##gff-version 3 Q12879 UniProtKB Signal peptide 1 22 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Chain 23 1464 . . . ID=PRO_0000011573;Note=Glutamate receptor ionotropic%2C NMDA 2A Q12879 UniProtKB Topological domain 23 555 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Transmembrane 556 576 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Topological domain 577 600 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Intramembrane 601 620 . . . Note=Discontinuously helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Topological domain 621 625 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Transmembrane 626 645 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Topological domain 646 816 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Transmembrane 817 837 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Topological domain 838 1464 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Region 599 620 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B7ZSK1 Q12879 UniProtKB Region 997 1083 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q12879 UniProtKB Region 1335 1372 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q12879 UniProtKB Motif 1462 1464 . . . Note=PDZ-binding;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q12879 UniProtKB Compositional bias 1019 1036 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q12879 UniProtKB Compositional bias 1037 1083 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q12879 UniProtKB Compositional bias 1353 1372 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q12879 UniProtKB Binding site 44 44 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Binding site 128 128 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Binding site 266 266 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Binding site 282 282 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Binding site 511 513 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26875626,ECO:0000269|PubMed:26919761,ECO:0000269|PubMed:28105280,ECO:0007744|PDB:5H8F,ECO:0007744|PDB:5H8H,ECO:0007744|PDB:5H8N,ECO:0007744|PDB:5H8Q,ECO:0007744|PDB:5I2K,ECO:0007744|PDB:5I2N,ECO:0007744|PDB:5KCJ,ECO:0007744|PDB:5KDT,ECO:0007744|PDB:5TP9,ECO:0007744|PDB:5TPA;Dbxref=PMID:26875626,PMID:26919761,PMID:28105280 Q12879 UniProtKB Binding site 518 518 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26875626,ECO:0000269|PubMed:26919761,ECO:0000269|PubMed:28105280,ECO:0007744|PDB:5H8F,ECO:0007744|PDB:5H8H,ECO:0007744|PDB:5H8N,ECO:0007744|PDB:5H8Q,ECO:0007744|PDB:5I2K,ECO:0007744|PDB:5I2N,ECO:0007744|PDB:5KCJ,ECO:0007744|PDB:5KDT,ECO:0007744|PDB:5TP9,ECO:0007744|PDB:5TPA;Dbxref=PMID:26875626,PMID:26919761,PMID:28105280 Q12879 UniProtKB Binding site 689 690 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Binding site 730 731 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Site 614 614 . . . Note=Functional determinant of NMDA receptors;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q12879 UniProtKB Modified residue 882 882 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35436 Q12879 UniProtKB Modified residue 890 890 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35436 Q12879 UniProtKB Modified residue 929 929 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35436 Q12879 UniProtKB Modified residue 1025 1025 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Modified residue 1059 1059 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35436 Q12879 UniProtKB Modified residue 1062 1062 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Modified residue 1198 1198 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Modified residue 1291 1291 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Glycosylation 75 75 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Glycosylation 340 340 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Glycosylation 380 380 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Glycosylation 443 443 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Glycosylation 444 444 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Glycosylation 541 541 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Glycosylation 687 687 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q12879 UniProtKB Disulfide bond 87 320 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Disulfide bond 429 455 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26875626,ECO:0000269|PubMed:26919761,ECO:0000269|PubMed:28105280,ECO:0007744|PDB:5H8F,ECO:0007744|PDB:5H8H,ECO:0007744|PDB:5H8N,ECO:0007744|PDB:5H8Q,ECO:0007744|PDB:5I2K,ECO:0007744|PDB:5I2N,ECO:0007744|PDB:5KCJ,ECO:0007744|PDB:5KDT,ECO:0007744|PDB:5TP9,ECO:0007744|PDB:5TPA;Dbxref=PMID:26875626,PMID:26919761,PMID:28105280 Q12879 UniProtKB Disulfide bond 436 456 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26875626,ECO:0000269|PubMed:26919761,ECO:0000269|PubMed:28105280,ECO:0007744|PDB:5H8F,ECO:0007744|PDB:5H8H,ECO:0007744|PDB:5H8N,ECO:0007744|PDB:5H8Q,ECO:0007744|PDB:5I2K,ECO:0007744|PDB:5I2N,ECO:0007744|PDB:5KCJ,ECO:0007744|PDB:5KDT,ECO:0007744|PDB:5TP9,ECO:0007744|PDB:5TPA;Dbxref=PMID:26875626,PMID:26919761,PMID:28105280 Q12879 UniProtKB Disulfide bond 745 800 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q00959 Q12879 UniProtKB Alternative sequence 1259 1464 . . . ID=VSP_044300;Note=In isoform 2. NPATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV->MTNAWLLGDAPRTLTNTRCHPRR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q12879 UniProtKB Natural variant 57 57 . . . ID=VAR_067725;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 79 79 . . . ID=VAR_070345;Note=In FESD. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=dbSNP:rs1250662891,PMID:23933819 Q12879 UniProtKB Natural variant 143 143 . . . ID=VAR_079929;Note=Found in a patient with autism spectrum disorder%3B uncertain significance. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=PMID:22833210 Q12879 UniProtKB Natural variant 183 183 . . . ID=VAR_067726;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation%3B also found in a patient with epilepsy with centrotemporal spike. F->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21499247,ECO:0000269|PubMed:23933819;Dbxref=dbSNP:rs587780353,PMID:21499247,PMID:23933819 Q12879 UniProtKB Natural variant 184 184 . . . ID=VAR_070346;Note=In FESD%3B uncertain significance. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933820;Dbxref=PMID:23933820 Q12879 UniProtKB Natural variant 189 189 . . . ID=VAR_079930;Note=Found in a patient with schizophrenia%3B uncertain significance. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs1377082706,PMID:22833210 Q12879 UniProtKB Natural variant 231 231 . . . ID=VAR_070347;Note=In FESD%3B uncertain significance. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=PMID:23933819 Q12879 UniProtKB Natural variant 243 243 . . . ID=VAR_070348;Note=In FESD%3B results in reduced high-affinity zinc mediated inhibition. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=PMID:23933819 Q12879 UniProtKB Natural variant 252 252 . . . ID=VAR_067727;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs868215122,PMID:21499247 Q12879 UniProtKB Natural variant 270 270 . . . ID=VAR_010938;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8061049;Dbxref=PMID:8061049 Q12879 UniProtKB Natural variant 278 278 . . . ID=VAR_067728;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs148531310,PMID:21499247 Q12879 UniProtKB Natural variant 290 290 . . . ID=VAR_070349;Note=In FESD. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=dbSNP:rs199528312,PMID:23933819 Q12879 UniProtKB Natural variant 295 295 . . . ID=VAR_070350;Note=In FESD%3B uncertain significance. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933820;Dbxref=dbSNP:rs568484876,PMID:23933820 Q12879 UniProtKB Natural variant 336 336 . . . ID=VAR_079931;Note=P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs148511104,PMID:22833210 Q12879 UniProtKB Natural variant 349 349 . . . ID=VAR_071624;Note=Found in a cutaneous malignant melanoma sample. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24455489;Dbxref=PMID:24455489 Q12879 UniProtKB Natural variant 370 370 . . . ID=VAR_070351;Note=In FESD. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=dbSNP:rs761168789,PMID:23933819 Q12879 UniProtKB Natural variant 371 371 . . . ID=VAR_067729;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs149344082,PMID:21499247 Q12879 UniProtKB Natural variant 373 373 . . . ID=VAR_067730;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 380 380 . . . ID=VAR_078109;Note=Found in a patient with neonatal onset epileptic encephalopathy%3B uncertain significance. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27864847;Dbxref=dbSNP:rs1057519551,PMID:27864847 Q12879 UniProtKB Natural variant 436 436 . . . ID=VAR_070352;Note=In FESD%3B decreased protein abundance%3B loss of localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by increased glutamate potency and decreased glycine potency. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933819,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs1555496111,PMID:23933819,PMID:27839871 Q12879 UniProtKB Natural variant 449 449 . . . ID=VAR_067731;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs139033056,PMID:21499247 Q12879 UniProtKB Natural variant 452 452 . . . ID=VAR_079932;Note=No effect on localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by increased glutamate potency. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22833210,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs145956175,PMID:22833210,PMID:27839871 Q12879 UniProtKB Natural variant 459 459 . . . ID=VAR_067732;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 483 483 . . . ID=VAR_070353;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27839871;Dbxref=PMID:23933820,PMID:27839871 Q12879 UniProtKB Natural variant 504 504 . . . ID=VAR_070354;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B no significant effect on calcium ion transmembrane import into cytosol. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs1360906241,PMID:23933820,PMID:27839871 Q12879 UniProtKB Natural variant 506 506 . . . ID=VAR_079933;Note=In FESD%3B no effect on localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by increased glutamate potency. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs796052543,PMID:27839871 Q12879 UniProtKB Natural variant 518 518 . . . ID=VAR_070355;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by affected receptor kinetics. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs397518470,PMID:23933820,PMID:27839871 Q12879 UniProtKB Natural variant 531 531 . . . ID=VAR_070356;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by affected receptor kinetics. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933818,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs397518468,PMID:23933818,PMID:27839871 Q12879 UniProtKB Natural variant 547 547 . . . ID=VAR_070357;Note=In FESD. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=PMID:23933819 Q12879 UniProtKB Natural variant 548 548 . . . ID=VAR_070358;Note=In FESD%3B no effect on localization to the cell membrane%3B loss of glutamate-gated calcium ion channel activity. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:28095420;Dbxref=PMID:23933820,PMID:28095420 Q12879 UniProtKB Natural variant 552 552 . . . ID=VAR_069382;Note=In FESD%3B no effect on localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by increased glutamate and glycine potency with delay in rise time and slower deactivation time course. P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23033978,ECO:0000269|PubMed:28095420;Dbxref=dbSNP:rs397518450,PMID:23033978,PMID:28095420 Q12879 UniProtKB Natural variant 576 576 . . . ID=VAR_079934;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=PMID:22833210 Q12879 UniProtKB Natural variant 595 595 . . . ID=VAR_067733;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs551688681,PMID:21499247 Q12879 UniProtKB Natural variant 598 598 . . . ID=VAR_067734;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 615 615 . . . ID=VAR_065899;Note=In FESD%3B the mutant receptor has decreased calcium permeability%3B shows a dominant-negative effect. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20890276;Dbxref=dbSNP:rs397518447,PMID:20890276 Q12879 UniProtKB Natural variant 649 649 . . . ID=VAR_069383;Note=In FESD. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs397514557,PMID:23033978 Q12879 UniProtKB Natural variant 652 652 . . . ID=VAR_070359;Note=In FESD%3B affects receptor kinetics. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933820;Dbxref=dbSNP:rs397518471,PMID:23933820 Q12879 UniProtKB Natural variant 653 653 . . . ID=VAR_067735;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 669 669 . . . ID=VAR_070360;Note=In FESD%3B no effect on localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by increased glutamate and glycine potency. K->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27839871;Dbxref=PMID:23933820,PMID:27839871 Q12879 UniProtKB Natural variant 685 685 . . . ID=VAR_079935;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs796052548,PMID:27839871 Q12879 UniProtKB Natural variant 694 694 . . . ID=VAR_070361;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency and decreased open probability. I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27839871;Dbxref=PMID:23933820,PMID:27839871 Q12879 UniProtKB Natural variant 699 699 . . . ID=VAR_070362;Note=In FESD%3B no effect on localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by increased glutamate potency and decreased open probability. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933819,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs1555491648,PMID:23933819,PMID:27839871 Q12879 UniProtKB Natural variant 705 705 . . . ID=VAR_070363;Note=In FESD%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency and decreased open probability. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933819,ECO:0000269|PubMed:27839871;Dbxref=PMID:23933819,PMID:27839871 Q12879 UniProtKB Natural variant 712 712 . . . ID=VAR_067736;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs143031592,PMID:21499247 Q12879 UniProtKB Natural variant 714 714 . . . ID=VAR_070364;Note=In FESD%3B decreased protein abundance%3B no effect on localization to the cell membrane%3B no significant effect on calcium ion transmembrane import into cytosol. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933819,ECO:0000269|PubMed:27839871;Dbxref=PMID:23933819,PMID:27839871 Q12879 UniProtKB Natural variant 716 716 . . . ID=VAR_078110;Note=In FESD%3B uncertain significance. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27864847;Dbxref=dbSNP:rs1057519552,PMID:27864847 Q12879 UniProtKB Natural variant 716 716 . . . ID=VAR_070365;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs762659685,PMID:23933820,PMID:27839871 Q12879 UniProtKB Natural variant 727 727 . . . ID=VAR_070366;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency and decreased open probability. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933819,ECO:0000269|PubMed:27839871;Dbxref=dbSNP:rs1555488144,PMID:23933819,PMID:27839871 Q12879 UniProtKB Natural variant 731 731 . . . ID=VAR_070367;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B decreased glutamate-gated calcium ion channel activity characterized by drastically decreased glutamate agonist potency%2C decreased glycine agonist potency%2C reduced amplitude of current response%2C shortened synaptic-like response time course%2C decreased channel open probability and enhanced sensitivity to negative allosteric modulators. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27839871,ECO:0000269|PubMed:28182669;Dbxref=dbSNP:rs796052549,PMID:23933820,PMID:27839871,PMID:28182669 Q12879 UniProtKB Natural variant 734 734 . . . ID=VAR_070368;Note=In FESD%3B no effect on localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933819,ECO:0000269|PubMed:27839871;Dbxref=PMID:23933819,PMID:27839871 Q12879 UniProtKB Natural variant 740 740 . . . ID=VAR_067737;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. G->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 762 762 . . . ID=VAR_071625;Note=Found in a cutaneous malignant melanoma sample. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24455489;Dbxref=PMID:24455489 Q12879 UniProtKB Natural variant 772 772 . . . ID=VAR_070369;Note=In FESD%3B decreased protein abundance%3B decreased localization to the cell membrane%3B changed glutamate-gated calcium ion channel activity characterized by decreased glutamate potency and decreased open probability. K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23933819,ECO:0000269|PubMed:27839871;Dbxref=PMID:23933819,PMID:27839871 Q12879 UniProtKB Natural variant 812 812 . . . ID=VAR_072750;Note=In FESD%3B increase in receptor response to agonists%3B decrease in the actions of endogenous negative modulators%3B increase in channel open probability%3B prolonged deactivation time course. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24504326;Dbxref=PMID:24504326 Q12879 UniProtKB Natural variant 814 814 . . . ID=VAR_070370;Note=In FESD%3B uncertain significance. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=dbSNP:rs780654733,PMID:23933819 Q12879 UniProtKB Natural variant 817 817 . . . ID=VAR_071626;Note=In FESD%3B gain-of-function characterized by enhanced agonist potency%2C reduced sensitivity to endogenous negative inhibitors%2C prolonged synaptic-like response time course%2C increased single-channel mean open time and increased channel open probability. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:24903190,ECO:0000269|PubMed:28126851;Dbxref=dbSNP:rs796052551,PMID:24903190,PMID:28126851 Q12879 UniProtKB Natural variant 852 852 . . . ID=VAR_079936;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs150316865,PMID:22833210 Q12879 UniProtKB Natural variant 884 884 . . . ID=VAR_078690;Note=Found in a patient with autism%3B uncertain significance. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26637798;Dbxref=dbSNP:rs777684328,PMID:26637798 Q12879 UniProtKB Natural variant 889 889 . . . ID=VAR_067738;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21499247,ECO:0000269|PubMed:24455489;Dbxref=PMID:21499247,PMID:24455489 Q12879 UniProtKB Natural variant 904 904 . . . ID=VAR_070371;Note=In FESD. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=dbSNP:rs1555482933,PMID:23933819 Q12879 UniProtKB Natural variant 920 920 . . . ID=VAR_067739;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 922 922 . . . ID=VAR_079937;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs200037904,PMID:22833210 Q12879 UniProtKB Natural variant 929 929 . . . ID=VAR_067740;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs767268773,PMID:21499247 Q12879 UniProtKB Natural variant 933 933 . . . ID=VAR_070372;Note=In FESD%3B uncertain significance. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933820;Dbxref=dbSNP:rs933322445,PMID:23933820 Q12879 UniProtKB Natural variant 937 937 . . . ID=VAR_079938;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs769602505,PMID:22833210 Q12879 UniProtKB Natural variant 962 962 . . . ID=VAR_067741;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs765370528,PMID:21499247 Q12879 UniProtKB Natural variant 968 968 . . . ID=VAR_079939;Note=Found in a patient with schizophrenia%3B uncertain significance. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=PMID:22833210 Q12879 UniProtKB Natural variant 976 976 . . . ID=VAR_070373;Note=In FESD. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933819;Dbxref=dbSNP:rs886039239,PMID:23933819 Q12879 UniProtKB Natural variant 989 989 . . . ID=VAR_078111;Note=Found in a patient with neonatal onset epileptic encephalopathy%3B uncertain significance. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27864847;Dbxref=dbSNP:rs531782747,PMID:27864847 Q12879 UniProtKB Natural variant 998 998 . . . ID=VAR_079940;Note=Found in a patient with schizophrenia%3B uncertain significance. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs1258974659,PMID:22833210 Q12879 UniProtKB Natural variant 1064 1064 . . . ID=VAR_079941;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs138809301,PMID:22833210 Q12879 UniProtKB Natural variant 1073 1073 . . . ID=VAR_067742;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 1074 1074 . . . ID=VAR_067743;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs867432846,PMID:21499247 Q12879 UniProtKB Natural variant 1132 1132 . . . ID=VAR_071627;Note=Found in a cutaneous malignant melanoma sample. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24455489;Dbxref=PMID:24455489 Q12879 UniProtKB Natural variant 1133 1133 . . . ID=VAR_071628;Note=Found in a cutaneous malignant melanoma sample. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24455489;Dbxref=PMID:24455489 Q12879 UniProtKB Natural variant 1153 1153 . . . ID=VAR_067744;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs267604687,PMID:21499247 Q12879 UniProtKB Natural variant 1175 1175 . . . ID=VAR_067745;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs867464241,PMID:21499247 Q12879 UniProtKB Natural variant 1229 1229 . . . ID=VAR_079942;Note=Found in a patient with schizophrenia%3B uncertain significance. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22833210;Dbxref=dbSNP:rs747136651,PMID:22833210 Q12879 UniProtKB Natural variant 1251 1251 . . . ID=VAR_070374;Note=In FESD. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23933820;Dbxref=PMID:23933820 Q12879 UniProtKB Natural variant 1276 1276 . . . ID=VAR_067746;Note=Found in a patient with continuous spike-wave discharges during slow-wave sleep%3B uncertain significance%3B also found in a patient with drug-resistant focal epilepsy%3B uncertain significance%3B also found in a cutaneous malignant melanoma sample as somatic mutation%3B uncertain significance. A->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21499247,ECO:0000269|PubMed:22833210,ECO:0000269|PubMed:23933820,ECO:0000269|PubMed:27864847;Dbxref=dbSNP:rs145063086,PMID:21499247,PMID:22833210,PMID:23933820,PMID:27864847 Q12879 UniProtKB Natural variant 1285 1285 . . . ID=VAR_067747;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs367543132,PMID:21499247 Q12879 UniProtKB Natural variant 1318 1318 . . . ID=VAR_067748;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs774419037,PMID:21499247 Q12879 UniProtKB Natural variant 1366 1366 . . . ID=VAR_067749;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 1421 1421 . . . ID=VAR_067750;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Natural variant 1425 1425 . . . ID=VAR_067751;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs976259560,PMID:21499247 Q12879 UniProtKB Natural variant 1426 1426 . . . ID=VAR_067752;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=dbSNP:rs138415164,PMID:21499247 Q12879 UniProtKB Natural variant 1462 1462 . . . ID=VAR_067753;Note=Found in a cutaneous malignant melanoma sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21499247;Dbxref=PMID:21499247 Q12879 UniProtKB Mutagenesis 552 552 . . . Note=Changed glutamate-gated calcium ion channel activity characterized by increased desensitization. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28095420;Dbxref=PMID:28095420 Q12879 UniProtKB Mutagenesis 552 552 . . . Note=Changed glutamate-gated calcium ion channel activity characterized by accelerated response activation time and increased desensitization. P->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28095420;Dbxref=PMID:28095420 Q12879 UniProtKB Mutagenesis 552 552 . . . Note=Changed glutamate-gated calcium ion channel activity characterized by increased desensitization. P->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28095420;Dbxref=PMID:28095420 Q12879 UniProtKB Mutagenesis 552 552 . . . Note=Changed glutamate-gated calcium ion channel activity characterized by increased glutamate and glycine potency with delay in rise time and slower deactivation time course. P->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28095420;Dbxref=PMID:28095420 Q12879 UniProtKB Mutagenesis 552 552 . . . Note=No effect on localization to the cell membrane. Changed glutamate-gated calcium ion channel activity characterized by increased desensitization. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28095420;Dbxref=PMID:28095420 Q12879 UniProtKB Mutagenesis 552 552 . . . Note=No effect on localization to the cell membrane. Changed glutamate-gated calcium ion channel activity characterized by decreased response amplitude and changed desensitization without effect on response rise time or deactivation time course. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28095420;Dbxref=PMID:28095420 Q12879 UniProtKB Beta strand 35 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 42 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 48 54 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 68 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 79 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 92 94 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 98 101 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 108 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 124 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 129 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 144 148 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 151 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 171 176 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 180 192 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 204 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 215 219 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 224 230 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 233 244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Turn 245 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 254 257 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 259 261 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 277 280 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 283 286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 288 309 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 335 339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 352 354 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 356 358 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 362 366 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 372 377 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 380 382 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 405 410 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Turn 414 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 417 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Turn 424 426 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5KCJ Q12879 UniProtKB Beta strand 434 442 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 449 458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 459 471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 474 479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 482 485 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 487 489 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5I2K Q12879 UniProtKB Beta strand 492 494 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5I2K Q12879 UniProtKB Helix 495 501 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 506 508 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 516 519 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 522 524 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 528 538 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 556 577 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 600 613 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 625 654 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 668 671 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 673 675 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 676 678 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 682 684 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 686 688 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5I2K Q12879 UniProtKB Helix 689 697 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 699 705 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 706 708 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 713 721 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 726 731 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 732 740 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 743 745 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5I2N Q12879 UniProtKB Beta strand 747 750 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Turn 751 753 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 756 761 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Beta strand 764 766 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5I2K Q12879 UniProtKB Helix 772 784 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 787 795 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H8F Q12879 UniProtKB Helix 799 802 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Turn 814 817 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Helix 818 840 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EU7 Q12879 UniProtKB Beta strand 1461 1464 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3NFL