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Q12870

- TCF15_HUMAN

UniProt

Q12870 - TCF15_HUMAN

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Protein
Transcription factor 15
Gene
TCF15, BHLHA40, BHLHEC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. death Source: Ensembl
  2. ear development Source: Ensembl
  3. eating behavior Source: Ensembl
  4. mesoderm development Source: ProtInc
  5. muscle organ morphogenesis Source: Ensembl
  6. neuromuscular process controlling posture Source: Ensembl
  7. paraxial mesoderm development Source: Ensembl
  8. post-anal tail morphogenesis Source: Ensembl
  9. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  10. respiratory system process Source: Ensembl
  11. skeletal system morphogenesis Source: Ensembl
  12. skin development Source: Ensembl
  13. somitogenesis Source: Ensembl
  14. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 15
Short name:
TCF-15
Alternative name(s):
Class A basic helix-loop-helix protein 40
Short name:
bHLHa40
Paraxis
Protein bHLH-EC2
Gene namesi
Name:TCF15
Synonyms:BHLHA40, BHLHEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11627. TCF15.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Transcription factor 15
PRO_0000127460Add
BLAST

Proteomic databases

PaxDbiQ12870.
PRIDEiQ12870.

PTM databases

PhosphoSiteiQ12870.

Expressioni

Gene expression databases

BgeeiQ12870.
CleanExiHS_TCF15.
GenevestigatoriQ12870.

Organism-specific databases

HPAiHPA046827.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein By similarity.

Protein-protein interaction databases

BioGridi112799. 1 interaction.
STRINGi9606.ENSP00000246080.

Structurei

3D structure databases

ProteinModelPortaliQ12870.
SMRiQ12870. Positions 66-128.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 12453bHLH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 6615Gly-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG246787.
HOVERGENiHBG036149.
InParanoidiQ12870.
KOiK09070.
OMAiCLKVRGV.
OrthoDBiEOG7G1V82.
PhylomeDBiQ12870.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12870-1 [UniParc]FASTAAdd to Basket

« Hide

MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG    50
PGPGGGRRAG GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP 100
TEPVDRKLSK IETVRLASSY IAHLANVLLL GDSADDGQPC FRAAGSAKGA 150
VPAAADGGRQ PRSICTFCLS NQRKGGGRRD LGGSCLKVRG VAPLRGPRR 199
Length:199
Mass (Da):20,816
Last modified:October 17, 2006 - v3
Checksum:iA3BF546A24ACF68A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141V → L in AAA19969. 1 Publication
Sequence conflicti155 – 1584ADGG → PTR in AAA19969. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U08336 mRNA. Translation: AAA19969.1.
AL133231 Genomic DNA. Translation: CAC00470.1.
CCDSiCCDS33432.1.
PIRiA57717.
RefSeqiNP_004600.2. NM_004609.3.
UniGeneiHs.437.

Genome annotation databases

EnsembliENST00000246080; ENSP00000246080; ENSG00000125878.
GeneIDi6939.
KEGGihsa:6939.

Polymorphism databases

DMDMi116242817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U08336 mRNA. Translation: AAA19969.1 .
AL133231 Genomic DNA. Translation: CAC00470.1 .
CCDSi CCDS33432.1.
PIRi A57717.
RefSeqi NP_004600.2. NM_004609.3.
UniGenei Hs.437.

3D structure databases

ProteinModelPortali Q12870.
SMRi Q12870. Positions 66-128.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112799. 1 interaction.
STRINGi 9606.ENSP00000246080.

PTM databases

PhosphoSitei Q12870.

Polymorphism databases

DMDMi 116242817.

Proteomic databases

PaxDbi Q12870.
PRIDEi Q12870.

Protocols and materials databases

DNASUi 6939.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246080 ; ENSP00000246080 ; ENSG00000125878 .
GeneIDi 6939.
KEGGi hsa:6939.

Organism-specific databases

CTDi 6939.
GeneCardsi GC20M000532.
HGNCi HGNC:11627. TCF15.
HPAi HPA046827.
MIMi 601010. gene.
neXtProti NX_Q12870.
PharmGKBi PA36382.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG246787.
HOVERGENi HBG036149.
InParanoidi Q12870.
KOi K09070.
OMAi CLKVRGV.
OrthoDBi EOG7G1V82.
PhylomeDBi Q12870.
TreeFami TF315153.

Miscellaneous databases

GenomeRNAii 6939.
NextBioi 27157.
PROi Q12870.
SOURCEi Search...

Gene expression databases

Bgeei Q12870.
CleanExi HS_TCF15.
Genevestigatori Q12870.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites."
    Quertermous E.E., Hidai H., Blanar M.A., Quertermous T.
    Proc. Natl. Acad. Sci. U.S.A. 91:7066-7070(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Umbilical vein.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTCF15_HUMAN
AccessioniPrimary (citable) accession number: Q12870
Secondary accession number(s): Q9NQQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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