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Protein

Heat shock protein 75 kDa, mitochondrial

Gene

TRAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119ATPBy similarity1
Binding sitei158ATPBy similarity1
Binding sitei171ATPBy similarity1
Binding sitei205ATP; via amide nitrogenBy similarity1
Binding sitei402ATPBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • protein kinase binding Source: ParkinsonsUK-UCL
  • tumor necrosis factor receptor binding Source: UniProtKB

GO - Biological processi

  • chaperone-mediated protein folding Source: ParkinsonsUK-UCL
  • negative regulation of cellular respiration Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source: ParkinsonsUK-UCL
  • negative regulation of reactive oxygen species biosynthetic process Source: ParkinsonsUK-UCL
  • response to stress Source: InterPro
  • translational attenuation Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126602-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 75 kDa, mitochondrial
Short name:
HSP 75
Alternative name(s):
TNFR-associated protein 1
Tumor necrosis factor type 1 receptor-associated protein
Short name:
TRAP-1
Gene namesi
Name:TRAP1
Synonyms:HSP75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:16264. TRAP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • lipid particle Source: ParkinsonsUK-UCL
  • membrane Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial intermembrane space Source: ParkinsonsUK-UCL
  • mitochondrial matrix Source: UniProtKB
  • mitochondrion Source: ParkinsonsUK-UCL
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10131.
OpenTargetsiENSG00000126602.
PharmGKBiPA36781.

Chemistry databases

ChEMBLiCHEMBL1075132.
GuidetoPHARMACOLOGYi2909.

Polymorphism and mutation databases

BioMutaiTRAP1.
DMDMi67477458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 59MitochondrionBy similarityAdd BLAST59
ChainiPRO_000001360460 – 704Heat shock protein 75 kDa, mitochondrialAdd BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineBy similarity1
Modified residuei174PhosphothreonineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei262N6-acetyllysineBy similarity1
Modified residuei324N6-acetyllysineBy similarity1
Modified residuei332N6-acetyllysineCombined sources1
Modified residuei424N6-acetyllysineCombined sources1
Modified residuei431N6-acetyllysineBy similarity1
Modified residuei466N6-acetyllysineCombined sources1
Modified residuei494PhosphothreonineCombined sources1
Modified residuei568PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ12931.
MaxQBiQ12931.
PaxDbiQ12931.
PeptideAtlasiQ12931.
PRIDEiQ12931.

2D gel databases

REPRODUCTION-2DPAGEIPI00030275.

PTM databases

iPTMnetiQ12931.
PhosphoSitePlusiQ12931.
SwissPalmiQ12931.

Expressioni

Tissue specificityi

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.1 Publication

Gene expression databases

BgeeiENSG00000126602.
CleanExiHS_TRAP1.
ExpressionAtlasiQ12931. baseline and differential.
GenevisibleiQ12931. HS.

Organism-specific databases

HPAiHPA041082.
HPA044227.

Interactioni

Subunit structurei

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.2 Publications

GO - Molecular functioni

  • protein kinase binding Source: ParkinsonsUK-UCL
  • tumor necrosis factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115435. 78 interactors.
DIPiDIP-6250N.
IntActiQ12931. 39 interactors.
MINTiMINT-1510364.
STRINGi9606.ENSP00000246957.

Chemistry databases

BindingDBiQ12931.

Structurei

Secondary structure

1704
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi86 – 95Combined sources10
Helixi98 – 107Combined sources10
Helixi108 – 110Combined sources3
Helixi111 – 134Combined sources24
Beta strandi143 – 148Combined sources6
Turni149 – 152Combined sources4
Beta strandi153 – 158Combined sources6
Helixi165 – 176Combined sources12
Helixi179 – 187Combined sources9
Helixi194 – 201Combined sources8
Helixi203 – 205Combined sources3
Helixi206 – 209Combined sources4
Beta strandi212 – 220Combined sources9
Beta strandi222 – 225Combined sources4
Beta strandi228 – 233Combined sources6
Beta strandi235 – 237Combined sources3
Beta strandi239 – 243Combined sources5
Beta strandi249 – 257Combined sources9
Helixi262 – 265Combined sources4
Helixi267 – 278Combined sources12
Beta strandi285 – 287Combined sources3
Turni298 – 300Combined sources3
Helixi303 – 305Combined sources3
Helixi308 – 319Combined sources12
Beta strandi325 – 348Combined sources24
Beta strandi363 – 367Combined sources5
Beta strandi370 – 375Combined sources6
Helixi377 – 379Combined sources3
Helixi382 – 384Combined sources3
Beta strandi388 – 395Combined sources8
Beta strandi402 – 405Combined sources4
Helixi409 – 432Combined sources24
Helixi434 – 454Combined sources21
Helixi458 – 465Combined sources8
Beta strandi470 – 472Combined sources3
Helixi483 – 488Combined sources6
Beta strandi497 – 501Combined sources5
Helixi505 – 510Combined sources6
Helixi512 – 518Combined sources7
Turni519 – 521Combined sources3
Beta strandi524 – 527Combined sources4
Helixi532 – 539Combined sources8
Beta strandi541 – 544Combined sources4
Beta strandi545 – 549Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z1FX-ray2.70A60-561[»]
4Z1GX-ray3.10A60-561[»]
4Z1HX-ray2.90A60-561[»]
4Z1IX-ray3.30A/B/C/D60-561[»]
5F3KX-ray1.82A/B60-294[»]
5F5RX-ray1.85A/B60-294[»]
5HPHX-ray2.43A/B60-554[»]
ProteinModelPortaliQ12931.
SMRiQ12931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031987.
HOVERGENiHBG103147.
InParanoidiQ12931.
KOiK09488.
OMAiMLLTNMN.
OrthoDBiEOG091G03C9.
PhylomeDBiQ12931.
TreeFamiTF315234.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12931-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARELRALLL WGRRLRPLLR APALAAVPGG KPILCPRRTT AQLGPRRNPA
60 70 80 90 100
WSLQAGRLFS TQTAEDKEEP LHSIISSTES VQGSTSKHEF QAETKKLLDI
110 120 130 140 150
VARSLYSEKE VFIRELISNA SDALEKLRHK LVSDGQALPE MEIHLQTNAE
160 170 180 190 200
KGTITIQDTG IGMTQEELVS NLGTIARSGS KAFLDALQNQ AEASSKIIGQ
210 220 230 240 250
FGVGFYSAFM VADRVEVYSR SAAPGSLGYQ WLSDGSGVFE IAEASGVRTG
260 270 280 290 300
TKIIIHLKSD CKEFSSEARV RDVVTKYSNF VSFPLYLNGR RMNTLQAIWM
310 320 330 340 350
MDPKDVREWQ HEEFYRYVAQ AHDKPRYTLH YKTDAPLNIR SIFYVPDMKP
360 370 380 390 400
SMFDVSRELG SSVALYSRKV LIQTKATDIL PKWLRFIRGV VDSEDIPLNL
410 420 430 440 450
SRELLQESAL IRKLRDVLQQ RLIKFFIDQS KKDAEKYAKF FEDYGLFMRE
460 470 480 490 500
GIVTATEQEV KEDIAKLLRY ESSALPSGQL TSLSEYASRM RAGTRNIYYL
510 520 530 540 550
CAPNRHLAEH SPYYEAMKKK DTEVLFCFEQ FDELTLLHLR EFDKKKLISV
560 570 580 590 600
ETDIVVDHYK EEKFEDRSPA AECLSEKETE ELMAWMRNVL GSRVTNVKVT
610 620 630 640 650
LRLDTHPAMV TVLEMGAARH FLRMQQLAKT QEERAQLLQP TLEINPRHAL
660 670 680 690 700
IKKLNQLRAS EPGLAQLLVD QIYENAMIAA GLVDDPRAMV GRLNELLVKA

LERH
Length:704
Mass (Da):80,110
Last modified:June 7, 2005 - v3
Checksum:i4B16DE3D2B9E0285
GO
Isoform 2 (identifier: Q12931-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-82: Missing.

Note: No experimental confirmation available.
Show »
Length:651
Mass (Da):74,267
Checksum:iA0B8927FC74C41F2
GO

Sequence cautioni

The sequence AAA87704 differs from that shown. Reason: Frameshift at position 656.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 19PLL → ALR in AAA87704 (PubMed:7876093).Curated3
Sequence conflicti53L → M in AAC02679 (PubMed:8756626).Curated1
Sequence conflicti360G → D in BAG61180 (PubMed:14702039).Curated1
Sequence conflicti475 – 476Missing in AAC02679 (PubMed:8756626).Curated2
Sequence conflicti488 – 491SRMR → AHW in AAC02679 (PubMed:8756626).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016108307R → G.2 PublicationsCorresponds to variant rs13926dbSNPEnsembl.1
Natural variantiVAR_049625395D → E.1 PublicationCorresponds to variant rs1136948dbSNPEnsembl.1
Natural variantiVAR_061272572E → K.Corresponds to variant rs55766649dbSNPEnsembl.1
Natural variantiVAR_049626692R → H.Corresponds to variant rs2791dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05506130 – 82Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154108 mRNA. Translation: AAF15314.1.
AK299127 mRNA. Translation: BAG61180.1.
AC005203 Genomic DNA. Translation: AAC24722.1.
AC006111 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85338.1.
CH471112 Genomic DNA. Translation: EAW85340.1.
BC018950 mRNA. Translation: AAH18950.1.
BC023585 mRNA. Translation: AAH23585.1.
U12595 mRNA. Translation: AAA87704.1. Frameshift.
AF043254 mRNA. Translation: AAC02679.1.
CCDSiCCDS10508.1. [Q12931-1]
CCDS61824.1. [Q12931-2]
RefSeqiNP_001258978.1. NM_001272049.1. [Q12931-2]
NP_057376.2. NM_016292.2. [Q12931-1]
UniGeneiHs.30345.

Genome annotation databases

EnsembliENST00000246957; ENSP00000246957; ENSG00000126602. [Q12931-1]
ENST00000538171; ENSP00000442070; ENSG00000126602. [Q12931-2]
GeneIDi10131.
KEGGihsa:10131.
UCSCiuc002cvt.4. human. [Q12931-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154108 mRNA. Translation: AAF15314.1.
AK299127 mRNA. Translation: BAG61180.1.
AC005203 Genomic DNA. Translation: AAC24722.1.
AC006111 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85338.1.
CH471112 Genomic DNA. Translation: EAW85340.1.
BC018950 mRNA. Translation: AAH18950.1.
BC023585 mRNA. Translation: AAH23585.1.
U12595 mRNA. Translation: AAA87704.1. Frameshift.
AF043254 mRNA. Translation: AAC02679.1.
CCDSiCCDS10508.1. [Q12931-1]
CCDS61824.1. [Q12931-2]
RefSeqiNP_001258978.1. NM_001272049.1. [Q12931-2]
NP_057376.2. NM_016292.2. [Q12931-1]
UniGeneiHs.30345.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z1FX-ray2.70A60-561[»]
4Z1GX-ray3.10A60-561[»]
4Z1HX-ray2.90A60-561[»]
4Z1IX-ray3.30A/B/C/D60-561[»]
5F3KX-ray1.82A/B60-294[»]
5F5RX-ray1.85A/B60-294[»]
5HPHX-ray2.43A/B60-554[»]
ProteinModelPortaliQ12931.
SMRiQ12931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115435. 78 interactors.
DIPiDIP-6250N.
IntActiQ12931. 39 interactors.
MINTiMINT-1510364.
STRINGi9606.ENSP00000246957.

Chemistry databases

BindingDBiQ12931.
ChEMBLiCHEMBL1075132.
GuidetoPHARMACOLOGYi2909.

PTM databases

iPTMnetiQ12931.
PhosphoSitePlusiQ12931.
SwissPalmiQ12931.

Polymorphism and mutation databases

BioMutaiTRAP1.
DMDMi67477458.

2D gel databases

REPRODUCTION-2DPAGEIPI00030275.

Proteomic databases

EPDiQ12931.
MaxQBiQ12931.
PaxDbiQ12931.
PeptideAtlasiQ12931.
PRIDEiQ12931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246957; ENSP00000246957; ENSG00000126602. [Q12931-1]
ENST00000538171; ENSP00000442070; ENSG00000126602. [Q12931-2]
GeneIDi10131.
KEGGihsa:10131.
UCSCiuc002cvt.4. human. [Q12931-1]

Organism-specific databases

CTDi10131.
DisGeNETi10131.
GeneCardsiTRAP1.
H-InvDBHIX0012776.
HGNCiHGNC:16264. TRAP1.
HPAiHPA041082.
HPA044227.
MIMi606219. gene.
neXtProtiNX_Q12931.
OpenTargetsiENSG00000126602.
PharmGKBiPA36781.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031987.
HOVERGENiHBG103147.
InParanoidiQ12931.
KOiK09488.
OMAiMLLTNMN.
OrthoDBiEOG091G03C9.
PhylomeDBiQ12931.
TreeFamiTF315234.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126602-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiTRAP1. human.
GeneWikiiTRAP1.
GenomeRNAii10131.
PROiQ12931.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126602.
CleanExiHS_TRAP1.
ExpressionAtlasiQ12931. baseline and differential.
GenevisibleiQ12931. HS.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRAP1_HUMAN
AccessioniPrimary (citable) accession number: Q12931
Secondary accession number(s): B4DR68
, D3DUC8, F5H897, O43642, O75235, Q9UHL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.