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Protein

Transcription factor 15

Gene

TCF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. death Source: Ensembl
  2. ear development Source: Ensembl
  3. eating behavior Source: Ensembl
  4. establishment of epithelial cell apical/basal polarity Source: Ensembl
  5. mesenchymal to epithelial transition Source: Ensembl
  6. mesoderm development Source: ProtInc
  7. muscle organ morphogenesis Source: Ensembl
  8. neuromuscular process controlling posture Source: Ensembl
  9. paraxial mesoderm development Source: Ensembl
  10. post-anal tail morphogenesis Source: Ensembl
  11. regulation of gene expression involved in extracellular matrix organization Source: Ensembl
  12. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  13. respiratory system process Source: Ensembl
  14. skeletal system morphogenesis Source: Ensembl
  15. skin development Source: Ensembl
  16. somitogenesis Source: Ensembl
  17. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 15
Short name:
TCF-15
Alternative name(s):
Class A basic helix-loop-helix protein 40
Short name:
bHLHa40
Paraxis
Protein bHLH-EC2
Gene namesi
Name:TCF15
Synonyms:BHLHA40, BHLHEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11627. TCF15.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Transcription factor 15PRO_0000127460Add
BLAST

Proteomic databases

PaxDbiQ12870.
PRIDEiQ12870.

PTM databases

PhosphoSiteiQ12870.

Expressioni

Gene expression databases

BgeeiQ12870.
CleanExiHS_TCF15.
GenevestigatoriQ12870.

Organism-specific databases

HPAiHPA046827.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

Protein-protein interaction databases

BioGridi112799. 1 interaction.
STRINGi9606.ENSP00000246080.

Structurei

3D structure databases

ProteinModelPortaliQ12870.
SMRiQ12870. Positions 66-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 12453bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 6615Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG246787.
GeneTreeiENSGT00760000119097.
HOVERGENiHBG036149.
InParanoidiQ12870.
KOiK09070.
OMAiNQRKGGS.
OrthoDBiEOG7G1V82.
PhylomeDBiQ12870.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12870-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG
60 70 80 90 100
PGPGGGRRAG GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP
110 120 130 140 150
TEPVDRKLSK IETVRLASSY IAHLANVLLL GDSADDGQPC FRAAGSAKGA
160 170 180 190
VPAAADGGRQ PRSICTFCLS NQRKGGGRRD LGGSCLKVRG VAPLRGPRR
Length:199
Mass (Da):20,816
Last modified:October 17, 2006 - v3
Checksum:iA3BF546A24ACF68A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141V → L in AAA19969. (PubMed:8041747)Curated
Sequence conflicti155 – 1584ADGG → PTR in AAA19969. (PubMed:8041747)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08336 mRNA. Translation: AAA19969.1.
AL133231 Genomic DNA. Translation: CAC00470.1.
CCDSiCCDS33432.1.
PIRiA57717.
RefSeqiNP_004600.2. NM_004609.3.
UniGeneiHs.437.

Genome annotation databases

EnsembliENST00000246080; ENSP00000246080; ENSG00000125878.
GeneIDi6939.
KEGGihsa:6939.

Polymorphism databases

DMDMi116242817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08336 mRNA. Translation: AAA19969.1.
AL133231 Genomic DNA. Translation: CAC00470.1.
CCDSiCCDS33432.1.
PIRiA57717.
RefSeqiNP_004600.2. NM_004609.3.
UniGeneiHs.437.

3D structure databases

ProteinModelPortaliQ12870.
SMRiQ12870. Positions 66-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112799. 1 interaction.
STRINGi9606.ENSP00000246080.

PTM databases

PhosphoSiteiQ12870.

Polymorphism databases

DMDMi116242817.

Proteomic databases

PaxDbiQ12870.
PRIDEiQ12870.

Protocols and materials databases

DNASUi6939.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246080; ENSP00000246080; ENSG00000125878.
GeneIDi6939.
KEGGihsa:6939.

Organism-specific databases

CTDi6939.
GeneCardsiGC20M000584.
HGNCiHGNC:11627. TCF15.
HPAiHPA046827.
MIMi601010. gene.
neXtProtiNX_Q12870.
PharmGKBiPA36382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG246787.
GeneTreeiENSGT00760000119097.
HOVERGENiHBG036149.
InParanoidiQ12870.
KOiK09070.
OMAiNQRKGGS.
OrthoDBiEOG7G1V82.
PhylomeDBiQ12870.
TreeFamiTF315153.

Miscellaneous databases

GenomeRNAii6939.
NextBioi27157.
PROiQ12870.
SOURCEiSearch...

Gene expression databases

BgeeiQ12870.
CleanExiHS_TCF15.
GenevestigatoriQ12870.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites."
    Quertermous E.E., Hidai H., Blanar M.A., Quertermous T.
    Proc. Natl. Acad. Sci. U.S.A. 91:7066-7070(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Umbilical vein.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTCF15_HUMAN
AccessioniPrimary (citable) accession number: Q12870
Secondary accession number(s): Q9NQQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 17, 2006
Last modified: January 7, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.