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Q12870 (TCF15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor 15

Short name=TCF-15
Alternative name(s):
Class A basic helix-loop-helix protein 40
Short name=bHLHa40
Paraxis
Protein bHLH-EC2
Gene names
Name:TCF15
Synonyms:BHLHA40, BHLHEC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdeath

Inferred from electronic annotation. Source: Ensembl

ear development

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from electronic annotation. Source: Ensembl

mesoderm development

Traceable author statement Ref.1. Source: ProtInc

muscle organ morphogenesis

Inferred from electronic annotation. Source: Ensembl

neuromuscular process controlling posture

Inferred from electronic annotation. Source: Ensembl

paraxial mesoderm development

Inferred from electronic annotation. Source: Ensembl

post-anal tail morphogenesis

Inferred from electronic annotation. Source: Ensembl

regulation of transcription from RNA polymerase II promoter

Traceable author statement PubMed 8825648. Source: ProtInc

respiratory system process

Inferred from electronic annotation. Source: Ensembl

skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

skin development

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1PubMed 8825648. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Transcription factor 15
PRO_0000127460

Regions

Domain72 – 12453bHLH
Compositional bias52 – 6615Gly-rich

Experimental info

Sequence conflict1141V → L in AAA19969. Ref.1
Sequence conflict155 – 1584ADGG → PTR in AAA19969. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q12870 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: A3BF546A24ACF68A

FASTA19920,816
        10         20         30         40         50         60 
MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG PGPGGGRRAG 

        70         80         90        100        110        120 
GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP TEPVDRKLSK IETVRLASSY 

       130        140        150        160        170        180 
IAHLANVLLL GDSADDGQPC FRAAGSAKGA VPAAADGGRQ PRSICTFCLS NQRKGGGRRD 

       190 
LGGSCLKVRG VAPLRGPRR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites."
Quertermous E.E., Hidai H., Blanar M.A., Quertermous T.
Proc. Natl. Acad. Sci. U.S.A. 91:7066-7070(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Umbilical vein.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U08336 mRNA. Translation: AAA19969.1.
AL133231 Genomic DNA. Translation: CAC00470.1.
CCDSCCDS33432.1.
PIRA57717.
RefSeqNP_004600.2. NM_004609.3.
UniGeneHs.437.

3D structure databases

ProteinModelPortalQ12870.
SMRQ12870. Positions 66-128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112799. 1 interaction.
STRING9606.ENSP00000246080.

PTM databases

PhosphoSiteQ12870.

Polymorphism databases

DMDM116242817.

Proteomic databases

PaxDbQ12870.
PRIDEQ12870.

Protocols and materials databases

DNASU6939.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246080; ENSP00000246080; ENSG00000125878.
GeneID6939.
KEGGhsa:6939.

Organism-specific databases

CTD6939.
GeneCardsGC20M000532.
HGNCHGNC:11627. TCF15.
HPAHPA046827.
MIM601010. gene.
neXtProtNX_Q12870.
PharmGKBPA36382.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG246787.
HOVERGENHBG036149.
InParanoidQ12870.
KOK09070.
OMACLKVRGV.
OrthoDBEOG7G1V82.
PhylomeDBQ12870.
TreeFamTF315153.

Gene expression databases

BgeeQ12870.
CleanExHS_TCF15.
GenevestigatorQ12870.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6939.
NextBio27157.
PROQ12870.
SOURCESearch...

Entry information

Entry nameTCF15_HUMAN
AccessionPrimary (citable) accession number: Q12870
Secondary accession number(s): Q9NQQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM