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Protein

Oviduct-specific glycoprotein

Gene

OVGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fertilization

Enzyme and pathway databases

ReactomeiR-HSA-1300644. Interaction With The Zona Pellucida.

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Oviduct-specific glycoprotein
Alternative name(s):
Estrogen-dependent oviduct protein
Mucin-9
Oviductal glycoprotein
Oviductin
Gene namesi
Name:OVGP1
Synonyms:MUC9, OGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8524. OVGP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32852.

Polymorphism and mutation databases

BioMutaiOVGP1.
DMDMi2493676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 678657Oviduct-specific glycoproteinPRO_0000011973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence analysis
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence analysis
Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence analysis
Glycosylationi648 – 6481N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ12889.
PRIDEiQ12889.

PTM databases

PhosphoSiteiQ12889.

Expressioni

Tissue specificityi

Oviduct.

Gene expression databases

BgeeiQ12889.
CleanExiHS_OVGP1.
GenevisibleiQ12889. HS.

Organism-specific databases

HPAiHPA062205.

Interactioni

Protein-protein interaction databases

BioGridi111056. 1 interaction.
IntActiQ12889. 2 interactions.
MINTiMINT-1380039.
STRINGi9606.ENSP00000358747.

Structurei

3D structure databases

ProteinModelPortaliQ12889.
SMRiQ12889. Positions 22-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111109.
HOVERGENiHBG011684.
InParanoidiQ12889.
KOiK17526.
OMAiGAKKHWI.
OrthoDBiEOG7ZGX3G.
PhylomeDBiQ12889.
TreeFamiTF315610.

Family and domain databases

Gene3Di3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKLLLWVGL VLVLKHHDGA AHKLVCYFTN WAHSRPGPAS ILPHDLDPFL
60 70 80 90 100
CTHLIFAFAS MNNNQIVAKD LQDEKILYPE FNKLKERNRE LKTLLSIGGW
110 120 130 140 150
NFGTSRFTTM LSTFANREKF IASVISLLRT HDFDGLDLFF LYPGLRGSPM
160 170 180 190 200
HDRWTFLFLI EELLFAFRKE ALLTMRPRLL LSAAVSGVPH IVQTSYDVRF
210 220 230 240 250
LGRLLDFINV LSYDLHGSWE RFTGHNSPLF SLPEDPKSSA YAMNYWRKLG
260 270 280 290 300
APSEKLIMGI PTYGRTFRLL KASKNGLQAR AIGPASPGKY TKQEGFLAYF
310 320 330 340 350
EICSFVWGAK KHWIDYQYVP YANKGKEWVG YDNAISFSYK AWFIRREHFG
360 370 380 390 400
GAMVWTLDMD DVRGTFCGTG PFPLVYVLND ILVRAEFSST SLPQFWLSSA
410 420 430 440 450
VNSSSTDPER LAVTTAWTTD SKILPPGGEA GVTEIHGKCE NMTITPRGTT
460 470 480 490 500
VTPTKETVSL GKHTVALGEK TEITGAMTMT SVGHQSMTPG EKALTPVGHQ
510 520 530 540 550
SVTTGQKTLT SVGYQSVTPG EKTLTPVGHQ SVTPVSHQSV SPGGTTMTPV
560 570 580 590 600
HFQTETLRQN TVAPRRKAVA REKVTVPSRN ISVTPEGQTM PLRGENLTSE
610 620 630 640 650
VGTHPRMGNL GLQMEAENRM MLSSSPVIQL PEQTPLAFDN RFVPIYGNHS
660 670
SVNSVTPQTS PLSLKKEIPE NSAVDEEA
Length:678
Mass (Da):75,421
Last modified:November 1, 1997 - v1
Checksum:i245F2CEDCE92768B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti511 – 5111S → P in AAB04126 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321D → E.
Corresponds to variant rs17027633 [ dbSNP | Ensembl ].
VAR_049199
Natural varianti477 – 4771M → T.1 Publication
Corresponds to variant rs2485319 [ dbSNP | Ensembl ].
VAR_024459
Natural varianti479 – 4791M → V.
Corresponds to variant rs3767607 [ dbSNP | Ensembl ].
VAR_049200
Natural varianti514 – 5141Y → H.1 Publication
Corresponds to variant rs1126656 [ dbSNP | Ensembl ].
VAR_049201
Natural varianti526 – 5261P → S.
Corresponds to variant rs12096782 [ dbSNP | Ensembl ].
VAR_061190
Natural varianti536 – 5361S → G.
Corresponds to variant rs3767609 [ dbSNP | Ensembl ].
VAR_049202
Natural varianti604 – 6041H → Q.
Corresponds to variant rs10067 [ dbSNP | Ensembl ].
VAR_024460
Natural varianti662 – 6621L → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035752
Natural varianti676 – 6761E → Q.1 Publication
Corresponds to variant rs7825 [ dbSNP | Ensembl ].
VAR_016109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09550 mRNA. Translation: AAA86946.1.
U58010
, U58001, U58002, U58003, U58004, U58005, U58006, U58007, U58008, U58009 Genomic DNA. Translation: AAB04126.1.
AL390195 Genomic DNA. Translation: CAC36039.1.
BC126177 mRNA. Translation: AAI26178.1.
BC136406 mRNA. Translation: AAI36407.1.
CCDSiCCDS834.1.
RefSeqiNP_002548.3. NM_002557.3.
UniGeneiHs.1154.

Genome annotation databases

EnsembliENST00000369732; ENSP00000358747; ENSG00000085465.
GeneIDi5016.
KEGGihsa:5016.
UCSCiuc001eba.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09550 mRNA. Translation: AAA86946.1.
U58010
, U58001, U58002, U58003, U58004, U58005, U58006, U58007, U58008, U58009 Genomic DNA. Translation: AAB04126.1.
AL390195 Genomic DNA. Translation: CAC36039.1.
BC126177 mRNA. Translation: AAI26178.1.
BC136406 mRNA. Translation: AAI36407.1.
CCDSiCCDS834.1.
RefSeqiNP_002548.3. NM_002557.3.
UniGeneiHs.1154.

3D structure databases

ProteinModelPortaliQ12889.
SMRiQ12889. Positions 22-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111056. 1 interaction.
IntActiQ12889. 2 interactions.
MINTiMINT-1380039.
STRINGi9606.ENSP00000358747.

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

PTM databases

PhosphoSiteiQ12889.

Polymorphism and mutation databases

BioMutaiOVGP1.
DMDMi2493676.

Proteomic databases

PaxDbiQ12889.
PRIDEiQ12889.

Protocols and materials databases

DNASUi5016.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369732; ENSP00000358747; ENSG00000085465.
GeneIDi5016.
KEGGihsa:5016.
UCSCiuc001eba.4. human.

Organism-specific databases

CTDi5016.
GeneCardsiOVGP1.
HGNCiHGNC:8524. OVGP1.
HPAiHPA062205.
MIMi603578. gene.
neXtProtiNX_Q12889.
PharmGKBiPA32852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000111109.
HOVERGENiHBG011684.
InParanoidiQ12889.
KOiK17526.
OMAiGAKKHWI.
OrthoDBiEOG7ZGX3G.
PhylomeDBiQ12889.
TreeFamiTF315610.

Enzyme and pathway databases

ReactomeiR-HSA-1300644. Interaction With The Zona Pellucida.

Miscellaneous databases

GeneWikiiOVGP1.
GenomeRNAii5016.
NextBioi19310.
PROiQ12889.
SOURCEiSearch...

Gene expression databases

BgeeiQ12889.
CleanExiHS_OVGP1.
GenevisibleiQ12889. HS.

Family and domain databases

Gene3Di3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein."
    Arias E.B., Verhage H.G., Jaffe R.C.
    Biol. Reprod. 51:685-694(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Oviduct.
  2. "Human oviductal glycoprotein gene."
    Jaffe R.C.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-477; HIS-514 AND GLN-676.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-662.

Entry informationi

Entry nameiOVGP1_HUMAN
AccessioniPrimary (citable) accession number: Q12889
Secondary accession number(s): A0AV19, B9EGE1, Q15841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 16, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.