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Protein

Interleukin enhancer-binding factor 3

Gene

ILF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).By similarity2 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • double-stranded RNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129351-MONOMER.
SIGNORiQ12906.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 3
Alternative name(s):
Double-stranded RNA-binding protein 76
Short name:
DRBP76
M-phase phosphoprotein 4
Short name:
MPP4
Nuclear factor associated with dsRNA
Short name:
NFAR
Nuclear factor of activated T-cells 90 kDa
Short name:
NF-AT-90
Translational control protein 80
Short name:
TCP80
Gene namesi
Name:ILF3
Synonyms:DRBF, MPHOSPH4, NF90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6038. ILF3.

Subcellular locationi

  • Nucleusnucleolus
  • Cytoplasm
  • Nucleus

  • Note: Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrion Source: HPA
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3609.
OpenTargetsiENSG00000129351.
PharmGKBiPA29853.

Polymorphism and mutation databases

BioMutaiILF3.
DMDMi62512150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260701 – 894Interleukin enhancer-binding factor 3Add BLAST894

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei188Phosphothreonine; by PKR1 Publication1
Modified residuei190PhosphoserineCombined sources1
Modified residuei315Phosphothreonine; by PKR1 Publication1
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei382PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei460N6-acetyllysineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Modified residuei592PhosphothreonineCombined sources1
Modified residuei792PhosphoserineCombined sources1
Modified residuei810PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Isoform 4 (identifier: Q12906-4)
Modified residuei482PhosphoserineCombined sources1
Isoform 6 (identifier: Q12906-6)
Modified residuei482PhosphoserineCombined sources1
Isoform 7 (identifier: Q12906-7)
Modified residuei482PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.1 Publication
Methylated by protein arginine N-methyltransferase 1.
Arg-609 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ12906.
MaxQBiQ12906.
PaxDbiQ12906.
PeptideAtlasiQ12906.
PRIDEiQ12906.
TopDownProteomicsiQ12906-1. [Q12906-1]

2D gel databases

SWISS-2DPAGEQ12906.

PTM databases

iPTMnetiQ12906.
PhosphoSitePlusiQ12906.
SwissPalmiQ12906.

Miscellaneous databases

PMAP-CutDBQ12906.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000129351.
ExpressionAtlasiQ12906. baseline and differential.
GenevisibleiQ12906. HS.

Organism-specific databases

HPAiHPA001897.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2.11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NSP034963EBI-78756,EBI-2547442From a different organism.
PRMT1Q998732EBI-78756,EBI-78738
VP35Q051276EBI-78756,EBI-6148294From a different organism.

Protein-protein interaction databases

BioGridi109822. 345 interactors.
DIPiDIP-29853N.
IntActiQ12906. 87 interactors.
MINTiMINT-4999319.
STRINGi9606.ENSP00000404121.

Structurei

Secondary structure

1894
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi528 – 535Combined sources8
Beta strandi541 – 548Combined sources8
Beta strandi554 – 561Combined sources8
Beta strandi564 – 572Combined sources9
Helixi573 – 588Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L33NMR-A521-600[»]
3P1XX-ray1.90A/B520-594[»]
ProteinModelPortaliQ12906.
SMRiQ12906.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12906.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 378DZFPROSITE-ProRule annotationAdd BLAST374
Domaini398 – 467DRBM 1PROSITE-ProRule annotationAdd BLAST70
Domaini524 – 590DRBM 2PROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni609 – 894Interaction with PRMT11 PublicationAdd BLAST286

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi371 – 389Bipartite nuclear localization signalSequence analysisAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi385 – 389Poly-Lys5
Compositional biasi634 – 637Poly-Pro4
Compositional biasi640 – 659Arg/Gly-richAdd BLAST20
Compositional biasi701 – 709Poly-Gly9
Compositional biasi794 – 798Poly-Gly5

Sequence similaritiesi

Contains 2 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation
Contains 1 DZF domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3792. Eukaryota.
ENOG410XPBY. LUCA.
GeneTreeiENSGT00550000074528.
HOVERGENiHBG069915.
InParanoidiQ12906.
KOiK13090.
OMAiQSQYSNY.
OrthoDBiEOG091G022L.
PhylomeDBiQ12906.
TreeFamiTF320194.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR014720. dsRBD_dom.
IPR006561. DZF_dom.
IPR033099. ILF3/NF90.
[Graphical view]
PANTHERiPTHR10910:SF34. PTHR10910:SF34. 2 hits.
PfamiPF00035. dsrm. 2 hits.
PF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
SM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 2 hits.
PS51703. DZF. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12906-1) [UniParc]FASTAAdd to basket
Also known as: NFAR-2, ILF3-E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPMRIFVND DRHVMAKHSS VYPTQEELEA VQNMVSHTER ALKAVSDWID
60 70 80 90 100
EQEKGSSEQA ESDNMDVPPE DDSKEGAGEQ KTEHMTRTLR GVMRVGLVAK
110 120 130 140 150
GLLLKGDLDL ELVLLCKEKP TTALLDKVAD NLAIQLAAVT EDKYEILQSV
160 170 180 190 200
DDAAIVIKNT KEPPLSLTIH LTSPVVREEM EKVLAGETLS VNDPPDVLDR
210 220 230 240 250
QKCLAALASL RHAKWFQARA NGLKSCVIVI RVLRDLCTRV PTWGPLRGWP
260 270 280 290 300
LELLCEKSIG TANRPMGAGE ALRRVLECLA SGIVMPDGSG IYDPCEKEAT
310 320 330 340 350
DAIGHLDRQQ REDITQSAQH ALRLAAFGQL HKVLGMDPLP SKMPKKPKNE
360 370 380 390 400
NPVDYTVQIP PSTTYAITPM KRPMEEDGEE KSPSKKKKKI QKKEEKAEPP
410 420 430 440 450
QAMNALMRLN QLKPGLQYKL VSQTGPVHAP IFTMSVEVDG NSFEASGPSK
460 470 480 490 500
KTAKLHVAVK VLQDMGLPTG AEGRDSSKGE DSAEETEAKP AVVAPAPVVE
510 520 530 540 550
AVSTPSAAFP SDATAEQGPI LTKHGKNPVM ELNEKRRGLK YELISETGGS
560 570 580 590 600
HDKRFVMEVE VDGQKFQGAG SNKKVAKAYA ALAALEKLFP DTPLALDANK
610 620 630 640 650
KKRAPVPVRG GPKFAAKPHN PGFGMGGPMH NEVPPPPNLR GRGRGGSIRG
660 670 680 690 700
RGRGRGFGGA NHGGYMNAGA GYGSYGYGGN SATAGYSQFY SNGGHSGNAS
710 720 730 740 750
GGGGGGGGGS SGYGSYYQGD NYNSPVPPKH AGKKQPHGGQ QKPSYGSGYQ
760 770 780 790 800
SHQGQQQSYN QSPYSNYGPP QGKQKGYNHG QGSYSYSNSY NSPGGGGGSD
810 820 830 840 850
YNYESKFNYS GSGGRSGGNS YGSGGASYNP GSHGGYGGGS GGGSSYQGKQ
860 870 880 890
GGYSQSNYNS PGSGQNYSGP PSSYQSSQGG YGRNADHSMN YQYR
Length:894
Mass (Da):95,338
Last modified:April 12, 2005 - v3
Checksum:i20903ABD0331F370
GO
Isoform 2 (identifier: Q12906-2) [UniParc]FASTAAdd to basket
Also known as: NFAR-1, DRBP76

The sequence of this isoform differs from the canonical sequence as follows:
     688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS
     703-894: Missing.

Show »
Length:702
Mass (Da):76,033
Checksum:i3DDE63929988DED4
GO
Isoform 3 (identifier: Q12906-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-764: YSNGGHSGNA...QQQSYNQSPY → SRPPPPSRPR...LRVSGNSVCL
     765-894: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:764
Mass (Da):82,802
Checksum:i3C7C7565F5980B1E
GO
Isoform 4 (identifier: Q12906-4) [UniParc]FASTAAdd to basket
Also known as: DRBP76 Alpha, ILF3-A

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ
     688-694: QFYSNGG → KCAFLSV
     695-894: Missing.

Show »
Length:698
Mass (Da):75,508
Checksum:iF4ECBD8A7C428905
GO
Isoform 5 (identifier: Q12906-5) [UniParc]FASTAAdd to basket
Also known as: DRBP76 Delta, Gamma, ILF3-C

The sequence of this isoform differs from the canonical sequence as follows:
     687-690: SQFY → TGFV
     691-894: Missing.

Show »
Length:690
Mass (Da):74,607
Checksum:i8DEC4DC15E80A8C5
GO
Isoform 6 (identifier: Q12906-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ
     688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS
     703-894: Missing.

Show »
Length:706
Mass (Da):76,502
Checksum:iBC0B5D61BC51129C
GO
Isoform 7 (identifier: Q12906-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ

Note: Gene prediction based on EST data.Combined sources
Show »
Length:898
Mass (Da):95,808
Checksum:i83A1755F05408949
GO

Sequence cautioni

The sequence AAA20994 differs from that shown. Sequencing errors.Curated
The sequence AAH48314 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101G → C in AAD51098 (PubMed:11438536).Curated1
Sequence conflicti101G → C in AAD51099 (PubMed:11438536).Curated1
Sequence conflicti101G → C in AAK07424 (PubMed:11161820).Curated1
Sequence conflicti101G → C in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti260G → V in AAD33966 (PubMed:10400669).Curated1
Sequence conflicti260G → V in CAA66918 (PubMed:8885239).Curated1
Sequence conflicti647S → T in AAD33966 (PubMed:10400669).Curated1
Sequence conflicti647S → T in AAK07424 (PubMed:11161820).Curated1
Sequence conflicti647S → T in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti688 – 689QF → N in AAF82687 (Ref. 13) Curated2
Sequence conflicti763P → L in CAC01407 (PubMed:11167023).Curated1
Sequence conflicti797G → R in CAC01124 (PubMed:11167023).Curated1
Sequence conflicti797G → R in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti799S → SGS in AAF82685 (Ref. 13) Curated1
Sequence conflicti813G → E in AAK07425 (PubMed:11161820).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02215950D → H.1 PublicationCorresponds to variant rs1064493dbSNPEnsembl.1
Natural variantiVAR_048906501A → S.Corresponds to variant rs34520379dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003883516E → ENVKQ in isoform 4, isoform 6 and isoform 7. 3 Publications1
Alternative sequenceiVSP_003886687 – 690SQFY → TGFV in isoform 5. 1 Publication4
Alternative sequenceiVSP_003888688 – 702QFYSN…NASGG → DFFTDCYGYHDFGSS in isoform 2 and isoform 6. 7 PublicationsAdd BLAST15
Alternative sequenceiVSP_003884688 – 694QFYSNGG → KCAFLSV in isoform 4. 1 Publication7
Alternative sequenceiVSP_003890690 – 764YSNGG…NQSPY → SRPPPPSRPRCCVVRCSGSP CGPSCDPYLAVFGTPCLQWF VSCHYNFVWVEFLSFCSSVS LCLFTLRVSGNSVCL in isoform 3. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_003887691 – 894Missing in isoform 5. 1 PublicationAdd BLAST204
Alternative sequenceiVSP_003885695 – 894Missing in isoform 4. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_003889703 – 894Missing in isoform 2 and isoform 6. 7 PublicationsAdd BLAST192
Alternative sequenceiVSP_003891765 – 894Missing in isoform 3. 2 PublicationsAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10324 mRNA. Translation: AAA20994.1. Sequence problems.
AF147209 mRNA. Translation: AAD33966.1.
AF141870 mRNA. Translation: AAD37575.1.
AJ271741 Genomic DNA. Translation: CAC01121.1.
AJ271741 Genomic DNA. Translation: CAC01122.1.
AJ271741 Genomic DNA. Translation: CAC01123.1.
AJ271741 Genomic DNA. Translation: CAC01124.1.
AJ271744 mRNA. Translation: CAC01404.1.
AJ271745 mRNA. Translation: CAC01405.1.
AJ271746 mRNA. Translation: CAC01406.1.
AJ271747 mRNA. Translation: CAC01407.1.
AF167569 mRNA. Translation: AAD51098.1.
AF167570 mRNA. Translation: AAD51099.1.
AF320244
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243 Genomic DNA. Translation: AAK07424.1.
AF320247
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243, AF320245, AF320246 Genomic DNA. Translation: AAK07425.1.
AK291617 mRNA. Translation: BAF84306.1.
AC011475 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84132.1.
BC048314 mRNA. Translation: AAH48314.1. Sequence problems.
BC064836 mRNA. Translation: AAH64836.1.
X98264 mRNA. Translation: CAA66917.1.
X98265 mRNA. Translation: CAA66918.1.
AF202445 Genomic DNA. Translation: AAF82685.1.
AF202445 Genomic DNA. Translation: AAF82686.1.
AF202445 Genomic DNA. Translation: AAF82687.1.
AF007140 mRNA. Translation: AAC19152.1.
CCDSiCCDS12246.1. [Q12906-1]
CCDS12247.1. [Q12906-2]
CCDS45965.1. [Q12906-7]
CCDS45966.1. [Q12906-5]
CCDS45967.1. [Q12906-6]
PIRiB54857.
RefSeqiNP_001131145.1. NM_001137673.1. [Q12906-6]
NP_004507.2. NM_004516.3. [Q12906-2]
NP_036350.2. NM_012218.3. [Q12906-1]
NP_060090.2. NM_017620.2. [Q12906-7]
NP_703194.1. NM_153464.2. [Q12906-5]
XP_011526286.2. XM_011527984.2. [Q12906-7]
XP_016882252.1. XM_017026763.1. [Q12906-7]
UniGeneiHs.465885.

Genome annotation databases

EnsembliENST00000250241; ENSP00000250241; ENSG00000129351. [Q12906-5]
ENST00000407004; ENSP00000384660; ENSG00000129351. [Q12906-6]
ENST00000449870; ENSP00000404121; ENSG00000129351. [Q12906-7]
ENST00000588657; ENSP00000468181; ENSG00000129351. [Q12906-7]
ENST00000589998; ENSP00000465219; ENSG00000129351. [Q12906-2]
ENST00000590261; ENSP00000468156; ENSG00000129351. [Q12906-1]
ENST00000592763; ENSP00000465515; ENSG00000129351. [Q12906-4]
GeneIDi3609.
KEGGihsa:3609.
UCSCiuc002mpl.3. human. [Q12906-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10324 mRNA. Translation: AAA20994.1. Sequence problems.
AF147209 mRNA. Translation: AAD33966.1.
AF141870 mRNA. Translation: AAD37575.1.
AJ271741 Genomic DNA. Translation: CAC01121.1.
AJ271741 Genomic DNA. Translation: CAC01122.1.
AJ271741 Genomic DNA. Translation: CAC01123.1.
AJ271741 Genomic DNA. Translation: CAC01124.1.
AJ271744 mRNA. Translation: CAC01404.1.
AJ271745 mRNA. Translation: CAC01405.1.
AJ271746 mRNA. Translation: CAC01406.1.
AJ271747 mRNA. Translation: CAC01407.1.
AF167569 mRNA. Translation: AAD51098.1.
AF167570 mRNA. Translation: AAD51099.1.
AF320244
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243 Genomic DNA. Translation: AAK07424.1.
AF320247
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243, AF320245, AF320246 Genomic DNA. Translation: AAK07425.1.
AK291617 mRNA. Translation: BAF84306.1.
AC011475 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84132.1.
BC048314 mRNA. Translation: AAH48314.1. Sequence problems.
BC064836 mRNA. Translation: AAH64836.1.
X98264 mRNA. Translation: CAA66917.1.
X98265 mRNA. Translation: CAA66918.1.
AF202445 Genomic DNA. Translation: AAF82685.1.
AF202445 Genomic DNA. Translation: AAF82686.1.
AF202445 Genomic DNA. Translation: AAF82687.1.
AF007140 mRNA. Translation: AAC19152.1.
CCDSiCCDS12246.1. [Q12906-1]
CCDS12247.1. [Q12906-2]
CCDS45965.1. [Q12906-7]
CCDS45966.1. [Q12906-5]
CCDS45967.1. [Q12906-6]
PIRiB54857.
RefSeqiNP_001131145.1. NM_001137673.1. [Q12906-6]
NP_004507.2. NM_004516.3. [Q12906-2]
NP_036350.2. NM_012218.3. [Q12906-1]
NP_060090.2. NM_017620.2. [Q12906-7]
NP_703194.1. NM_153464.2. [Q12906-5]
XP_011526286.2. XM_011527984.2. [Q12906-7]
XP_016882252.1. XM_017026763.1. [Q12906-7]
UniGeneiHs.465885.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L33NMR-A521-600[»]
3P1XX-ray1.90A/B520-594[»]
ProteinModelPortaliQ12906.
SMRiQ12906.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109822. 345 interactors.
DIPiDIP-29853N.
IntActiQ12906. 87 interactors.
MINTiMINT-4999319.
STRINGi9606.ENSP00000404121.

PTM databases

iPTMnetiQ12906.
PhosphoSitePlusiQ12906.
SwissPalmiQ12906.

Polymorphism and mutation databases

BioMutaiILF3.
DMDMi62512150.

2D gel databases

SWISS-2DPAGEQ12906.

Proteomic databases

EPDiQ12906.
MaxQBiQ12906.
PaxDbiQ12906.
PeptideAtlasiQ12906.
PRIDEiQ12906.
TopDownProteomicsiQ12906-1. [Q12906-1]

Protocols and materials databases

DNASUi3609.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250241; ENSP00000250241; ENSG00000129351. [Q12906-5]
ENST00000407004; ENSP00000384660; ENSG00000129351. [Q12906-6]
ENST00000449870; ENSP00000404121; ENSG00000129351. [Q12906-7]
ENST00000588657; ENSP00000468181; ENSG00000129351. [Q12906-7]
ENST00000589998; ENSP00000465219; ENSG00000129351. [Q12906-2]
ENST00000590261; ENSP00000468156; ENSG00000129351. [Q12906-1]
ENST00000592763; ENSP00000465515; ENSG00000129351. [Q12906-4]
GeneIDi3609.
KEGGihsa:3609.
UCSCiuc002mpl.3. human. [Q12906-1]

Organism-specific databases

CTDi3609.
DisGeNETi3609.
GeneCardsiILF3.
H-InvDBHIX0014753.
HGNCiHGNC:6038. ILF3.
HPAiHPA001897.
MIMi603182. gene.
neXtProtiNX_Q12906.
OpenTargetsiENSG00000129351.
PharmGKBiPA29853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3792. Eukaryota.
ENOG410XPBY. LUCA.
GeneTreeiENSGT00550000074528.
HOVERGENiHBG069915.
InParanoidiQ12906.
KOiK13090.
OMAiQSQYSNY.
OrthoDBiEOG091G022L.
PhylomeDBiQ12906.
TreeFamiTF320194.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129351-MONOMER.
SIGNORiQ12906.

Miscellaneous databases

ChiTaRSiILF3. human.
EvolutionaryTraceiQ12906.
GeneWikiiILF3.
GenomeRNAii3609.
PMAP-CutDBQ12906.
PROiQ12906.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129351.
ExpressionAtlasiQ12906. baseline and differential.
GenevisibleiQ12906. HS.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR014720. dsRBD_dom.
IPR006561. DZF_dom.
IPR033099. ILF3/NF90.
[Graphical view]
PANTHERiPTHR10910:SF34. PTHR10910:SF34. 2 hits.
PfamiPF00035. dsrm. 2 hits.
PF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
SM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 2 hits.
PS51703. DZF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILF3_HUMAN
AccessioniPrimary (citable) accession number: Q12906
Secondary accession number(s): A8K6F2
, G5E9M5, O43409, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 185 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.