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Q12918

- KLRB1_HUMAN

UniProt

Q12918 - KLRB1_HUMAN

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Protein

Killer cell lectin-like receptor subfamily B member 1

Gene

KLRB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.3 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: ProtInc
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily B member 1
Alternative name(s):
C-type lectin domain family 5 member B
HNKR-P1a
Short name:
NKR-P1A
Natural killer cell surface protein P1A
CD_antigen: CD161
Gene namesi
Name:KLRB1
Synonyms:CLEC5B, NKRP1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6373. KLRB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini67 – 225159ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Killer cell lectin-like receptor subfamily B member 1PRO_0000260000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi94 ↔ 105PROSITE-ProRule annotation
Disulfide bondi122 ↔ 210PROSITE-ProRule annotation
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi189 ↔ 202PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated. Contains sialic acid residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ12918.
PRIDEiQ12918.

Expressioni

Tissue specificityi

Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.2 Publications

Inductioni

By IL12/interleukin-12 in NK cells.1 Publication

Gene expression databases

BgeeiQ12918.
CleanExiHS_KLRB1.
GenevestigatoriQ12918.

Organism-specific databases

HPAiHPA039113.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.4 Publications

Protein-protein interaction databases

IntActiQ12918. 1 interaction.
STRINGi9606.ENSP00000229402.

Structurei

3D structure databases

ProteinModelPortaliQ12918.
SMRiQ12918. Positions 92-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 211111C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307083.
GeneTreeiENSGT00730000110837.
HOGENOMiHOG000074586.
HOVERGENiHBG052267.
InParanoidiQ12918.
KOiK06543.
OMAiNNSLADC.
OrthoDBiEOG7KH9M1.
PhylomeDBiQ12918.
TreeFamiTF337735.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12918-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL
60 70 80 90 100
LVLVVTGLSV SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ
110 120 130 140 150
LREKCLLFSH TVNPWNNSLA DCSTKESSLL LIRDKDELIH TQNLIRDKAI
160 170 180 190 200
LFWIGLNFSL SEKNWKWING SFLNSNDLEI RGDAKENSCI SISQTSVYSE
210 220
YCSTEIRWIC QKELTPVRNK VYPDS
Length:225
Mass (Da):25,415
Last modified:November 1, 1996 - v1
Checksum:i01BFA925445B83B0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti168 – 1681I → T.1 Publication
Corresponds to variant rs1135816 [ dbSNP | Ensembl ].
VAR_028981

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11276 mRNA. Translation: AAA21605.1.
BC113997 mRNA. Translation: AAI13998.1.
BC114516 mRNA. Translation: AAI14517.1.
CCDSiCCDS8601.1.
PIRiI38700.
RefSeqiNP_002249.1. NM_002258.2.
UniGeneiHs.169824.

Genome annotation databases

EnsembliENST00000229402; ENSP00000229402; ENSG00000111796.
GeneIDi3820.
KEGGihsa:3820.
UCSCiuc010sgt.2. human.

Polymorphism databases

DMDMi74722301.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

NKRP1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11276 mRNA. Translation: AAA21605.1 .
BC113997 mRNA. Translation: AAI13998.1 .
BC114516 mRNA. Translation: AAI14517.1 .
CCDSi CCDS8601.1.
PIRi I38700.
RefSeqi NP_002249.1. NM_002258.2.
UniGenei Hs.169824.

3D structure databases

ProteinModelPortali Q12918.
SMRi Q12918. Positions 92-214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q12918. 1 interaction.
STRINGi 9606.ENSP00000229402.

Polymorphism databases

DMDMi 74722301.

Proteomic databases

PaxDbi Q12918.
PRIDEi Q12918.

Protocols and materials databases

DNASUi 3820.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229402 ; ENSP00000229402 ; ENSG00000111796 .
GeneIDi 3820.
KEGGi hsa:3820.
UCSCi uc010sgt.2. human.

Organism-specific databases

CTDi 3820.
GeneCardsi GC12M010497.
HGNCi HGNC:6373. KLRB1.
HPAi HPA039113.
MIMi 602890. gene.
neXtProti NX_Q12918.
PharmGKBi PA30162.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307083.
GeneTreei ENSGT00730000110837.
HOGENOMi HOG000074586.
HOVERGENi HBG052267.
InParanoidi Q12918.
KOi K06543.
OMAi NNSLADC.
OrthoDBi EOG7KH9M1.
PhylomeDBi Q12918.
TreeFami TF337735.

Miscellaneous databases

GeneWikii KLRB1.
GenomeRNAii 3820.
NextBioi 15015.
PROi Q12918.
SOURCEi Search...

Gene expression databases

Bgeei Q12918.
CleanExi HS_KLRB1.
Genevestigatori Q12918.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes."
    Lanier L.L., Chang C., Phillips J.H.
    J. Immunol. 153:2417-2428(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, HOMODIMERIZATION, TISSUE SPECIFICITY, FUNCTION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-168.
  3. "IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation."
    Poggi A., Costa P., Tomasello E., Moretta L.
    Eur. J. Immunol. 28:1611-1616(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY IL12.
  4. "CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver."
    Iiai T., Watanabe H., Suda T., Okamoto H., Abo T., Hatakeyama K.
    Clin. Exp. Immunol. 129:92-98(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: INTERACTION WITH CLEC2D.
  6. "Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor."
    Rosen D.B., Bettadapura J., Alsharifi M., Mathew P.A., Warren H.S., Lanier L.L.
    J. Immunol. 175:7796-7799(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC2D.
  7. "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase."
    Pozo D., Vales-Gomez M., Mavaddat N., Williamson S.C., Chisholm S.E., Reyburn H.
    J. Immunol. 176:2397-2406(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SMPD1.
  8. "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)."
    Christiansen D., Mouhtouris E., Milland J., Zingoni A., Santoni A., Sandrin M.S.
    Xenotransplantation 13:440-446(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A LECTIN.
  9. "Characterization of alternatively spliced transcript variants of CLEC2D gene."
    Germain C., Bihl F., Zahn S., Poupon G., Dumaurier M.J., Rampanarivo H.H., Padkjaer S.B., Spee P., Braud V.M.
    J. Biol. Chem. 285:36207-36215(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC2D.

Entry informationi

Entry nameiKLRB1_HUMAN
AccessioniPrimary (citable) accession number: Q12918
Secondary accession number(s): Q24K24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3