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Q12893

- TM115_HUMAN

UniProt

Q12893 - TM115_HUMAN

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Protein

Transmembrane protein 115

Gene
TMEM115, PL6, LUCA11.2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115
Alternative name(s):
Placental protein 6
Short name:
PP6
Protein PL6
Gene namesi
Name:TMEM115
Synonyms:PL6
ORF Names:LUCA11.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30055. TMEM115.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3523Helical; Reviewed predictionAdd
BLAST
Transmembranei43 – 6321Helical; Reviewed predictionAdd
BLAST
Transmembranei98 – 12023Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14923Helical; Reviewed predictionAdd
BLAST
Transmembranei164 – 18320Helical; Reviewed predictionAdd
BLAST
Transmembranei190 – 20819Helical; Reviewed predictionAdd
BLAST
Transmembranei223 – 24523Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Transmembrane protein 115PRO_0000058451Add
BLAST

Proteomic databases

MaxQBiQ12893.
PaxDbiQ12893.
PeptideAtlasiQ12893.
PRIDEiQ12893.

PTM databases

PhosphoSiteiQ12893.

Expressioni

Tissue specificityi

Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain.

Gene expression databases

BgeeiQ12893.
CleanExiHS_TMEM115.
GenevestigatoriQ12893.

Organism-specific databases

HPAiCAB006319.
HPA015497.

Interactioni

Protein-protein interaction databases

BioGridi116254. 2 interactions.
IntActiQ12893. 2 interactions.
STRINGi9606.ENSP00000266025.

Structurei

3D structure databases

ProteinModelPortaliQ12893.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251000.
HOGENOMiHOG000007827.
HOVERGENiHBG027575.
InParanoidiQ12893.
OMAiARQHFLA.
OrthoDBiEOG7XH6QP.
PhylomeDBiQ12893.
TreeFamiTF315100.

Family and domain databases

InterProiIPR013861. DUF1751_Mem_euk.
[Graphical view]
PfamiPF08551. DUF1751. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12893-1 [UniParc]FASTAAdd to Basket

« Hide

MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG    50
YLFPPNFWIW TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI 100
FFSVVNVSVG LLGAFAYLLT YMASFNLVYL FTVRIHGALG FLGGVLVALK 150
QTMGDCVVLR VPQVRVSVMP MLLLALLLLL RLATLLQSPA LASYGFGLLS 200
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHSLLVKV 250
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED 300
QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT 350
L 351
Length:351
Mass (Da):38,197
Last modified:November 1, 1996 - v1
Checksum:i8CFBF66322FDEEFC
GO

Sequence cautioni

The sequence AAB67308.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09584 mRNA. Translation: AAA92281.1.
CR457020 mRNA. Translation: CAG33301.1.
AC002481 Genomic DNA. Translation: AAB67308.1. Sequence problems.
Z84492 Genomic DNA. Translation: CAM28372.2.
CH471055 Genomic DNA. Translation: EAW65115.1.
BC011948 mRNA. Translation: AAH11948.1.
BC017367 mRNA. Translation: AAH17367.1.
CCDSiCCDS2828.1.
PIRiG01430.
RefSeqiNP_008955.1. NM_007024.4.
UniGeneiHs.91566.

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062.
GeneIDi11070.
KEGGihsa:11070.
UCSCiuc003dan.1. human.

Polymorphism databases

DMDMi24638130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09584 mRNA. Translation: AAA92281.1 .
CR457020 mRNA. Translation: CAG33301.1 .
AC002481 Genomic DNA. Translation: AAB67308.1 . Sequence problems.
Z84492 Genomic DNA. Translation: CAM28372.2 .
CH471055 Genomic DNA. Translation: EAW65115.1 .
BC011948 mRNA. Translation: AAH11948.1 .
BC017367 mRNA. Translation: AAH17367.1 .
CCDSi CCDS2828.1.
PIRi G01430.
RefSeqi NP_008955.1. NM_007024.4.
UniGenei Hs.91566.

3D structure databases

ProteinModelPortali Q12893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116254. 2 interactions.
IntActi Q12893. 2 interactions.
STRINGi 9606.ENSP00000266025.

PTM databases

PhosphoSitei Q12893.

Polymorphism databases

DMDMi 24638130.

Proteomic databases

MaxQBi Q12893.
PaxDbi Q12893.
PeptideAtlasi Q12893.
PRIDEi Q12893.

Protocols and materials databases

DNASUi 11070.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266025 ; ENSP00000266025 ; ENSG00000126062 .
GeneIDi 11070.
KEGGi hsa:11070.
UCSCi uc003dan.1. human.

Organism-specific databases

CTDi 11070.
GeneCardsi GC03M050392.
HGNCi HGNC:30055. TMEM115.
HPAi CAB006319.
HPA015497.
MIMi 607069. gene.
neXtProti NX_Q12893.
PharmGKBi PA143485636.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251000.
HOGENOMi HOG000007827.
HOVERGENi HBG027575.
InParanoidi Q12893.
OMAi ARQHFLA.
OrthoDBi EOG7XH6QP.
PhylomeDBi Q12893.
TreeFami TF315100.

Miscellaneous databases

GenomeRNAii 11070.
NextBioi 42086.
PROi Q12893.
SOURCEi Search...

Gene expression databases

Bgeei Q12893.
CleanExi HS_TMEM115.
Genevestigatori Q12893.

Family and domain databases

InterProi IPR013861. DUF1751_Mem_euk.
[Graphical view ]
Pfami PF08551. DUF1751. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human cDNA that is homozygously deleted in small cell lung cancer and located to 3p21.3."
    Latif F., Duh F.-M., Bader S., Lerman M.I., Minna J.D.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Muscle.
  6. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
    The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    Lerman M.I., Minna J.D.
    Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM115_HUMAN
AccessioniPrimary (citable) accession number: Q12893
Secondary accession number(s): A2IDB7
, O14568, Q6IAY4, Q9UIX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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