Reviewed, UniProtKB/Swiss-Prot Q12926 (ELAV2_HUMAN)

Names and origin

Protein names

Recommended name:
    ELAV-like protein 2
Alternative name(s):
    Hu-antigen B
      Short name=HuB
    ELAV-like neuronal protein 1
    Nervous system-specific RNA-binding protein Hel-N1

Gene names

Name:	ELAVL2
Synonyms:	HUB

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.
Subunit structure	Interacts with IGF2BP1. Ref.6
Tissue specificity	Brain; neural-specific.
Sequence similarities	Belongs to the RRM elav family. Contains 3 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Ref.1 Traceable author statement. Source: ProtInc
Molecular function	mRNA 3'-UTR binding Ref.1 Traceable author statement. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: InterPro protein binding Ref.6 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12926-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12926-2)

The sequence of this isoform differs from the canonical sequence as follows:
     239-251: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	ELAV-like protein 2		PRO_0000081579
Regions
	Domain	39 – 117	79	RRM 1
	Domain	125 – 205	81	RRM 2
	Domain	276 – 354	79	RRM 3
Amino acid modifications
	Modified residue	221	1	Phosphoserine Ref.7 Ref.8
Natural variations
	Alternative sequence	239 – 251	13	Missing in isoform 2.		VSP_005788
Experimental info
	Sequence conflict	335	1	A → R Ref.1
	Sequence conflict	335	1	A → R Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 18, 2006. Version 2. Checksum: 15E87088FC546DDC	FASTA	359	39,504
	10 20 30 40 50 60 METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG 70 80 90 100 110 120 SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA 130 140 150 160 170 180 SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE 190 200 210 220 230 240 EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD 250 260 270 280 290 300 NLLNMAYGVK RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG 310 320 330 340 350 AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA
	Isoform 2. Checksum: F1EC0F69EE5D15DD	FASTA	346	38,015
	10 20 30 40 50 60 METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM TQEELKSLFG 70 80 90 100 110 120 SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA 130 140 150 160 170 180 SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGISRGVGF IRFDKRIEAE 190 200 210 220 230 240 EAIKGLNGQK PPGATEPITV KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRFS 250 260 270 280 290 300 PMTIDGMTSL AGINIPGHPG TGWCIFVYNL APDADESILW QMFGPFGAVT NVKVIRDFNT 310 320 330 340 NKCKGFGFVT MTNYDEAAMA IASLNGYRLG DRVLQVSFKT NKTHKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor." King P.H., Levine T.D., Fremeau R.T. Jr., Keene J.D. J. Neurosci. 14:1943-1952(1994) [PubMed: 8158249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1." Gao F.B., Carson C.C., Levine T., Keene J.D. Proc. Natl. Acad. Sci. U.S.A. 91:11207-11211(1994) [PubMed: 7972035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Medulloblastoma.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[6]	"Molecular composition of IMP1 ribonucleoprotein granules." Joeson L., Vikesaa J., Krogh A., Nielsen L.K., Hansen T., Borup R., Johnsen A.H., Christiansen J., Nielsen F.C. Mol. Cell. Proteomics 6:798-811(2007) [PubMed: 17289661] [Abstract] Cited for: INTERACTION WITH IGF2BP1.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, MASS SPECTROMETRY.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12431 mRNA. Translation: AAA69698.1. U29943 mRNA. Translation: AAA70417.1. AB209294 mRNA. Translation: BAD92531.1. Different initiation. AL161628, AL445623 Genomic DNA. Translation: CAI13376.1. AL161628 Genomic DNA. Translation: CAC22160.1. BC030692 mRNA. Translation: AAH30692.1.
IPI	IPI00030250. IPI00219967.
PIR	I38726. I39077.
RefSeq	NP_004423.2.
UniGene	Hs.166109
3D structure databases
SMR	Q12926. Positions 37-203, 39-355.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12926.
PTM databases
PhosphoSite	Q12926.
Proteomic databases
PRIDE	Q12926.
Genome annotation databases
Ensembl	ENST00000359598; ENSP00000352612; ENSG00000107105; Homo sapiens. [Genome view] ENST00000380117; ENSP00000369460; ENSG00000107105; Homo sapiens. [Genome view] ENST00000397312; ENSP00000380479; ENSG00000107105; Homo sapiens. [Genome view]
GeneID	1993.
KEGG	hsa:1993.
UCSC	uc003zps.1. human. uc003zpu.1. human.
Organism-specific databases
CTD	1993.
GeneCards	GC09M023680.
H-InvDB	HIX0007958.
HGNC	HGNC:3313. ELAVL2.
HPA	CAB022222.
MIM	601673. gene.
PharmGKB	PA27741.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13608.
HOVERGEN	Q12926.
InParanoid	Q12926.
OrthoDB	EOG9VHNS4.
PhylomeDB	Q12926.
Gene expression databases
ArrayExpress	Q12926.
Bgee	Q12926.
CleanEx	HS_ELAVL2.
Genevestigator	Q12926.
GermOnline	ENSG00000107105. Homo sapiens.
Family and domain databases
InterPro	IPR012677. a_b_plait_nuc_bd. IPR006548. ELAD_HUD_SF. IPR002343. Hud_Sxl_RNA. IPR000504. RRM_RNP1. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 3 hits.
Pfam	PF00076. RRM_1. 3 hits. [Graphical view]
PRINTS	PR00961. HUDSXLRNA.
SMART	SM00360. RRM. 3 hits. [Graphical view]
TIGRFAMs	TIGR01661. ELAV_HUD_SF. 1 hit.
PROSITE	PS50102. RRM. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	8059.
SOURCE	Search...

Entry information

Entry name

ELAV2_HUMAN

Accession

Primary (citable) accession number: Q12926
Secondary accession number(s): Q13235 , Q59G15, Q8NEM4, Q9H1Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	April 18, 2006
Last modified:	February 9, 2010
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.