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Protein

Lymphoid-restricted membrane protein

Gene

LRMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.

GO - Biological processi

  • immune system process Source: UniProtKB-KW
  • single fertilization Source: UniProtKB-KW
  • vesicle fusion Source: ProtInc
  • vesicle targeting Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Fertilization, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphoid-restricted membrane protein
Alternative name(s):
Protein Jaw1
Cleaved into the following chain:
Gene namesi
Name:LRMP
Synonyms:JAW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6690. LRMP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 495495CytoplasmicSequence analysisAdd
BLAST
Transmembranei496 – 51621Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini517 – 55539LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • microtubule organizing center Source: UniProtKB-SubCell
  • nuclear envelope Source: UniProtKB-SubCell
  • spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30450.

Polymorphism and mutation databases

BioMutaiLRMP.
DMDMi317373427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Lymphoid-restricted membrane proteinPRO_0000084483Add
BLAST
Chaini1 – ?Processed lymphoid-restricted membrane proteinPRO_0000296244

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911PhosphothreonineCombined sources
Modified residuei363 – 3631PhosphoserineCombined sources
Modified residuei370 – 3701PhosphoserineCombined sources
Modified residuei424 – 4241PhosphoserineBy similarity

Post-translational modificationi

The removal of the C-terminal lumenal domain occurs by proteolytic processing.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ12912.
MaxQBiQ12912.
PaxDbiQ12912.
PeptideAtlasiQ12912.
PRIDEiQ12912.

PTM databases

iPTMnetiQ12912.
PhosphoSiteiQ12912.

Expressioni

Tissue specificityi

Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles.2 Publications

Gene expression databases

BgeeiENSG00000118308.
CleanExiHS_LRMP.
ExpressionAtlasiQ12912. baseline and differential.
GenevisibleiQ12912. HS.

Organism-specific databases

HPAiHPA002967.
HPA018505.

Interactioni

Subunit structurei

Interacts (via coiled-coil domain) with ITPR3.By similarity

Protein-protein interaction databases

BioGridi110213. 3 interactions.
IntActiQ12912. 6 interactions.
STRINGi9606.ENSP00000346442.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili227 – 341115Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi351 – 3544Poly-Asp

Sequence similaritiesi

Belongs to the LRMP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGGG. Eukaryota.
ENOG4112CA2. LUCA.
GeneTreeiENSGT00530000063722.
HOGENOMiHOG000169746.
HOVERGENiHBG079425.
InParanoidiQ12912.
OMAiLEHILWP.
OrthoDBiEOG091G0JV9.
PhylomeDBiQ12912.
TreeFamiTF331789.

Family and domain databases

InterProiIPR008677. MRVI1.
[Graphical view]
PANTHERiPTHR15352. PTHR15352. 1 hit.
PfamiPF05781. MRVI1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN
60 70 80 90 100
LSGCIRMNDD PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS
110 120 130 140 150
SDPGLEILNM ASCDLDRNSL CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD
160 170 180 190 200
STSKDKTILN LEAKEEPETI EEHKKEHASG DSVVSPLPVT TVKSVNLRQS
210 220 230 240 250
ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD LAEENLKKEI
260 270 280 290 300
TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA
310 320 330 340 350
INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE
360 370 380 390 400
DDDDCQIKKR SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR
410 420 430 440 450
RSSSWRILGS KQSEHRPSLP RFISTYSWAD AEEEKCELKT KDDSEPSGEE
460 470 480 490 500
TVERTRKPSL SEKKNNPSKW DVSSVYDTIA SWATNLKSSI RKANKALWLS
510 520 530 540 550
IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI LWPFTRLRHN

GPPPV
Length:555
Mass (Da):62,122
Last modified:January 11, 2011 - v3
Checksum:iFAFA4B94DCEB1A42
GO
Isoform 2 (identifier: Q12912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:499
Mass (Da):56,213
Checksum:i4AAED58CD8C43B9E
GO

Sequence cautioni

The sequence AAH29391 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAI26418 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811E → G in AAA21604 (PubMed:8021504).Curated
Sequence conflicti113 – 1131C → R in BAG64339 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941T → A.
Corresponds to variant rs6487451 [ dbSNP | Ensembl ].
VAR_054545
Natural varianti197 – 1971L → V.3 Publications
Corresponds to variant rs7969931 [ dbSNP | Ensembl ].
VAR_054546
Natural varianti241 – 2411L → W.1 Publication
Corresponds to variant rs1063159 [ dbSNP | Ensembl ].
VAR_054547
Natural varianti253 – 2531C → S.2 Publications
Corresponds to variant rs1908946 [ dbSNP | Ensembl ].
VAR_054548

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5656Missing in isoform 2. 1 PublicationVSP_036471Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10485 mRNA. Translation: AAA21604.1.
AK303256 mRNA. Translation: BAG64339.1.
AC023510 Genomic DNA. No translation available.
BC029391 mRNA. Translation: AAH29391.1. Sequence problems.
BC126417 mRNA. Translation: AAI26418.1. Different initiation.
CCDSiCCDS8701.1. [Q12912-2]
PIRiI38656.
RefSeqiNP_001191055.1. NM_001204126.1. [Q12912-2]
NP_001191056.1. NM_001204127.1. [Q12912-2]
NP_006143.2. NM_006152.3. [Q12912-2]
XP_005253427.1. XM_005253370.3. [Q12912-2]
XP_005253429.1. XM_005253372.2. [Q12912-2]
XP_005253431.1. XM_005253374.3. [Q12912-2]
XP_006719139.1. XM_006719076.2. [Q12912-2]
XP_011518969.1. XM_011520667.1. [Q12912-2]
UniGeneiHs.124922.

Genome annotation databases

EnsembliENST00000354454; ENSP00000346442; ENSG00000118308. [Q12912-2]
ENST00000547044; ENSP00000450246; ENSG00000118308. [Q12912-2]
ENST00000548766; ENSP00000446496; ENSG00000118308. [Q12912-2]
GeneIDi4033.
KEGGihsa:4033.
UCSCiuc001rgh.4. human. [Q12912-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10485 mRNA. Translation: AAA21604.1.
AK303256 mRNA. Translation: BAG64339.1.
AC023510 Genomic DNA. No translation available.
BC029391 mRNA. Translation: AAH29391.1. Sequence problems.
BC126417 mRNA. Translation: AAI26418.1. Different initiation.
CCDSiCCDS8701.1. [Q12912-2]
PIRiI38656.
RefSeqiNP_001191055.1. NM_001204126.1. [Q12912-2]
NP_001191056.1. NM_001204127.1. [Q12912-2]
NP_006143.2. NM_006152.3. [Q12912-2]
XP_005253427.1. XM_005253370.3. [Q12912-2]
XP_005253429.1. XM_005253372.2. [Q12912-2]
XP_005253431.1. XM_005253374.3. [Q12912-2]
XP_006719139.1. XM_006719076.2. [Q12912-2]
XP_011518969.1. XM_011520667.1. [Q12912-2]
UniGeneiHs.124922.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110213. 3 interactions.
IntActiQ12912. 6 interactions.
STRINGi9606.ENSP00000346442.

PTM databases

iPTMnetiQ12912.
PhosphoSiteiQ12912.

Polymorphism and mutation databases

BioMutaiLRMP.
DMDMi317373427.

Proteomic databases

EPDiQ12912.
MaxQBiQ12912.
PaxDbiQ12912.
PeptideAtlasiQ12912.
PRIDEiQ12912.

Protocols and materials databases

DNASUi4033.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354454; ENSP00000346442; ENSG00000118308. [Q12912-2]
ENST00000547044; ENSP00000450246; ENSG00000118308. [Q12912-2]
ENST00000548766; ENSP00000446496; ENSG00000118308. [Q12912-2]
GeneIDi4033.
KEGGihsa:4033.
UCSCiuc001rgh.4. human. [Q12912-1]

Organism-specific databases

CTDi4033.
GeneCardsiLRMP.
HGNCiHGNC:6690. LRMP.
HPAiHPA002967.
HPA018505.
MIMi602003. gene.
neXtProtiNX_Q12912.
PharmGKBiPA30450.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGGG. Eukaryota.
ENOG4112CA2. LUCA.
GeneTreeiENSGT00530000063722.
HOGENOMiHOG000169746.
HOVERGENiHBG079425.
InParanoidiQ12912.
OMAiLEHILWP.
OrthoDBiEOG091G0JV9.
PhylomeDBiQ12912.
TreeFamiTF331789.

Miscellaneous databases

ChiTaRSiLRMP. human.
GenomeRNAii4033.
PROiQ12912.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118308.
CleanExiHS_LRMP.
ExpressionAtlasiQ12912. baseline and differential.
GenevisibleiQ12912. HS.

Family and domain databases

InterProiIPR008677. MRVI1.
[Graphical view]
PANTHERiPTHR15352. PTHR15352. 1 hit.
PfamiPF05781. MRVI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRMP_HUMAN
AccessioniPrimary (citable) accession number: Q12912
Secondary accession number(s): A0AVM2, B4E077, Q8N301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-57 is the initiator methionine. However, according to PubMed:8021504, the initiator methionine is coded by a non-canonical CTG leucine codon; This leucine codon is in an excellent Kozak consensus located 39 bp upstream of the corresponding first mouse ATG.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.