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Protein

Zinc finger protein 155

Gene

ZNF155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 155
Gene namesi
Name:ZNF155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000204920.10
HGNCiHGNC:12940 ZNF155
MIMi604086 gene
neXtProtiNX_Q12901

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37524

Polymorphism and mutation databases

BioMutaiZNF155
DMDMi292495098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474311 – 538Zinc finger protein 155Add BLAST538

Proteomic databases

PaxDbiQ12901
PeptideAtlasiQ12901
PRIDEiQ12901

PTM databases

iPTMnetiQ12901
PhosphoSitePlusiQ12901

Expressioni

Gene expression databases

BgeeiENSG00000204920
CleanExiHS_ZNF155
ExpressionAtlasiQ12901 baseline and differential
GenevisibleiQ12901 HS

Organism-specific databases

HPAiHPA003220

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113505, 4 interactors
IntActiQ12901, 7 interactors
STRINGi9606.ENSP00000270014

Structurei

3D structure databases

ProteinModelPortaliQ12901
SMRiQ12901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ12901
KOiK09228
OMAiHRTYRKD
OrthoDBiEOG091G02KC
PhylomeDBiQ12901
TreeFamiTF341885

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12901-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTFKEAVTF KDVAVVFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGHQ
60 70 80 90 100
PFHQDTCHFL REEKFWMMGT ATQREGNSGG KIQTELESVP EAGAHEEWSC
110 120 130 140 150
QQIWEQIAKD LTRSQDSIIN NSQFFENGDV PSQVEAGLPT IHTGQKPSQG
160 170 180 190 200
GKCKQSISDV PIFDLPQQLY SEEKSYTCDE CGKSICYISA LHVHQRVHVG
210 220 230 240 250
EKLFMCDVCG KEFSQSSHLQ THQRVHTGEK PFKCEQCGKG FSRRSALNVH
260 270 280 290 300
RKLHTGEKPY ICEACGKAFI HDSQLKEHKR IHTGEKPFKC DICGKTFYFR
310 320 330 340 350
SRLKSHSMVH TGEKPFRCDT CDKSFHQRSA LNRHCMVHTG EKPYRCEQCG
360 370 380 390 400
KGFIGRLDFY KHQVVHTGEK PYNCKECGKS FRWSSCLLNH QRVHSGEKSF
410 420 430 440 450
KCEECGKGFY TNSQLSSHQR SHSGEKPYKC EECGKGYVTK FNLDLHQRVH
460 470 480 490 500
TGERPYNCKE CGKNFSRASS ILNHKRLHCQ KKPFKCEDCG KRLVHRTYRK
510 520 530
DQPRDYSGEN PSKCEDCGRR YKRRLNLDIL LSLFLNDT
Length:538
Mass (Da):62,081
Last modified:March 23, 2010 - v4
Checksum:i3F552DC6A0D84352
GO
Isoform 2 (identifier: Q12901-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MTTFK → MIKRSKVLVFCSKIME

Note: No experimental confirmation available.
Show »
Length:549
Mass (Da):63,367
Checksum:iB4A7FDED34AAF5AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169L → S in AAF04102 (PubMed:12743021).Curated1
Sequence conflicti322D → G in BAG59807 (PubMed:14702039).Curated1
Sequence conflicti326H → K in AAC50268 (PubMed:7557990).Curated1
Sequence conflicti351K → T in BAG59807 (PubMed:14702039).Curated1
Sequence conflicti427P → S in BAG59807 (PubMed:14702039).Curated1
Sequence conflicti463 – 464KN → RT in AAC50268 (PubMed:7557990).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060272157I → F4 PublicationsCorresponds to variant dbSNP:rs398235Ensembl.1
Natural variantiVAR_069362231P → L1 PublicationCorresponds to variant dbSNP:rs58537897Ensembl.1
Natural variantiVAR_060273251R → H4 PublicationsCorresponds to variant dbSNP:rs448921Ensembl.1
Natural variantiVAR_057399379K → R. Corresponds to variant dbSNP:rs2302411Ensembl.1
Natural variantiVAR_035571474H → R in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0472071 – 5MTTFK → MIKRSKVLVFCSKIME in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187986 mRNA Translation: AAF04102.1
AC018725 Genomic DNA Translation: AAF18684.1
AK297360 mRNA Translation: BAG59807.1
AK314510 mRNA Translation: BAG37110.1
AC006213 Genomic DNA No translation available.
BC075050 mRNA Translation: AAH75050.1
BC075051 mRNA Translation: AAH75051.1
BC126377 mRNA Translation: AAI26378.1
BC130381 mRNA Translation: AAI30382.1
U09852 mRNA Translation: AAC50268.1
CCDSiCCDS12634.1 [Q12901-1]
CCDS58668.1 [Q12901-2]
PIRiI38620
RefSeqiNP_001247415.1, NM_001260486.1
NP_001247416.1, NM_001260487.1
NP_001247417.1, NM_001260488.1
NP_003436.3, NM_003445.3
NP_932355.2, NM_198089.2
XP_005259272.1, XM_005259215.3 [Q12901-1]
XP_011525580.1, XM_011527278.2 [Q12901-2]
XP_011525581.1, XM_011527279.2 [Q12901-2]
XP_016882737.1, XM_017027248.1 [Q12901-2]
UniGeneiHs.279567
Hs.502127

Genome annotation databases

EnsembliENST00000270014; ENSP00000270014; ENSG00000204920 [Q12901-1]
ENST00000407951; ENSP00000385163; ENSG00000204920 [Q12901-2]
ENST00000590615; ENSP00000465691; ENSG00000204920 [Q12901-1]
ENST00000611002; ENSP00000481677; ENSG00000204920 [Q12901-1]
GeneIDi7711
KEGGihsa:7711
UCSCiuc002oxy.3 human [Q12901-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN155_HUMAN
AccessioniPrimary (citable) accession number: Q12901
Secondary accession number(s): A2BDE6
, B2RB63, B4DM95, J3KQ08, Q6AZZ8, Q9UIE1, Q9UK14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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