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Protein

Transcription factor 15

Gene

TCF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 15
Short name:
TCF-15
Alternative name(s):
Class A basic helix-loop-helix protein 40
Short name:
bHLHa40
Paraxis
Protein bHLH-EC2
Gene namesi
Name:TCF15
Synonyms:BHLHA40, BHLHEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125878.5
HGNCiHGNC:11627 TCF15
MIMi601010 gene
neXtProtiNX_Q12870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6939
OpenTargetsiENSG00000125878
PharmGKBiPA36382

Polymorphism and mutation databases

BioMutaiTCF15
DMDMi116242817

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274601 – 199Transcription factor 15Add BLAST199

Proteomic databases

PaxDbiQ12870
PeptideAtlasiQ12870
PRIDEiQ12870

PTM databases

iPTMnetiQ12870
PhosphoSitePlusiQ12870

Expressioni

Gene expression databases

BgeeiENSG00000125878
CleanExiHS_TCF15
GenevisibleiQ12870 HS

Organism-specific databases

HPAiHPA050998
HPA060221

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112799, 1 interactor
STRINGi9606.ENSP00000246080

Structurei

3D structure databases

ProteinModelPortaliQ12870
SMRiQ12870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 124bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 66Gly-richAdd BLAST15

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOVERGENiHBG036149
InParanoidiQ12870
KOiK09070
OMAiFAMLRPV
OrthoDBiEOG091G0RR2
PhylomeDBiQ12870
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q12870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG
60 70 80 90 100
PGPGGGRRAG GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP
110 120 130 140 150
TEPVDRKLSK IETVRLASSY IAHLANVLLL GDSADDGQPC FRAAGSAKGA
160 170 180 190
VPAAADGGRQ PRSICTFCLS NQRKGGGRRD LGGSCLKVRG VAPLRGPRR
Length:199
Mass (Da):20,816
Last modified:October 17, 2006 - v3
Checksum:iA3BF546A24ACF68A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114V → L in AAA19969 (PubMed:8041747).Curated1
Sequence conflicti155 – 158ADGG → PTR in AAA19969 (PubMed:8041747).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08336 mRNA Translation: AAA19969.1
AL133231 Genomic DNA No translation available.
CCDSiCCDS33432.1
PIRiA57717
RefSeqiNP_004600.2, NM_004609.3
UniGeneiHs.437

Genome annotation databases

EnsembliENST00000246080; ENSP00000246080; ENSG00000125878
GeneIDi6939
KEGGihsa:6939
UCSCiuc002wdz.4 human

Similar proteinsi

Entry informationi

Entry nameiTCF15_HUMAN
AccessioniPrimary (citable) accession number: Q12870
Secondary accession number(s): Q9NQQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health