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Protein

ELAV-like protein 2

Gene

ELAVL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • regulation of transcription, DNA-templated Source: ProtInc

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
ELAV-like neuronal protein 1
Hu-antigen B
Short name:
HuB
Nervous system-specific RNA-binding protein Hel-N1
Gene namesi
Name:ELAVL2
Synonyms:HUB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107105.14.
HGNCiHGNC:3313. ELAVL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1993.
OpenTargetsiENSG00000107105.
PharmGKBiPA27741.

Polymorphism and mutation databases

BioMutaiELAVL2.
DMDMi93141258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815791 – 359ELAV-like protein 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ12926.
MaxQBiQ12926.
PaxDbiQ12926.
PeptideAtlasiQ12926.
PRIDEiQ12926.

PTM databases

iPTMnetiQ12926.
PhosphoSitePlusiQ12926.

Expressioni

Tissue specificityi

Brain; neural-specific.

Gene expression databases

BgeeiENSG00000107105.
CleanExiHS_ELAVL2.
ExpressionAtlasiQ12926. baseline and differential.
GenevisibleiQ12926. HS.

Organism-specific databases

HPAiCAB022222.

Interactioni

Subunit structurei

Interacts with IGF2BP1.1 Publication

Protein-protein interaction databases

BioGridi108308. 130 interactors.
IntActiQ12926. 4 interactors.
STRINGi9606.ENSP00000369460.

Structurei

3D structure databases

ProteinModelPortaliQ12926.
SMRiQ12926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 117RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini125 – 205RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini276 – 354RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ12926.
KOiK13208.
PhylomeDBiQ12926.
TreeFamiTF313377.

Family and domain databases

CDDicd12650. RRM1_Hu. 1 hit.
cd12775. RRM2_HuB. 1 hit.
cd12654. RRM3_HuB. 1 hit.
InterProiView protein in InterPro
IPR006548. ELAD_HU_SF.
IPR034775. ELAV/Hu_RRM1.
IPR034999. HuB_RRM2.
IPR034914. HuB_RRM3.
IPR002343. Hud_Sxl_RNA.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 3 hits.
PRINTSiPR00961. HUDSXLRNA.
SMARTiView protein in SMART
SM00360. RRM. 3 hits.
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12926-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM
60 70 80 90 100
TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL
110 120 130 140 150
NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV
210 220 230 240 250
KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK
260 270 280 290 300
RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG
310 320 330 340 350
AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS

FKTNKTHKA
Length:359
Mass (Da):39,504
Last modified:April 18, 2006 - v2
Checksum:i15E87088FC546DDC
GO
Isoform 2 (identifier: Q12926-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-251: Missing.

Show »
Length:346
Mass (Da):38,015
Checksum:iF1EC0F69EE5D15DD
GO

Sequence cautioni

The sequence BAD92531 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335A → R (PubMed:8158249).Curated1
Sequence conflicti335A → R (PubMed:7972035).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005788239 – 251Missing in isoform 2. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12431 mRNA. Translation: AAA69698.1.
U29943 mRNA. Translation: AAA70417.1.
AB209294 mRNA. Translation: BAD92531.1. Different initiation.
AL161628, AL445623 Genomic DNA. Translation: CAI13376.1.
AL161628 Genomic DNA. Translation: CAC22160.1.
CH471071 Genomic DNA. Translation: EAW58581.1.
CH471071 Genomic DNA. Translation: EAW58582.1.
BC030692 mRNA. Translation: AAH30692.1.
CCDSiCCDS55298.1. [Q12926-2]
CCDS6515.1. [Q12926-1]
PIRiI38726.
I39077.
RefSeqiNP_001164666.1. NM_001171195.1. [Q12926-2]
NP_001164668.1. NM_001171197.1. [Q12926-2]
NP_004423.2. NM_004432.3. [Q12926-1]
XP_016869908.1. XM_017014419.1. [Q12926-1]
XP_016869909.1. XM_017014420.1. [Q12926-1]
XP_016869910.1. XM_017014421.1. [Q12926-1]
XP_016869911.1. XM_017014422.1. [Q12926-1]
XP_016869912.1. XM_017014423.1. [Q12926-1]
XP_016869913.1. XM_017014424.1. [Q12926-2]
XP_016869914.1. XM_017014425.1. [Q12926-2]
UniGeneiHs.166109.

Genome annotation databases

EnsembliENST00000223951; ENSP00000223951; ENSG00000107105. [Q12926-2]
ENST00000380117; ENSP00000369460; ENSG00000107105. [Q12926-1]
ENST00000397312; ENSP00000380479; ENSG00000107105. [Q12926-1]
ENST00000544538; ENSP00000440998; ENSG00000107105. [Q12926-1]
GeneIDi1993.
KEGGihsa:1993.
UCSCiuc003zps.4. human. [Q12926-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELAV2_HUMAN
AccessioniPrimary (citable) accession number: Q12926
Secondary accession number(s): D3DRK3
, Q13235, Q59G15, Q8NEM4, Q9H1Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 18, 2006
Last modified: September 27, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families