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Protein

Interferon-related developmental regulator 2

Gene

IFRD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-related developmental regulator 2
Alternative name(s):
Protein SKMC15
Gene namesi
Name:IFRD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:5457. IFRD2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29692.

Polymorphism and mutation databases

BioMutaiIFRD2.
DMDMi327478577.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Interferon-related developmental regulator 2PRO_0000153289Add
BLAST

Proteomic databases

EPDiQ12894.
MaxQBiQ12894.
PaxDbiQ12894.
PRIDEiQ12894.

PTM databases

iPTMnetiQ12894.
PhosphoSiteiQ12894.

Expressioni

Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

BgeeiQ12894.
CleanExiHS_IFRD2.
ExpressionAtlasiQ12894. baseline and differential.
GenevisibleiQ12894. HS.

Organism-specific databases

HPAiHPA019702.
HPA031525.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
OAS3Q9Y6K52EBI-2512448,EBI-6115729

Protein-protein interaction databases

BioGridi113616. 20 interactions.
IntActiQ12894. 14 interactions.
STRINGi9606.ENSP00000398971.

Structurei

3D structure databases

ProteinModelPortaliQ12894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFRD family.Curated

Phylogenomic databases

eggNOGiKOG2842. Eukaryota.
ENOG410XSIZ. LUCA.
GeneTreeiENSGT00390000013347.
HOGENOMiHOG000252918.
HOVERGENiHBG052089.
InParanoidiQ12894.
OMAiWARRRIY.
OrthoDBiEOG7CZK5H.
PhylomeDBiQ12894.
TreeFamiTF313638.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006921. Interferon-rel_develop_reg_C.
IPR007701. Interferon-rel_develop_reg_N.
[Graphical view]
PfamiPF05004. IFRD. 1 hit.
PF04836. IFRD_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12894-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWNSPSRRP VWQGGAPRED GGARGVWLPS SGQVSAQRTG RRLVGLEPTP
60 70 80 90 100
TGSLTPRPPR PVPGMPRARK GNTLRKGGQR RGGGARSSAQ ADSGSSDDEA
110 120 130 140 150
ASEARSTASE CPSLLSTTAE DSLGGDVVDE QGQQEDLEEK LKEYVDCLTD
160 170 180 190 200
KSAKTRQGAL ESLRLALASR LLPDFLLERR LTLADALEKC LKKGKGEEQA
210 220 230 240 250
LAAAVLGLLC VQLGPGPKGE ELFHSLQPLL VSVLSDSTAS PAARLHCASA
260 270 280 290 300
LGLGCYVAAA DIQDLVSCLA CLESVFSRFY GLGGSSTSPV VPASLHGLLS
310 320 330 340 350
AALQAWALLL TICPSTQISH ILDRQLPRLP QLLSSESVNL RIAAGETIAL
360 370 380 390 400
LFELARDLEE EFVYEDMEAL CSVLRTLATD SNKYRAKADR RRQRSTFRAV
410 420 430 440 450
LHSVEGGECE EEIVRFGFEV LYMDSWARHR IYAAFKEVLG SGMHHHLQNN
460 470 480 490 500
ELLRDIFGLG PVLLLDATAL KACKVPRFEK HLYNAAAFKA RTKARSRVRD

KRADIL
Length:506
Mass (Da):54,814
Last modified:April 5, 2011 - v3
Checksum:i07E026CEADF973E8
GO
Isoform 2 (identifier: Q12894-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MAWNSPSRRPVWQ → MGPKKSWRSH...SGISSFSLVD

Show »
Length:608
Mass (Da):65,598
Checksum:i6277F0358CBF3C2D
GO

Sequence cautioni

The sequence AAH01327.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH01676.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH07265.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH07437.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti502 – 5021R → Q.1 Publication
Corresponds to variant rs2229648 [ dbSNP | Ensembl ].
VAR_029302

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MAWNS…RPVWQ → MGPKKSWRSHFFPLPEVWLL LLLSQALSPSHGPQTQAGVG LVWSVPLPSALRSQSCLGAP LRDASELTTVHLFPTRGWGA RRALWVHSSASASSAASRRR LRAQASGISSFSLVD in isoform 2. 1 PublicationVSP_057033Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12395 mRNA. Translation: CAA73027.1.
U73167 Genomic DNA. Translation: AAC02728.1.
CH471055 Genomic DNA. Translation: EAW65070.1.
BC001327 mRNA. Translation: AAH01327.1. Different initiation.
BC001676 mRNA. Translation: AAH01676.1. Different initiation.
BC007265 mRNA. Translation: AAH07265.1. Different initiation.
BC007437 mRNA. Translation: AAH07437.3. Different initiation.
BI826806 mRNA. No translation available.
U09585 mRNA. Translation: AAC16924.1.
CCDSiCCDS77746.1. [Q12894-1]
RefSeqiNP_006755.4. NM_006764.4. [Q12894-1]
UniGeneiHs.315177.
Hs.743323.

Genome annotation databases

EnsembliENST00000417626; ENSP00000402849; ENSG00000214706. [Q12894-1]
GeneIDi7866.
KEGGihsa:7866.
UCSCiuc011bdp.2. human. [Q12894-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12395 mRNA. Translation: CAA73027.1.
U73167 Genomic DNA. Translation: AAC02728.1.
CH471055 Genomic DNA. Translation: EAW65070.1.
BC001327 mRNA. Translation: AAH01327.1. Different initiation.
BC001676 mRNA. Translation: AAH01676.1. Different initiation.
BC007265 mRNA. Translation: AAH07265.1. Different initiation.
BC007437 mRNA. Translation: AAH07437.3. Different initiation.
BI826806 mRNA. No translation available.
U09585 mRNA. Translation: AAC16924.1.
CCDSiCCDS77746.1. [Q12894-1]
RefSeqiNP_006755.4. NM_006764.4. [Q12894-1]
UniGeneiHs.315177.
Hs.743323.

3D structure databases

ProteinModelPortaliQ12894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113616. 20 interactions.
IntActiQ12894. 14 interactions.
STRINGi9606.ENSP00000398971.

PTM databases

iPTMnetiQ12894.
PhosphoSiteiQ12894.

Polymorphism and mutation databases

BioMutaiIFRD2.
DMDMi327478577.

Proteomic databases

EPDiQ12894.
MaxQBiQ12894.
PaxDbiQ12894.
PRIDEiQ12894.

Protocols and materials databases

DNASUi7866.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417626; ENSP00000402849; ENSG00000214706. [Q12894-1]
GeneIDi7866.
KEGGihsa:7866.
UCSCiuc011bdp.2. human. [Q12894-1]

Organism-specific databases

CTDi7866.
GeneCardsiIFRD2.
H-InvDBHIX0003317.
HGNCiHGNC:5457. IFRD2.
HPAiHPA019702.
HPA031525.
MIMi602725. gene.
neXtProtiNX_Q12894.
PharmGKBiPA29692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2842. Eukaryota.
ENOG410XSIZ. LUCA.
GeneTreeiENSGT00390000013347.
HOGENOMiHOG000252918.
HOVERGENiHBG052089.
InParanoidiQ12894.
OMAiWARRRIY.
OrthoDBiEOG7CZK5H.
PhylomeDBiQ12894.
TreeFamiTF313638.

Miscellaneous databases

ChiTaRSiIFRD2. human.
GenomeRNAii7866.
NextBioi13655076.
PROiQ12894.
SOURCEiSearch...

Gene expression databases

BgeeiQ12894.
CleanExiHS_IFRD2.
ExpressionAtlasiQ12894. baseline and differential.
GenevisibleiQ12894. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006921. Interferon-rel_develop_reg_C.
IPR007701. Interferon-rel_develop_reg_N.
[Graphical view]
PfamiPF05004. IFRD. 1 hit.
PF04836. IFRD_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Buanne P., Incerti B., Tirone F.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-502.
    Tissue: Cervix, Kidney, Muscle and Placenta.
  5. "The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21."
    Latif F., Duh F.-M., Bader S., Sekido Y., Li H., Geil L., Zbar B., Minna J.D., Lerman M.I.
    Hum. Genet. 99:334-341(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 66-506 (ISOFORM 1/2).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiIFRD2_HUMAN
AccessioniPrimary (citable) accession number: Q12894
Secondary accession number(s): Q9BVB4, Q9UJ88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 5, 2011
Last modified: April 13, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-65 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.