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Q12870

- TCF15_HUMAN

UniProt

Q12870 - TCF15_HUMAN

Protein

Transcription factor 15

Gene

TCF15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. death Source: Ensembl
    2. ear development Source: Ensembl
    3. eating behavior Source: Ensembl
    4. mesoderm development Source: ProtInc
    5. muscle organ morphogenesis Source: Ensembl
    6. neuromuscular process controlling posture Source: Ensembl
    7. paraxial mesoderm development Source: Ensembl
    8. post-anal tail morphogenesis Source: Ensembl
    9. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    10. respiratory system process Source: Ensembl
    11. skeletal system morphogenesis Source: Ensembl
    12. skin development Source: Ensembl
    13. somitogenesis Source: Ensembl
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor 15
    Short name:
    TCF-15
    Alternative name(s):
    Class A basic helix-loop-helix protein 40
    Short name:
    bHLHa40
    Paraxis
    Protein bHLH-EC2
    Gene namesi
    Name:TCF15
    Synonyms:BHLHA40, BHLHEC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11627. TCF15.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36382.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Transcription factor 15PRO_0000127460Add
    BLAST

    Proteomic databases

    PaxDbiQ12870.
    PRIDEiQ12870.

    PTM databases

    PhosphoSiteiQ12870.

    Expressioni

    Gene expression databases

    BgeeiQ12870.
    CleanExiHS_TCF15.
    GenevestigatoriQ12870.

    Organism-specific databases

    HPAiHPA046827.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.By similarity

    Protein-protein interaction databases

    BioGridi112799. 1 interaction.
    STRINGi9606.ENSP00000246080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12870.
    SMRiQ12870. Positions 66-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 12453bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi52 – 6615Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG246787.
    HOVERGENiHBG036149.
    InParanoidiQ12870.
    KOiK09070.
    OMAiCLKVRGV.
    OrthoDBiEOG7G1V82.
    PhylomeDBiQ12870.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12870-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG    50
    PGPGGGRRAG GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP 100
    TEPVDRKLSK IETVRLASSY IAHLANVLLL GDSADDGQPC FRAAGSAKGA 150
    VPAAADGGRQ PRSICTFCLS NQRKGGGRRD LGGSCLKVRG VAPLRGPRR 199
    Length:199
    Mass (Da):20,816
    Last modified:October 17, 2006 - v3
    Checksum:iA3BF546A24ACF68A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141V → L in AAA19969. (PubMed:8041747)Curated
    Sequence conflicti155 – 1584ADGG → PTR in AAA19969. (PubMed:8041747)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08336 mRNA. Translation: AAA19969.1.
    AL133231 Genomic DNA. Translation: CAC00470.1.
    CCDSiCCDS33432.1.
    PIRiA57717.
    RefSeqiNP_004600.2. NM_004609.3.
    UniGeneiHs.437.

    Genome annotation databases

    EnsembliENST00000246080; ENSP00000246080; ENSG00000125878.
    GeneIDi6939.
    KEGGihsa:6939.

    Polymorphism databases

    DMDMi116242817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08336 mRNA. Translation: AAA19969.1 .
    AL133231 Genomic DNA. Translation: CAC00470.1 .
    CCDSi CCDS33432.1.
    PIRi A57717.
    RefSeqi NP_004600.2. NM_004609.3.
    UniGenei Hs.437.

    3D structure databases

    ProteinModelPortali Q12870.
    SMRi Q12870. Positions 66-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112799. 1 interaction.
    STRINGi 9606.ENSP00000246080.

    PTM databases

    PhosphoSitei Q12870.

    Polymorphism databases

    DMDMi 116242817.

    Proteomic databases

    PaxDbi Q12870.
    PRIDEi Q12870.

    Protocols and materials databases

    DNASUi 6939.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246080 ; ENSP00000246080 ; ENSG00000125878 .
    GeneIDi 6939.
    KEGGi hsa:6939.

    Organism-specific databases

    CTDi 6939.
    GeneCardsi GC20M000532.
    HGNCi HGNC:11627. TCF15.
    HPAi HPA046827.
    MIMi 601010. gene.
    neXtProti NX_Q12870.
    PharmGKBi PA36382.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246787.
    HOVERGENi HBG036149.
    InParanoidi Q12870.
    KOi K09070.
    OMAi CLKVRGV.
    OrthoDBi EOG7G1V82.
    PhylomeDBi Q12870.
    TreeFami TF315153.

    Miscellaneous databases

    GenomeRNAii 6939.
    NextBioi 27157.
    PROi Q12870.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q12870.
    CleanExi HS_TCF15.
    Genevestigatori Q12870.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites."
      Quertermous E.E., Hidai H., Blanar M.A., Quertermous T.
      Proc. Natl. Acad. Sci. U.S.A. 91:7066-7070(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Umbilical vein.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTCF15_HUMAN
    AccessioniPrimary (citable) accession number: Q12870
    Secondary accession number(s): Q9NQQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3