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Protein

Interleukin enhancer-binding factor 2

Gene

ILF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.4 Publications

GO - Molecular functioni

  • ATP binding Source: InterPro
  • DNA binding Source: UniProtKB
  • double-stranded RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transferase activity Source: InterPro

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 2
Alternative name(s):
Nuclear factor of activated T-cells 45 kDa
Gene namesi
Name:ILF2
Synonyms:NF45
ORF Names:PRO3063
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143621.16
HGNCiHGNC:6037 ILF2
MIMi603181 gene
neXtProtiNX_Q12905

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3608
OpenTargetsiENSG00000143621
PharmGKBiPA29852

Polymorphism and mutation databases

BioMutaiILF2
DMDMi62510764

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260631 – 390Interleukin enhancer-binding factor 2Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei16Omega-N-methylarginine; alternateCombined sources1
Modified residuei24Omega-N-methylarginineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei388PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ12905
MaxQBiQ12905
PaxDbiQ12905
PeptideAtlasiQ12905
PRIDEiQ12905

2D gel databases

SWISS-2DPAGEiQ12905

PTM databases

iPTMnetiQ12905
PhosphoSitePlusiQ12905
SwissPalmiQ12905

Expressioni

Gene expression databases

BgeeiENSG00000143621
CleanExiHS_ILF2
ExpressionAtlasiQ12905 baseline and differential
GenevisibleiQ12905 HS

Organism-specific databases

HPAiHPA007484

Interactioni

Subunit structurei

Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPIDQ087524EBI-357925,EBI-716596

Protein-protein interaction databases

BioGridi109821, 295 interactors
CORUMiQ12905
IntActiQ12905, 85 interactors
MINTiQ12905
STRINGi9606.ENSP00000355011

Structurei

3D structure databases

ProteinModelPortaliQ12905
SMRiQ12905
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 371DZFPROSITE-ProRule annotationAdd BLAST348

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi366 – 372Poly-Glu7
Compositional biasi381 – 384Poly-Glu4

Phylogenomic databases

eggNOGiKOG3793 Eukaryota
ENOG410XQCJ LUCA
GeneTreeiENSGT00550000074528
HOVERGENiHBG052120
InParanoidiQ12905
KOiK13089
OMAiYEKPPER
OrthoDBiEOG091G0HP1
PhylomeDBiQ12905
TreeFamiTF320194

Family and domain databases

InterProiView protein in InterPro
IPR006116 2-5-oligoadenylate_synth_N
IPR006561 DZF_dom
PfamiView protein in Pfam
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS51703 DZF, 1 hit

Sequencei

Sequence statusi: Complete.

Q12905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE
60 70 80 90 100
TSFSEALLKR NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE
110 120 130 140 150
EVRQVGSYKK GTMTTGHNVA DLVVILKILP TLEAVAALGN KVVESLRAQD
160 170 180 190 200
PSEVLTMLTN ETGFEISSSD ATVKILITTV PPNLRKLDPE LHLDIKVLQS
210 220 230 240 250
ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL TPWILDLLGH
260 270 280 290 300
YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT
310 320 330 340 350
VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI
360 370 380 390
VTPSEKAYEK PPEKKEGEEE EENTEEPPQG EEEESMETQE
Length:390
Mass (Da):43,062
Last modified:April 12, 2005 - v2
Checksum:i75BAD022DCD4EE01
GO

Sequence cautioni

The sequence AAA20993 differs from that shown. Reason: Frameshift at position 376.Curated
The sequence AAF29591 differs from that shown. Chimeric cDNA.Curated
The sequence CAI13611 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10323 mRNA Translation: AAA20993.1 Frameshift.
AY099265 Genomic DNA Translation: AAM45141.1
AK313364 mRNA Translation: BAG36164.1
AL713889 Genomic DNA Translation: CAI13610.1
AL713889 Genomic DNA Translation: CAI13611.1 Sequence problems.
AL713889, AL592150 Genomic DNA Translation: CAI13612.1
AL592150, AL713889 Genomic DNA Translation: CAI18796.1
CH471121 Genomic DNA Translation: EAW53286.1
BC000382 mRNA Translation: AAH00382.1
AF113702 mRNA Translation: AAF29591.1 Sequence problems.
CCDSiCCDS1050.1
PIRiA54857
RefSeqiNP_001254738.1, NM_001267809.1
NP_004506.2, NM_004515.3
UniGeneiHs.75117

Genome annotation databases

EnsembliENST00000361891; ENSP00000355011; ENSG00000143621
GeneIDi3608
KEGGihsa:3608
UCSCiuc001fcr.5 human

Similar proteinsi

Entry informationi

Entry nameiILF2_HUMAN
AccessioniPrimary (citable) accession number: Q12905
Secondary accession number(s): A6NDB0
, B2R8G7, Q5SR10, Q5SR11, Q7L7R3, Q9BWD4, Q9P1N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: April 25, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health