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Protein

Interleukin enhancer-binding factor 2

Gene

ILF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.4 Publications

GO - Molecular functioni

  • ATP binding Source: InterPro
  • DNA binding Source: UniProtKB
  • double-stranded RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transferase activity Source: InterPro

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 2
Alternative name(s):
Nuclear factor of activated T-cells 45 kDa
Gene namesi
Name:ILF2
Synonyms:NF45
ORF Names:PRO3063
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6037. ILF2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • ficolin-1-rich granule lumen Source: Reactome
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
  • specific granule lumen Source: Reactome
  • tertiary granule lumen Source: Reactome

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3608.
OpenTargetsiENSG00000143621.
PharmGKBiPA29852.

Polymorphism and mutation databases

BioMutaiILF2.
DMDMi62510764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260631 – 390Interleukin enhancer-binding factor 2Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei16Omega-N-methylarginine; alternateCombined sources1
Modified residuei24Omega-N-methylarginineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei388PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ12905.
MaxQBiQ12905.
PaxDbiQ12905.
PeptideAtlasiQ12905.
PRIDEiQ12905.

2D gel databases

SWISS-2DPAGEiQ12905.

PTM databases

iPTMnetiQ12905.
PhosphoSitePlusiQ12905.
SwissPalmiQ12905.

Expressioni

Gene expression databases

BgeeiENSG00000143621.
CleanExiHS_ILF2.
ExpressionAtlasiQ12905. baseline and differential.
GenevisibleiQ12905. HS.

Organism-specific databases

HPAiHPA007484.

Interactioni

Subunit structurei

Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPIDQ087524EBI-357925,EBI-716596

Protein-protein interaction databases

BioGridi109821. 278 interactors.
IntActiQ12905. 78 interactors.
MINTiMINT-4999942.
STRINGi9606.ENSP00000355011.

Structurei

3D structure databases

ProteinModelPortaliQ12905.
SMRiQ12905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 371DZFPROSITE-ProRule annotationAdd BLAST348

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi366 – 372Poly-Glu7
Compositional biasi381 – 384Poly-Glu4

Phylogenomic databases

eggNOGiKOG3793. Eukaryota.
ENOG410XQCJ. LUCA.
GeneTreeiENSGT00550000074528.
HOVERGENiHBG052120.
InParanoidiQ12905.
KOiK13089.
OMAiYEKPPER.
OrthoDBiEOG091G0HP1.
PhylomeDBiQ12905.
TreeFamiTF320194.

Family and domain databases

InterProiView protein in InterPro
IPR006116. 2-5-oligoadenylate_synth_N.
IPR006561. DZF_dom.
PfamiView protein in Pfam
PF07528. DZF. 1 hit.
SMARTiView protein in SMART
SM00572. DZF. 1 hit.
PROSITEiView protein in PROSITE
PS51703. DZF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE
60 70 80 90 100
TSFSEALLKR NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE
110 120 130 140 150
EVRQVGSYKK GTMTTGHNVA DLVVILKILP TLEAVAALGN KVVESLRAQD
160 170 180 190 200
PSEVLTMLTN ETGFEISSSD ATVKILITTV PPNLRKLDPE LHLDIKVLQS
210 220 230 240 250
ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL TPWILDLLGH
260 270 280 290 300
YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT
310 320 330 340 350
VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI
360 370 380 390
VTPSEKAYEK PPEKKEGEEE EENTEEPPQG EEEESMETQE
Length:390
Mass (Da):43,062
Last modified:April 12, 2005 - v2
Checksum:i75BAD022DCD4EE01
GO

Sequence cautioni

The sequence AAA20993 differs from that shown. Reason: Frameshift at position 376.Curated
The sequence AAF29591 differs from that shown. Chimeric cDNA.Curated
The sequence CAI13611 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10323 mRNA. Translation: AAA20993.1. Frameshift.
AY099265 Genomic DNA. Translation: AAM45141.1.
AK313364 mRNA. Translation: BAG36164.1.
AL713889 Genomic DNA. Translation: CAI13610.1.
AL713889 Genomic DNA. Translation: CAI13611.1. Sequence problems.
AL713889, AL592150 Genomic DNA. Translation: CAI13612.1.
AL592150, AL713889 Genomic DNA. Translation: CAI18796.1.
CH471121 Genomic DNA. Translation: EAW53286.1.
BC000382 mRNA. Translation: AAH00382.1.
AF113702 mRNA. Translation: AAF29591.1. Sequence problems.
CCDSiCCDS1050.1.
PIRiA54857.
RefSeqiNP_001254738.1. NM_001267809.1.
NP_004506.2. NM_004515.3.
UniGeneiHs.75117.

Genome annotation databases

EnsembliENST00000361891; ENSP00000355011; ENSG00000143621.
GeneIDi3608.
KEGGihsa:3608.
UCSCiuc001fcr.5. human.

Similar proteinsi

Entry informationi

Entry nameiILF2_HUMAN
AccessioniPrimary (citable) accession number: Q12905
Secondary accession number(s): A6NDB0
, B2R8G7, Q5SR10, Q5SR11, Q7L7R3, Q9BWD4, Q9P1N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: August 30, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot