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Protein

Zinc finger protein 155

Gene

ZNF155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159882-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 155
Gene namesi
Name:ZNF155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12940. ZNF155.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204920.
PharmGKBiPA37524.

Polymorphism and mutation databases

BioMutaiZNF155.
DMDMi292495098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474311 – 538Zinc finger protein 155Add BLAST538

Proteomic databases

PaxDbiQ12901.
PeptideAtlasiQ12901.
PRIDEiQ12901.

PTM databases

iPTMnetiQ12901.
PhosphoSitePlusiQ12901.

Expressioni

Gene expression databases

BgeeiENSG00000204920.
CleanExiHS_ZNF155.
ExpressionAtlasiQ12901. baseline and differential.
GenevisibleiQ12901. HS.

Organism-specific databases

HPAiHPA003220.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10227379,EBI-10172290
KRTAP10-9P604113EBI-10227379,EBI-10172052
MDFIQ997503EBI-10227379,EBI-724076

Protein-protein interaction databases

BioGridi113505. 4 interactors.
IntActiQ12901. 6 interactors.
STRINGi9606.ENSP00000270014.

Structurei

3D structure databases

ProteinModelPortaliQ12901.
SMRiQ12901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ12901.
KOiK09228.
OMAiHRTYRKD.
OrthoDBiEOG091G02KC.
PhylomeDBiQ12901.
TreeFamiTF341885.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12901-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTFKEAVTF KDVAVVFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGHQ
60 70 80 90 100
PFHQDTCHFL REEKFWMMGT ATQREGNSGG KIQTELESVP EAGAHEEWSC
110 120 130 140 150
QQIWEQIAKD LTRSQDSIIN NSQFFENGDV PSQVEAGLPT IHTGQKPSQG
160 170 180 190 200
GKCKQSISDV PIFDLPQQLY SEEKSYTCDE CGKSICYISA LHVHQRVHVG
210 220 230 240 250
EKLFMCDVCG KEFSQSSHLQ THQRVHTGEK PFKCEQCGKG FSRRSALNVH
260 270 280 290 300
RKLHTGEKPY ICEACGKAFI HDSQLKEHKR IHTGEKPFKC DICGKTFYFR
310 320 330 340 350
SRLKSHSMVH TGEKPFRCDT CDKSFHQRSA LNRHCMVHTG EKPYRCEQCG
360 370 380 390 400
KGFIGRLDFY KHQVVHTGEK PYNCKECGKS FRWSSCLLNH QRVHSGEKSF
410 420 430 440 450
KCEECGKGFY TNSQLSSHQR SHSGEKPYKC EECGKGYVTK FNLDLHQRVH
460 470 480 490 500
TGERPYNCKE CGKNFSRASS ILNHKRLHCQ KKPFKCEDCG KRLVHRTYRK
510 520 530
DQPRDYSGEN PSKCEDCGRR YKRRLNLDIL LSLFLNDT
Length:538
Mass (Da):62,081
Last modified:March 23, 2010 - v4
Checksum:i3F552DC6A0D84352
GO
Isoform 2 (identifier: Q12901-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MTTFK → MIKRSKVLVFCSKIME

Note: No experimental confirmation available.
Show »
Length:549
Mass (Da):63,367
Checksum:iB4A7FDED34AAF5AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169L → S in AAF04102 (PubMed:12743021).Curated1
Sequence conflicti322D → G in BAG59807 (PubMed:14702039).Curated1
Sequence conflicti326H → K in AAC50268 (PubMed:7557990).Curated1
Sequence conflicti351K → T in BAG59807 (PubMed:14702039).Curated1
Sequence conflicti427P → S in BAG59807 (PubMed:14702039).Curated1
Sequence conflicti463 – 464KN → RT in AAC50268 (PubMed:7557990).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060272157I → F.4 PublicationsCorresponds to variant rs398235dbSNPEnsembl.1
Natural variantiVAR_069362231P → L.1 PublicationCorresponds to variant rs58537897dbSNPEnsembl.1
Natural variantiVAR_060273251R → H.4 PublicationsCorresponds to variant rs448921dbSNPEnsembl.1
Natural variantiVAR_057399379K → R.Corresponds to variant rs2302411dbSNPEnsembl.1
Natural variantiVAR_035571474H → R in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0472071 – 5MTTFK → MIKRSKVLVFCSKIME in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187986 mRNA. Translation: AAF04102.1.
AC018725 Genomic DNA. Translation: AAF18684.1.
AK297360 mRNA. Translation: BAG59807.1.
AK314510 mRNA. Translation: BAG37110.1.
AC006213 Genomic DNA. No translation available.
BC075050 mRNA. Translation: AAH75050.1.
BC075051 mRNA. Translation: AAH75051.1.
BC126377 mRNA. Translation: AAI26378.1.
BC130381 mRNA. Translation: AAI30382.1.
U09852 mRNA. Translation: AAC50268.1.
CCDSiCCDS12634.1. [Q12901-1]
CCDS58668.1. [Q12901-2]
PIRiI38620.
RefSeqiNP_001247415.1. NM_001260486.1.
NP_001247416.1. NM_001260487.1.
NP_001247417.1. NM_001260488.1.
NP_003436.3. NM_003445.3.
NP_932355.2. NM_198089.2.
XP_005259272.1. XM_005259215.3. [Q12901-1]
XP_011525580.1. XM_011527278.2. [Q12901-2]
XP_011525581.1. XM_011527279.2. [Q12901-2]
XP_016882737.1. XM_017027248.1. [Q12901-2]
UniGeneiHs.279567.
Hs.502127.

Genome annotation databases

EnsembliENST00000270014; ENSP00000270014; ENSG00000204920. [Q12901-1]
ENST00000407951; ENSP00000385163; ENSG00000204920. [Q12901-2]
ENST00000590615; ENSP00000465691; ENSG00000204920. [Q12901-1]
ENST00000611002; ENSP00000481677; ENSG00000204920. [Q12901-1]
GeneIDi7711.
KEGGihsa:7711.
UCSCiuc002oxy.3. human. [Q12901-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187986 mRNA. Translation: AAF04102.1.
AC018725 Genomic DNA. Translation: AAF18684.1.
AK297360 mRNA. Translation: BAG59807.1.
AK314510 mRNA. Translation: BAG37110.1.
AC006213 Genomic DNA. No translation available.
BC075050 mRNA. Translation: AAH75050.1.
BC075051 mRNA. Translation: AAH75051.1.
BC126377 mRNA. Translation: AAI26378.1.
BC130381 mRNA. Translation: AAI30382.1.
U09852 mRNA. Translation: AAC50268.1.
CCDSiCCDS12634.1. [Q12901-1]
CCDS58668.1. [Q12901-2]
PIRiI38620.
RefSeqiNP_001247415.1. NM_001260486.1.
NP_001247416.1. NM_001260487.1.
NP_001247417.1. NM_001260488.1.
NP_003436.3. NM_003445.3.
NP_932355.2. NM_198089.2.
XP_005259272.1. XM_005259215.3. [Q12901-1]
XP_011525580.1. XM_011527278.2. [Q12901-2]
XP_011525581.1. XM_011527279.2. [Q12901-2]
XP_016882737.1. XM_017027248.1. [Q12901-2]
UniGeneiHs.279567.
Hs.502127.

3D structure databases

ProteinModelPortaliQ12901.
SMRiQ12901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113505. 4 interactors.
IntActiQ12901. 6 interactors.
STRINGi9606.ENSP00000270014.

PTM databases

iPTMnetiQ12901.
PhosphoSitePlusiQ12901.

Polymorphism and mutation databases

BioMutaiZNF155.
DMDMi292495098.

Proteomic databases

PaxDbiQ12901.
PeptideAtlasiQ12901.
PRIDEiQ12901.

Protocols and materials databases

DNASUi7711.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270014; ENSP00000270014; ENSG00000204920. [Q12901-1]
ENST00000407951; ENSP00000385163; ENSG00000204920. [Q12901-2]
ENST00000590615; ENSP00000465691; ENSG00000204920. [Q12901-1]
ENST00000611002; ENSP00000481677; ENSG00000204920. [Q12901-1]
GeneIDi7711.
KEGGihsa:7711.
UCSCiuc002oxy.3. human. [Q12901-1]

Organism-specific databases

CTDi7711.
GeneCardsiZNF155.
HGNCiHGNC:12940. ZNF155.
HPAiHPA003220.
MIMi604086. gene.
neXtProtiNX_Q12901.
OpenTargetsiENSG00000204920.
PharmGKBiPA37524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ12901.
KOiK09228.
OMAiHRTYRKD.
OrthoDBiEOG091G02KC.
PhylomeDBiQ12901.
TreeFamiTF341885.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159882-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7711.
PROiQ12901.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204920.
CleanExiHS_ZNF155.
ExpressionAtlasiQ12901. baseline and differential.
GenevisibleiQ12901. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN155_HUMAN
AccessioniPrimary (citable) accession number: Q12901
Secondary accession number(s): A2BDE6
, B2RB63, B4DM95, J3KQ08, Q6AZZ8, Q9UIE1, Q9UK14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: November 30, 2016
This is version 152 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.