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UniProtKB/Swiss-Prot Q12906 (ILF3_HUMAN)
Last modified
July 7, 2009.
Version 104.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
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Names and origin
| Protein names | Recommended name: Interleukin enhancer-binding factor 3 Alternative name(s): Nuclear factor of activated T-cells 90 kDa Short name=NF-AT-90 Double-stranded RNA-binding protein 76 Short name=DRBP76 Translational control protein 80 Short name=TCP80 Nuclear factor associated with dsRNA Short name=NFAR M-phase phosphoprotein 4 Short name=MPP4 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 894 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Ref.1 Ref.10 |
| Subunit structure | Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Ref.10 Ref.13 Ref.14 Ref.15 Ref.17 Ref.19 |
| Subcellular location | |
| Tissue specificity | Ubiquitous. |
| Post-translational modification | Phosphorylated by RNA-dependent protein kinase (EIF2AK2). Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Methylated by protein arginine N-methyltransferase 1. Ref.20 Arg-609 is dimethylated, probably to asymmetric dimethylarginine. Ref.20 |
| Sequence similarities | Contains 2 DRBM (double-stranded RNA-binding) domains. Contains 1 DZF domain. |
| Sequence caution | The sequence AAA20994.1 differs from that shown. Reason: Miscellaneous discrepancy. Sequencing errors. The sequence AAH48314.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| NDRG1 | Q92597 | 1 | EBI-288405,EBI-716486 | |
| PRMT1 | Q99873 | 2 | EBI-78756,EBI-78738 |
Alternative products
| This entry describes 6 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q12906-1) Also known as: NFAR-2; ILF3-E; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q12906-2) Also known as: NFAR-1; DRBP76; The sequence of this isoform differs from the canonical sequence as follows: 688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS 703-894: Missing. | ||||||
| Isoform 3 (identifier: Q12906-3) The sequence of this isoform differs from the canonical sequence as follows: 690-764: YSNGGHSGNA...QQQSYNQSPY → SRPPPPSRPR...LRVSGNSVCL 765-894: Missing. | ||||||
| Isoform 4 (identifier: Q12906-4) Also known as: DRBP76 Alpha; ILF3-A; The sequence of this isoform differs from the canonical sequence as follows: 516-516: E → ENVKQ 688-694: QFYSNGG → KCAFLSV 695-894: Missing. | ||||||
| Isoform 5 (identifier: Q12906-5) Also known as: DRBP76 Delta; Gamma; ILF3-C; The sequence of this isoform differs from the canonical sequence as follows: 687-690: SQFY → TGFV 691-894: Missing. | ||||||
| Isoform 6 (identifier: Q12906-6) The sequence of this isoform differs from the canonical sequence as follows: 516-516: E → ENVKQ 688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS 703-894: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 894 | 894 | Interleukin enhancer-binding factor 3 | PRO_0000126070 | |||||
Regions | |||||||||
| Domain | 94 – 342 | 249 | DZF | ||||||
| Domain | 398 – 467 | 70 | DRBM 1 | ||||||
| Domain | 524 – 590 | 67 | DRBM 2 | ||||||
| Region | 609 – 894 | 286 | Interaction with PRMT1 | ||||||
| Motif | 371 – 389 | 19 | Bipartite nuclear localization signal Potential | ||||||
| Compositional bias | 385 – 389 | 5 | Poly-Lys | ||||||
| Compositional bias | 634 – 637 | 4 | Poly-Pro | ||||||
| Compositional bias | 640 – 659 | 20 | Arg/Gly-rich | ||||||
| Compositional bias | 701 – 709 | 9 | Poly-Gly | ||||||
| Compositional bias | 794 – 798 | 5 | Poly-Gly | ||||||
Amino acid modifications | |||||||||
| Modified residue | 62 | 1 | Phosphoserine Ref.21 | ||||||
| Modified residue | 190 | 1 | Phosphoserine Ref.23 Ref.28 | ||||||
| Modified residue | 382 | 1 | Phosphoserine Ref.22 Ref.23 Ref.26 | ||||||
| Modified residue | 384 | 1 | Phosphoserine Ref.26 | ||||||
| Modified residue | 482 | 1 | Phosphoserine Ref.23 Ref.28 | ||||||
| Modified residue | 486 | 1 | Phosphothreonine Ref.27 | ||||||
| Modified residue | 579 | 1 | Phosphotyrosine Ref.28 | ||||||
| Modified residue | 592 | 1 | Phosphothreonine Ref.21 Ref.23 Ref.24 Ref.25 Ref.28 | ||||||
| Modified residue | 609 | 1 | Omega-N-methylated arginine Ref.20 | ||||||
| Modified residue | 792 | 1 | Phosphoserine Ref.28 | ||||||
| Modified residue | 810 | 1 | Phosphoserine Ref.28 | ||||||
| Modified residue | 812 | 1 | Phosphoserine Ref.25 Ref.28 | ||||||
Natural variations | |||||||||
| Alternative sequence | 516 | 1 | E → ENVKQ in isoform 4 and isoform 6. | VSP_003883 | |||||
| Alternative sequence | 687 – 690 | 4 | SQFY → TGFV in isoform 5. | VSP_003886 | |||||
| Alternative sequence | 688 – 702 | 15 | QFYSN…NASGG → DFFTDCYGYHDFGSS in isoform 2 and isoform 6. | VSP_003888 | |||||
| Alternative sequence | 688 – 694 | 7 | QFYSNGG → KCAFLSV in isoform 4. | VSP_003884 | |||||
| Alternative sequence | 690 – 764 | 75 | YSNGG…NQSPY → SRPPPPSRPRCCVVRCSGSP CGPSCDPYLAVFGTPCLQWF VSCHYNFVWVEFLSFCSSVS LCLFTLRVSGNSVCL in isoform 3. | VSP_003890 | |||||
| Alternative sequence | 691 – 894 | 204 | Missing in isoform 5. | VSP_003887 | |||||
| Alternative sequence | 695 – 894 | 200 | Missing in isoform 4. | VSP_003885 | |||||
| Alternative sequence | 703 – 894 | 192 | Missing in isoform 2 and isoform 6. | VSP_003889 | |||||
| Alternative sequence | 765 – 894 | 130 | Missing in isoform 3. | VSP_003891 | |||||
| Natural variant | 50 | 1 | D → H: dbSNP rs1064493. Ref.6 | VAR_022159 | |||||
| Natural variant | 501 | 1 | A → S: dbSNP rs34520379. | VAR_048906 | |||||
Experimental info | |||||||||
| Sequence conflict | 101 | 1 | G → C Ref.5 | ||||||
| Sequence conflict | 101 | 1 | G → C Ref.6 | ||||||
| Sequence conflict | 260 | 1 | G → V in AAD33966. Ref.2 | ||||||
| Sequence conflict | 260 | 1 | G → V in CAA66918. Ref.9 | ||||||
| Sequence conflict | 647 | 1 | S → T Ref.2 | ||||||
| Sequence conflict | 647 | 1 | S → T Ref.6 | ||||||
| Sequence conflict | 688 – 689 | 2 | QF → N in AAF82687. Ref.11 | ||||||
| Sequence conflict | 763 | 1 | P → L in CAC01407. Ref.4 | ||||||
| Sequence conflict | 797 | 1 | G → R in CAC01124. Ref.4 | ||||||
| Sequence conflict | 797 | 1 | G → R in AAK07425. Ref.6 | ||||||
| Sequence conflict | 799 | 1 | S → SGS in AAF82685. Ref.11 | ||||||
| Sequence conflict | 813 | 1 | G → E in AAK07425. Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90." Kao P.N., Chen L., Brock G., Ng J., Kenny J., Smith A.J., Corthesy B. J. Biol. Chem. 269:20691-20699(1994) [PubMed: 7519613] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-41; 491-510 AND 555-565, FUNCTION. Tissue: T-cell lymphoma. |
| [2] | "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR." Patel R.C., Vestal D.J., Xu Z., Bandyopadhyay S., Guo W., Erme S.M., Williams B.R., Sen G.C. J. Biol. Chem. 274:20432-20437(1999) [PubMed: 10400669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Cervix carcinoma. |
| [3] | "Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs." Xu Y.-H., Grabowski G.A. Mol. Genet. Metab. 68:441-454(1999) [PubMed: 10607473] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), CHARACTERIZATION. Tissue: Liver. |
| [4] | "Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene." Duchange N., Pidoux J., Camus E., Sauvaget D. Gene 261:345-353(2000) [PubMed: 11167023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 4 AND 5), ALTERNATIVE SPLICING. Tissue: Melanoma. |
| [5] | "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR." Saunders L.R., Perkins D.J., Balachandran S., Michaels R., Ford R., Mayeda A., Barber G.N. J. Biol. Chem. 276:32300-32312(2001) [PubMed: 11438536] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION. |
| [6] | "The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13." Saunders L.R., Jurecic V., Barber G.N. Genomics 71:256-259(2001) [PubMed: 11161820] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANT HIS-50. Tissue: T-cell. |
| [7] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Placenta. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Duodenum and Uterus. |
| [9] | "Identification of novel M phase phosphoproteins by expression cloning." Matsumoto-Taniura N., Pirollet F., Monroe R., Gerace L., Westendorf J.M. Mol. Biol. Cell 7:1455-1469(1996) [PubMed: 8885239] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-611. Tissue: Blood and Cervix. |
| [10] | "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45." Ting N.S.Y., Kao P.N., Chan D.W., Lintott L.G., Lees-Miller S.P. J. Biol. Chem. 273:2136-2145(1998) [PubMed: 9442054] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-10, FUNCTION, INTERACTION WITH G22P1; PRKDC AND XRCC5. |
| [11] | "Structure and functional characterization of hDRBF gene." MacArdle J., Cantarella G.M., Veyrune J.-L., Krasnoselskaya I., Kumar A. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 188-894 (ISOFORMS 1; 2 AND 3). |
| [12] | Yu W., Sarginson J., Gibbs R.A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 587-894 (ISOFORM 1). Tissue: Brain. |
| [13] | "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity." Satoh M., Shaheen V.M., Kao P.N., Okano T., Shaw M., Yoshida H., Richards H.B., Reeves W.H. J. Biol. Chem. 274:34598-34604(1999) [PubMed: 10574923] [Abstract] Cited for: INTERACTION WITH ILF2. |
| [14] | "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3." Tang J., Kao P.N., Herschman H.R. J. Biol. Chem. 275:19866-19876(2000) [PubMed: 10749851] [Abstract] Cited for: INTERACTION WITH PRMT1. |
| [15] | "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins." Brownawell A.M., Macara I.G. J. Cell Biol. 156:53-64(2002) [PubMed: 11777942] [Abstract] Cited for: IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX WITH XPO5; RAN AND DOUBLE-STRANDED RNA, INTERACTION WITH XPO5. |
| [16] | "Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed: 12429849] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [17] | "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells." Reichman T.W., Muniz L.C., Mathews M.B. Mol. Cell. Biol. 22:343-356(2002) [PubMed: 11739746] [Abstract] Cited for: INTERACTION WITH ILF2. |
| [18] | "Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3." Gwizdek C., Ossareh-Nazari B., Brownawell A.M., Evers S., Macara I.G., Dargemont C. J. Biol. Chem. 279:884-891(2004) [PubMed: 14570900] [Abstract] Cited for: IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX WITH XPO5; RAN AND VA1 RNA. |
| [19] | "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5." Chen T., Brownawell A.M., Macara I.G. Mol. Cell. Biol. 24:6608-6619(2004) [PubMed: 15254228] [Abstract] Cited for: IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX WITH XPO5; RAN; ZNF346 AND DOUBLE-STRANDED RNA, INTERACTION WITH XPO5 AND ZNF346. |
| [20] | "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC." Ong S.E., Mittler G., Mann M. Nat. Methods 1:119-126(2004) [PubMed: 15782174] [Abstract] Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-609, MASS SPECTROMETRY. |
| [21] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND THR-592, MASS SPECTROMETRY. Tissue: Epithelium. |
| [22] | "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry." Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J., Bodenmiller B., Watts J.D., Hood L., Aebersold R. Nat. Methods 2:591-598(2005) [PubMed: 16094384] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382, MASS SPECTROMETRY. Tissue: T-cell. |
| [23] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190; SER-382; SER-482 AND THR-592, MASS SPECTROMETRY. Tissue: Epithelium. |
| [24] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-592, MASS SPECTROMETRY. Tissue: Epithelium. |
| [25] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-592 AND SER-812, MASS SPECTROMETRY. Tissue: Epithelium. |
| [26] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND SER-384, MASS SPECTROMETRY. |
| [27] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-486, MASS SPECTROMETRY. |
| [28] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190; SER-482; TYR-579; THR-592; SER-792; SER-810 AND SER-812, MASS SPECTROMETRY. |
| [29] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U10324 mRNA. Translation: AAA20994.1. Sequence problems. AF147209 mRNA. Translation: AAD33966.1. AF141870 mRNA. Translation: AAD37575.1. AJ271741 Genomic DNA. Translation: CAC01121.1. AJ271741 Genomic DNA. Translation: CAC01122.1. AJ271741 Genomic DNA. Translation: CAC01123.1. AJ271741 Genomic DNA. Translation: CAC01124.1. AJ271744 mRNA. Translation: CAC01404.1. AJ271745 mRNA. Translation: CAC01405.1. AJ271746 mRNA. Translation: CAC01406.1. AJ271747 mRNA. Translation: CAC01407.1. AF167569 mRNA. Translation: AAD51098.1. AF167570 mRNA. Translation: AAD51099.1. AF320244 AF320243 Genomic DNA. Translation: AAK07424.1. AF320247 AF320246 Genomic DNA. Translation: AAK07425.1. AK291617 mRNA. Translation: BAF84306.1. BC048314 mRNA. Translation: AAH48314.1. Sequence problems. BC064836 mRNA. Translation: AAH64836.1. X98264 mRNA. Translation: CAA66917.1. X98265 mRNA. Translation: CAA66918.1. AF202445 Genomic DNA. Translation: AAF82685.1. AF202445 Genomic DNA. Translation: AAF82686.1. AF202445 Genomic DNA. Translation: AAF82687.1. AF007140 mRNA. Translation: AAC19152.1. | |
| IPI | IPI00219330. IPI00298788. IPI00298789. IPI00414335. IPI00418313. IPI00556173. |
| PIR | B54857. |
| RefSeq | NP_001131145.1. NP_004507.2. NP_036350.2. NP_060090.2. NP_703194.1. |
| UniGene | Hs.465885 |
3D structure databases | |
| SMR | Q12906. Positions 403-470. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q12906. 6 interactions. |
PTM databases | |
| PhosphoSite | Q12906. |
2-D gel databases | |
| SWISS-2DPAGE | Q12906. |
Proteomic databases | |
| PRIDE | Q12906. |
Genome annotation databases | |
| Ensembl | ENSG00000129351. Homo sapiens. [Contig view] |
| GeneID | 3609. |
| KEGG | hsa:3609. |
| UCSC | uc002mpk.1. human. uc002mpl.1. human. uc002mpm.1. human. uc002mpn.1. human. uc002mpo.1. human. |
Organism-specific databases | |
| GeneCards | GC19P010625. |
| H-InvDB | HIX0014753. |
| HGNC | HGNC:6038. ILF3. |
| HPA | HPA001897. |
| MIM | 603182. gene. |
| PharmGKB | PA29853. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q12906. |
| OMA | Q12906. DYNYESK. |
Gene expression databases | |
| ArrayExpress | Q12906. |
| Bgee | Q12906. |
| GermOnline | ENSG00000129351. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001159. Ds-RNA_bd. IPR006561. DZF. [Graphical view] |
| Pfam | PF00035. dsrm. 2 hits. PF07528. DZF. 1 hit. [Graphical view] |
| SMART | SM00358. DSRM. 2 hits. SM00572. DZF. 1 hit. [Graphical view] |
| PROSITE | PS50137. DS_RBD. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 14109. |
| PMAP-CutDB | Q12906. |
| SOURCE | Search... |
Entry information
| Entry name | ILF3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q12906 Secondary accession number(s): A8K6F2 Q9UNA2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


