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Q12918

- KLRB1_HUMAN

UniProt

Q12918 - KLRB1_HUMAN

Protein

Killer cell lectin-like receptor subfamily B member 1

Gene

KLRB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.3 Publications

    GO - Molecular functioni

    1. carbohydrate binding Source: ProtInc
    2. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell lectin-like receptor subfamily B member 1
    Alternative name(s):
    C-type lectin domain family 5 member B
    HNKR-P1a
    Short name:
    NKR-P1A
    Natural killer cell surface protein P1A
    CD_antigen: CD161
    Gene namesi
    Name:KLRB1
    Synonyms:CLEC5B, NKRP1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6373. KLRB1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30162.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225Killer cell lectin-like receptor subfamily B member 1PRO_0000260000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi94 ↔ 105PROSITE-ProRule annotation
    Disulfide bondi122 ↔ 210PROSITE-ProRule annotation
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi189 ↔ 202PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated. Contains sialic acid residues.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ12918.
    PRIDEiQ12918.

    Expressioni

    Tissue specificityi

    Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.2 Publications

    Inductioni

    By IL12/interleukin-12 in NK cells.1 Publication

    Gene expression databases

    BgeeiQ12918.
    CleanExiHS_KLRB1.
    GenevestigatoriQ12918.

    Organism-specific databases

    HPAiHPA039113.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.4 Publications

    Protein-protein interaction databases

    IntActiQ12918. 1 interaction.
    STRINGi9606.ENSP00000229402.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12918.
    SMRiQ12918. Positions 92-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini67 – 225159ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 211111C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307083.
    HOGENOMiHOG000074586.
    HOVERGENiHBG052267.
    InParanoidiQ12918.
    KOiK06543.
    OMAiNNSLADC.
    OrthoDBiEOG7KH9M1.
    PhylomeDBiQ12918.
    TreeFamiTF337735.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12918-1 [UniParc]FASTAAdd to Basket

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    MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL    50
    LVLVVTGLSV SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ 100
    LREKCLLFSH TVNPWNNSLA DCSTKESSLL LIRDKDELIH TQNLIRDKAI 150
    LFWIGLNFSL SEKNWKWING SFLNSNDLEI RGDAKENSCI SISQTSVYSE 200
    YCSTEIRWIC QKELTPVRNK VYPDS 225
    Length:225
    Mass (Da):25,415
    Last modified:November 1, 1996 - v1
    Checksum:i01BFA925445B83B0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti168 – 1681I → T.1 Publication
    Corresponds to variant rs1135816 [ dbSNP | Ensembl ].
    VAR_028981

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11276 mRNA. Translation: AAA21605.1.
    BC113997 mRNA. Translation: AAI13998.1.
    BC114516 mRNA. Translation: AAI14517.1.
    CCDSiCCDS8601.1.
    PIRiI38700.
    RefSeqiNP_002249.1. NM_002258.2.
    UniGeneiHs.169824.

    Genome annotation databases

    EnsembliENST00000229402; ENSP00000229402; ENSG00000111796.
    GeneIDi3820.
    KEGGihsa:3820.
    UCSCiuc010sgt.2. human.

    Polymorphism databases

    DMDMi74722301.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    NKRP1

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11276 mRNA. Translation: AAA21605.1 .
    BC113997 mRNA. Translation: AAI13998.1 .
    BC114516 mRNA. Translation: AAI14517.1 .
    CCDSi CCDS8601.1.
    PIRi I38700.
    RefSeqi NP_002249.1. NM_002258.2.
    UniGenei Hs.169824.

    3D structure databases

    ProteinModelPortali Q12918.
    SMRi Q12918. Positions 92-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q12918. 1 interaction.
    STRINGi 9606.ENSP00000229402.

    Polymorphism databases

    DMDMi 74722301.

    Proteomic databases

    PaxDbi Q12918.
    PRIDEi Q12918.

    Protocols and materials databases

    DNASUi 3820.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229402 ; ENSP00000229402 ; ENSG00000111796 .
    GeneIDi 3820.
    KEGGi hsa:3820.
    UCSCi uc010sgt.2. human.

    Organism-specific databases

    CTDi 3820.
    GeneCardsi GC12M010255.
    HGNCi HGNC:6373. KLRB1.
    HPAi HPA039113.
    MIMi 602890. gene.
    neXtProti NX_Q12918.
    PharmGKBi PA30162.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307083.
    HOGENOMi HOG000074586.
    HOVERGENi HBG052267.
    InParanoidi Q12918.
    KOi K06543.
    OMAi NNSLADC.
    OrthoDBi EOG7KH9M1.
    PhylomeDBi Q12918.
    TreeFami TF337735.

    Miscellaneous databases

    GeneWikii KLRB1.
    GenomeRNAii 3820.
    NextBioi 15015.
    PROi Q12918.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q12918.
    CleanExi HS_KLRB1.
    Genevestigatori Q12918.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes."
      Lanier L.L., Chang C., Phillips J.H.
      J. Immunol. 153:2417-2428(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, HOMODIMERIZATION, TISSUE SPECIFICITY, FUNCTION.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-168.
    3. "IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation."
      Poggi A., Costa P., Tomasello E., Moretta L.
      Eur. J. Immunol. 28:1611-1616(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY IL12.
    4. "CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver."
      Iiai T., Watanabe H., Suda T., Okamoto H., Abo T., Hatakeyama K.
      Clin. Exp. Immunol. 129:92-98(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. Cited for: INTERACTION WITH CLEC2D.
    6. "Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor."
      Rosen D.B., Bettadapura J., Alsharifi M., Mathew P.A., Warren H.S., Lanier L.L.
      J. Immunol. 175:7796-7799(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLEC2D.
    7. "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase."
      Pozo D., Vales-Gomez M., Mavaddat N., Williamson S.C., Chisholm S.E., Reyburn H.
      J. Immunol. 176:2397-2406(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SMPD1.
    8. "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)."
      Christiansen D., Mouhtouris E., Milland J., Zingoni A., Santoni A., Sandrin M.S.
      Xenotransplantation 13:440-446(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A LECTIN.
    9. "Characterization of alternatively spliced transcript variants of CLEC2D gene."
      Germain C., Bihl F., Zahn S., Poupon G., Dumaurier M.J., Rampanarivo H.H., Padkjaer S.B., Spee P., Braud V.M.
      J. Biol. Chem. 285:36207-36215(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLEC2D.

    Entry informationi

    Entry nameiKLRB1_HUMAN
    AccessioniPrimary (citable) accession number: Q12918
    Secondary accession number(s): Q24K24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3