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Q12899 (TRI26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 26
Alternative name(s):
Acid finger protein
Short name=AFP
RING finger protein 95
Zinc finger protein 173
Gene names
Name:TRIM26
Synonyms:RNF95, ZNF173
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 539539Tripartite motif-containing protein 26
PRO_0000056235

Regions

Domain295 – 539245B30.2/SPRY
Zinc finger16 – 5742RING-type
Zinc finger97 – 13842B box-type
Coiled coil188 – 22740 Potential
Compositional bias388 – 40013Poly-Glu
Compositional bias422 – 43211Poly-Glu

Natural variations

Natural variant1971Q → H.
Corresponds to variant rs17194565 [ dbSNP | Ensembl ].
VAR_052138

Sequences

Sequence LengthMass (Da)Tools
Q12899 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 842A71C41F2E2348

FASTA53962,166
        10         20         30         40         50         60 
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF 

        70         80         90        100        110        120 
KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL 

       130        140        150        160        170        180 
CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK 

       190        200        210        220        230        240 
LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS 

       250        260        270        280        290        300 
ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF 

       310        320        330        340        350        360 
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS 

       370        380        390        400        410        420 
KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG 

       430        440        450        460        470        480 
DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL 

       490        500        510        520        530 
FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC."
Chu T.W., Capossela A., Coleman R., Goei V.L., Nallur G., Gruen J.R.
Genomics 29:229-239(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions."
Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. expand/collapse author list , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Peripheral blood leukocyte.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09825 mRNA. Translation: AAA93131.1.
BA000025 Genomic DNA. Translation: BAB63330.1.
AB088090 Genomic DNA. Translation: BAC54923.1.
AB202086 Genomic DNA. Translation: BAE78607.1.
AB103596 Genomic DNA. Translation: BAF31258.1.
AL844220 Genomic DNA. Translation: CAI18614.1.
BX248419 Genomic DNA. Translation: CAM26023.1.
CR788282 Genomic DNA. Translation: CAQ07461.1.
CR388382 Genomic DNA. Translation: CAQ08631.1.
BX927189, BX927221 Genomic DNA. Translation: CAQ09454.1.
BX927221, BX927189 Genomic DNA. Translation: CAQ10305.1.
CR759838 Genomic DNA. Translation: CAQ11096.1.
CH471081 Genomic DNA. Translation: EAX03272.1.
BC024039 mRNA. Translation: AAH24039.1.
BC032297 mRNA. Translation: AAH32297.1.
CCDSCCDS4678.1.
RefSeqNP_001229712.1. NM_001242783.1.
NP_003440.1. NM_003449.4.
XP_005249431.1. XM_005249374.1.
XP_005249432.1. XM_005249375.1.
XP_005249433.1. XM_005249376.1.
XP_005249434.1. XM_005249377.1.
XP_005249435.1. XM_005249378.1.
XP_005272927.1. XM_005272870.1.
XP_005272928.1. XM_005272871.1.
XP_005272929.1. XM_005272872.2.
XP_005274944.1. XM_005274887.2.
XP_005274945.1. XM_005274888.2.
XP_005274947.1. XM_005274890.2.
XP_005274948.1. XM_005274891.2.
XP_005275079.1. XM_005275022.2.
XP_005275080.1. XM_005275023.2.
XP_005275082.1. XM_005275025.2.
XP_005275083.1. XM_005275026.2.
XP_005275216.1. XM_005275159.1.
XP_005275217.1. XM_005275160.1.
XP_005275218.1. XM_005275161.1.
XP_005275509.1. XM_005275452.2.
XP_005275510.1. XM_005275453.2.
XP_005275512.1. XM_005275455.2.
XP_005275513.1. XM_005275456.2.
XP_005275647.1. XM_005275590.1.
XP_005275648.1. XM_005275591.1.
XP_005275649.1. XM_005275592.2.
XP_005275650.1. XM_005275593.1.
XP_005275651.1. XM_005275594.1.
XP_006715243.1. XM_006715180.1.
XP_006725563.1. XM_006725500.1.
UniGeneHs.485041.
Hs.731863.

3D structure databases

ProteinModelPortalQ12899.
SMRQ12899. Positions 7-56, 313-526.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113515. 24 interactions.
DIPDIP-52853N.
IntActQ12899. 21 interactions.
MINTMINT-4993084.
STRING9606.ENSP00000415328.

PTM databases

PhosphoSiteQ12899.

Polymorphism databases

DMDM17380344.

Proteomic databases

MaxQBQ12899.
PaxDbQ12899.
PRIDEQ12899.

Protocols and materials databases

DNASU7726.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327357; ENSP00000331131; ENSG00000137313.
ENST00000383607; ENSP00000373102; ENSG00000137313.
ENST00000396558; ENSP00000379806; ENSG00000137313.
ENST00000415923; ENSP00000415755; ENSG00000231002.
ENST00000422349; ENSP00000396188; ENSG00000234046.
ENST00000425523; ENSP00000393011; ENSG00000228881.
ENST00000425831; ENSP00000394371; ENSG00000231641.
ENST00000427535; ENSP00000398545; ENSG00000234046.
ENST00000428486; ENSP00000414248; ENSG00000231002.
ENST00000432326; ENSP00000407876; ENSG00000231641.
ENST00000433314; ENSP00000402395; ENSG00000226060.
ENST00000436219; ENSP00000390258; ENSG00000230230.
ENST00000437089; ENSP00000395491; ENSG00000234127.
ENST00000438384; ENSP00000416737; ENSG00000231641.
ENST00000438908; ENSP00000409182; ENSG00000230230.
ENST00000439094; ENSP00000389203; ENSG00000228881.
ENST00000445259; ENSP00000407294; ENSG00000234046.
ENST00000447711; ENSP00000408233; ENSG00000226060.
ENST00000450392; ENSP00000394421; ENSG00000231002.
ENST00000453195; ENSP00000391879; ENSG00000234127.
ENST00000454678; ENSP00000410446; ENSG00000234127.
ENST00000455000; ENSP00000392805; ENSG00000230230.
ENST00000456093; ENSP00000406707; ENSG00000226060.
ENST00000456770; ENSP00000415328; ENSG00000228881.
GeneID7726.
KEGGhsa:7726.
UCSCuc003npr.3. human.

Organism-specific databases

CTD7726.
GeneCardsGC06M030152.
GC06Mi30089.
GC06Mj30142.
GC06Mk30142.
GC06Ml30197.
GC06Mm30230.
GC06Mn30141.
GC06Mo30141.
HGNCHGNC:12962. TRIM26.
HPAHPA044975.
HPA050456.
MIM600830. gene.
neXtProtNX_Q12899.
PharmGKBPA37544.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291505.
HOGENOMHOG000234133.
HOVERGENHBG001357.
InParanoidQ12899.
KOK12008.
OMAGREKFKT.
PhylomeDBQ12899.
TreeFamTF342569.

Gene expression databases

ArrayExpressQ12899.
BgeeQ12899.
CleanExHS_TRIM26.
GenevestigatorQ12899.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7726.
NextBio29920.
PROQ12899.
SOURCESearch...

Entry information

Entry nameTRI26_HUMAN
AccessionPrimary (citable) accession number: Q12899
Secondary accession number(s): A6NG96, Q5SRL2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM