Q12870 (TCF15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor 15
Short name=TCF-15

Alternative name(s):
Class A basic helix-loop-helix protein 40
Short name=bHLHa40
Paraxis
Protein bHLH-EC2

Gene names

Name:	TCF15
Synonyms:	BHLHA40, BHLHEC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	death Inferred from electronic annotation. Source: Compara ear development Inferred from electronic annotation. Source: Compara eating behavior Inferred from electronic annotation. Source: Compara mesoderm development Traceable author statement Ref.1. Source: ProtInc muscle organ morphogenesis Inferred from electronic annotation. Source: Compara neuromuscular process controlling posture Inferred from electronic annotation. Source: Compara paraxial mesoderm development Inferred from electronic annotation. Source: Compara post-anal tail morphogenesis Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Traceable author statement PubMed 8825648. Source: ProtInc respiratory system process Inferred from electronic annotation. Source: Compara skeletal system morphogenesis Inferred from electronic annotation. Source: Compara skin development Inferred from electronic annotation. Source: Compara somitogenesis Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1PubMed 8825648. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Transcription factor 15		PRO_0000127460
Regions
	Domain	72 – 124	53	bHLH
	Compositional bias	52 – 66	15	Gly-rich
Experimental info
	Sequence conflict	114	1	V → L in AAA19969. Ref.1
	Sequence conflict	155 – 158	4	ADGG → PTR in AAA19969. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q12870 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: A3BF546A24ACF68A	FASTA	199	20,816
	10 20 30 40 50 60 MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG PGPGGGRRAG 70 80 90 100 110 120 GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP TEPVDRKLSK IETVRLASSY 130 140 150 160 170 180 IAHLANVLLL GDSADDGQPC FRAAGSAKGA VPAAADGGRQ PRSICTFCLS NQRKGGGRRD 190 LGGSCLKVRG VAPLRGPRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites." Quertermous E.E., Hidai H., Blanar M.A., Quertermous T. Proc. Natl. Acad. Sci. U.S.A. 91:7066-7070(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Umbilical vein.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U08336 mRNA. Translation: AAA19969.1. AL133231 Genomic DNA. Translation: CAC00470.1.
IPI	IPI00010762.
PIR	A57717.
RefSeq	NP_004600.2. NM_004609.3.
UniGene	Hs.437.
3D structure databases
ProteinModelPortal	Q12870.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000246080.
PTM databases
PhosphoSite	Q12870.
Polymorphism databases
DMDM	116242817.
Proteomic databases
PaxDb	Q12870.
PRIDE	Q12870.
Protocols and materials databases
DNASU	6939.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000246080; ENSP00000246080; ENSG00000125878.
GeneID	6939.
KEGG	hsa:6939.
Organism-specific databases
CTD	6939.
GeneCards	GC20M000532.
HGNC	HGNC:11627. TCF15.
HPA	HPA046827.
MIM	601010. gene.
neXtProt	NX_Q12870.
PharmGKB	PA36382.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246787.
HOVERGEN	HBG036149.
InParanoid	Q12870.
KO	K09070.
OMA	NQRKGGS.
OrthoDB	EOG4ZPDWJ.
PhylomeDB	Q12870.
Gene expression databases
Bgee	Q12870.
CleanEx	HS_TCF15.
Genevestigator	Q12870.
GermOnline	ENSG00000125878. Homo sapiens.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6939.
NextBio	27157.
SOURCE	Search...

Entry information

Entry name

TCF15_HUMAN

Accession

Primary (citable) accession number: Q12870
Secondary accession number(s): Q9NQQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.