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Protein

Transmembrane protein 115

Gene

TMEM115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell proliferation Source: UniProtKB
  • protein glycosylation Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115Curated
Alternative name(s):
Placental protein 6Curated
Protein PL6Curated
Gene namesi
Name:TMEM115Imported
Synonyms:PL6Imported
ORF Names:LUCA11.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30055. TMEM115.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicCuratedAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini41 – 9757LumenalCuratedAdd
BLAST
Transmembranei98 – 11821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini119 – 1268CytoplasmicCurated
Transmembranei127 – 14721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini148 – 16518LumenalCuratedAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini187 – 351165Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485636.

Polymorphism and mutation databases

BioMutaiTMEM115.
DMDMi24638130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Transmembrane protein 115PRO_0000058451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12893.
PaxDbiQ12893.
PeptideAtlasiQ12893.
PRIDEiQ12893.

PTM databases

PhosphoSiteiQ12893.

Expressioni

Tissue specificityi

Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242).2 Publications

Gene expression databases

BgeeiQ12893.
CleanExiHS_TMEM115.
ExpressionAtlasiQ12893. baseline and differential.
GenevisibleiQ12893. HS.

Organism-specific databases

HPAiCAB006319.
HPA015497.

Interactioni

Subunit structurei

Homooligomer (PubMed:24806965). Interacts with COPB1 (PubMed:24806965). May interact with LMAN1 (PubMed:24806965). Interacts with the COG complex; probably through COG3 (PubMed:24806965).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-8633987,EBI-7131783

Protein-protein interaction databases

BioGridi116254. 3 interactions.
IntActiQ12893. 3 interactions.
STRINGi9606.ENSP00000266025.

Structurei

3D structure databases

ProteinModelPortaliQ12893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 205205Mediates homooligomerization1 PublicationAdd
BLAST
Regioni206 – 22924Mediates localization to the Golgi1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251000.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ12893.
OMAiRAEPRMI.
OrthoDBiEOG7XH6QP.
PhylomeDBiQ12893.
TreeFamiTF315100.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG
60 70 80 90 100
YLFPPNFWIW TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI
110 120 130 140 150
FFSVVNVSVG LLGAFAYLLT YMASFNLVYL FTVRIHGALG FLGGVLVALK
160 170 180 190 200
QTMGDCVVLR VPQVRVSVMP MLLLALLLLL RLATLLQSPA LASYGFGLLS
210 220 230 240 250
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHSLLVKV
260 270 280 290 300
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
310 320 330 340 350
QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT

L
Length:351
Mass (Da):38,197
Last modified:November 1, 1996 - v1
Checksum:i8CFBF66322FDEEFC
GO

Sequence cautioni

The sequence AAB67308.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09584 mRNA. Translation: AAA92281.1.
CR457020 mRNA. Translation: CAG33301.1.
AC002481 Genomic DNA. Translation: AAB67308.1. Sequence problems.
Z84492 Genomic DNA. Translation: CAM28372.2.
CH471055 Genomic DNA. Translation: EAW65115.1.
BC011948 mRNA. Translation: AAH11948.1.
BC017367 mRNA. Translation: AAH17367.1.
CCDSiCCDS2828.1.
PIRiG01430.
RefSeqiNP_008955.1. NM_007024.4.
UniGeneiHs.91566.

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062.
GeneIDi11070.
KEGGihsa:11070.
UCSCiuc003dan.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09584 mRNA. Translation: AAA92281.1.
CR457020 mRNA. Translation: CAG33301.1.
AC002481 Genomic DNA. Translation: AAB67308.1. Sequence problems.
Z84492 Genomic DNA. Translation: CAM28372.2.
CH471055 Genomic DNA. Translation: EAW65115.1.
BC011948 mRNA. Translation: AAH11948.1.
BC017367 mRNA. Translation: AAH17367.1.
CCDSiCCDS2828.1.
PIRiG01430.
RefSeqiNP_008955.1. NM_007024.4.
UniGeneiHs.91566.

3D structure databases

ProteinModelPortaliQ12893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116254. 3 interactions.
IntActiQ12893. 3 interactions.
STRINGi9606.ENSP00000266025.

PTM databases

PhosphoSiteiQ12893.

Polymorphism and mutation databases

BioMutaiTMEM115.
DMDMi24638130.

Proteomic databases

MaxQBiQ12893.
PaxDbiQ12893.
PeptideAtlasiQ12893.
PRIDEiQ12893.

Protocols and materials databases

DNASUi11070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062.
GeneIDi11070.
KEGGihsa:11070.
UCSCiuc003dan.1. human.

Organism-specific databases

CTDi11070.
GeneCardsiGC03M050392.
HGNCiHGNC:30055. TMEM115.
HPAiCAB006319.
HPA015497.
MIMi607069. gene.
neXtProtiNX_Q12893.
PharmGKBiPA143485636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251000.
GeneTreeiENSGT00390000002470.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ12893.
OMAiRAEPRMI.
OrthoDBiEOG7XH6QP.
PhylomeDBiQ12893.
TreeFamiTF315100.

Miscellaneous databases

GenomeRNAii11070.
NextBioi42086.
PROiQ12893.
SOURCEiSearch...

Gene expression databases

BgeeiQ12893.
CleanExiHS_TMEM115.
ExpressionAtlasiQ12893. baseline and differential.
GenevisibleiQ12893. HS.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
    The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    Lerman M.I., Minna J.D.
    Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Muscle.
  6. "Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours."
    Ivanova A.V., Vortmeyer A., Ivanov S.V., Nickerson M.L., Maher E.R., Lerman M.I.
    J. Pathol. 214:46-57(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport."
    Ong Y.S., Tran T.H., Gounko N.V., Hong W.
    J. Cell Sci. 127:2825-2839(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COPB1; LMAN1; COG3, HOMOOLIGOMERIZATION, REGION, TOPOLOGY.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTM115_HUMAN
AccessioniPrimary (citable) accession number: Q12893
Secondary accession number(s): A2IDB7
, O14568, Q6IAY4, Q9UIX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.