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Q12893 (TM115_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 115
Alternative name(s):
Placental protein 6
Short name=PP6
Protein PL6
Gene names
Name:TMEM115
Synonyms:PL6
ORF Names:LUCA11.2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain.

Sequence caution

The sequence AAB67308.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Transmembrane protein 115
PRO_0000058451

Regions

Transmembrane13 – 3523Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane98 – 12023Helical; Potential
Transmembrane127 – 14923Helical; Potential
Transmembrane164 – 18320Helical; Potential
Transmembrane190 – 20819Helical; Potential
Transmembrane223 – 24523Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q12893 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8CFBF66322FDEEFC

FASTA35138,197
        10         20         30         40         50         60 
MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG YLFPPNFWIW 

        70         80         90        100        110        120 
TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI FFSVVNVSVG LLGAFAYLLT 

       130        140        150        160        170        180 
YMASFNLVYL FTVRIHGALG FLGGVLVALK QTMGDCVVLR VPQVRVSVMP MLLLALLLLL 

       190        200        210        220        230        240 
RLATLLQSPA LASYGFGLLS SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA 

       250        260        270        280        290        300 
NLVHSLLVKV KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED 

       310        320        330        340        350 
QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT L 

« Hide

References

« Hide 'large scale' references
[1]"A novel human cDNA that is homozygously deleted in small cell lung cancer and located to 3p21.3."
Latif F., Duh F.-M., Bader S., Lerman M.I., Minna J.D.
Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Muscle.
[6]"The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
Lerman M.I., Minna J.D.
Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09584 mRNA. Translation: AAA92281.1.
CR457020 mRNA. Translation: CAG33301.1.
AC002481 Genomic DNA. Translation: AAB67308.1. Sequence problems.
Z84492 Genomic DNA. Translation: CAM28372.2.
CH471055 Genomic DNA. Translation: EAW65115.1.
BC011948 mRNA. Translation: AAH11948.1.
BC017367 mRNA. Translation: AAH17367.1.
CCDSCCDS2828.1.
PIRG01430.
RefSeqNP_008955.1. NM_007024.4.
UniGeneHs.91566.

3D structure databases

ProteinModelPortalQ12893.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116254. 2 interactions.
IntActQ12893. 2 interactions.
STRING9606.ENSP00000266025.

PTM databases

PhosphoSiteQ12893.

Polymorphism databases

DMDM24638130.

Proteomic databases

MaxQBQ12893.
PaxDbQ12893.
PeptideAtlasQ12893.
PRIDEQ12893.

Protocols and materials databases

DNASU11070.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266025; ENSP00000266025; ENSG00000126062.
GeneID11070.
KEGGhsa:11070.
UCSCuc003dan.1. human.

Organism-specific databases

CTD11070.
GeneCardsGC03M050392.
HGNCHGNC:30055. TMEM115.
HPACAB006319.
HPA015497.
MIM607069. gene.
neXtProtNX_Q12893.
PharmGKBPA143485636.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251000.
HOGENOMHOG000007827.
HOVERGENHBG027575.
InParanoidQ12893.
OMAARQHFLA.
OrthoDBEOG7XH6QP.
PhylomeDBQ12893.
TreeFamTF315100.

Gene expression databases

BgeeQ12893.
CleanExHS_TMEM115.
GenevestigatorQ12893.

Family and domain databases

InterProIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamPF08551. DUF1751. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi11070.
NextBio42086.
PROQ12893.
SOURCESearch...

Entry information

Entry nameTM115_HUMAN
AccessionPrimary (citable) accession number: Q12893
Secondary accession number(s): A2IDB7 expand/collapse secondary AC list , O14568, Q6IAY4, Q9UIX3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM