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Protein

Interleukin enhancer-binding factor 2

Gene

ILF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.4 Publications

GO - Molecular functioni

  • ATP binding Source: InterPro
  • DNA binding Source: UniProtKB
  • double-stranded RNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • transferase activity Source: InterPro

GO - Biological processi

  • immune response Source: InterPro
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 2
Alternative name(s):
Nuclear factor of activated T-cells 45 kDa
Gene namesi
Name:ILF2
Synonyms:NF45
ORF Names:PRO3063
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6037. ILF2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29852.

Polymorphism and mutation databases

BioMutaiILF2.
DMDMi62510764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Interleukin enhancer-binding factor 2PRO_0000126063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei68 – 681PhosphoserineCombined sources
Modified residuei388 – 3881PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ12905.
MaxQBiQ12905.
PaxDbiQ12905.
PeptideAtlasiQ12905.
PRIDEiQ12905.

2D gel databases

SWISS-2DPAGEQ12905.

PTM databases

iPTMnetiQ12905.
PhosphoSiteiQ12905.
SwissPalmiQ12905.

Expressioni

Gene expression databases

BgeeiENSG00000143621.
CleanExiHS_ILF2.
ExpressionAtlasiQ12905. baseline and differential.
GenevisibleiQ12905. HS.

Organism-specific databases

HPAiHPA007484.

Interactioni

Subunit structurei

Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPIDQ087524EBI-357925,EBI-716596

Protein-protein interaction databases

BioGridi109821. 270 interactions.
IntActiQ12905. 68 interactions.
MINTiMINT-4999942.
STRINGi9606.ENSP00000355011.

Structurei

3D structure databases

ProteinModelPortaliQ12905.
SMRiQ12905. Positions 29-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 371348DZFPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi366 – 3727Poly-Glu
Compositional biasi381 – 3844Poly-Glu

Sequence similaritiesi

Contains 1 DZF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3793. Eukaryota.
ENOG410XQCJ. LUCA.
GeneTreeiENSGT00550000074528.
HOVERGENiHBG052120.
InParanoidiQ12905.
KOiK13089.
OMAiYEKPPER.
OrthoDBiEOG091G0HP1.
PhylomeDBiQ12905.
TreeFamiTF320194.

Family and domain databases

InterProiIPR006116. 2-5-oligoadenylate_synth_N.
IPR006561. DZF_dom.
[Graphical view]
PfamiPF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS51703. DZF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE
60 70 80 90 100
TSFSEALLKR NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE
110 120 130 140 150
EVRQVGSYKK GTMTTGHNVA DLVVILKILP TLEAVAALGN KVVESLRAQD
160 170 180 190 200
PSEVLTMLTN ETGFEISSSD ATVKILITTV PPNLRKLDPE LHLDIKVLQS
210 220 230 240 250
ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL TPWILDLLGH
260 270 280 290 300
YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT
310 320 330 340 350
VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI
360 370 380 390
VTPSEKAYEK PPEKKEGEEE EENTEEPPQG EEEESMETQE
Length:390
Mass (Da):43,062
Last modified:April 12, 2005 - v2
Checksum:i75BAD022DCD4EE01
GO

Sequence cautioni

The sequence AAA20993 differs from that shown. Reason: Frameshift at position 376. Curated
The sequence AAF29591 differs from that shown.Chimeric cDNA.Curated
The sequence CAI13611 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10323 mRNA. Translation: AAA20993.1. Frameshift.
AY099265 Genomic DNA. Translation: AAM45141.1.
AK313364 mRNA. Translation: BAG36164.1.
AL713889 Genomic DNA. Translation: CAI13610.1.
AL713889 Genomic DNA. Translation: CAI13611.1. Sequence problems.
AL713889, AL592150 Genomic DNA. Translation: CAI13612.1.
AL592150, AL713889 Genomic DNA. Translation: CAI18796.1.
CH471121 Genomic DNA. Translation: EAW53286.1.
BC000382 mRNA. Translation: AAH00382.1.
AF113702 mRNA. Translation: AAF29591.1. Sequence problems.
CCDSiCCDS1050.1.
PIRiA54857.
RefSeqiNP_001254738.1. NM_001267809.1.
NP_004506.2. NM_004515.3.
UniGeneiHs.75117.

Genome annotation databases

EnsembliENST00000361891; ENSP00000355011; ENSG00000143621.
GeneIDi3608.
KEGGihsa:3608.
UCSCiuc001fcr.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10323 mRNA. Translation: AAA20993.1. Frameshift.
AY099265 Genomic DNA. Translation: AAM45141.1.
AK313364 mRNA. Translation: BAG36164.1.
AL713889 Genomic DNA. Translation: CAI13610.1.
AL713889 Genomic DNA. Translation: CAI13611.1. Sequence problems.
AL713889, AL592150 Genomic DNA. Translation: CAI13612.1.
AL592150, AL713889 Genomic DNA. Translation: CAI18796.1.
CH471121 Genomic DNA. Translation: EAW53286.1.
BC000382 mRNA. Translation: AAH00382.1.
AF113702 mRNA. Translation: AAF29591.1. Sequence problems.
CCDSiCCDS1050.1.
PIRiA54857.
RefSeqiNP_001254738.1. NM_001267809.1.
NP_004506.2. NM_004515.3.
UniGeneiHs.75117.

3D structure databases

ProteinModelPortaliQ12905.
SMRiQ12905. Positions 29-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109821. 270 interactions.
IntActiQ12905. 68 interactions.
MINTiMINT-4999942.
STRINGi9606.ENSP00000355011.

PTM databases

iPTMnetiQ12905.
PhosphoSiteiQ12905.
SwissPalmiQ12905.

Polymorphism and mutation databases

BioMutaiILF2.
DMDMi62510764.

2D gel databases

SWISS-2DPAGEQ12905.

Proteomic databases

EPDiQ12905.
MaxQBiQ12905.
PaxDbiQ12905.
PeptideAtlasiQ12905.
PRIDEiQ12905.

Protocols and materials databases

DNASUi3608.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361891; ENSP00000355011; ENSG00000143621.
GeneIDi3608.
KEGGihsa:3608.
UCSCiuc001fcr.5. human.

Organism-specific databases

CTDi3608.
GeneCardsiILF2.
HGNCiHGNC:6037. ILF2.
HPAiHPA007484.
MIMi603181. gene.
neXtProtiNX_Q12905.
PharmGKBiPA29852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3793. Eukaryota.
ENOG410XQCJ. LUCA.
GeneTreeiENSGT00550000074528.
HOVERGENiHBG052120.
InParanoidiQ12905.
KOiK13089.
OMAiYEKPPER.
OrthoDBiEOG091G0HP1.
PhylomeDBiQ12905.
TreeFamiTF320194.

Miscellaneous databases

ChiTaRSiILF2. human.
GeneWikiiILF2.
GenomeRNAii3608.
PROiQ12905.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143621.
CleanExiHS_ILF2.
ExpressionAtlasiQ12905. baseline and differential.
GenevisibleiQ12905. HS.

Family and domain databases

InterProiIPR006116. 2-5-oligoadenylate_synth_N.
IPR006561. DZF_dom.
[Graphical view]
PfamiPF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00572. DZF. 1 hit.
[Graphical view]
PROSITEiPS51703. DZF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILF2_HUMAN
AccessioniPrimary (citable) accession number: Q12905
Secondary accession number(s): A6NDB0
, B2R8G7, Q5SR10, Q5SR11, Q7L7R3, Q9BWD4, Q9P1N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.