt S.S., Storer M., Xia Z., Bejjani B.A., Ou Z., Wiszniewska J., Driscoll D.J., Maisenbacher M.K., Bolivar J., Bauer M., Zackai E.H., McDonald-McGinn D., Nowaczyk M.M., Murray M., Hustead V., Mascotti K. expand/collapse author list , Schultz R., Hallam L., McRae D., Nicholson A.G., Newbury R., Durham-O'Donnell J., Knight G., Kini U., Shaikh T.H., Martin V., Tyreman M., Simonic I., Willatt L., Paterson J., Mehta S., Rajan D., Fitzgerald T., Gribble S., Prigmore E., Patel A., Shaffer L.G., Carter N.P., Cheung S.W., Langston C., Shaw-Smith C.
Am. J. Hum. Genet. 84:780-791(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN ACDMPV.
[8]"Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain."
Sen P., Yang Y., Navarro C., Silva I., Szafranski P., Kolodziejska K.E., Dharmadhikari A.V., Mostafa H., Kozakewich H., Kearney D., Cahill J.B., Whitt M., Bilic M., Margraf L., Charles A., Goldblatt J., Gibson K., Lantz P.E. expand/collapse author list , Garvin A.J., Petty J., Kiblawi Z., Zuppan C., McConkie-Rosell A., McDonald M.T., Peterson-Carmichael S.L., Gaede J.T., Shivanna B., Schady D., Friedlich P.S., Hays S.R., Palafoll I.V., Siebers-Renelt U., Bohring A., Finn L.S., Siebert J.R., Galambos C., Nguyen L., Riley M., Chassaing N., Vigouroux A., Rocha G., Fernandes S., Brumbaugh J., Roberts K., Ho-Ming L., Lo I.F., Lam S., Gerychova R., Jezova M., Valaskova I., Fellmann F., Afshar K., Giannoni E., Muhlethaler V., Liang J., Beckmann J.S., Lioy J., Deshmukh H., Srinivasan L., Swarr D.T., Sloman M., Shaw-Smith C., van Loon R.L., Hagman C., Sznajer Y., Barrea C., Galant C., Detaille T., Wambach J.A., Cole F.S., Hamvas A., Prince L.S., Diderich K.E., Brooks A.S., Verdijk R.M., Ravindranathan H., Sugo E., Mowat D., Baker M.L., Langston C., Welty S., Stankiewicz P.
Hum. Mutat. 34:801-811(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ACDMPV GLN-49; SER-49; PHE-52; CYS-53; ASN-74; ILE-85; LEU-85; SER-85; TRP-86; GLU-91; VAL-91; MET-96; HIS-97; GLN-98; LEU-101; LEU-106; 113-LEU--GLY-119 DEL; ASP-119; LEU-126; LEU-139 AND TRP-330.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13219 mRNA. Translation: AAC50399.1. Different initiation.
AF085343, AF085342 Genomic DNA. Translation: AAC61576.1. Different initiation.
AK314167 mRNA. Translation: BAG36851.1. Frameshift.
AC009108 Genomic DNA. No translation available.
BC089442 mRNA. Translation: AAH89442.1. Different initiation.
CCDSCCDS10957.2.
PIRS51624.
RefSeqNP_001442.2. NM_001451.2.
UniGeneHs.155591.

3D structure databases

ProteinModelPortalQ12946.
SMRQ12946. Positions 48-137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000262426.

PTM databases

PhosphoSiteQ12946.

Polymorphism databases

DMDM238054293.

Proteomic databases

MaxQBQ12946.
PaxDbQ12946.
PRIDEQ12946.

Protocols and materials databases

DNASU2294.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262426; ENSP00000262426; ENSG00000103241.
GeneID2294.
KEGGhsa:2294.
UCSCuc002fjl.3. human.

Organism-specific databases

CTD2294.
GeneCardsGC16P086544.
HGNCHGNC:3809. FOXF1.
HPAHPA028886.
MIM265380. phenotype.
601089. gene.
neXtProtNX_Q12946.
Orphanet210122. Congenital alveolar capillary dysplasia.
PharmGKBPA28226.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000060124.
HOVERGENHBG051644.
InParanoidQ12946.
KOK09399.
OMAMTAEVQQ.
OrthoDBEOG7D59PX.
PhylomeDBQ12946.
TreeFamTF351598.

Enzyme and pathway databases

SignaLinkQ12946.

Gene expression databases

BgeeQ12946.
CleanExHS_FOXF1.
GenevestigatorQ12946.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFOXF1.
GenomeRNAi2294.
NextBio9311.
PROQ12946.
SOURCESearch...

Entry information

Entry nameFOXF1_HUMAN
AccessionPrimary (citable) accession number: Q12946
Secondary accession number(s): B2RAF4, Q5FWE5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM