Reviewed, UniProtKB/Swiss-Prot Q12923 (PTN13_HUMAN)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein phosphatase non-receptor type 13
    EC=3.1.3.48
Alternative name(s):
    Protein-tyrosine phosphatase 1E
      Short name=PTP-E1
      Short name=hPTPE1
    PTP-BAS
    Protein-tyrosine phosphatase PTPL1
    Fas-associated protein-tyrosine phosphatase 1
      Short name=FAP-1

Gene names

Name:	PTPN13
Synonyms:	PNP1, PTP1E, PTPL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7 and ARHGAP29. Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 KIND domain. Contains 5 PDZ (DHR) domains. Contains 1 tyrosine-protein phosphatase domain.
Sequence caution	The sequence AAH39610.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Molecular function	Hydrolase Protein phosphatase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Ref.3 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct protein tyrosine phosphatase activity Ref.6 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FAS	P25445	1	EBI-355227,EBI-494743
PDCD10	Q9BUL8	1	EBI-355268,EBI-740195
STK25	O00506	1	EBI-355268,EBI-618295

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12923-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12923-2)

The sequence of this isoform differs from the canonical sequence as follows:
     884-1074: Missing.

Isoform 3 (identifier: Q12923-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1056-1074: Missing.

Isoform 4 (identifier: Q12923-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1383-1383: T → TVLFDK

Note: May be due to a competing donnor splice site.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2485

2485

Tyrosine-protein phosphatase non-receptor type 13

PRO_0000219435

Regions

Domain

3 – 190

188

KIND

Domain

572 – 872

301

FERM

Domain

1093 – 1178

86

PDZ 1

Domain

1368 – 1452

85

PDZ 2

Domain

1501 – 1588

88

PDZ 3

Domain

1788 – 1868

81

PDZ 4

Domain

1882 – 1965

84

PDZ 5

Domain

2213 – 2467

255

Tyrosine-protein phosphatase

Coiled coil

469 – 504

36

Potential

Compositional bias

56 – 59

4

Poly-Leu

Compositional bias

1742 – 1749

8

Poly-Ser

Sites

Active site

2408

1

Phosphocysteine intermediate By similarity

Natural variations

Alternative sequence

884 – 1074

191

Missing in isoform 2.

VSP_000496

Alternative sequence

1056 – 1074

19

Missing in isoform 3.

VSP_000497

Alternative sequence

1383

1

T → TVLFDK in isoform 4.

VSP_007921

Natural variant

1356

1

F → L: dbSNP rs10033029.

VAR_048359

Natural variant

1419

1

L → P Ref.13

VAR_016200

Natural variant

1522

1

I → M: dbSNP rs2230600. Ref.13

VAR_016201

Natural variant

1625

1

E → K: dbSNP rs12500797.

VAR_024373

Natural variant

1744

1

S → P: dbSNP rs17012064.

VAR_048360

Natural variant

2081

1

Y → D: dbSNP rs989902.

VAR_024374

Natural variant

2458

1

I → V: dbSNP rs34226837.

VAR_048361

Experimental info

Sequence conflict

1134 – 1135

2

LD → FH in CAA56563. Ref.3

Sequence conflict

1216 – 1229

14

KDHHW…LRHIS → DLSRSHCHVYLAHL Ref.5

Sequence conflict

1238 – 1239

2

GL → A in CAA56124. Ref.5

Sequence conflict

1357

1

S → P in CAA56124. Ref.5

Sequence conflict

1362 – 1363

2

KP → RS in CAA56124. Ref.5

Sequence conflict

1383

1

T → TVLFDK in AAB60339. Ref.1

Sequence conflict

1383

1

T → TVLFDK in AAC41755. Ref.1

Sequence conflict

1538

1

P → A in CAA56563. Ref.3

Sequence conflict

1649

1

R → K in CAA56124. Ref.5

Sequence conflict

1698 – 1714

17

KSQED…YPQKI → RVKKIPFVPCFTILRKR in CAA56124. Ref.5

Sequence conflict

1797

1

G → A in CAA56563. Ref.3

Sequence conflict

1856 – 1857

2

AA → G in CAA56124. Ref.5

Sequence conflict

2069

1

A → S in CAA56124. Ref.5

Sequence conflict

2206 – 2210

5

GLLDQ → VARS in CAA56124. Ref.5

Secondary structure

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2485

Helix Strand Turn

Details...

Beta strand

1366 – 1372

7

Beta strand

1374 – 1377

4

Beta strand

1380 – 1383

4

Beta strand

1386 – 1388

3

Beta strand

1390 – 1393

4

Beta strand

1396 – 1400

5

Helix

1405 – 1408

4

Beta strand

1417 – 1421

5

Helix

1431 – 1439

9

Beta strand

1443 – 1450

8

Helix

2175 – 2179

5

Beta strand

2188 – 2190

3

Helix

2194 – 2209

16

Helix

2212 – 2220

9

Helix

2231 – 2233

3

Helix

2235 – 2238

4

Turn

2257 – 2260

4

Beta strand

2264 – 2272

9

Beta strand

2275 – 2282

8

Helix

2287 – 2289

3

Helix

2290 – 2299

10

Beta strand

2304 – 2307

4

Beta strand

2311 – 2313

3

Beta strand

2331 – 2346

16

Beta strand

2348 – 2359

12

Turn

2360 – 2363

4

Beta strand

2364 – 2373

10

Helix

2385 – 2398

14

Beta strand

2404 – 2407

4

Beta strand

2409 – 2412

4

Helix

2413 – 2429

17

Helix

2436 – 2444

9

Helix

2454 – 2475

22

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 8D1B31597C66962B	FASTA	2,485	276,906
	10 20 30 40 50 60 MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS LADPAALGFI ISPWSLLLLP 70 80 90 100 110 120 SGSVSFTDEN ISNQDLRAFT APEVLQNQSL TSLSDVEKIH IYSLGMTLYW GADYEVPQSQ 130 140 150 160 170 180 PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSYVK HLVKLVLGNL 190 200 210 220 230 240 SGTDQLSCNS EQKPDRSQAI RDRLRGKGLP TGRSSTSDVL DIQKPPLSHQ TFLNKGLSKS 250 260 270 280 290 300 MGFLSIKDTQ DENYFKDILS DNSGREDSEN TFSPYQFKTS GPEKKPIPGI DVLSKKKIWA 310 320 330 340 350 360 SSMDLLCTAD RDFSSGETAT YRRCHPEAVT VRTSTTPRKK EARYSDGSIA LDIFGPQKMD 370 380 390 400 410 420 PIYHTRELPT SSAISSALDR IRERQKKLQV LREAMNVEEP VRRYKTYHGD VFSTSSESPS 430 440 450 460 470 480 IISSESDFRQ VRRSEASKRF ESSSGLPGVD ETLSQGQSQR PSRQYETPFE GNLINQEIML 490 500 510 520 530 540 KRQEEELMQL QAKMALRQSR LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG 550 560 570 580 590 600 PEFVKMTIEP FISLDLPRSI LTKKGKNEDN RRKVNIMLLN GQRLELTCDT KTICKDVFDM 610 620 630 640 650 660 VVAHIGLVEH HLFALATLKD NEYFFVDPDL KLTKVAPEGW KEEPKKKTKA TVNFTLFFRI 670 680 690 700 710 720 KFFMDDVSLI QHTLTCHQYY LQLRKDILEE RMHCDDETSL LLASLALQAE YGDYQPEVHG 730 740 750 760 770 780 VSYFRMEHYL PARVMEKLDL SYIKEELPKL HNTYVGASEK ETELEFLKVC QRLTEYGVHF 790 800 810 820 830 840 HRVHPEKKSQ TGILLGVCSK GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD 850 860 870 880 890 900 GIKHGFQTDN SKICQYLLHL CSYQHKFQLQ MRARQSNQDA QDIERASFRS LNLQAESVRG 910 920 930 940 950 960 FNMGRAISTG SLASSTLNKL AVRPLSVQAE ILKRLSCSEL SLYQPLQNSS KEKNDKASWE 970 980 990 1000 1010 1020 EKPREMSKSY HDLSQASLYP HRKNVIVNME PPPQTVAELV GKPSHQMSRS DAESLAGVTK 1030 1040 1050 1060 1070 1080 LNNSKSVASL NRSPERRKHE SDSSSIEDPG QAYVLGMTMH SSGNSSSQVP LKENDVLHKR 1090 1100 1110 1120 1130 1140 WSIVSSPERE ITLVNLKKDA KYGLGFQIIG GEKMGRLDLG IFISSVAPGG PADLDGCLKP 1150 1160 1170 1180 1190 1200 GDRLISVNSV SLEGVSHHAA IEILQNAPED VTLVISQPKE KISKVPSTPV HLTNEMKNYM 1210 1220 1230 1240 1250 1260 KKSSYMQDSA IDSSSKDHHW SRGTLRHISE NSFGPSGGLR EGSLSSQDSR TESASLSQSQ 1270 1280 1290 1300 1310 1320 VNGFFASHLG DQTWQESQHG SPSPSVISKA TEKETFTDSN QSKTKKPGIS DVTDYSDRGD 1330 1340 1350 1360 1370 1380 SDMDEATYSS SQDHQTPKQE SSSSVNTSNK MNFKTFSSSP PKPGDIFEVE LAKNDNSLGI 1390 1400 1410 1420 1430 1440 SVTGGVNTSV RHGGIYVKAV IPQGAAESDG RIHKGDRVLA VNGVSLEGAT HKQAVETLRN 1450 1460 1470 1480 1490 1500 TGQVVHLLLE KGQSPTSKEH VPVTPQCTLS DQNAQGQGPE KVKKTTQVKD YSFVTEENTF 1510 1520 1530 1540 1550 1560 EVKLFKNSSG LGFSFSREDN LIPEQINASI VRVKKLFPGQ PAAESGKIDV GDVILKVNGA 1570 1580 1590 1600 1610 1620 SLKGLSQQEV ISALRGTAPE VFLLLCRPPP GVLPEIDTAL LTPLQSPAQV LPNSSKDSSQ 1630 1640 1650 1660 1670 1680 PSCVEQSTSS DENEMSDKSK KQCKSPSRRD SYSDSSGSGE DDLVTAPANI SNSTWSSALH 1690 1700 1710 1720 1730 1740 QTLSNMVSQA QSHHEAPKSQ EDTICTMFYY PQKIPNKPEF EDSNPSPLPP DMAPGQSYQP 1750 1760 1770 1780 1790 1800 QSESASSSSM DKYHIHHISE PTRQENWTPL KNDLENHLED FELEVELLIT LIKSEKGSLG 1810 1820 1830 1840 1850 1860 FTVTKGNQRI GCYVHDVIQD PAKSDGRLKP GDRLIKVNDT DVTNMTHTDA VNLLRAASKT 1870 1880 1890 1900 1910 1920 VRLVIGRVLE LPRIPMLPHL LPDITLTCNK EELGFSLCGG HDSLYQVVYI SDINPRSVAA 1930 1940 1950 1960 1970 1980 IEGNLQLLDV IHYVNGVSTQ GMTLEEVNRA LDMSLPSLVL KATRNDLPVV PSSKRSAVSA 1990 2000 2010 2020 2030 2040 PKSTKGNGSY SVGSCSQPAL TPNDSFSTVA GEEINEISYP KGKCSTYQIK GSPNLTLPKE 2050 2060 2070 2080 2090 2100 SYIQEDDIYD DSQEAEVIQS LLDVVDEEAQ NLLNENNAAG YSCGPGTLKM NGKLSEERTE 2110 2120 2130 2140 2150 2160 DTDCDGSPLP EYFTEATKMN GCEEYCEEKV KSESLIQKPQ EKKTDDDEIT WGNDELPIER 2170 2180 2190 2200 2210 2220 TNHEDSDKDH SFLTNDELAV LPVVKVLPSG KYTGANLKSV IRVLRGLLDQ GIPSKELENL 2230 2240 2250 2260 2270 2280 QELKPLDQCL IGQTKENRRK NRYKNILPYD ATRVPLGDEG GYINASFIKI PVGKEEFVYI 2290 2300 2310 2320 2330 2340 ACQGPLPTTV GDFWQMIWEQ KSTVIAMMTQ EVEGEKIKCQ RYWPNILGKT TMVSNRLRLA 2350 2360 2370 2380 2390 2400 LVRMQQLKGF VVRAMTLEDI QTREVRHISH LNFTAWPDHD TPSQPDDLLT FISYMRHIHR 2410 2420 2430 2440 2450 2460 SGPIITHCSA GIGRSGTLIC IDVVLGLISQ DLDFDISDLV RCMRLQRHGM VQTEDQYIFC 2470 2480 YQVILYVLTR LQAEEEQKQQ PQLLK
	Isoform 2. Checksum: ABBFA4BCD60FF56F	FASTA	2,294	255,926
	10 20 30 40 50 60 MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS LADPAALGFI ISPWSLLLLP 70 80 90 100 110 120 SGSVSFTDEN ISNQDLRAFT APEVLQNQSL TSLSDVEKIH IYSLGMTLYW GADYEVPQSQ 130 140 150 160 170 180 PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSYVK HLVKLVLGNL 190 200 210 220 230 240 SGTDQLSCNS EQKPDRSQAI RDRLRGKGLP TGRSSTSDVL DIQKPPLSHQ TFLNKGLSKS 250 260 270 280 290 300 MGFLSIKDTQ DENYFKDILS DNSGREDSEN TFSPYQFKTS GPEKKPIPGI DVLSKKKIWA 310 320 330 340 350 360 SSMDLLCTAD RDFSSGETAT YRRCHPEAVT VRTSTTPRKK EARYSDGSIA LDIFGPQKMD 370 380 390 400 410 420 PIYHTRELPT SSAISSALDR IRERQKKLQV LREAMNVEEP VRRYKTYHGD VFSTSSESPS 430 440 450 460 470 480 IISSESDFRQ VRRSEASKRF ESSSGLPGVD ETLSQGQSQR PSRQYETPFE GNLINQEIML 490 500 510 520 530 540 KRQEEELMQL QAKMALRQSR LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG 550 560 570 580 590 600 PEFVKMTIEP FISLDLPRSI LTKKGKNEDN RRKVNIMLLN GQRLELTCDT KTICKDVFDM 610 620 630 640 650 660 VVAHIGLVEH HLFALATLKD NEYFFVDPDL KLTKVAPEGW KEEPKKKTKA TVNFTLFFRI 670 680 690 700 710 720 KFFMDDVSLI QHTLTCHQYY LQLRKDILEE RMHCDDETSL LLASLALQAE YGDYQPEVHG 730 740 750 760 770 780 VSYFRMEHYL PARVMEKLDL SYIKEELPKL HNTYVGASEK ETELEFLKVC QRLTEYGVHF 790 800 810 820 830 840 HRVHPEKKSQ TGILLGVCSK GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD 850 860 870 880 890 900 GIKHGFQTDN SKICQYLLHL CSYQHKFQLQ MRARQSNQDA QDIDVLHKRW SIVSSPEREI 910 920 930 940 950 960 TLVNLKKDAK YGLGFQIIGG EKMGRLDLGI FISSVAPGGP ADLDGCLKPG DRLISVNSVS 970 980 990 1000 1010 1020 LEGVSHHAAI EILQNAPEDV TLVISQPKEK ISKVPSTPVH LTNEMKNYMK KSSYMQDSAI 1030 1040 1050 1060 1070 1080 DSSSKDHHWS RGTLRHISEN SFGPSGGLRE GSLSSQDSRT ESASLSQSQV NGFFASHLGD 1090 1100 1110 1120 1130 1140 QTWQESQHGS PSPSVISKAT EKETFTDSNQ SKTKKPGISD VTDYSDRGDS DMDEATYSSS 1150 1160 1170 1180 1190 1200 QDHQTPKQES SSSVNTSNKM NFKTFSSSPP KPGDIFEVEL AKNDNSLGIS VTGGVNTSVR 1210 1220 1230 1240 1250 1260 HGGIYVKAVI PQGAAESDGR IHKGDRVLAV NGVSLEGATH KQAVETLRNT GQVVHLLLEK 1270 1280 1290 1300 1310 1320 GQSPTSKEHV PVTPQCTLSD QNAQGQGPEK VKKTTQVKDY SFVTEENTFE VKLFKNSSGL 1330 1340 1350 1360 1370 1380 GFSFSREDNL IPEQINASIV RVKKLFPGQP AAESGKIDVG DVILKVNGAS LKGLSQQEVI 1390 1400 1410 1420 1430 1440 SALRGTAPEV FLLLCRPPPG VLPEIDTALL TPLQSPAQVL PNSSKDSSQP SCVEQSTSSD 1450 1460 1470 1480 1490 1500 ENEMSDKSKK QCKSPSRRDS YSDSSGSGED DLVTAPANIS NSTWSSALHQ TLSNMVSQAQ 1510 1520 1530 1540 1550 1560 SHHEAPKSQE DTICTMFYYP QKIPNKPEFE DSNPSPLPPD MAPGQSYQPQ SESASSSSMD 1570 1580 1590 1600 1610 1620 KYHIHHISEP TRQENWTPLK NDLENHLEDF ELEVELLITL IKSEKGSLGF TVTKGNQRIG 1630 1640 1650 1660 1670 1680 CYVHDVIQDP AKSDGRLKPG DRLIKVNDTD VTNMTHTDAV NLLRAASKTV RLVIGRVLEL 1690 1700 1710 1720 1730 1740 PRIPMLPHLL PDITLTCNKE ELGFSLCGGH DSLYQVVYIS DINPRSVAAI EGNLQLLDVI 1750 1760 1770 1780 1790 1800 HYVNGVSTQG MTLEEVNRAL DMSLPSLVLK ATRNDLPVVP SSKRSAVSAP KSTKGNGSYS 1810 1820 1830 1840 1850 1860 VGSCSQPALT PNDSFSTVAG EEINEISYPK GKCSTYQIKG SPNLTLPKES YIQEDDIYDD 1870 1880 1890 1900 1910 1920 SQEAEVIQSL LDVVDEEAQN LLNENNAAGY SCGPGTLKMN GKLSEERTED TDCDGSPLPE 1930 1940 1950 1960 1970 1980 YFTEATKMNG CEEYCEEKVK SESLIQKPQE KKTDDDEITW GNDELPIERT NHEDSDKDHS 1990 2000 2010 2020 2030 2040 FLTNDELAVL PVVKVLPSGK YTGANLKSVI RVLRGLLDQG IPSKELENLQ ELKPLDQCLI 2050 2060 2070 2080 2090 2100 GQTKENRRKN RYKNILPYDA TRVPLGDEGG YINASFIKIP VGKEEFVYIA CQGPLPTTVG 2110 2120 2130 2140 2150 2160 DFWQMIWEQK STVIAMMTQE VEGEKIKCQR YWPNILGKTT MVSNRLRLAL VRMQQLKGFV 2170 2180 2190 2200 2210 2220 VRAMTLEDIQ TREVRHISHL NFTAWPDHDT PSQPDDLLTF ISYMRHIHRS GPIITHCSAG 2230 2240 2250 2260 2270 2280 IGRSGTLICI DVVLGLISQD LDFDISDLVR CMRLQRHGMV QTEDQYIFCY QVILYVLTRL 2290 QAEEEQKQQP QLLK
	Isoform 3. Checksum: 5BDCC226F2DEC19D	FASTA	2,466	274,932
	10 20 30 40 50 60 MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS LADPAALGFI ISPWSLLLLP 70 80 90 100 110 120 SGSVSFTDEN ISNQDLRAFT APEVLQNQSL TSLSDVEKIH IYSLGMTLYW GADYEVPQSQ 130 140 150 160 170 180 PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSYVK HLVKLVLGNL 190 200 210 220 230 240 SGTDQLSCNS EQKPDRSQAI RDRLRGKGLP TGRSSTSDVL DIQKPPLSHQ TFLNKGLSKS 250 260 270 280 290 300 MGFLSIKDTQ DENYFKDILS DNSGREDSEN TFSPYQFKTS GPEKKPIPGI DVLSKKKIWA 310 320 330 340 350 360 SSMDLLCTAD RDFSSGETAT YRRCHPEAVT VRTSTTPRKK EARYSDGSIA LDIFGPQKMD 370 380 390 400 410 420 PIYHTRELPT SSAISSALDR IRERQKKLQV LREAMNVEEP VRRYKTYHGD VFSTSSESPS 430 440 450 460 470 480 IISSESDFRQ VRRSEASKRF ESSSGLPGVD ETLSQGQSQR PSRQYETPFE GNLINQEIML 490 500 510 520 530 540 KRQEEELMQL QAKMALRQSR LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG 550 560 570 580 590 600 PEFVKMTIEP FISLDLPRSI LTKKGKNEDN RRKVNIMLLN GQRLELTCDT KTICKDVFDM 610 620 630 640 650 660 VVAHIGLVEH HLFALATLKD NEYFFVDPDL KLTKVAPEGW KEEPKKKTKA TVNFTLFFRI 670 680 690 700 710 720 KFFMDDVSLI QHTLTCHQYY LQLRKDILEE RMHCDDETSL LLASLALQAE YGDYQPEVHG 730 740 750 760 770 780 VSYFRMEHYL PARVMEKLDL SYIKEELPKL HNTYVGASEK ETELEFLKVC QRLTEYGVHF 790 800 810 820 830 840 HRVHPEKKSQ TGILLGVCSK GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD 850 860 870 880 890 900 GIKHGFQTDN SKICQYLLHL CSYQHKFQLQ MRARQSNQDA QDIERASFRS LNLQAESVRG 910 920 930 940 950 960 FNMGRAISTG SLASSTLNKL AVRPLSVQAE ILKRLSCSEL SLYQPLQNSS KEKNDKASWE 970 980 990 1000 1010 1020 EKPREMSKSY HDLSQASLYP HRKNVIVNME PPPQTVAELV GKPSHQMSRS DAESLAGVTK 1030 1040 1050 1060 1070 1080 LNNSKSVASL NRSPERRKHE SDSSSIEDPG QAYVLDVLHK RWSIVSSPER EITLVNLKKD 1090 1100 1110 1120 1130 1140 AKYGLGFQII GGEKMGRLDL GIFISSVAPG GPADLDGCLK PGDRLISVNS VSLEGVSHHA 1150 1160 1170 1180 1190 1200 AIEILQNAPE DVTLVISQPK EKISKVPSTP VHLTNEMKNY MKKSSYMQDS AIDSSSKDHH 1210 1220 1230 1240 1250 1260 WSRGTLRHIS ENSFGPSGGL REGSLSSQDS RTESASLSQS QVNGFFASHL GDQTWQESQH 1270 1280 1290 1300 1310 1320 GSPSPSVISK ATEKETFTDS NQSKTKKPGI SDVTDYSDRG DSDMDEATYS SSQDHQTPKQ 1330 1340 1350 1360 1370 1380 ESSSSVNTSN KMNFKTFSSS PPKPGDIFEV ELAKNDNSLG ISVTGGVNTS VRHGGIYVKA 1390 1400 1410 1420 1430 1440 VIPQGAAESD GRIHKGDRVL AVNGVSLEGA THKQAVETLR NTGQVVHLLL EKGQSPTSKE 1450 1460 1470 1480 1490 1500 HVPVTPQCTL SDQNAQGQGP EKVKKTTQVK DYSFVTEENT FEVKLFKNSS GLGFSFSRED 1510 1520 1530 1540 1550 1560 NLIPEQINAS IVRVKKLFPG QPAAESGKID VGDVILKVNG ASLKGLSQQE VISALRGTAP 1570 1580 1590 1600 1610 1620 EVFLLLCRPP PGVLPEIDTA LLTPLQSPAQ VLPNSSKDSS QPSCVEQSTS SDENEMSDKS 1630 1640 1650 1660 1670 1680 KKQCKSPSRR DSYSDSSGSG EDDLVTAPAN ISNSTWSSAL HQTLSNMVSQ AQSHHEAPKS 1690 1700 1710 1720 1730 1740 QEDTICTMFY YPQKIPNKPE FEDSNPSPLP PDMAPGQSYQ PQSESASSSS MDKYHIHHIS 1750 1760 1770 1780 1790 1800 EPTRQENWTP LKNDLENHLE DFELEVELLI TLIKSEKGSL GFTVTKGNQR IGCYVHDVIQ 1810 1820 1830 1840 1850 1860 DPAKSDGRLK PGDRLIKVND TDVTNMTHTD AVNLLRAASK TVRLVIGRVL ELPRIPMLPH 1870 1880 1890 1900 1910 1920 LLPDITLTCN KEELGFSLCG GHDSLYQVVY ISDINPRSVA AIEGNLQLLD VIHYVNGVST 1930 1940 1950 1960 1970 1980 QGMTLEEVNR ALDMSLPSLV LKATRNDLPV VPSSKRSAVS APKSTKGNGS YSVGSCSQPA 1990 2000 2010 2020 2030 2040 LTPNDSFSTV AGEEINEISY PKGKCSTYQI KGSPNLTLPK ESYIQEDDIY DDSQEAEVIQ 2050 2060 2070 2080 2090 2100 SLLDVVDEEA QNLLNENNAA GYSCGPGTLK MNGKLSEERT EDTDCDGSPL PEYFTEATKM 2110 2120 2130 2140 2150 2160 NGCEEYCEEK VKSESLIQKP QEKKTDDDEI TWGNDELPIE RTNHEDSDKD HSFLTNDELA 2170 2180 2190 2200 2210 2220 VLPVVKVLPS GKYTGANLKS VIRVLRGLLD QGIPSKELEN LQELKPLDQC LIGQTKENRR 2230 2240 2250 2260 2270 2280 KNRYKNILPY DATRVPLGDE GGYINASFIK IPVGKEEFVY IACQGPLPTT VGDFWQMIWE 2290 2300 2310 2320 2330 2340 QKSTVIAMMT QEVEGEKIKC QRYWPNILGK TTMVSNRLRL ALVRMQQLKG FVVRAMTLED 2350 2360 2370 2380 2390 2400 IQTREVRHIS HLNFTAWPDH DTPSQPDDLL TFISYMRHIH RSGPIITHCS AGIGRSGTLI 2410 2420 2430 2440 2450 2460 CIDVVLGLIS QDLDFDISDL VRCMRLQRHG MVQTEDQYIF CYQVILYVLT RLQAEEEQKQ QPQLLK
	Isoform 4. Checksum: 8D1FE03D9738A247	FASTA	2,490	277,508
	10 20 30 40 50 60 MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQELFRKVS LADPAALGFI ISPWSLLLLP 70 80 90 100 110 120 SGSVSFTDEN ISNQDLRAFT APEVLQNQSL TSLSDVEKIH IYSLGMTLYW GADYEVPQSQ 130 140 150 160 170 180 PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSYVK HLVKLVLGNL 190 200 210 220 230 240 SGTDQLSCNS EQKPDRSQAI RDRLRGKGLP TGRSSTSDVL DIQKPPLSHQ TFLNKGLSKS 250 260 270 280 290 300 MGFLSIKDTQ DENYFKDILS DNSGREDSEN TFSPYQFKTS GPEKKPIPGI DVLSKKKIWA 310 320 330 340 350 360 SSMDLLCTAD RDFSSGETAT YRRCHPEAVT VRTSTTPRKK EARYSDGSIA LDIFGPQKMD 370 380 390 400 410 420 PIYHTRELPT SSAISSALDR IRERQKKLQV LREAMNVEEP VRRYKTYHGD VFSTSSESPS 430 440 450 460 470 480 IISSESDFRQ VRRSEASKRF ESSSGLPGVD ETLSQGQSQR PSRQYETPFE GNLINQEIML 490 500 510 520 530 540 KRQEEELMQL QAKMALRQSR LSLYPGDTIK ASMLDITRDP LREIALETAM TQRKLRNFFG 550 560 570 580 590 600 PEFVKMTIEP FISLDLPRSI LTKKGKNEDN RRKVNIMLLN GQRLELTCDT KTICKDVFDM 610 620 630 640 650 660 VVAHIGLVEH HLFALATLKD NEYFFVDPDL KLTKVAPEGW KEEPKKKTKA TVNFTLFFRI 670 680 690 700 710 720 KFFMDDVSLI QHTLTCHQYY LQLRKDILEE RMHCDDETSL LLASLALQAE YGDYQPEVHG 730 740 750 760 770 780 VSYFRMEHYL PARVMEKLDL SYIKEELPKL HNTYVGASEK ETELEFLKVC QRLTEYGVHF 790 800 810 820 830 840 HRVHPEKKSQ TGILLGVCSK GVLVFEVHNG VRTLVLRFPW RETKKISFSK KKITLQNTSD 850 860 870 880 890 900 GIKHGFQTDN SKICQYLLHL CSYQHKFQLQ MRARQSNQDA QDIERASFRS LNLQAESVRG 910 920 930 940 950 960 FNMGRAISTG SLASSTLNKL AVRPLSVQAE ILKRLSCSEL SLYQPLQNSS KEKNDKASWE 970 980 990 1000 1010 1020 EKPREMSKSY HDLSQASLYP HRKNVIVNME PPPQTVAELV GKPSHQMSRS DAESLAGVTK 1030 1040 1050 1060 1070 1080 LNNSKSVASL NRSPERRKHE SDSSSIEDPG QAYVLGMTMH SSGNSSSQVP LKENDVLHKR 1090 1100 1110 1120 1130 1140 WSIVSSPERE ITLVNLKKDA KYGLGFQIIG GEKMGRLDLG IFISSVAPGG PADLDGCLKP 1150 1160 1170 1180 1190 1200 GDRLISVNSV SLEGVSHHAA IEILQNAPED VTLVISQPKE KISKVPSTPV HLTNEMKNYM 1210 1220 1230 1240 1250 1260 KKSSYMQDSA IDSSSKDHHW SRGTLRHISE NSFGPSGGLR EGSLSSQDSR TESASLSQSQ 1270 1280 1290 1300 1310 1320 VNGFFASHLG DQTWQESQHG SPSPSVISKA TEKETFTDSN QSKTKKPGIS DVTDYSDRGD 1330 1340 1350 1360 1370 1380 SDMDEATYSS SQDHQTPKQE SSSSVNTSNK MNFKTFSSSP PKPGDIFEVE LAKNDNSLGI 1390 1400 1410 1420 1430 1440 SVTVLFDKGG VNTSVRHGGI YVKAVIPQGA AESDGRIHKG DRVLAVNGVS LEGATHKQAV 1450 1460 1470 1480 1490 1500 ETLRNTGQVV HLLLEKGQSP TSKEHVPVTP QCTLSDQNAQ GQGPEKVKKT TQVKDYSFVT 1510 1520 1530 1540 1550 1560 EENTFEVKLF KNSSGLGFSF SREDNLIPEQ INASIVRVKK LFPGQPAAES GKIDVGDVIL 1570 1580 1590 1600 1610 1620 KVNGASLKGL SQQEVISALR GTAPEVFLLL CRPPPGVLPE IDTALLTPLQ SPAQVLPNSS 1630 1640 1650 1660 1670 1680 KDSSQPSCVE QSTSSDENEM SDKSKKQCKS PSRRDSYSDS SGSGEDDLVT APANISNSTW 1690 1700 1710 1720 1730 1740 SSALHQTLSN MVSQAQSHHE APKSQEDTIC TMFYYPQKIP NKPEFEDSNP SPLPPDMAPG 1750 1760 1770 1780 1790 1800 QSYQPQSESA SSSSMDKYHI HHISEPTRQE NWTPLKNDLE NHLEDFELEV ELLITLIKSE 1810 1820 1830 1840 1850 1860 KGSLGFTVTK GNQRIGCYVH DVIQDPAKSD GRLKPGDRLI KVNDTDVTNM THTDAVNLLR 1870 1880 1890 1900 1910 1920 AASKTVRLVI GRVLELPRIP MLPHLLPDIT LTCNKEELGF SLCGGHDSLY QVVYISDINP 1930 1940 1950 1960 1970 1980 RSVAAIEGNL QLLDVIHYVN GVSTQGMTLE EVNRALDMSL PSLVLKATRN DLPVVPSSKR 1990 2000 2010 2020 2030 2040 SAVSAPKSTK GNGSYSVGSC SQPALTPNDS FSTVAGEEIN EISYPKGKCS TYQIKGSPNL 2050 2060 2070 2080 2090 2100 TLPKESYIQE DDIYDDSQEA EVIQSLLDVV DEEAQNLLNE NNAAGYSCGP GTLKMNGKLS 2110 2120 2130 2140 2150 2160 EERTEDTDCD GSPLPEYFTE ATKMNGCEEY CEEKVKSESL IQKPQEKKTD DDEITWGNDE 2170 2180 2190 2200 2210 2220 LPIERTNHED SDKDHSFLTN DELAVLPVVK VLPSGKYTGA NLKSVIRVLR GLLDQGIPSK 2230 2240 2250 2260 2270 2280 ELENLQELKP LDQCLIGQTK ENRRKNRYKN ILPYDATRVP LGDEGGYINA SFIKIPVGKE 2290 2300 2310 2320 2330 2340 EFVYIACQGP LPTTVGDFWQ MIWEQKSTVI AMMTQEVEGE KIKCQRYWPN ILGKTTMVSN 2350 2360 2370 2380 2390 2400 RLRLALVRMQ QLKGFVVRAM TLEDIQTREV RHISHLNFTA WPDHDTPSQP DDLLTFISYM 2410 2420 2430 2440 2450 2460 RHIHRSGPII THCSAGIGRS GTLICIDVVL GLISQDLDFD ISDLVRCMRL QRHGMVQTED 2470 2480 2490 QYIFCYQVIL YVLTRLQAEE EQKQQPQLLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases." Banville D., Ahmad S., Stocco R., Shen S.-H. J. Biol. Chem. 269:22320-22327(1994) [PubMed: 8071359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Mammary carcinoma.
[2]	"Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats." Maekawa K., Imagawa N., Nagamatsu M., Harada S. FEBS Lett. 337:200-206(1994) [PubMed: 8287977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING. Tissue: Leukemia.
[3]	"Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins." Saras J., Claesson-Welsh L., Heldin C.-H., Gonez L.J. J. Biol. Chem. 269:24082-24089(1994) [PubMed: 7929060] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fibroblast.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1323-1922 (ISOFORM 1). Tissue: Brain and Eye.
[5]	Wang H.-Y. Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1216-2485. Tissue: Pancreas.
[6]	"FAP-1: a protein tyrosine phosphatase that associates with Fas." Sato T., Irie S., Kitada S., Reed J.C. Science 268:411-415(1995) [PubMed: 7536343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1279-1883 (ISOFORM 4). Tissue: Brain.
[7]	"Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation." Irie S., Hachiya T., Rabizadeh S., Maruyama W., Mukai J., Li Y., Reed J.C., Bredesen D.E., Sato T.A. FEBS Lett. 460:191-198(1999) [PubMed: 10544233] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1323-1821, INTERACTION WITH NGFR.
[8]	"A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1." Saras J., Franzen P., Aspenstroem P., Hellman U., Gonez L.J., Heldin C.-H. J. Biol. Chem. 272:24333-24338(1997) [PubMed: 9305890] [Abstract] Cited for: INTERACTION WITH ARHGAP29.
[9]	"ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E." Murthy K.K., Clark K., Fortin Y., Shen S.-H., Banville D. J. Biol. Chem. 274:20679-20687(1999) [PubMed: 10400701] [Abstract] Cited for: INTERACTION WITH TRIP6.
[10]	"Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1." Kimber W.A., Deak M., Prescott A.R., Alessi D.R. Biochem. J. 376:525-535(2003) [PubMed: 14516276] [Abstract] Cited for: INTERACTION WITH PLEKHA1 AND PLEKHA2.
[11]	"Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor." Kozlov G., Gehring K., Ekiel I. Biochemistry 39:2572-2580(2000) [PubMed: 10704206] [Abstract] Cited for: STRUCTURE BY NMR OF 1361-1456 UNCOMPLEXED AND IN COMPLEX WITH THE C-TERMINUS OF TNFRSF6.
[12]	"Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions." Kozlov G., Banville D., Gehring K., Ekiel I. J. Mol. Biol. 320:813-820(2002) [PubMed: 12095257] [Abstract] Cited for: STRUCTURE BY NMR OF 1361-1456 IN COMPLEX WITH THE C-TERMINUS OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR RA-GEF-2.
[13]	"Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." Yoshida S., Harada H., Nagai H., Fukino K., Teramoto A., Emi M. J. Hum. Genet. 47:614-619(2002) [PubMed: 12436199] [Abstract] Cited for: VARIANTS PRO-1419 AND MET-1522.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBLGenBankDDBJ

U12128 mRNA. Translation: AAB60339.1.
D21209 mRNA. Translation: BAA04750.1.
D21210 mRNA. Translation: BAA04751.1.
D21211 mRNA. Translation: BAA04752.1.
X80289 mRNA. Translation: CAA56563.1.
BC039610 mRNA. Translation: AAH39610.1. Sequence problems.
BC140777 mRNA. Translation: AAI40778.1.
X79676 mRNA. Translation: CAA56124.1.
L34583 mRNA. Translation: AAC41755.1.
AF233323 mRNA. Translation: AAF63474.1.

IPI

IPI00006714.
IPI00030246.
IPI00337648.
IPI00472958.

PIR

A54971.
I67629.
I67630.

RefSeq

NP_006255.1.
NP_542414.1.
NP_542415.1.
NP_542416.1.

UniGene

Hs.436142

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1D5G	NMR	-	A	1361-1456	[»]
1Q7X	NMR	-	A	1358-1459	[»]
1WCH	X-ray	1.85	A	2163-2477	[»]
3PDZ	NMR	-	A	1361-1456	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q12923. 5 interactions.

PTM databases

PhosphoSite

Q12923.

Proteomic databases

PRIDE

Q12923.

Genome annotation databases

Ensembl

ENSG00000163629. Homo sapiens. [Contig view]

GeneID

5783.

KEGG

hsa:5783.

Organism-specific databases

GeneCards

GC04P087817.

H-InvDB

HIX0004354.

HGNC

HGNC:9646. PTPN13.

HPA

CAB002213.

MIM

600267. gene.

PharmGKB

PA33988.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q12923.

OMA

Q12923. SQDSRTE.

Enzyme and pathway databases

BRENDA

3.1.3.48. 247.

Pathway_Interaction_DB

ephrinbrevpathway. Ephrin B reverse signaling.
faspathway. FAS signaling pathway (CD95).
fcer1pathway. Fc-epsilon receptor I signaling in mast cells.

Gene expression databases

ArrayExpress

Q12923.

Bgee

Q12923.

GermOnline

ENSG00000163629. Homo sapiens.

Family and domain databases

InterPro

IPR019749. Band_41_domain.
IPR019750. Band_41_sg.
IPR014352. FERM/acyl-CoA_bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011019. KIND.
IPR001478. PDZ/DHR/GLGF.
IPR011993. PH_type.
IPR000387. Tyr_Pase.
IPR016130. Tyr_Pase_AS.
IPR012153. Tyr_Pase_non-rcpt_typ-13.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Gene3D

G3DSA:1.20.80.10. ACBP. 1 hit.
G3DSA:2.30.29.30. PH_type. 1 hit.

Pfam

PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 4 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]

PIRSF

PIRSF000933. Tyr-Ptase_nr13. 1 hit.

PRINTS

PR00935. BAND41.
PR00700. PRTYPHPHTASE.

SMART

SM00295. B41. 1 hit.
SM00750. KIND. 1 hit.
SM00228. PDZ. 5 hits.
SM00194. PTPc. 1 hit.
[Graphical view]

PROSITE

PS00660. FERM_1. False negative.
PS00661. FERM_2. False negative.
PS50057. FERM_3. 1 hit.
PS51377. KIND. 1 hit.
PS50106. PDZ. 5 hits.
PS00383. TYR_PHOSPHATASE_1. False negative.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

ProtoNet

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Other Resources

NextBio

22492.

SOURCE

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Entry information

Entry name

PTN13_HUMAN

Accession

Primary (citable) accession number: Q12923
Secondary accession number(s): B2RTR0 , Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)