Reviewed,
UniProtKB/Swiss-Prot Q12879 (NMDE1_HUMAN)
Last modified
November 25, 2008.
Version 88.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glutamate [NMDA] receptor subunit epsilon-1 Alternative name(s): N-methyl D-aspartate receptor subtype 2A Short name=NMDAR2A Short name=NR2A Short name=hNR2A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1464 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. |
| Subunit structure | Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 By similarity. |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. |
| Sequence similarities | Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification] |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 1464 | 1442 | Glutamate [NMDA] receptor subunit epsilon-1 | PRO_0000011573 | |||||
Regions | |||||||||
| Topological domain | 23 – 555 | 533 | Extracellular Potential | ||||||
| Transmembrane | 556 – 576 | 21 | Potential | ||||||
| Topological domain | 577 – 633 | 57 | Cytoplasmic Potential | ||||||
| Transmembrane | 634 – 654 | 21 | Potential | ||||||
| Topological domain | 655 – 816 | 162 | Extracellular Potential | ||||||
| Transmembrane | 817 – 837 | 21 | Potential | ||||||
| Topological domain | 838 – 1464 | 627 | Cytoplasmic Potential | ||||||
| Region | 511 – 513 | 3 | Glutamate binding By similarity | ||||||
| Region | 689 – 690 | 2 | Glutamate binding By similarity | ||||||
| Motif | 1462 – 1464 | 3 | PDZ-binding By similarity | ||||||
Sites | |||||||||
| Binding site | 518 | 1 | Glutamate By similarity | ||||||
| Binding site | 731 | 1 | Glutamate; via amide nitrogen By similarity | ||||||
| Site | 614 | 1 | Functional determinant of NMDA receptors By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 888 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 912 | 1 | Phosphoserine | ||||||
| Modified residue | 917 | 1 | Phosphoserine | ||||||
| Modified residue | 929 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 943 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 1025 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 1337 | 1 | Phosphoserine | ||||||
| Modified residue | 1459 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 75 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 340 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 380 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 443 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 444 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 541 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 270 | 1 | K → E | VAR_010938 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein." Foldes R.L., Adams S.L., Fantaske R.P., Kamboj R.K. Biochim. Biophys. Acta 1223:155-159(1994) [PubMed: 8061049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-270. |
| [2] | "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors." Hess S.D., Daggett L.P., Crona J., Deal C., Lu C.-C., Urrutia A., Chavez-Noriega L., Ellis S.B., Johnson E.C., Velicelebi G. J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed: 8768735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum. |
| [3] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1337, MASS SPECTROMETRY. Tissue: Epithelium. |
| [4] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-912 AND SER-917, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U09002 mRNA. Translation: AAB60343.1. U90277 mRNA. Translation: AAB49992.1. | |
| PIR | S47555. |
| RefSeq | NP_000824.1. NP_001127879.1. NP_001127880.1. |
| UniGene | Hs.567280 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FTK based on UniProtKB P19491. |
| SMR | Q12879. Positions 404-539, 661-801. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q12879. |
Genome annotation databases | |
| Ensembl | ENSG00000183454. Homo sapiens. [Contig view] |
| GeneID | 2903. |
| KEGG | hsa:2903. |
Organism-specific databases | |
| H-InvDB | HIX0038671. |
| HGNC | HGNC:4585. GRIN2A. |
| HPA | HPA004692. |
| MIM | 138253. gene. |
| PharmGKB | PA28979. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | Q12879. |
Gene expression databases | |
| ArrayExpress | Q12879. |
| CleanEx | HS_GRIN2A. |
| GermOnline | ENSG00000183454. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR015683. Glutamate_receptor-rel. IPR001320. Iontro_glu_rcpt. IPR001508. NMDA_rcpt. [Graphical view] |
| PANTHER | PTHR18966. Glut_Rec_Related. 1 hit. |
| Pfam | PF00060. Lig_chan. 1 hit. [Graphical view] |
| PRINTS | PR00177. NMDARECEPTOR. |
| SMART | SM00079. PBPe. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00949. Felbamate. DB00145. Glycine. DB00142. L-Glutamic Acid. DB00836. Loperamide. DB01043. Memantine. |
| LinkHub | Q12879. |
| NextBio | 11495. |
| SOURCE | Search... |
Entry information
| Entry name | NMDE1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q12879 Secondary accession number(s): O00669 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


