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Q12893

- TM115_HUMAN

UniProt

Q12893 - TM115_HUMAN

Protein

Transmembrane protein 115

Gene

TMEM115

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. negative regulation of cell proliferation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 115
    Alternative name(s):
    Placental protein 6
    Short name:
    PP6
    Protein PL6
    Gene namesi
    Name:TMEM115
    Synonyms:PL6
    ORF Names:LUCA11.2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30055. TMEM115.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485636.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Transmembrane protein 115PRO_0000058451Add
    BLAST

    Proteomic databases

    MaxQBiQ12893.
    PaxDbiQ12893.
    PeptideAtlasiQ12893.
    PRIDEiQ12893.

    PTM databases

    PhosphoSiteiQ12893.

    Expressioni

    Tissue specificityi

    Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain.

    Gene expression databases

    BgeeiQ12893.
    CleanExiHS_TMEM115.
    GenevestigatoriQ12893.

    Organism-specific databases

    HPAiCAB006319.
    HPA015497.

    Interactioni

    Protein-protein interaction databases

    BioGridi116254. 2 interactions.
    IntActiQ12893. 2 interactions.
    STRINGi9606.ENSP00000266025.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12893.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 12023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 20819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei223 – 24523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251000.
    HOGENOMiHOG000007827.
    HOVERGENiHBG027575.
    InParanoidiQ12893.
    OMAiARQHFLA.
    OrthoDBiEOG7XH6QP.
    PhylomeDBiQ12893.
    TreeFamiTF315100.

    Family and domain databases

    InterProiIPR013861. DUF1751_Mem_euk.
    [Graphical view]
    PfamiPF08551. DUF1751. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12893-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG    50
    YLFPPNFWIW TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI 100
    FFSVVNVSVG LLGAFAYLLT YMASFNLVYL FTVRIHGALG FLGGVLVALK 150
    QTMGDCVVLR VPQVRVSVMP MLLLALLLLL RLATLLQSPA LASYGFGLLS 200
    SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHSLLVKV 250
    KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED 300
    QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT 350
    L 351
    Length:351
    Mass (Da):38,197
    Last modified:November 1, 1996 - v1
    Checksum:i8CFBF66322FDEEFC
    GO

    Sequence cautioni

    The sequence AAB67308.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09584 mRNA. Translation: AAA92281.1.
    CR457020 mRNA. Translation: CAG33301.1.
    AC002481 Genomic DNA. Translation: AAB67308.1. Sequence problems.
    Z84492 Genomic DNA. Translation: CAM28372.2.
    CH471055 Genomic DNA. Translation: EAW65115.1.
    BC011948 mRNA. Translation: AAH11948.1.
    BC017367 mRNA. Translation: AAH17367.1.
    CCDSiCCDS2828.1.
    PIRiG01430.
    RefSeqiNP_008955.1. NM_007024.4.
    UniGeneiHs.91566.

    Genome annotation databases

    EnsembliENST00000266025; ENSP00000266025; ENSG00000126062.
    GeneIDi11070.
    KEGGihsa:11070.
    UCSCiuc003dan.1. human.

    Polymorphism databases

    DMDMi24638130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09584 mRNA. Translation: AAA92281.1 .
    CR457020 mRNA. Translation: CAG33301.1 .
    AC002481 Genomic DNA. Translation: AAB67308.1 . Sequence problems.
    Z84492 Genomic DNA. Translation: CAM28372.2 .
    CH471055 Genomic DNA. Translation: EAW65115.1 .
    BC011948 mRNA. Translation: AAH11948.1 .
    BC017367 mRNA. Translation: AAH17367.1 .
    CCDSi CCDS2828.1.
    PIRi G01430.
    RefSeqi NP_008955.1. NM_007024.4.
    UniGenei Hs.91566.

    3D structure databases

    ProteinModelPortali Q12893.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116254. 2 interactions.
    IntActi Q12893. 2 interactions.
    STRINGi 9606.ENSP00000266025.

    PTM databases

    PhosphoSitei Q12893.

    Polymorphism databases

    DMDMi 24638130.

    Proteomic databases

    MaxQBi Q12893.
    PaxDbi Q12893.
    PeptideAtlasi Q12893.
    PRIDEi Q12893.

    Protocols and materials databases

    DNASUi 11070.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266025 ; ENSP00000266025 ; ENSG00000126062 .
    GeneIDi 11070.
    KEGGi hsa:11070.
    UCSCi uc003dan.1. human.

    Organism-specific databases

    CTDi 11070.
    GeneCardsi GC03M050392.
    HGNCi HGNC:30055. TMEM115.
    HPAi CAB006319.
    HPA015497.
    MIMi 607069. gene.
    neXtProti NX_Q12893.
    PharmGKBi PA143485636.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251000.
    HOGENOMi HOG000007827.
    HOVERGENi HBG027575.
    InParanoidi Q12893.
    OMAi ARQHFLA.
    OrthoDBi EOG7XH6QP.
    PhylomeDBi Q12893.
    TreeFami TF315100.

    Miscellaneous databases

    GenomeRNAii 11070.
    NextBioi 42086.
    PROi Q12893.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q12893.
    CleanExi HS_TMEM115.
    Genevestigatori Q12893.

    Family and domain databases

    InterProi IPR013861. DUF1751_Mem_euk.
    [Graphical view ]
    Pfami PF08551. DUF1751. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human cDNA that is homozygously deleted in small cell lung cancer and located to 3p21.3."
      Latif F., Duh F.-M., Bader S., Lerman M.I., Minna J.D.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Muscle.
    6. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
      The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
      Lerman M.I., Minna J.D.
      Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTM115_HUMAN
    AccessioniPrimary (citable) accession number: Q12893
    Secondary accession number(s): A2IDB7
    , O14568, Q6IAY4, Q9UIX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3