Q12912 (LRMP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lymphoid-restricted membrane protein

Alternative name(s):
Protein Jaw1

Cleaved into the following chain:

1. Processed lymphoid-restricted membrane protein

Gene names

Name:	LRMP
Synonyms:	JAW1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Processed lymphoid-restricted membrane protein: Cytoplasm By similarity Ref.1. Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity Ref.1.
Tissue specificity	Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Ref.1
Post-translational modification	The removal of the C-terminal lumenal domain occurs by proteolytic processing By similarity.
Caution	It is uncertain whether Met-1 or Met-57 is the initiator methionine. However, according to Ref.1, the initiator methionine is coded by a non-canonical CTG leucine codon; This leucine codon is in an excellent Kozak consensus located 39 bp upstream of the corresponding first mouse ATG.
Sequence caution	The sequence AAH29391.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame. The sequence AAI26418.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	vesicle fusion Traceable author statement Ref.1. Source: ProtInc vesicle targeting Traceable author statement Ref.1. Source: ProtInc
Cellular_component	endoplasmic reticulum membrane Traceable author statement PubMed 8798562. Source: ProtInc integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12912-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12912-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Lymphoid-restricted membrane protein		PRO_0000084483
	Chain	1 – ?		Processed lymphoid-restricted membrane protein		PRO_0000296244
Regions
	Topological domain	1 – 495	495	Cytoplasmic Potential
	Transmembrane	496 – 516	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	517 – 555	39	Lumenal Potential
	Coiled coil	227 – 341	115	Potential
	Compositional bias	351 – 354	4	Poly-Asp
Amino acid modifications
	Modified residue	366	1	Phosphoserine By similarity
	Modified residue	370	1	Phosphoserine By similarity
	Modified residue	375	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1 – 56	56	Missing in isoform 2.		VSP_036471
	Natural variant	94	1	T → A. Corresponds to variant rs6487451 [ dbSNP | Ensembl ].		VAR_054545
	Natural variant	197	1	L → V. Ref.1 Ref.2 Ref.4 Corresponds to variant rs7969931 [ dbSNP | Ensembl ].		VAR_054546
	Natural variant	241	1	L → W. Ref.1 Corresponds to variant rs1063159 [ dbSNP | Ensembl ].		VAR_054547
	Natural variant	253	1	C → S. Ref.1 Ref.4 Corresponds to variant rs1908946 [ dbSNP | Ensembl ].		VAR_054548
Experimental info
	Sequence conflict	81	1	E → G in AAA21604. Ref.1
	Sequence conflict	113	1	C → R in BAG64339. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: FAFA4B94DCEB1A42	FASTA	555	62,122
	10 20 30 40 50 60 MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN LSGCIRMNDD 70 80 90 100 110 120 PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS SDPGLEILNM ASCDLDRNSL 130 140 150 160 170 180 CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD STSKDKTILN LEAKEEPETI EEHKKEHASG 190 200 210 220 230 240 DSVVSPLPVT TVKSVNLRQS ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD 250 260 270 280 290 300 LAEENLKKEI TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA 310 320 330 340 350 360 INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE DDDDCQIKKR 370 380 390 400 410 420 SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR RSSSWRILGS KQSEHRPSLP 430 440 450 460 470 480 RFISTYSWAD AEEEKCELKT KDDSEPSGEE TVERTRKPSL SEKKNNPSKW DVSSVYDTIA 490 500 510 520 530 540 SWATNLKSSI RKANKALWLS IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI 550 LWPFTRLRHN GPPPV
	Isoform 2 [UniParc]. Checksum: 4AAED58CD8C43B9E	FASTA	499	56,213
	10 20 30 40 50 60 MNDDPSMEEN GVERVCPESL LQSREYSSLP LPRHTSSTDG TITSSDPGLE ILNMASCDLD 70 80 90 100 110 120 RNSLCKKEED TRSASPTIEA QGTSPAHDNI AFQDSTSKDK TILNLEAKEE PETIEEHKKE 130 140 150 160 170 180 HASGDSVVSP LPVTTVKSVN LRQSENTSAN EKEVEAEFLR LSLGFKCDWF TLEKRVKLEE 190 200 210 220 230 240 RSRDLAEENL KKEITNCLKL LESLTPLCED DNQAQEIIKK LEKSIKFLSQ CAARVASRAE 250 260 270 280 290 300 MLGAINQESR VSKAVEVMIQ HVENLKRMYA KEHAELEELK QVLLQNERSF NPLEDDDDCQ 310 320 330 340 350 360 IKKRSASLNS KPSSLRRVTI ASLPRNIGNA GMVAGMENND RFSRRSSSWR ILGSKQSEHR 370 380 390 400 410 420 PSLPRFISTY SWADAEEEKC ELKTKDDSEP SGEETVERTR KPSLSEKKNN PSKWDVSSVY 430 440 450 460 470 480 DTIASWATNL KSSIRKANKA LWLSIAFIVL FAALMSFLTG QLFQKSVDAA PTQQEDSWTS 490 LEHILWPFTR LRHNGPPPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Jaw1, a lymphoid-restricted membrane protein localized to the endoplasmic reticulum." Behrens T.W., Jagadeesh J., Scherle P., Kearns G., Yewdell J., Staudt L.M. J. Immunol. 153:682-690(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-197; TRP-241 AND SER-253.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-197. Tissue: Thymus.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-197 AND SER-253. Tissue: Brain and Testis.
[5]	Bienvenut W.V. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 165-193; 209-216; 223-230; 283-290; 295-306; 310-322; 345-358; 374-381; 422-435 AND 470-487, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10485 mRNA. Translation: AAA21604.1. AK303256 mRNA. Translation: BAG64339.1. AC023510 Genomic DNA. No translation available. BC029391 mRNA. Translation: AAH29391.1. Sequence problems. BC126417 mRNA. Translation: AAI26418.1. Different initiation.
IPI	IPI00006158. IPI00477421.
PIR	I38656.
RefSeq	NP_001191055.1. NM_001204126.1. NP_001191056.1. NM_001204127.1. NP_006143.2. NM_006152.3.
UniGene	Hs.124922.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q12912. 6 interactions.
STRING	9606.ENSP00000354805.
PTM databases
PhosphoSite	Q12912.
Polymorphism databases
DMDM	224471845.
Proteomic databases
PaxDb	Q12912.
PRIDE	Q12912.
Protocols and materials databases
DNASU	4033.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354454; ENSP00000346442; ENSG00000118308. ENST00000547044; ENSP00000450246; ENSG00000118308. ENST00000548766; ENSP00000446496; ENSG00000118308.
GeneID	4033.
KEGG	hsa:4033.
UCSC	uc001rgh.3. human.
Organism-specific databases
CTD	4033.
GeneCards	GC12P025205.
HGNC	HGNC:6690. LRMP.
HPA	HPA002967. HPA018505.
MIM	602003. gene.
neXtProt	NX_Q12912.
PharmGKB	PA30450.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40887.
HOGENOM	HOG000169746.
HOVERGEN	HBG079425.
InParanoid	Q12912.
OMA	YDTIASW.
OrthoDB	EOG441QC8.
Gene expression databases
ArrayExpress	Q12912.
Bgee	Q12912.
CleanEx	HS_LRMP.
Genevestigator	Q12912.
GermOnline	ENSG00000118308. Homo sapiens.
Family and domain databases
InterPro	IPR008677. MRVI1. [Graphical view]
PANTHER	PTHR15352. PTHR15352. 1 hit.
Pfam	PF05781. MRVI1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LRMP. human.
GenomeRNAi	4033.
NextBio	15798.
SOURCE	Search...

Entry information

Entry name

LRMP_HUMAN

Accession

Primary (citable) accession number: Q12912
Secondary accession number(s): A0AVM2, B4E077, Q8N301

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.