Reviewed,
UniProtKB/Swiss-Prot Q12931 (TRAP1_HUMAN)
Last modified
June 16, 2009.
Version 93.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Heat shock protein 75 kDa, mitochondrial Short name=HSP 75 Alternative name(s): Tumor necrosis factor type 1 receptor-associated protein Short name=TRAP-1 TNFR-associated protein 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 704 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Chaperone that expresses an ATPase activity. |
| Subunit structure | Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. |
| Subcellular location | |
| Tissue specificity | Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta. |
| Sequence similarities | Belongs to the heat shock protein 90 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Coding sequence diversity | Polymorphism |
| Domain | Transit peptide |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Chaperone |
| PTM | Acetylation Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: InterPro response to stressInferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tumor necrosis factor receptor binding Ref.3Non-traceable author statement. Source: UniProtKB unfolded protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 59 | 59 | Mitochondrion By similarity | ||||||
| Chain | 60 – 704 | 645 | Heat shock protein 75 kDa, mitochondrial | PRO_0000013604 | |||||
Sites | |||||||||
| Binding site | 119 | 1 | ATP By similarity | ||||||
| Binding site | 158 | 1 | ATP By similarity | ||||||
| Binding site | 171 | 1 | ATP By similarity | ||||||
| Binding site | 205 | 1 | ATP; via amide nitrogen By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 87 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 366 | 1 | Phosphotyrosine Ref.7 | ||||||
| Modified residue | 494 | 1 | Phosphothreonine Ref.8 | ||||||
Natural variations | |||||||||
| Natural variant | 307 | 1 | R → G: dbSNP rs13926. Ref.1 Ref.3 | VAR_016108 | |||||
| Natural variant | 395 | 1 | D → E: dbSNP rs1136948. Ref.5 | VAR_049625 | |||||
| Natural variant | 692 | 1 | R → H: dbSNP rs2791. | VAR_049626 | |||||
Experimental info | |||||||||
| Sequence conflict | 17 – 19 | 3 | PLL → ALR in AAA87704. Ref.3 | ||||||
| Sequence conflict | 53 | 1 | L → M in AAC02679. Ref.5 | ||||||
| Sequence conflict | 475 – 476 | 2 | Missing in AAC02679. Ref.5 | ||||||
| Sequence conflict | 488 – 491 | 4 | SRMR → AHW in AAC02679. Ref.5 | ||||||
| Sequence conflict | 656 – 704 | 49 | QLRAS…ALERH → HCAQASLAWLSCWWIRYTRT P Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses." Simmons A.D., Musy M.M., Lopes C.S., Hwang L.-Y., Yang Y.-P., Lovett M. Hum. Mol. Genet. 8:2155-2164(1999) [PubMed: 10545594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-307. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Eye. |
| [3] | "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor." Song H.Y., Dunbar J.D., Zhang Y.X., Guo D., Donner D.B. J. Biol. Chem. 270:3574-3581(1995) [PubMed: 7876093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-704, VARIANT GLY-307. |
| [4] | Ricke D.O., Bruce D., Mundt M., Doggett N., Munk C., Saunders E., Robinson D., Jones M., Buckingham J., Chasteen L., Thompson S., Goodwin L., Bryant J., Tesmer J., Meincke L., Longmire J., White S., Ueng S. Deaven L.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 32-677. |
| [5] | "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock." Chen C.-F., Chen Y., Dai K., Chen P.-L., Riley D.J., Lee W.-H. Mol. Cell. Biol. 16:4691-4699(1996) [PubMed: 8756626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-704, VARIANT GLU-395. |
| [6] | "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties." Felts S.J., Owen B.A.L., Nguyen P., Trepel J., Donner D.B., Toft D.O. J. Biol. Chem. 275:3305-3312(2000) [PubMed: 10652318] [Abstract] Cited for: CHARACTERIZATION. |
| [7] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-366, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-494, MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF154108 mRNA. Translation: AAF15314.1. BC018950 mRNA. Translation: AAH18950.1. BC023585 mRNA. Translation: AAH23585.1. U12595 mRNA. Translation: AAA87704.1. AC005203 Genomic DNA. Translation: AAC24722.1. AF043254 mRNA. Translation: AAC02679.1. | |
| IPI | IPI00030275. |
| RefSeq | NP_057376.2. |
| UniGene | Hs.30345 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AMW based on UniProtKB P02829. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:6250N. |
| IntAct | Q12931. 2 interactions. |
PTM databases | |
| PhosphoSite | Q12931. |
2-D gel databases | |
| REPRODUCTION-2DPAGE | IPI00030275. |
Proteomic databases | |
| PeptideAtlas | Q12931. |
| PRIDE | Q12931. |
Genome annotation databases | |
| Ensembl | ENSG00000126602. Homo sapiens. [Contig view] |
| GeneID | 10131. |
| KEGG | hsa:10131. |
| NMPDR | fig|9606.3.peg.11646. |
Organism-specific databases | |
| GeneCards | GC16M003648. |
| H-InvDB | HIX0012774. HIX0012776. |
| HGNC | HGNC:16264. TRAP1. |
| HPA | CAB004281. |
| MIM | 606219. gene. |
| PharmGKB | PA36781. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q12931. |
| HOVERGEN | Q12931. |
| OMA | Q12931. TEVLFCY. |
Gene expression databases | |
| Bgee | Q12931. |
| CleanEx | HS_TRAP1. |
| GermOnline | ENSG00000126602. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR003594. ATP_bd_ATPase. IPR019805. Heat_shock_protein_90_CS. IPR001404. Hsp90. [Graphical view] |
| PANTHER | PTHR11528. Hsp90. 1 hit. |
| Pfam | PF02518. HATPase_c. 1 hit. PF00183. HSP90. 4 hits. [Graphical view] |
| PIRSF | PIRSF002583. Hsp90. 1 hit. |
| PRINTS | PR00775. HEATSHOCK90. |
| SMART | SM00387. HATPase_c. 1 hit. [Graphical view] |
| PROSITE | PS00298. HSP90. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 38323. |
| SOURCE | Search... |
Entry information
| Entry name | TRAP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q12931 Secondary accession number(s): O43642, O75235, Q9UHL5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


