Reviewed,
UniProtKB/Swiss-Prot Q12888 (TP53B_HUMAN)
Last modified
November 25, 2008.
Version 93.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tumor suppressor p53-binding protein 1 Short name=p53-binding protein 1 Short name=p53BP1 Short name=53BP1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1972 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May have a role in checkpoint signaling during mitosis By similarity. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage. |
| Subunit structure | Interacts with IFI202A By similarity. Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3. |
| Subcellular location | Nucleus. Kinetochore. Note= Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks. |
| Post-translational modification | Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. |
| Sequence similarities | Contains 2 BRCT domains. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| BRCA1 | P38398 | 1 | EBI-396540,EBI-349905 | |
| H2AFX | P16104 | 1 | EBI-396540,EBI-494830 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q12888-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q12888-2) The sequence of this isoform differs from the canonical sequence as follows: 1-1: M → MPGEQM |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1972 | 1972 | Tumor suppressor p53-binding protein 1 | PRO_0000072643 | |||||
Regions | |||||||||
| Domain | 1724 – 1848 | 125 | BRCT 1 | ||||||
| Domain | 1864 – 1964 | 101 | BRCT 2 | ||||||
| Region | 1495 – 1523 | 29 | Interaction with dimethylated histone H4 | ||||||
| Motif | 1396 – 1403 | 8 | GAR | ||||||
| Compositional bias | 1642 – 1646 | 5 | Poly-Ser | ||||||
| Compositional bias | 1760 – 1764 | 5 | Poly-Glu | ||||||
Amino acid modifications | |||||||||
| Modified residue | 105 | 1 | Phosphoserine | ||||||
| Modified residue | 166 | 1 | Phosphoserine | ||||||
| Modified residue | 176 | 1 | Phosphoserine Probable | ||||||
| Modified residue | 178 | 1 | Phosphoserine Probable | ||||||
| Modified residue | 222 | 1 | Phosphoserine | ||||||
| Modified residue | 265 | 1 | Phosphoserine | ||||||
| Modified residue | 294 | 1 | Phosphoserine | ||||||
| Modified residue | 302 | 1 | Phosphothreonine | ||||||
| Modified residue | 316 | 1 | Phosphoserine | ||||||
| Modified residue | 380 | 1 | Phosphoserine | ||||||
| Modified residue | 395 | 1 | Phosphoserine | ||||||
| Modified residue | 398 | 1 | Phosphoserine | ||||||
| Modified residue | 452 | 1 | Phosphoserine | ||||||
| Modified residue | 500 | 1 | Phosphoserine | ||||||
| Modified residue | 523 | 1 | Phosphoserine | ||||||
| Modified residue | 525 | 1 | Phosphoserine | ||||||
| Modified residue | 543 | 1 | Phosphothreonine | ||||||
| Modified residue | 548 | 1 | Phosphothreonine | ||||||
| Modified residue | 552 | 1 | Phosphoserine | ||||||
| Modified residue | 566 | 1 | Phosphoserine | ||||||
| Modified residue | 580 | 1 | Phosphoserine | ||||||
| Modified residue | 625 | 1 | Phosphoserine | ||||||
| Modified residue | 635 | 1 | Phosphoserine | ||||||
| Modified residue | 639 | 1 | Phosphoserine | ||||||
| Modified residue | 640 | 1 | Phosphoserine | ||||||
| Modified residue | 659 | 1 | Phosphoserine | ||||||
| Modified residue | 660 | 1 | Phosphoserine | ||||||
| Modified residue | 662 | 1 | Phosphoserine | ||||||
| Modified residue | 750 | 1 | Phosphothreonine | ||||||
| Modified residue | 751 | 1 | Phosphoserine | ||||||
| Modified residue | 754 | 1 | Phosphoserine | ||||||
| Modified residue | 755 | 1 | Phosphoserine | ||||||
| Modified residue | 771 | 1 | Phosphoserine | ||||||
| Modified residue | 782 | 1 | Phosphoserine | ||||||
| Modified residue | 784 | 1 | Phosphoserine | ||||||
| Modified residue | 809 | 1 | Phosphoserine | ||||||
| Modified residue | 831 | 1 | Phosphoserine | ||||||
| Modified residue | 855 | 1 | Phosphothreonine | ||||||
| Modified residue | 876 | 1 | Phosphoserine | ||||||
| Modified residue | 877 | 1 | Phosphoserine | ||||||
| Modified residue | 892 | 1 | Phosphoserine | ||||||
| Modified residue | 993 | 1 | Phosphoserine | ||||||
| Modified residue | 996 | 1 | Phosphothreonine | ||||||
| Modified residue | 999 | 1 | Phosphoserine | ||||||
| Modified residue | 1002 | 1 | Phosphoserine | ||||||
| Modified residue | 1028 | 1 | Phosphoserine | ||||||
| Modified residue | 1056 | 1 | Phosphothreonine | ||||||
| Modified residue | 1068 | 1 | Phosphoserine | ||||||
| Modified residue | 1094 | 1 | Phosphoserine | ||||||
| Modified residue | 1101 | 1 | Phosphoserine | ||||||
| Modified residue | 1104 | 1 | Phosphoserine | ||||||
| Modified residue | 1114 | 1 | Phosphoserine | ||||||
| Modified residue | 1171 | 1 | Phosphothreonine | ||||||
| Modified residue | 1214 | 1 | Phosphothreonine | ||||||
| Modified residue | 1216 | 1 | Phosphoserine | ||||||
| Modified residue | 1219 | 1 | Phosphoserine | ||||||
| Modified residue | 1290 | 1 | Phosphoserine | ||||||
| Modified residue | 1316 | 1 | Phosphoserine | ||||||
| Modified residue | 1317 | 1 | Phosphoserine | ||||||
| Modified residue | 1320 | 1 | Phosphoserine | ||||||
| Modified residue | 1362 | 1 | Phosphoserine | ||||||
| Modified residue | 1368 | 1 | Phosphoserine | ||||||
| Modified residue | 1372 | 1 | Phosphothreonine | ||||||
| Modified residue | 1426 | 1 | Phosphoserine | ||||||
| Modified residue | 1430 | 1 | Phosphoserine | ||||||
| Modified residue | 1435 | 1 | Phosphoserine | ||||||
| Modified residue | 1462 | 1 | Phosphoserine | ||||||
| Modified residue | 1609 | 1 | Phosphothreonine | ||||||
| Modified residue | 1618 | 1 | Phosphoserine | ||||||
| Modified residue | 1631 | 1 | Phosphoserine | ||||||
| Modified residue | 1634 | 1 | Phosphoserine | ||||||
| Modified residue | 1635 | 1 | Phosphoserine | ||||||
| Modified residue | 1638 | 1 | Phosphothreonine | ||||||
| Modified residue | 1647 | 1 | Phosphothreonine | ||||||
| Modified residue | 1672 | 1 | Phosphothreonine | ||||||
| Modified residue | 1673 | 1 | Phosphoserine | ||||||
| Modified residue | 1678 | 1 | Phosphoserine | ||||||
| Modified residue | 1701 | 1 | Phosphoserine | ||||||
| Modified residue | 1705 | 1 | Phosphoserine | ||||||
| Modified residue | 1709 | 1 | Phosphothreonine | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 | 1 | M → MPGEQM in isoform 2. | VSP_018390 | |||||
| Natural variant | 353 | 1 | D → E: dbSNP rs560191. | VAR_022172 | |||||
| Natural variant | 412 | 1 | G → S: dbSNP rs689647. | VAR_022173 | |||||
| Natural variant | 648 | 1 | M → V: dbSNP rs45443496. | VAR_022174 | |||||
| Natural variant | 699 | 1 | Q → R: dbSNP rs34823068. | VAR_022175 | |||||
| Natural variant | 841 | 1 | D → G: dbSNP rs34185035. | VAR_034558 | |||||
| Natural variant | 1014 | 1 | E → G: dbSNP rs45470395. | VAR_022176 | |||||
| Natural variant | 1026 | 1 | V → A: dbSNP rs45482998. | VAR_022177 | |||||
| Natural variant | 1136 | 1 | K → Q: dbSNP rs2602141. | VAR_022178 | |||||
| Natural variant | 1137 | 1 | E → K: dbSNP rs34740611. | ||||||

Clusters with