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Q128P8

- PNCB_POLSJ

UniProt

Q128P8 - PNCB_POLSJ

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciPSP296591:GHI4-3801-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:Bpro_3080
    OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
    Taxonomic identifieri296591 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
    ProteomesiUP000001983: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Nicotinate phosphoribosyltransferasePRO_1000129476Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi296591.Bpro_3080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ128P8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiSIVCKVI.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q128P8-1 [UniParc]FASTAAdd to Basket

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    MIITSLLDTD LYKFTMMQVV LHQFPGAEVE YRFKCRNAGA PGIGKLAPYV    50
    NEIREEIRGL CNLRFQDAEL AYLKAMRFIK SDFVDFLGIF KLNEKYVSVT 100
    ALPSGEIEVS IKGPWLHTIL FEIPVLAIIN EVYFRNTQKQ PDLTEGRKRL 150
    DTKILELQAD GLRELKIADY GTRRRFGKVW HEEVLRTLVT RLGTGMSGQL 200
    AGTSNVLFAM KLGLTPLGTM AHEYLQACQA LGPRLRDSQV FGFESWAREY 250
    RGDLGIALSD VYGMSAFLRD FDMYFCKLFD GARHDSGDPF EWGERMLAHY 300
    VKNRVDPRTK TLIFSDALTV PRTIELYQQF RGRCQLAFGI GTNLTNDLGY 350
    EPLQIVIKMI RCNGQPVAKL SDTPSKNMCE DEKYLAYLRQ VFEIG 395
    Length:395
    Mass (Da):45,099
    Last modified:August 22, 2006 - v1
    Checksum:i80870C7E825DB858
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000316 Genomic DNA. Translation: ABE44994.1.
    RefSeqiWP_011483990.1. NC_007948.1.
    YP_549892.1. NC_007948.1.

    Genome annotation databases

    EnsemblBacteriaiABE44994; ABE44994; Bpro_3080.
    GeneIDi4014238.
    KEGGipol:Bpro_3080.
    PATRICi22959360. VBIPolSp102244_3135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000316 Genomic DNA. Translation: ABE44994.1 .
    RefSeqi WP_011483990.1. NC_007948.1.
    YP_549892.1. NC_007948.1.

    3D structure databases

    ProteinModelPortali Q128P8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 296591.Bpro_3080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE44994 ; ABE44994 ; Bpro_3080 .
    GeneIDi 4014238.
    KEGGi pol:Bpro_3080.
    PATRICi 22959360. VBIPolSp102244_3135.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi SIVCKVI.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci PSP296591:GHI4-3801-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JS666 / ATCC BAA-500.

    Entry informationi

    Entry nameiPNCB_POLSJ
    AccessioniPrimary (citable) accession number: Q128P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3