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Protein

Tripartite motif-containing protein 26

Gene

TRIM26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri97 – 138B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • innate immune response Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral release from host cell Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137313-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 26
Alternative name(s):
Acid finger protein
Short name:
AFP
RING finger protein 95
Zinc finger protein 173
Gene namesi
Name:TRIM26
Synonyms:RNF95, ZNF173
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12962. TRIM26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7726.
OpenTargetsiENSG00000137313.
ENSG00000226060.
ENSG00000228881.
ENSG00000230230.
ENSG00000231002.
ENSG00000231641.
ENSG00000234046.
ENSG00000234127.
PharmGKBiPA37544.

Polymorphism and mutation databases

BioMutaiTRIM26.
DMDMi17380344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562351 – 539Tripartite motif-containing protein 26Add BLAST539

Proteomic databases

EPDiQ12899.
PaxDbiQ12899.
PeptideAtlasiQ12899.
PRIDEiQ12899.

PTM databases

iPTMnetiQ12899.
PhosphoSitePlusiQ12899.

Expressioni

Gene expression databases

BgeeiENSG00000137313.
CleanExiHS_TRIM26.
ExpressionAtlasiQ12899. baseline and differential.
GenevisibleiQ12899. HS.

Organism-specific databases

HPAiHPA044975.
HPA050456.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-2341136,EBI-717810
MAGEA6P433603EBI-2341136,EBI-1045155
THAP1Q9NVV95EBI-2341136,EBI-741515

Protein-protein interaction databases

BioGridi113515. 67 interactors.
DIPiDIP-52853N.
IntActiQ12899. 46 interactors.
MINTiMINT-4993084.
STRINGi9606.ENSP00000391879.

Structurei

3D structure databases

ProteinModelPortaliQ12899.
SMRiQ12899.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 539B30.2/SPRYPROSITE-ProRule annotationAdd BLAST245

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili188 – 227Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi388 – 400Poly-GluAdd BLAST13
Compositional biasi422 – 432Poly-GluAdd BLAST11

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri97 – 138B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG410Z766. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ12899.
KOiK12008.
OMAiGREKFKT.
OrthoDBiEOG091G0AKN.
PhylomeDBiQ12899.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR
60 70 80 90 100
PVCPLCKKPF KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK
110 120 130 140 150
LCERHREKLH YYCEDDGKLL CVMCRESREH RPHTAVLMEK AAQPHREKIL
160 170 180 190 200
NHLSTLRRDR DKIQGFQAKG EADILAALKK LQDQRQYIVA EFEQGHQFLR
210 220 230 240 250
EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS ELEGKAQQPA
260 270 280 290 300
AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF
310 320 330 340 350
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ
360 370 380 390 400
FDCEPGVLGS KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE
410 420 430 440 450
AGYGDGYDDW ETDEDEESLG DEEEEEEEEE EEVLESCMVG VARDSVKRKG
460 470 480 490 500
DLSLRPEDGV WALRLSSSGI WANTSPEAEL FPALRPRRVG IALDYEGGTV
510 520 530
TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP
Length:539
Mass (Da):62,166
Last modified:November 1, 1996 - v1
Checksum:i842A71C41F2E2348
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052138197Q → H.Corresponds to variant rs17194565dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09825 mRNA. Translation: AAA93131.1.
BA000025 Genomic DNA. Translation: BAB63330.1.
AB088090 Genomic DNA. Translation: BAC54923.1.
AB202086 Genomic DNA. Translation: BAE78607.1.
AB103596 Genomic DNA. Translation: BAF31258.1.
AL844220 Genomic DNA. Translation: CAI18614.1.
BX248419 Genomic DNA. Translation: CAM26023.1.
CR788282 Genomic DNA. Translation: CAQ07461.1.
CR388382 Genomic DNA. Translation: CAQ08631.1.
BX927189, BX927221 Genomic DNA. Translation: CAQ09454.1.
BX927221, BX927189 Genomic DNA. Translation: CAQ10305.1.
CR759838 Genomic DNA. Translation: CAQ11096.1.
CH471081 Genomic DNA. Translation: EAX03272.1.
BC024039 mRNA. Translation: AAH24039.1.
BC032297 mRNA. Translation: AAH32297.1.
CCDSiCCDS4678.1.
RefSeqiNP_001229712.1. NM_001242783.1.
NP_003440.1. NM_003449.4.
XP_005249431.1. XM_005249374.2.
XP_005249432.1. XM_005249375.2.
XP_005249433.1. XM_005249376.2.
XP_005249434.1. XM_005249377.2.
XP_005249435.1. XM_005249378.2.
XP_006715243.1. XM_006715180.2.
UniGeneiHs.485041.
Hs.731863.

Genome annotation databases

EnsembliENST00000327357; ENSP00000331131; ENSG00000137313.
ENST00000383607; ENSP00000373102; ENSG00000137313.
ENST00000396558; ENSP00000379806; ENSG00000137313.
ENST00000415923; ENSP00000415755; ENSG00000231002.
ENST00000422349; ENSP00000396188; ENSG00000234046.
ENST00000425523; ENSP00000393011; ENSG00000228881.
ENST00000425831; ENSP00000394371; ENSG00000231641.
ENST00000427535; ENSP00000398545; ENSG00000234046.
ENST00000428486; ENSP00000414248; ENSG00000231002.
ENST00000432326; ENSP00000407876; ENSG00000231641.
ENST00000433314; ENSP00000402395; ENSG00000226060.
ENST00000436219; ENSP00000390258; ENSG00000230230.
ENST00000437089; ENSP00000395491; ENSG00000234127.
ENST00000438384; ENSP00000416737; ENSG00000231641.
ENST00000438908; ENSP00000409182; ENSG00000230230.
ENST00000439094; ENSP00000389203; ENSG00000228881.
ENST00000445259; ENSP00000407294; ENSG00000234046.
ENST00000447711; ENSP00000408233; ENSG00000226060.
ENST00000450392; ENSP00000394421; ENSG00000231002.
ENST00000453195; ENSP00000391879; ENSG00000234127.
ENST00000454678; ENSP00000410446; ENSG00000234127.
ENST00000455000; ENSP00000392805; ENSG00000230230.
ENST00000456093; ENSP00000406707; ENSG00000226060.
ENST00000456770; ENSP00000415328; ENSG00000228881.
GeneIDi7726.
KEGGihsa:7726.
UCSCiuc003npr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09825 mRNA. Translation: AAA93131.1.
BA000025 Genomic DNA. Translation: BAB63330.1.
AB088090 Genomic DNA. Translation: BAC54923.1.
AB202086 Genomic DNA. Translation: BAE78607.1.
AB103596 Genomic DNA. Translation: BAF31258.1.
AL844220 Genomic DNA. Translation: CAI18614.1.
BX248419 Genomic DNA. Translation: CAM26023.1.
CR788282 Genomic DNA. Translation: CAQ07461.1.
CR388382 Genomic DNA. Translation: CAQ08631.1.
BX927189, BX927221 Genomic DNA. Translation: CAQ09454.1.
BX927221, BX927189 Genomic DNA. Translation: CAQ10305.1.
CR759838 Genomic DNA. Translation: CAQ11096.1.
CH471081 Genomic DNA. Translation: EAX03272.1.
BC024039 mRNA. Translation: AAH24039.1.
BC032297 mRNA. Translation: AAH32297.1.
CCDSiCCDS4678.1.
RefSeqiNP_001229712.1. NM_001242783.1.
NP_003440.1. NM_003449.4.
XP_005249431.1. XM_005249374.2.
XP_005249432.1. XM_005249375.2.
XP_005249433.1. XM_005249376.2.
XP_005249434.1. XM_005249377.2.
XP_005249435.1. XM_005249378.2.
XP_006715243.1. XM_006715180.2.
UniGeneiHs.485041.
Hs.731863.

3D structure databases

ProteinModelPortaliQ12899.
SMRiQ12899.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113515. 67 interactors.
DIPiDIP-52853N.
IntActiQ12899. 46 interactors.
MINTiMINT-4993084.
STRINGi9606.ENSP00000391879.

PTM databases

iPTMnetiQ12899.
PhosphoSitePlusiQ12899.

Polymorphism and mutation databases

BioMutaiTRIM26.
DMDMi17380344.

Proteomic databases

EPDiQ12899.
PaxDbiQ12899.
PeptideAtlasiQ12899.
PRIDEiQ12899.

Protocols and materials databases

DNASUi7726.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327357; ENSP00000331131; ENSG00000137313.
ENST00000383607; ENSP00000373102; ENSG00000137313.
ENST00000396558; ENSP00000379806; ENSG00000137313.
ENST00000415923; ENSP00000415755; ENSG00000231002.
ENST00000422349; ENSP00000396188; ENSG00000234046.
ENST00000425523; ENSP00000393011; ENSG00000228881.
ENST00000425831; ENSP00000394371; ENSG00000231641.
ENST00000427535; ENSP00000398545; ENSG00000234046.
ENST00000428486; ENSP00000414248; ENSG00000231002.
ENST00000432326; ENSP00000407876; ENSG00000231641.
ENST00000433314; ENSP00000402395; ENSG00000226060.
ENST00000436219; ENSP00000390258; ENSG00000230230.
ENST00000437089; ENSP00000395491; ENSG00000234127.
ENST00000438384; ENSP00000416737; ENSG00000231641.
ENST00000438908; ENSP00000409182; ENSG00000230230.
ENST00000439094; ENSP00000389203; ENSG00000228881.
ENST00000445259; ENSP00000407294; ENSG00000234046.
ENST00000447711; ENSP00000408233; ENSG00000226060.
ENST00000450392; ENSP00000394421; ENSG00000231002.
ENST00000453195; ENSP00000391879; ENSG00000234127.
ENST00000454678; ENSP00000410446; ENSG00000234127.
ENST00000455000; ENSP00000392805; ENSG00000230230.
ENST00000456093; ENSP00000406707; ENSG00000226060.
ENST00000456770; ENSP00000415328; ENSG00000228881.
GeneIDi7726.
KEGGihsa:7726.
UCSCiuc003npr.3. human.

Organism-specific databases

CTDi7726.
DisGeNETi7726.
GeneCardsiTRIM26.
HGNCiHGNC:12962. TRIM26.
HPAiHPA044975.
HPA050456.
MIMi600830. gene.
neXtProtiNX_Q12899.
OpenTargetsiENSG00000137313.
ENSG00000226060.
ENSG00000228881.
ENSG00000230230.
ENSG00000231002.
ENSG00000231641.
ENSG00000234046.
ENSG00000234127.
PharmGKBiPA37544.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG410Z766. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ12899.
KOiK12008.
OMAiGREKFKT.
OrthoDBiEOG091G0AKN.
PhylomeDBiQ12899.
TreeFamiTF342569.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137313-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiTRIM26. human.
GenomeRNAii7726.
PROiQ12899.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137313.
CleanExiHS_TRIM26.
ExpressionAtlasiQ12899. baseline and differential.
GenevisibleiQ12899. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI26_HUMAN
AccessioniPrimary (citable) accession number: Q12899
Secondary accession number(s): A6NG96, Q5SRL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.