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Protein

Transmembrane protein 115

Gene

TMEM115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • negative regulation of cell proliferation Source: UniProtKB
  • protein glycosylation Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126062-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115Curated
Alternative name(s):
Placental protein 6Curated
Protein PL6Curated
Gene namesi
Name:TMEM115Imported
Synonyms:PL6Imported
ORF Names:LUCA11.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30055. TMEM115.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicCuratedAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 97LumenalCuratedAdd BLAST57
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 126CytoplasmicCurated8
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 165LumenalCuratedAdd BLAST18
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 351Cytoplasmic1 PublicationAdd BLAST165

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11070.
OpenTargetsiENSG00000126062.
PharmGKBiPA143485636.

Polymorphism and mutation databases

BioMutaiTMEM115.
DMDMi24638130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584511 – 351Transmembrane protein 115Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ12893.
MaxQBiQ12893.
PaxDbiQ12893.
PeptideAtlasiQ12893.
PRIDEiQ12893.

PTM databases

iPTMnetiQ12893.
PhosphoSitePlusiQ12893.
SwissPalmiQ12893.

Expressioni

Tissue specificityi

Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242).2 Publications

Gene expression databases

BgeeiENSG00000126062.
CleanExiHS_TMEM115.
ExpressionAtlasiQ12893. baseline and differential.
GenevisibleiQ12893. HS.

Organism-specific databases

HPAiCAB006319.
HPA015497.

Interactioni

Subunit structurei

Homooligomer (PubMed:24806965). Interacts with COPB1 (PubMed:24806965). May interact with LMAN1 (PubMed:24806965). Interacts with the COG complex; probably through COG3 (PubMed:24806965).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-8633987,EBI-7131783

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116254. 7 interactors.
IntActiQ12893. 6 interactors.
STRINGi9606.ENSP00000266025.

Structurei

3D structure databases

ProteinModelPortaliQ12893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 205Mediates homooligomerization1 PublicationAdd BLAST205
Regioni206 – 229Mediates localization to the Golgi1 PublicationAdd BLAST24

Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2890. Eukaryota.
ENOG410XQM0. LUCA.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ12893.
OMAiIMAIISW.
OrthoDBiEOG091G0B9B.
PhylomeDBiQ12893.
TreeFamiTF315100.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG
60 70 80 90 100
YLFPPNFWIW TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI
110 120 130 140 150
FFSVVNVSVG LLGAFAYLLT YMASFNLVYL FTVRIHGALG FLGGVLVALK
160 170 180 190 200
QTMGDCVVLR VPQVRVSVMP MLLLALLLLL RLATLLQSPA LASYGFGLLS
210 220 230 240 250
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHSLLVKV
260 270 280 290 300
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
310 320 330 340 350
QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT

L
Length:351
Mass (Da):38,197
Last modified:November 1, 1996 - v1
Checksum:i8CFBF66322FDEEFC
GO

Sequence cautioni

The sequence AAB67308 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09584 mRNA. Translation: AAA92281.1.
CR457020 mRNA. Translation: CAG33301.1.
AC002481 Genomic DNA. Translation: AAB67308.1. Sequence problems.
Z84492 Genomic DNA. Translation: CAM28372.2.
CH471055 Genomic DNA. Translation: EAW65115.1.
BC011948 mRNA. Translation: AAH11948.1.
BC017367 mRNA. Translation: AAH17367.1.
CCDSiCCDS2828.1.
PIRiG01430.
RefSeqiNP_008955.1. NM_007024.4.
UniGeneiHs.91566.

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062.
GeneIDi11070.
KEGGihsa:11070.
UCSCiuc003dan.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09584 mRNA. Translation: AAA92281.1.
CR457020 mRNA. Translation: CAG33301.1.
AC002481 Genomic DNA. Translation: AAB67308.1. Sequence problems.
Z84492 Genomic DNA. Translation: CAM28372.2.
CH471055 Genomic DNA. Translation: EAW65115.1.
BC011948 mRNA. Translation: AAH11948.1.
BC017367 mRNA. Translation: AAH17367.1.
CCDSiCCDS2828.1.
PIRiG01430.
RefSeqiNP_008955.1. NM_007024.4.
UniGeneiHs.91566.

3D structure databases

ProteinModelPortaliQ12893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116254. 7 interactors.
IntActiQ12893. 6 interactors.
STRINGi9606.ENSP00000266025.

PTM databases

iPTMnetiQ12893.
PhosphoSitePlusiQ12893.
SwissPalmiQ12893.

Polymorphism and mutation databases

BioMutaiTMEM115.
DMDMi24638130.

Proteomic databases

EPDiQ12893.
MaxQBiQ12893.
PaxDbiQ12893.
PeptideAtlasiQ12893.
PRIDEiQ12893.

Protocols and materials databases

DNASUi11070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062.
GeneIDi11070.
KEGGihsa:11070.
UCSCiuc003dan.2. human.

Organism-specific databases

CTDi11070.
DisGeNETi11070.
GeneCardsiTMEM115.
HGNCiHGNC:30055. TMEM115.
HPAiCAB006319.
HPA015497.
MIMi607069. gene.
neXtProtiNX_Q12893.
OpenTargetsiENSG00000126062.
PharmGKBiPA143485636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2890. Eukaryota.
ENOG410XQM0. LUCA.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ12893.
OMAiIMAIISW.
OrthoDBiEOG091G0B9B.
PhylomeDBiQ12893.
TreeFamiTF315100.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126062-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

GenomeRNAii11070.
PROiQ12893.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126062.
CleanExiHS_TMEM115.
ExpressionAtlasiQ12893. baseline and differential.
GenevisibleiQ12893. HS.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM115_HUMAN
AccessioniPrimary (citable) accession number: Q12893
Secondary accession number(s): A2IDB7
, O14568, Q6IAY4, Q9UIX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.