Q12872 (SFSWA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Splicing factor, suppressor of white-apricot homolog

Alternative name(s):
Splicing factor, arginine/serine-rich 8
Suppressor of white apricot protein homolog

Gene names

Name:	SFSWAP
Synonyms:	SFRS8, SWAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	951 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. Ref.5
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 2 SURP motif repeats.

Ontologies

Keywords
Biological process	Transcription Transcription regulation mRNA processing mRNA splicing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	RNA-binding
Molecular function	Repressor
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA splice site selection Traceable author statement Ref.5. Source: ProtInc negative regulation of mRNA splicing, via spliceosome Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12872-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12872-2)

The sequence of this isoform differs from the canonical sequence as follows:
     801-801: R → RSRVTASPGTLRAEPCQSSASVTAAAEPGSYQAASTTTRFDSASSFEGKPGKT

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 951

951

Splicing factor, suppressor of white-apricot homolog

PRO_0000081934

Regions

Repeat

211 – 253

43

SURP motif 1

Repeat

459 – 499

41

SURP motif 2

Compositional bias

165 – 168

4

Poly-Glu

Compositional bias

287 – 290

4

Poly-Asp

Compositional bias

382 – 385

4

Poly-Pro

Compositional bias

413 – 416

4

Poly-Pro

Compositional bias

420 – 424

5

Poly-Pro

Compositional bias

434 – 440

7

Poly-Thr

Compositional bias

451 – 454

4

Poly-Pro

Compositional bias

616 – 619

4

Poly-Ser

Compositional bias

660 – 663

4

Poly-Ala

Compositional bias

754 – 763

10

Poly-Lys

Compositional bias

789 – 951

163

Arg/Ser-rich (RS domain)

Compositional bias

850 – 853

4

Poly-Lys

Amino acid modifications

Modified residue

283

1

Phosphoserine Ref.8 Ref.9

Modified residue

315

1

N6-acetyllysine Ref.10

Modified residue

604

1

Phosphoserine Ref.8 Ref.11 Ref.12

Modified residue

642

1

Phosphothreonine Ref.7

Modified residue

909

1

Phosphoserine Ref.8 Ref.9

Natural variations

Alternative sequence

801

1

R → RSRVTASPGTLRAEPCQSSA SVTAAAEPGSYQAASTTTRF DSASSFEGKPGKT in isoform 2.

VSP_044786

Natural variant

52

1

L → Q. Ref.1
Corresponds to variant rs1051207 [ dbSNP | Ensembl ].

VAR_046442

Natural variant

122

1

L → F.
Corresponds to variant rs1051314 [ dbSNP | Ensembl ].

VAR_046443

Natural variant

136

1

L → F. Ref.1
Corresponds to variant rs1131564 [ dbSNP | Ensembl ].

VAR_046444

Natural variant

421

1

L → P. Ref.1 Ref.3 Ref.4
Corresponds to variant rs1982528 [ dbSNP | Ensembl ].

VAR_021789

Natural variant

512

1

G → S.
Corresponds to variant rs34541796 [ dbSNP | Ensembl ].

VAR_057248

Natural variant

538

1

E → G.
Corresponds to variant rs34744641 [ dbSNP | Ensembl ].

VAR_057249

Natural variant

887

1

A → E.
Corresponds to variant rs34729193 [ dbSNP | Ensembl ].

VAR_057250

Experimental info

Sequence conflict

236

1

R → P in AAA19604. Ref.1

Sequence conflict

493

1

H → Y in AAA19604. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

951

Helix Strand Turn

Details...

Beta strand

192 – 194

3

Beta strand

198 – 200

3

Helix

206 – 221

16

Helix

224 – 233

10

Helix

241 – 243

3

Helix

249 – 262

14

Turn

454 – 456

3

Helix

457 – 469

13

Helix

472 – 481

10

Helix

484 – 486

3

Beta strand

490 – 492

3

Helix

496 – 509

14

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 23, 2010. Version 3. Checksum: A942D589F4B6BF47	FASTA	951	104,822
	10 20 30 40 50 60 MYGASGGRAK PERKSGAKEE AGPGGAGGGG SRVELLVFGY ACKLFRDDER ALAQEQGQHL 70 80 90 100 110 120 IPWMGDHKIL IDRYDGRGHL HDLSEYDAEY STWNRDYQLS EEEARIEALC DEERYLALHT 130 140 150 160 170 180 DLLEEEARQE EEYKRLSEAL AEDGSYNAVG FTYGSDYYDP SEPTEEEEPS KQREKNEAEN 190 200 210 220 230 240 LEENEEPFVA PLGLSVPSDV ELPPTAKMHA IIERTASFVC RQGAQFEIML KAKQARNSQF 250 260 270 280 290 300 DFLRFDHYLN PYYKFIQKAM KEGRYTVLAE NKSDEKKKSG VSSDNEDDDD EEDGNYLHPS 310 320 330 340 350 360 LFASKKCNRL EELMKPLKVV DPDHPLAALV RKAQADSSTP TPHNADGAPV QPSQVEYTAD 370 380 390 400 410 420 STVAAMYYSY YMLPDGTYCL APPPPGIDVT TYYSTLPAGV TVSNSPGVTT TAPPPPGTTP 430 440 450 460 470 480 LPPPTTAETS SGATSTTTTT SALAPVAAII PPPPDVQPVI DKLAEYVARN GLKFETSVRA 490 500 510 520 530 540 KNDQRFEFLQ PWHQYNAYYE FKKQFFLQKE GGDSMQAVSA PEEAPTDSAP EKPSDAGEDG 550 560 570 580 590 600 APEDAAEVGA RAGSGGKKEA SSSKTVPDGK LVKASFAPIS FAIKAKENDL LPLEKNRVKL 610 620 630 640 650 660 DDDSDDDEES KEGQESSSSA ANTNPAVAPP CVVVEEKKPQ LTQEELEAKQ AKQKLEDRLA 670 680 690 700 710 720 AAAREKLAQA SKESKEKQLQ AERKRKAALF LQTLKNPLPE AEAGKIEESP FSVEESSTTP 730 740 750 760 770 780 CPLLTGGRPL PTLEVKPPDR PSSKSKDPPR EEEKEKKKKK HKKRSRTRSR SPKYHSSSKS 790 800 810 820 830 840 RSRSHSKAKH SLPSAYRTVR RSRSRSRSPR RRAHSPERRR EERSVPTAYR VSRSPGASRK 850 860 870 880 890 900 RTRSRSPHEK KKKRRSRSRT KSKARSQSVS PSKQAAPRPA APAAHSAHSA SVSPVESRGS 910 920 930 940 950 SQERSRGVSQ EKEAQISSAI VSSVQSKITQ DLMAKVRAML AASKNLQTSA S
	Isoform 2 [UniParc]. Checksum: C67AFFE577FF7CA4	FASTA	1,003	110,012
	10 20 30 40 50 60 MYGASGGRAK PERKSGAKEE AGPGGAGGGG SRVELLVFGY ACKLFRDDER ALAQEQGQHL 70 80 90 100 110 120 IPWMGDHKIL IDRYDGRGHL HDLSEYDAEY STWNRDYQLS EEEARIEALC DEERYLALHT 130 140 150 160 170 180 DLLEEEARQE EEYKRLSEAL AEDGSYNAVG FTYGSDYYDP SEPTEEEEPS KQREKNEAEN 190 200 210 220 230 240 LEENEEPFVA PLGLSVPSDV ELPPTAKMHA IIERTASFVC RQGAQFEIML KAKQARNSQF 250 260 270 280 290 300 DFLRFDHYLN PYYKFIQKAM KEGRYTVLAE NKSDEKKKSG VSSDNEDDDD EEDGNYLHPS 310 320 330 340 350 360 LFASKKCNRL EELMKPLKVV DPDHPLAALV RKAQADSSTP TPHNADGAPV QPSQVEYTAD 370 380 390 400 410 420 STVAAMYYSY YMLPDGTYCL APPPPGIDVT TYYSTLPAGV TVSNSPGVTT TAPPPPGTTP 430 440 450 460 470 480 LPPPTTAETS SGATSTTTTT SALAPVAAII PPPPDVQPVI DKLAEYVARN GLKFETSVRA 490 500 510 520 530 540 KNDQRFEFLQ PWHQYNAYYE FKKQFFLQKE GGDSMQAVSA PEEAPTDSAP EKPSDAGEDG 550 560 570 580 590 600 APEDAAEVGA RAGSGGKKEA SSSKTVPDGK LVKASFAPIS FAIKAKENDL LPLEKNRVKL 610 620 630 640 650 660 DDDSDDDEES KEGQESSSSA ANTNPAVAPP CVVVEEKKPQ LTQEELEAKQ AKQKLEDRLA 670 680 690 700 710 720 AAAREKLAQA SKESKEKQLQ AERKRKAALF LQTLKNPLPE AEAGKIEESP FSVEESSTTP 730 740 750 760 770 780 CPLLTGGRPL PTLEVKPPDR PSSKSKDPPR EEEKEKKKKK HKKRSRTRSR SPKYHSSSKS 790 800 810 820 830 840 RSRSHSKAKH SLPSAYRTVR RSRVTASPGT LRAEPCQSSA SVTAAAEPGS YQAASTTTRF 850 860 870 880 890 900 DSASSFEGKP GKTSRSRSRS PRRRAHSPER RREERSVPTA YRVSRSPGAS RKRTRSRSPH 910 920 930 940 950 960 EKKKKRRSRS RTKSKARSQS VSPSKQAAPR PAAPAAHSAH SASVSPVESR GSSQERSRGV 970 980 990 1000 SQEKEAQISS AIVSSVQSKI TQDLMAKVRA MLAASKNLQT SAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot." Denhez F., Lafyatis R. J. Biol. Chem. 269:16170-16179(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-52; PHE-136 AND PRO-421. Tissue: Placenta.
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-421.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-421. Tissue: Brain and Skin.
[5]	"The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS." Sarkissian M., Winne A., Lafyatis R. J. Biol. Chem. 271:31106-31114(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-642, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-604 AND SER-909, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-909, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-315, MASS SPECTROMETRY.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604, MASS SPECTROMETRY.
[13]	"Solution structure of the SURP1 and SURP2 domain in splicing factor, arginine/serine-rich 8." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 189-282 AND 434-522.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U08377 mRNA. Translation: AAA19604.1.
AC117500 Genomic DNA. No translation available.
AC131009 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98526.1.
BC008707 mRNA. Translation: AAH08707.1.
BC015953 mRNA. Translation: AAH15953.1.
BC136678 mRNA. Translation: AAI36679.1.
BC144364 mRNA. Translation: AAI44365.1.

IPI

IPI00290094.
IPI00790550.

PIR

A54037.
B54037.
C54037.

RefSeq

NP_001248340.1. NM_001261411.1.
NP_004583.2. NM_004592.3.

UniGene

Hs.308171.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E5Z	NMR	-	A	434-522	[»]
2E60	NMR	-	A	189-282	[»]

ProteinModelPortal

Q12872.

SMR

Q12872. Positions 189-282, 455-522.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q12872. 2 interactions.

STRING

9606.ENSP00000261674.

PTM databases

PhosphoSite

Q12872.

Polymorphism databases

DMDM

292495067.

Proteomic databases

PaxDb

Q12872.

PRIDE

Q12872.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000261674; ENSP00000261674; ENSG00000061936.
ENST00000541286; ENSP00000437738; ENSG00000061936.

GeneID

6433.

KEGG

hsa:6433.

UCSC

uc001uja.1. human.

Organism-specific databases

CTD

6433.

GeneCards

GC12P132196.

H-InvDB

HIX0036782.

HGNC

HGNC:10790. SFSWAP.

HPA

HPA039362.
HPA040063.

MIM

601945. gene.

neXtProt

NX_Q12872.

PharmGKB

PA35706.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG289028.

HOVERGEN

HBG079184.

InParanoid

Q12872.

OMA

MYYSYYM.

OrthoDB

EOG4ZW59T.

PhylomeDB

Q12872.

Gene expression databases

ArrayExpress

Q12872.

Bgee

Q12872.

CleanEx

HS_SFRS8.

Genevestigator

Q12872.

GermOnline

ENSG00000061936. Homo sapiens.

Family and domain databases

InterPro

IPR000061. Surp.
IPR019147. SWAP_N_domain.
[Graphical view]

Pfam

PF09750. DRY_EERY. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]

SMART

SM00648. SWAP. 2 hits.
[Graphical view]

SUPFAM

SSF109905. SSF109905. 2 hits.

PROSITE

PS50128. SURP. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SFSWAP. human.

EvolutionaryTrace

Q12872.

GenomeRNAi

6433.

NextBio

24987.

SOURCE

Search...

Entry information

Entry name

SFSWA_HUMAN

Accession

Primary (citable) accession number: Q12872
Secondary accession number(s): B2RN45 , B7ZM97, F5H6B8, Q6PJF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	March 23, 2010
Last modified:	April 3, 2013
This is version 114 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.