Reviewed, UniProtKB/Swiss-Prot Q12899 (TRI26_HUMAN)

Names and origin

Protein names

Recommended name:
    Tripartite motif-containing protein 26
Alternative name(s):
    Zinc finger protein 173
    Acid finger protein
      Short name=AFP
    RING finger protein 95

Gene names

Name:	TRIM26
Synonyms:	RNF95, ZNF173

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Ref.1 Traceable author statement. Source: ProtInc protein binding Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 539	539	Tripartite motif-containing protein 26		PRO_0000056235
Regions
	Domain	295 – 539	245	B30.2/SPRY
	Zinc finger	16 – 57	42	RING-type
	Zinc finger	97 – 138	42	B box-type
	Coiled coil	188 – 227	40	Potential
	Compositional bias	388 – 400	13	Poly-Glu
	Compositional bias	422 – 432	11	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q12899-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 842A71C41F2E2348	FASTA	539	62,166
	10 20 30 40 50 60 MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF 70 80 90 100 110 120 KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL 130 140 150 160 170 180 CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK 190 200 210 220 230 240 LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS 250 260 270 280 290 300 ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF 310 320 330 340 350 360 QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS 370 380 390 400 410 420 KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG 430 440 450 460 470 480 DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL 490 500 510 520 530 FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC." Chu T.W., Capossela A., Coleman R., Goei V.L., Nallur G., Gruen J.R. Genomics 29:229-239(1995) [PubMed: 8530076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genome diversity in HLA: a new strategy for detection of genetic polymorphisms in expressed genes within the HLA class III and class I regions." Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U09825 mRNA. Translation: AAA93131.1. BA000025 Genomic DNA. Translation: BAB63330.1. AB088090 Genomic DNA. Translation: BAC54923.1. BC024039 mRNA. Translation: AAH24039.1. BC032297 mRNA. Translation: AAH32297.1.
RefSeq	NP_003440.1.
UniGene	Hs.485041
3D structure databases
HSSP	HSSP built from PDB template 1FRE based on UniProtKB Q92021.
ModBase	Search...
PTM databases
PhosphoSite	Q12899.
Genome annotation databases
Ensembl	ENSG00000137313. Homo sapiens. [Contig view] ENSG00000206421. Homo sapiens. [Contig view] ENSG00000206499. Homo sapiens. [Contig view]
GeneID	7726.
KEGG	hsa:7726.
Organism-specific databases
HGNC	HGNC:12962. TRIM26.
MIM	600830. gene.
PharmGKB	PA37544.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q12899.
HOVERGEN	Q12899.
Gene expression databases
ArrayExpress	Q12899.
CleanEx	HS_TRIM26.
GermOnline	ENSG00000137313. Homo sapiens.
Family and domain databases
InterPro	IPR001870. B302. IPR003879. Butyrophylin. IPR006574. PRY. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PRINTS	PR01406. BBOXZNFINGER. PR01407. BUTYPHLNCDUF.
SMART	SM00336. BBOX. 1 hit. SM00589. PRY. 1 hit. SM00184. RING. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	Q12899.
NextBio	29920.
SOURCE	Search...

Entry information

Entry name

TRI26_HUMAN

Accession

Primary (citable) accession number: Q12899

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)