Reviewed,
UniProtKB/Swiss-Prot Q12926 (ELAV2_HUMAN)
Last modified
February 9, 2010.
Version 85.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ELAV-like protein 2 Alternative name(s): Hu-antigen B Short name=HuB ELAV-like neuronal protein 1 Nervous system-specific RNA-binding protein Hel-N1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. |
| Subunit structure | Interacts with IGF2BP1. Ref.6 |
| Tissue specificity | Brain; neural-specific. |
| Sequence similarities | Belongs to the RRM elav family. Contains 3 RRM (RNA recognition motif) domains. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Domain | Repeat |
| Ligand | RNA-binding |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | mRNA 3'-UTR binding Ref.1 Traceable author statement. Source: ProtInc nucleotide bindingInferred from electronic annotation. Source: InterPro protein binding Ref.6Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q12926-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q12926-2) The sequence of this isoform differs from the canonical sequence as follows: 239-251: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | ELAV-like protein 2 | PRO_0000081579 | |||||
Regions | |||||||||
| Domain | 39 – 117 | 79 | RRM 1 | ||||||
| Domain | 125 – 205 | 81 | RRM 2 | ||||||
| Domain | 276 – 354 | 79 | RRM 3 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 221 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||
Natural variations | |||||||||
| Alternative sequence | 239 – 251 | 13 | Missing in isoform 2. | VSP_005788 | |||||
Experimental info | |||||||||
| Sequence conflict | 335 | 1 | A → R Ref.1 | ||||||
| Sequence conflict | 335 | 1 | A → R Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor." King P.H., Levine T.D., Fremeau R.T. Jr., Keene J.D. J. Neurosci. 14:1943-1952(1994) [PubMed: 8158249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. |
| [2] | "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1." Gao F.B., Carson C.C., Levine T., Keene J.D. Proc. Natl. Acad. Sci. U.S.A. 91:11207-11211(1994) [PubMed: 7972035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Medulloblastoma. |
| [3] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis. |
| [6] | "Molecular composition of IMP1 ribonucleoprotein granules." Joeson L., Vikesaa J., Krogh A., Nielsen L.K., Hansen T., Borup R., Johnsen A.H., Christiansen J., Nielsen F.C. Mol. Cell. Proteomics 6:798-811(2007) [PubMed: 17289661] [Abstract] Cited for: INTERACTION WITH IGF2BP1. |
| [7] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, MASS SPECTROMETRY. |
| [8] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U12431 mRNA. Translation: AAA69698.1. U29943 mRNA. Translation: AAA70417.1. AB209294 mRNA. Translation: BAD92531.1. Different initiation. AL161628, AL445623 Genomic DNA. Translation: CAI13376.1. AL161628 Genomic DNA. Translation: CAC22160.1. BC030692 mRNA. Translation: AAH30692.1. |
| IPI | IPI00030250. IPI00219967. |
| PIR | I38726. I39077. |
| RefSeq | NP_004423.2. |
| UniGene | Hs.166109 |
3D structure databases | |
| SMR | Q12926. Positions 37-203, 39-355. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q12926. |
PTM databases | |
| PhosphoSite | Q12926. |
Proteomic databases | |
| PRIDE | Q12926. |
Genome annotation databases | |
| Ensembl | ENST00000359598; ENSP00000352612; ENSG00000107105; Homo sapiens. [Genome view] ENST00000380117; ENSP00000369460; ENSG00000107105; Homo sapiens. [Genome view] ENST00000397312; ENSP00000380479; ENSG00000107105; Homo sapiens. [Genome view] |
| GeneID | 1993. |
| KEGG | hsa:1993. |
| UCSC | uc003zps.1. human. uc003zpu.1. human. |
Organism-specific databases | |
| CTD | 1993. |
| GeneCards | GC09M023680. |
| H-InvDB | HIX0007958. |
| HGNC | HGNC:3313. ELAVL2. |
| HPA | CAB022222. |
| MIM | 601673. gene. |
| PharmGKB | PA27741. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG13608. |
| HOVERGEN | Q12926. |
| InParanoid | Q12926. |
| OrthoDB | EOG9VHNS4. |
| PhylomeDB | Q12926. |
Gene expression databases | |
| ArrayExpress | Q12926. |
| Bgee | Q12926. |
| CleanEx | HS_ELAVL2. |
| Genevestigator | Q12926. |
| GermOnline | ENSG00000107105. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012677. a_b_plait_nuc_bd. IPR006548. ELAD_HUD_SF. IPR002343. Hud_Sxl_RNA. IPR000504. RRM_RNP1. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 3 hits. |
| Pfam | PF00076. RRM_1. 3 hits. [Graphical view] |
| PRINTS | PR00961. HUDSXLRNA. |
| SMART | SM00360. RRM. 3 hits. [Graphical view] |
| TIGRFAMs | TIGR01661. ELAV_HUD_SF. 1 hit. |
| PROSITE | PS50102. RRM. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 8059. |
| SOURCE | Search... |
Entry information
| Entry name | ELAV2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q12926 Secondary accession number(s): Q13235 Q9H1Q8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


